Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMN4_LEIMU

TriTrypDb:

LmxM.09.0345

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.528
CLV_NRD_NRD_1	205	207	PF00675	0.689
CLV_NRD_NRD_1	209	211	PF00675	0.662
CLV_PCSK_FUR_1	132	136	PF00082	0.487
CLV_PCSK_FUR_1	206	210	PF00082	0.620
CLV_PCSK_KEX2_1	134	136	PF00082	0.593
CLV_PCSK_KEX2_1	142	144	PF00082	0.488
CLV_PCSK_KEX2_1	207	209	PF00082	0.665
CLV_PCSK_KEX2_1	7	9	PF00082	0.562
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.553
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.762
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.562
CLV_PCSK_PC7_1	3	9	PF00082	0.562
CLV_PCSK_SKI1_1	61	65	PF00082	0.536
DEG_SPOP_SBC_1	121	125	PF00917	0.504
DOC_MAPK_gen_1	7	16	PF00069	0.530
DOC_MAPK_JIP1_4	10	16	PF00069	0.588
DOC_MAPK_MEF2A_6	7	15	PF00069	0.549
DOC_PP2B_PxIxI_1	10	16	PF00149	0.551
DOC_USP7_MATH_1	121	125	PF00917	0.648
DOC_USP7_MATH_1	130	134	PF00917	0.587
DOC_USP7_MATH_1	198	202	PF00917	0.734
DOC_WW_Pin1_4	113	118	PF00397	0.685
DOC_WW_Pin1_4	237	242	PF00397	0.550
DOC_WW_Pin1_4	40	45	PF00397	0.618
LIG_14-3-3_CanoR_1	169	175	PF00244	0.511
LIG_14-3-3_CanoR_1	209	217	PF00244	0.663
LIG_BIR_III_4	111	115	PF00653	0.517
LIG_FHA_1	121	127	PF00498	0.601
LIG_FHA_1	177	183	PF00498	0.710
LIG_FHA_1	53	59	PF00498	0.468
LIG_FHA_2	211	217	PF00498	0.683
LIG_LIR_Gen_1	89	100	PF02991	0.524
LIG_LIR_Nem_3	89	95	PF02991	0.543
LIG_NRP_CendR_1	243	244	PF00754	0.692
LIG_RPA_C_Plants	132	143	PF08784	0.468
LIG_SH2_STAP1	59	63	PF00017	0.423
LIG_TRAF2_1	43	46	PF00917	0.499
MOD_CDC14_SPxK_1	240	243	PF00782	0.508
MOD_CDK_SPxK_1	237	243	PF00069	0.497
MOD_CDK_SPxxK_3	237	244	PF00069	0.501
MOD_CDK_SPxxK_3	40	47	PF00069	0.621
MOD_CK1_1	124	130	PF00069	0.665
MOD_CK1_1	39	45	PF00069	0.774
MOD_CK2_1	40	46	PF00069	0.700
MOD_Cter_Amidation	204	207	PF01082	0.588
MOD_GlcNHglycan	117	120	PF01048	0.722
MOD_GlcNHglycan	138	141	PF01048	0.631
MOD_GlcNHglycan	144	147	PF01048	0.654
MOD_GlcNHglycan	52	55	PF01048	0.521
MOD_GlcNHglycan	88	91	PF01048	0.467
MOD_GlcNHglycan	96	99	PF01048	0.529
MOD_GSK3_1	120	127	PF00069	0.692
MOD_GSK3_1	138	145	PF00069	0.569
MOD_GSK3_1	36	43	PF00069	0.724
MOD_GSK3_1	79	86	PF00069	0.482
MOD_NEK2_1	122	127	PF00069	0.634
MOD_NEK2_1	138	143	PF00069	0.639
MOD_NEK2_1	154	159	PF00069	0.481
MOD_NEK2_1	168	173	PF00069	0.390
MOD_NEK2_1	221	226	PF00069	0.509
MOD_PIKK_1	182	188	PF00454	0.624
MOD_PKA_1	142	148	PF00069	0.518
MOD_PKA_2	136	142	PF00069	0.584
MOD_PKA_2	168	174	PF00069	0.504
MOD_PKB_1	208	216	PF00069	0.664
MOD_Plk_4	83	89	PF00069	0.479
MOD_ProDKin_1	113	119	PF00069	0.685
MOD_ProDKin_1	237	243	PF00069	0.554
MOD_ProDKin_1	40	46	PF00069	0.616
MOD_SUMO_for_1	6	9	PF00179	0.557
TRG_ENDOCYTIC_2	70	73	PF00928	0.539
TRG_ER_diArg_1	135	138	PF00400	0.578
TRG_ER_diArg_1	142	144	PF00400	0.527
TRG_ER_diArg_1	206	209	PF00400	0.614
TRG_NLS_MonoCore_2	205	210	PF00514	0.665
TRG_NLS_MonoExtC_3	205	210	PF00514	0.665
TRG_NLS_MonoExtN_4	132	138	PF00514	0.481
TRG_NLS_MonoExtN_4	206	211	PF00514	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I643	Leptomonas seymouri	46%	100%
A0A3S7WQK0	Leishmania donovani	82%	97%
A4HTU7	Leishmania infantum	82%	97%
E9AI35	Leishmania braziliensis	69%	100%
Q4QHZ1	Leishmania major	85%	100%