ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9AMN7_LEIMU

TriTrypDb:

LmxM.09.0365

Length:

210

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.384
CLV_NRD_NRD_1	67	69	PF00675	0.506
CLV_PCSK_KEX2_1	67	69	PF00082	0.506
CLV_PCSK_SKI1_1	148	152	PF00082	0.500
CLV_PCSK_SKI1_1	169	173	PF00082	0.369
CLV_PCSK_SKI1_1	47	51	PF00082	0.512
DEG_SPOP_SBC_1	180	184	PF00917	0.304
DOC_CDC14_PxL_1	150	158	PF14671	0.304
DOC_CYCLIN_RxL_1	164	173	PF00134	0.325
DOC_CYCLIN_RxL_1	44	54	PF00134	0.493
DOC_MAPK_MEF2A_6	195	204	PF00069	0.284
DOC_MAPK_MEF2A_6	99	107	PF00069	0.409
DOC_PP4_FxxP_1	151	154	PF00568	0.363
DOC_USP7_MATH_1	18	22	PF00917	0.627
DOC_USP7_MATH_1	6	10	PF00917	0.582
LIG_14-3-3_CanoR_1	124	132	PF00244	0.388
LIG_14-3-3_CanoR_1	195	204	PF00244	0.417
LIG_14-3-3_CanoR_1	22	31	PF00244	0.543
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BIR_III_4	130	134	PF00653	0.382
LIG_eIF4E_1	197	203	PF01652	0.325
LIG_EVH1_2	154	158	PF00568	0.304
LIG_FHA_1	181	187	PF00498	0.451
LIG_FHA_1	51	57	PF00498	0.503
LIG_FHA_2	22	28	PF00498	0.583
LIG_Pex14_2	145	149	PF04695	0.514
LIG_Pex14_2	158	162	PF04695	0.304
LIG_SH2_CRK	140	144	PF00017	0.446
LIG_SH2_CRK	197	201	PF00017	0.304
LIG_SH2_STAP1	197	201	PF00017	0.284
LIG_SH2_STAT3	191	194	PF00017	0.325
LIG_SUMO_SIM_anti_2	198	209	PF11976	0.284
LIG_SUMO_SIM_par_1	200	209	PF11976	0.436
LIG_TRAF2_1	58	61	PF00917	0.480
MOD_CK1_1	125	131	PF00069	0.334
MOD_CK1_1	21	27	PF00069	0.666
MOD_CK1_1	92	98	PF00069	0.628
MOD_CK2_1	21	27	PF00069	0.594
MOD_CK2_1	38	44	PF00069	0.394
MOD_CK2_1	55	61	PF00069	0.507
MOD_GlcNHglycan	1	4	PF01048	0.519
MOD_GlcNHglycan	124	127	PF01048	0.501
MOD_GlcNHglycan	197	200	PF01048	0.351
MOD_GSK3_1	1	8	PF00069	0.665
MOD_GSK3_1	18	25	PF00069	0.490
MOD_GSK3_1	202	209	PF00069	0.329
MOD_NEK2_1	1	6	PF00069	0.717
MOD_NEK2_1	202	207	PF00069	0.498
MOD_PKA_2	21	27	PF00069	0.565
TRG_DiLeu_BaEn_1	52	57	PF01217	0.518
TRG_DiLeu_BaEn_3	165	171	PF01217	0.278
TRG_DiLeu_BaEn_4	60	66	PF01217	0.452
TRG_ENDOCYTIC_2	140	143	PF00928	0.506
TRG_ENDOCYTIC_2	197	200	PF00928	0.304
TRG_ER_diArg_1	67	69	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ4	Leptomonas seymouri	54%	88%
A0A3S7WQK8	Leishmania donovani	92%	100%
A4H5L1	Leishmania braziliensis	75%	100%
A4HTV0	Leishmania infantum	92%	100%
Q4QHY8	Leishmania major	89%	100%