Putative DNA photolyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA photolyase, putative

Species:

Leishmania mexicana

UniProt:

E9AMN6_LEIMU

TriTrypDb:

LmxM.09.0360

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN6

Function

Biological processes
Term	Name	Level	Count
GO:0000719	photoreactive repair	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006290	pyrimidine dimer repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003904	deoxyribodipyrimidine photo-lyase activity	5	8
GO:0003913	DNA photolyase activity	4	8
GO:0016829	lyase activity	2	11
GO:0016830	carbon-carbon lyase activity	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0000166	nucleotide binding	3	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0050660	flavin adenine dinucleotide binding	4	1
GO:0071949	FAD binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	552	556	PF00656	0.594
CLV_NRD_NRD_1	104	106	PF00675	0.635
CLV_NRD_NRD_1	306	308	PF00675	0.308
CLV_NRD_NRD_1	351	353	PF00675	0.297
CLV_NRD_NRD_1	359	361	PF00675	0.246
CLV_NRD_NRD_1	584	586	PF00675	0.630
CLV_NRD_NRD_1	609	611	PF00675	0.312
CLV_NRD_NRD_1	642	644	PF00675	0.322
CLV_NRD_NRD_1	677	679	PF00675	0.301
CLV_NRD_NRD_1	912	914	PF00675	0.701
CLV_PCSK_FUR_1	582	586	PF00082	0.614
CLV_PCSK_KEX2_1	104	106	PF00082	0.802
CLV_PCSK_KEX2_1	306	308	PF00082	0.308
CLV_PCSK_KEX2_1	351	353	PF00082	0.296
CLV_PCSK_KEX2_1	359	361	PF00082	0.245
CLV_PCSK_KEX2_1	584	586	PF00082	0.630
CLV_PCSK_KEX2_1	642	644	PF00082	0.322
CLV_PCSK_KEX2_1	929	931	PF00082	0.701
CLV_PCSK_PC1ET2_1	929	931	PF00082	0.701
CLV_PCSK_SKI1_1	215	219	PF00082	0.460
CLV_PCSK_SKI1_1	520	524	PF00082	0.467
CLV_PCSK_SKI1_1	625	629	PF00082	0.469
CLV_PCSK_SKI1_1	656	660	PF00082	0.477
CLV_PCSK_SKI1_1	712	716	PF00082	0.274
CLV_PCSK_SKI1_1	929	933	PF00082	0.451
CLV_Separin_Metazoa	614	618	PF03568	0.390
CLV_Separin_Metazoa	763	767	PF03568	0.464
DEG_APCC_DBOX_1	519	527	PF00400	0.475
DEG_APCC_DBOX_1	633	641	PF00400	0.344
DEG_APCC_DBOX_1	711	719	PF00400	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DEG_SCF_FBW7_1	17	22	PF00400	0.676
DEG_SPOP_SBC_1	233	237	PF00917	0.561
DOC_CKS1_1	134	139	PF01111	0.631
DOC_CKS1_1	455	460	PF01111	0.537
DOC_CYCLIN_yCln2_LP_2	313	319	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.464
DOC_MAPK_DCC_7	323	333	PF00069	0.457
DOC_MAPK_DCC_7	817	825	PF00069	0.457
DOC_MAPK_gen_1	104	112	PF00069	0.580
DOC_MAPK_gen_1	306	315	PF00069	0.444
DOC_MAPK_gen_1	351	358	PF00069	0.501
DOC_MAPK_gen_1	594	604	PF00069	0.423
DOC_MAPK_HePTP_8	305	317	PF00069	0.444
DOC_MAPK_MEF2A_6	132	141	PF00069	0.526
