LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AMN2_LEIMU
TriTrypDb:
LmxM.09.0330
Length:
851

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9AMN2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN2

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 5
GO:0006163 purine nucleotide metabolic process 5 5
GO:0006164 purine nucleotide biosynthetic process 6 5
GO:0006171 cAMP biosynthetic process 8 5
GO:0006725 cellular aromatic compound metabolic process 3 5
GO:0006753 nucleoside phosphate metabolic process 4 5
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0006807 nitrogen compound metabolic process 2 5
GO:0008152 metabolic process 1 5
GO:0009058 biosynthetic process 2 5
GO:0009117 nucleotide metabolic process 5 5
GO:0009150 purine ribonucleotide metabolic process 6 5
GO:0009152 purine ribonucleotide biosynthetic process 7 5
GO:0009165 nucleotide biosynthetic process 6 5
GO:0009187 cyclic nucleotide metabolic process 6 5
GO:0009190 cyclic nucleotide biosynthetic process 7 5
GO:0009259 ribonucleotide metabolic process 5 5
GO:0009260 ribonucleotide biosynthetic process 6 5
GO:0009987 cellular process 1 5
GO:0018130 heterocycle biosynthetic process 4 5
GO:0019438 aromatic compound biosynthetic process 4 5
GO:0019637 organophosphate metabolic process 3 5
GO:0019693 ribose phosphate metabolic process 4 5
GO:0034641 cellular nitrogen compound metabolic process 3 5
GO:0034654 nucleobase-containing compound biosynthetic process 4 5
GO:0044237 cellular metabolic process 2 5
GO:0044238 primary metabolic process 2 5
GO:0044249 cellular biosynthetic process 3 5
GO:0044271 cellular nitrogen compound biosynthetic process 4 5
GO:0044281 small molecule metabolic process 2 5
GO:0046058 cAMP metabolic process 7 5
GO:0046390 ribose phosphate biosynthetic process 5 5
GO:0046483 heterocycle metabolic process 3 5
GO:0052652 cyclic purine nucleotide metabolic process 6 5
GO:0055086 nucleobase-containing small molecule metabolic process 3 5
GO:0071704 organic substance metabolic process 2 5
GO:0072521 purine-containing compound metabolic process 4 5
GO:0072522 purine-containing compound biosynthetic process 5 5
GO:0090407 organophosphate biosynthetic process 4 5
GO:1901135 carbohydrate derivative metabolic process 3 5
GO:1901137 carbohydrate derivative biosynthetic process 4 5
GO:1901293 nucleoside phosphate biosynthetic process 5 5
GO:1901360 organic cyclic compound metabolic process 3 5
GO:1901362 organic cyclic compound biosynthetic process 4 5
GO:1901564 organonitrogen compound metabolic process 3 5
GO:1901566 organonitrogen compound biosynthetic process 4 5
GO:1901576 organic substance biosynthetic process 3 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 262 266 PF00656 0.293
CLV_C14_Caspase3-7 647 651 PF00656 0.496
CLV_NRD_NRD_1 128 130 PF00675 0.615
CLV_NRD_NRD_1 205 207 PF00675 0.535
CLV_NRD_NRD_1 250 252 PF00675 0.510
CLV_NRD_NRD_1 599 601 PF00675 0.417
CLV_NRD_NRD_1 713 715 PF00675 0.593
CLV_NRD_NRD_1 787 789 PF00675 0.625
CLV_NRD_NRD_1 820 822 PF00675 0.606
CLV_PCSK_KEX2_1 128 130 PF00082 0.610
CLV_PCSK_KEX2_1 205 207 PF00082 0.535
CLV_PCSK_KEX2_1 249 251 PF00082 0.673