DOC_MAPK_MEF2A_6	225	234	PF00069	0.484
DOC_MAPK_MEF2A_6	308	317	PF00069	0.444
DOC_MAPK_MEF2A_6	597	604	PF00069	0.405
DOC_MAPK_RevD_3	596	611	PF00069	0.449
DOC_PP1_RVXF_1	654	660	PF00149	0.481
DOC_PP2B_LxvP_1	144	147	PF13499	0.571
DOC_PP2B_LxvP_1	17	20	PF13499	0.622
DOC_PP2B_LxvP_1	208	211	PF13499	0.564
DOC_PP2B_LxvP_1	313	316	PF13499	0.444
DOC_PP2B_PxIxI_1	265	271	PF00149	0.458
DOC_PP2B_PxIxI_1	403	409	PF00149	0.525
DOC_PP4_FxxP_1	278	281	PF00568	0.444
DOC_PP4_FxxP_1	761	764	PF00568	0.475
DOC_USP7_MATH_1	217	221	PF00917	0.488
DOC_USP7_MATH_1	248	252	PF00917	0.547
DOC_USP7_MATH_1	279	283	PF00917	0.468
DOC_USP7_MATH_1	514	518	PF00917	0.539
DOC_USP7_MATH_1	548	552	PF00917	0.490
DOC_USP7_MATH_1	829	833	PF00917	0.566
DOC_USP7_MATH_1	912	916	PF00917	0.694
DOC_USP7_MATH_1	923	927	PF00917	0.654
DOC_WW_Pin1_4	133	138	PF00397	0.633
DOC_WW_Pin1_4	15	20	PF00397	0.664
DOC_WW_Pin1_4	21	26	PF00397	0.685
DOC_WW_Pin1_4	288	293	PF00397	0.462
DOC_WW_Pin1_4	386	391	PF00397	0.735
DOC_WW_Pin1_4	454	459	PF00397	0.536
DOC_WW_Pin1_4	51	56	PF00397	0.660
DOC_WW_Pin1_4	596	601	PF00397	0.335
DOC_WW_Pin1_4	605	610	PF00397	0.299
DOC_WW_Pin1_4	870	875	PF00397	0.515
LIG_14-3-3_CanoR_1	178	184	PF00244	0.567
LIG_14-3-3_CanoR_1	186	190	PF00244	0.517
LIG_14-3-3_CanoR_1	656	662	PF00244	0.480
LIG_14-3-3_CanoR_1	736	740	PF00244	0.457
LIG_14-3-3_CanoR_1	831	838	PF00244	0.691
LIG_14-3-3_CanoR_1	902	907	PF00244	0.447
LIG_14-3-3_CterR_2	930	933	PF00244	0.452
LIG_AP2alpha_2	742	744	PF02296	0.444
LIG_Clathr_ClatBox_1	449	453	PF01394	0.352
LIG_deltaCOP1_diTrp_1	644	653	PF00928	0.309
LIG_deltaCOP1_diTrp_1	726	733	PF00928	0.444
LIG_FHA_1	134	140	PF00498	0.689
LIG_FHA_1	155	161	PF00498	0.746
LIG_FHA_1	16	22	PF00498	0.722
LIG_FHA_1	178	184	PF00498	0.614
LIG_FHA_1	234	240	PF00498	0.566
LIG_FHA_1	310	316	PF00498	0.533
LIG_FHA_1	486	492	PF00498	0.515
LIG_FHA_1	573	579	PF00498	0.397
LIG_FHA_1	666	672	PF00498	0.444
LIG_FHA_1	702	708	PF00498	0.444
LIG_FHA_2	200	206	PF00498	0.494
LIG_FHA_2	387	393	PF00498	0.633
LIG_FHA_2	504	510	PF00498	0.463
LIG_LIR_Apic_2	194	200	PF02991	0.507
LIG_LIR_Apic_2	277	281	PF02991	0.500
LIG_LIR_Apic_2	759	764	PF02991	0.475
LIG_LIR_Gen_1	540	548	PF02991	0.615
LIG_LIR_Gen_1	599	609	PF02991	0.391
LIG_LIR_Gen_1	644	653	PF02991	0.376
LIG_LIR_Gen_1	881	890	PF02991	0.565
LIG_LIR_Nem_3	274	278	PF02991	0.458
LIG_LIR_Nem_3	540	546	PF02991	0.601
LIG_LIR_Nem_3	599	604	PF02991	0.401
LIG_LIR_Nem_3	655	661	PF02991	0.485
LIG_LIR_Nem_3	738	744	PF02991	0.444
LIG_LIR_Nem_3	889	894	PF02991	0.539
LIG_LYPXL_SIV_4	483	491	PF13949	0.459
LIG_MYND_3	523	527	PF01753	0.528
LIG_NRBOX	714	720	PF00104	0.444
LIG_PCNA_yPIPBox_3	564	578	PF02747	0.458
LIG_PTB_Apo_2	746	753	PF02174	0.427
LIG_PTB_Apo_2	764	771	PF02174	0.522
LIG_PTB_Phospho_1	746	752	PF10480	0.427
LIG_PTB_Phospho_1	764	770	PF10480	0.522
LIG_REV1ctd_RIR_1	285	291	PF16727	0.475
LIG_SH2_NCK_1	484	488	PF00017	0.455
LIG_SH2_NCK_1	531	535	PF00017	0.446
LIG_SH2_PTP2	601	604	PF00017	0.396
LIG_SH2_SRC	346	349	PF00017	0.457
LIG_SH2_SRC	750	753	PF00017	0.501
LIG_SH2_SRC	852	855	PF00017	0.472
LIG_SH2_STAP1	531	535	PF00017	0.496
LIG_SH2_STAP1	591	595	PF00017	0.435
LIG_SH2_STAP1	852	856	PF00017	0.476
LIG_SH2_STAT3	841	844	PF00017	0.662
LIG_SH2_STAT5	189	192	PF00017	0.416
LIG_SH2_STAT5	197	200	PF00017	0.484
LIG_SH2_STAT5	601	604	PF00017	0.317
LIG_SH2_STAT5	770	773	PF00017	0.529
LIG_SH2_STAT5	781	784	PF00017	0.403
LIG_SH2_STAT5	796	799	PF00017	0.444
LIG_SH2_STAT5	814	817	PF00017	0.444
LIG_SH2_STAT5	876	879	PF00017	0.544
LIG_SH3_3	136	142	PF00018	0.685
LIG_SH3_3	477	483	PF00018	0.428
LIG_SH3_3	52	58	PF00018	0.653
LIG_SH3_3	844	850	PF00018	0.584
LIG_SH3_3	859	865	PF00018	0.570
LIG_SUMO_SIM_par_1	142	148	PF11976	0.642
LIG_SUMO_SIM_par_1	229	238	PF11976	0.413
LIG_SUMO_SIM_par_1	400	410	PF11976	0.605
LIG_SUMO_SIM_par_1	57	64	PF11976	0.593
LIG_TRAF2_1	34	37	PF00917	0.497
LIG_TRAF2_1	368	371	PF00917	0.501
LIG_TRAF2_1	398	401	PF00917	0.584
LIG_TRAF2_1	542	545	PF00917	0.536
LIG_UBA3_1	122	127	PF00899	0.610
LIG_WRC_WIRS_1	275	280	PF05994	0.360
LIG_WW_1	793	796	PF00397	0.281
MOD_CDC14_SPxK_1	291	294	PF00782	0.296
MOD_CDC14_SPxK_1	608	611	PF00782	0.305
MOD_CDK_SPK_2	605	610	PF00069	0.299
MOD_CDK_SPxK_1	288	294	PF00069	0.296
MOD_CDK_SPxK_1	605	611	PF00069	0.303
MOD_CK1_1	168	174	PF00069	0.710
MOD_CK1_1	220	226	PF00069	0.604
MOD_CK2_1	199	205	PF00069	0.508
MOD_CK2_1	365	371	PF00069	0.426
MOD_CK2_1	394	400	PF00069	0.684
MOD_CK2_1	503	509	PF00069	0.443
MOD_CK2_1	902	908	PF00069	0.686
MOD_Cter_Amidation	102	105	PF01082	0.636
MOD_GlcNHglycan	101	104	PF01048	0.530
MOD_GlcNHglycan	169	173	PF01048	0.735
MOD_GlcNHglycan	219	222	PF01048	0.713
MOD_GlcNHglycan	396	399	PF01048	0.609
MOD_GlcNHglycan	531	534	PF01048	0.557
MOD_GlcNHglycan	7	10	PF01048	0.472
MOD_GlcNHglycan	833	836	PF01048	0.608
MOD_GlcNHglycan	859	862	PF01048	0.554
MOD_GlcNHglycan	86	89	PF01048	0.654
MOD_GlcNHglycan	888	891	PF01048	0.421
MOD_GlcNHglycan	914	917	PF01048	0.680
MOD_GSK3_1	15	22	PF00069	0.724
MOD_GSK3_1	373	380	PF00069	0.326
MOD_GSK3_1	423	430	PF00069	0.620
MOD_GSK3_1	440	447	PF00069	0.337
MOD_GSK3_1	474	481	PF00069	0.411