CLV_PCSK_KEX2_1 599 601 PF00082 0.417
CLV_PCSK_KEX2_1 713 715 PF00082 0.584
CLV_PCSK_KEX2_1 787 789 PF00082 0.625
CLV_PCSK_KEX2_1 820 822 PF00082 0.532
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.673
CLV_PCSK_PC7_1 816 822 PF00082 0.507
CLV_PCSK_SKI1_1 442 446 PF00082 0.401
CLV_PCSK_SKI1_1 450 454 PF00082 0.377
CLV_PCSK_SKI1_1 542 546 PF00082 0.454
CLV_PCSK_SKI1_1 600 604 PF00082 0.312
CLV_PCSK_SKI1_1 638 642 PF00082 0.662
CLV_PCSK_SKI1_1 714 718 PF00082 0.674
CLV_PCSK_SKI1_1 726 730 PF00082 0.662
CLV_PCSK_SKI1_1 742 746 PF00082 0.491
CLV_PCSK_SKI1_1 771 775 PF00082 0.569
CLV_PCSK_SKI1_1 788 792 PF00082 0.583
CLV_PCSK_SKI1_1 821 825 PF00082 0.670
DEG_APCC_DBOX_1 12 20 PF00400 0.685
DEG_APCC_DBOX_1 507 515 PF00400 0.550
DEG_APCC_DBOX_1 725 733 PF00400 0.422
DEG_SCF_FBW7_1 172 177 PF00400 0.378
DEG_SPOP_SBC_1 408 412 PF00917 0.592
DEG_SPOP_SBC_1 642 646 PF00917 0.411
DOC_CDC14_PxL_1 686 694 PF14671 0.433
DOC_CDC14_PxL_1 98 106 PF14671 0.354
DOC_CKS1_1 571 576 PF01111 0.624
DOC_CYCLIN_yCln2_LP_2 728 734 PF00134 0.371
DOC_CYCLIN_yCln2_LP_2 773 779 PF00134 0.418
DOC_MAPK_gen_1 713 719 PF00069 0.375
DOC_MAPK_gen_1 816 824 PF00069 0.317
DOC_MAPK_MEF2A_6 20 29 PF00069 0.565
DOC_MAPK_MEF2A_6 735 743 PF00069 0.444
DOC_MAPK_MEF2A_6 755 763 PF00069 0.263
DOC_PP1_RVXF_1 740 746 PF00149 0.382
DOC_PP1_RVXF_1 769 775 PF00149 0.383
DOC_PP2B_LxvP_1 104 107 PF13499 0.383
DOC_PP2B_LxvP_1 490 493 PF13499 0.468
DOC_PP2B_LxvP_1 777 780 PF13499 0.429
DOC_PP2B_LxvP_1 824 827 PF13499 0.375
DOC_PP4_FxxP_1 147 150 PF00568 0.369
DOC_PP4_FxxP_1 681 684 PF00568 0.407
DOC_PP4_FxxP_1 793 796 PF00568 0.360
DOC_USP7_MATH_1 188 192 PF00917 0.333
DOC_USP7_MATH_1 626 630 PF00917 0.532
DOC_USP7_MATH_1 642 646 PF00917 0.511
DOC_USP7_MATH_1 663 667 PF00917 0.652
DOC_USP7_MATH_1 672 676 PF00917 0.538
DOC_USP7_MATH_1 695 699 PF00917 0.526
DOC_WW_Pin1_4 146 151 PF00397 0.408
DOC_WW_Pin1_4 170 175 PF00397 0.415
DOC_WW_Pin1_4 292 297 PF00397 0.461
DOC_WW_Pin1_4 311 316 PF00397 0.487
DOC_WW_Pin1_4 42 47 PF00397 0.342
DOC_WW_Pin1_4 548 553 PF00397 0.662
DOC_WW_Pin1_4 566 571 PF00397 0.690
DOC_WW_Pin1_4 653 658 PF00397 0.608
DOC_WW_Pin1_4 829 834 PF00397 0.500
LIG_14-3-3_CanoR_1 190 196 PF00244 0.475
LIG_14-3-3_CanoR_1 211 215 PF00244 0.486
LIG_14-3-3_CanoR_1 250 254 PF00244 0.273
LIG_14-3-3_CanoR_1 287 293 PF00244 0.410
LIG_14-3-3_CanoR_1 450 456 PF00244 0.542
LIG_14-3-3_CanoR_1 526 531 PF00244 0.666
LIG_14-3-3_CanoR_1 664 672 PF00244 0.494
LIG_14-3-3_CanoR_1 787 796 PF00244 0.417
LIG_14-3-3_CterR_2 848 851 PF00244 0.467
LIG_APCC_ABBA_1 257 262 PF00400 0.341
LIG_BIR_III_2 583 587 PF00653 0.571
LIG_BRCT_BRCA1_1 326 330 PF00533 0.203
LIG_EH_1 238 242 PF12763 0.387
LIG_FHA_1 129 135 PF00498 0.354
LIG_FHA_1 190 196 PF00498 0.415
LIG_FHA_1 382 388 PF00498 0.610
LIG_FHA_1 409 415 PF00498 0.536
LIG_FHA_1 543 549 PF00498 0.693
LIG_FHA_1 707 713 PF00498 0.560
LIG_FHA_1 723 729 PF00498 0.361
LIG_FHA_1 749 755 PF00498 0.420
LIG_FHA_1 837 843 PF00498 0.492
LIG_FHA_2 116 122 PF00498 0.359
LIG_FHA_2 171 177 PF00498 0.385
LIG_FHA_2 210 216 PF00498 0.373
LIG_FHA_2 426 432 PF00498 0.596
LIG_FHA_2 495 501 PF00498 0.586
LIG_FHA_2 592 598 PF00498 0.586