MOD_GSK3_1	585	592	PF00069	0.508
MOD_NEK2_1	122	127	PF00069	0.610
MOD_NEK2_1	298	303	PF00069	0.300
MOD_NEK2_1	309	314	PF00069	0.300
MOD_NEK2_1	341	346	PF00069	0.274
MOD_NEK2_1	45	50	PF00069	0.584
MOD_NEK2_1	529	534	PF00069	0.552
MOD_NEK2_1	638	643	PF00069	0.331
MOD_NEK2_1	657	662	PF00069	0.351
MOD_NEK2_1	701	706	PF00069	0.281
MOD_NEK2_1	83	88	PF00069	0.590
MOD_NEK2_2	924	929	PF00069	0.571
MOD_PIKK_1	154	160	PF00454	0.673
MOD_PIKK_1	220	226	PF00454	0.548
MOD_PIKK_1	341	347	PF00454	0.281
MOD_PIKK_1	546	552	PF00454	0.489
MOD_PIKK_1	589	595	PF00454	0.426
MOD_PKA_2	177	183	PF00069	0.556
MOD_PKA_2	185	191	PF00069	0.465
MOD_PKA_2	423	429	PF00069	0.593
MOD_PKA_2	478	484	PF00069	0.393
MOD_PKA_2	536	542	PF00069	0.666
MOD_PKA_2	583	589	PF00069	0.532
MOD_PKA_2	638	644	PF00069	0.327
MOD_PKA_2	735	741	PF00069	0.281
MOD_PKA_2	912	918	PF00069	0.697
MOD_Plk_1	168	174	PF00069	0.663
MOD_Plk_1	309	315	PF00069	0.312
MOD_Plk_1	373	379	PF00069	0.197
MOD_Plk_1	471	477	PF00069	0.442
MOD_Plk_1	924	930	PF00069	0.447
MOD_Plk_2-3	735	741	PF00069	0.281
MOD_Plk_4	185	191	PF00069	0.422
MOD_Plk_4	362	368	PF00069	0.356
MOD_Plk_4	373	379	PF00069	0.413
MOD_Plk_4	440	446	PF00069	0.343
MOD_Plk_4	514	520	PF00069	0.610
MOD_Plk_4	573	579	PF00069	0.397
MOD_Plk_4	881	887	PF00069	0.602
MOD_ProDKin_1	133	139	PF00069	0.633
MOD_ProDKin_1	15	21	PF00069	0.666
MOD_ProDKin_1	288	294	PF00069	0.307
MOD_ProDKin_1	386	392	PF00069	0.737
MOD_ProDKin_1	454	460	PF00069	0.536
MOD_ProDKin_1	51	57	PF00069	0.652
MOD_ProDKin_1	596	602	PF00069	0.333
MOD_ProDKin_1	605	611	PF00069	0.303
MOD_ProDKin_1	870	876	PF00069	0.508
MOD_SUMO_rev_2	673	681	PF00179	0.281
MOD_SUMO_rev_2	92	98	PF00179	0.486
TRG_DiLeu_BaEn_1	558	563	PF01217	0.310
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.697
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.281
TRG_DiLeu_LyEn_5	401	406	PF01217	0.561
TRG_ENDOCYTIC_2	275	278	PF00928	0.281
TRG_ENDOCYTIC_2	601	604	PF00928	0.355
TRG_ENDOCYTIC_2	612	615	PF00928	0.283
TRG_ENDOCYTIC_2	741	744	PF00928	0.281
TRG_ENDOCYTIC_2	80	83	PF00928	0.414
TRG_ER_diArg_1	305	307	PF00400	0.349
TRG_ER_diArg_1	351	353	PF00400	0.374
TRG_ER_diArg_1	358	360	PF00400	0.321
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXX3	Leptomonas seymouri	65%	92%
A0A1X0NMQ9	Trypanosomatidae	55%	100%
A0A3S7WQJ5	Leishmania donovani	93%	100%
A0A422N7E2	Trypanosoma rangeli	57%	100%
A4H5L0	Leishmania braziliensis	83%	100%
A4HTU9	Leishmania infantum	93%	100%
D0A9A9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
Q4QHY9	Leishmania major	92%	100%
V5B2X6	Trypanosoma cruzi	58%	100%