LIG_FHA_2 653 659 PF00498 0.435
LIG_FHA_2 671 677 PF00498 0.489
LIG_LIR_Apic_2 679 684 PF02991 0.406
LIG_LIR_Apic_2 791 796 PF02991 0.416
LIG_LIR_Gen_1 114 125 PF02991 0.359
LIG_LIR_Gen_1 173 183 PF02991 0.465
LIG_LIR_Gen_1 252 259 PF02991 0.270
LIG_LIR_Gen_1 284 292 PF02991 0.422
LIG_LIR_Gen_1 327 338 PF02991 0.210
LIG_LIR_Gen_1 746 754 PF02991 0.378
LIG_LIR_Nem_3 114 120 PF02991 0.323
LIG_LIR_Nem_3 173 178 PF02991 0.456
LIG_LIR_Nem_3 220 225 PF02991 0.369
LIG_LIR_Nem_3 23 29 PF02991 0.526
LIG_LIR_Nem_3 252 256 PF02991 0.349
LIG_LIR_Nem_3 284 288 PF02991 0.465
LIG_LIR_Nem_3 327 333 PF02991 0.209
LIG_LIR_Nem_3 746 750 PF02991 0.381
LIG_LIR_Nem_3 753 759 PF02991 0.383
LIG_LIR_Nem_3 768 773 PF02991 0.381
LIG_MAD2 10 18 PF02301 0.656
LIG_MAD2 99 107 PF02301 0.269
LIG_MYND_1 14 18 PF01753 0.655
LIG_NRBOX 591 597 PF00104 0.595
LIG_NRP_CendR_1 848 851 PF00754 0.667
LIG_PCNA_PIPBox_1 797 806 PF02747 0.386
LIG_Pex14_1 223 227 PF04695 0.290
LIG_Pex14_2 40 44 PF04695 0.365
LIG_SH2_CRK 550 554 PF00017 0.601
LIG_SH2_CRK 747 751 PF00017 0.422
LIG_SH2_CRK 76 80 PF00017 0.342
LIG_SH2_CRK 770 774 PF00017 0.441
LIG_SH2_GRB2like 843 846 PF00017 0.385
LIG_SH2_NCK_1 214 218 PF00017 0.383
LIG_SH2_NCK_1 347 351 PF00017 0.574
LIG_SH2_NCK_1 550 554 PF00017 0.601
LIG_SH2_NCK_1 66 70 PF00017 0.409
LIG_SH2_PTP2 185 188 PF00017 0.366
LIG_SH2_PTP2 26 29 PF00017 0.365
LIG_SH2_SRC 756 759 PF00017 0.432
LIG_SH2_STAP1 347 351 PF00017 0.574
LIG_SH2_STAP1 455 459 PF00017 0.560
LIG_SH2_STAP1 57 61 PF00017 0.380
LIG_SH2_STAT3 401 404 PF00017 0.605
LIG_SH2_STAT3 812 815 PF00017 0.301
LIG_SH2_STAT5 185 188 PF00017 0.366
LIG_SH2_STAT5 255 258 PF00017 0.345
LIG_SH2_STAT5 26 29 PF00017 0.407
LIG_SH2_STAT5 413 416 PF00017 0.555
LIG_SH2_STAT5 66 69 PF00017 0.387
LIG_SH2_STAT5 765 768 PF00017 0.335
LIG_SH2_STAT5 812 815 PF00017 0.334
LIG_SH2_STAT5 93 96 PF00017 0.357
LIG_SH3_3 201 207 PF00018 0.263
LIG_SH3_3 293 299 PF00018 0.406
LIG_SH3_3 546 552 PF00018 0.671
LIG_SH3_3 583 589 PF00018 0.723
LIG_SH3_3 636 642 PF00018 0.503
LIG_SH3_3 685 691 PF00018 0.496
LIG_SH3_3 728 734 PF00018 0.414
LIG_SH3_3 8 14 PF00018 0.727
LIG_SUMO_SIM_anti_2 262 273 PF11976 0.274
LIG_SUMO_SIM_anti_2 45 51 PF11976 0.355
LIG_SUMO_SIM_par_1 317 324 PF11976 0.329
LIG_SUMO_SIM_par_1 77 82 PF11976 0.323
LIG_TRAF2_1 428 431 PF00917 0.649
LIG_TYR_ITIM 754 759 PF00017 0.434
LIG_UBA3_1 47 55 PF00899 0.468
LIG_WRC_WIRS_1 219 224 PF05994 0.442
MOD_CDK_SPK_2 829 834 PF00069 0.529
MOD_CK1_1 151 157 PF00069 0.376
MOD_CK1_1 213 219 PF00069 0.644
MOD_CK1_1 311 317 PF00069 0.497
MOD_CK1_1 412 418 PF00069 0.451
MOD_CK1_1 513 519 PF00069 0.484
MOD_CK1_1 551 557 PF00069 0.655
MOD_CK1_1 620 626 PF00069 0.625
MOD_CK1_1 644 650 PF00069 0.679
MOD_CK1_1 666 672 PF00069 0.734
MOD_CK1_1 682 688 PF00069 0.654
MOD_CK1_1 693 699 PF00069 0.586
MOD_CK2_1 170 176 PF00069 0.505
MOD_CK2_1 209 215 PF00069 0.407
MOD_CK2_1 424 430 PF00069 0.477
MOD_CK2_1 494 500 PF00069 0.465
MOD_CK2_1 576 582 PF00069 0.648
MOD_CK2_1 670 676 PF00069 0.666
MOD_CK2_1 829 835 PF00069 0.677
MOD_GlcNHglycan 104 107 PF01048 0.481
MOD_GlcNHglycan 179 182 PF01048 0.562
MOD_GlcNHglycan 215 218 PF01048 0.545
MOD_GlcNHglycan 232 235 PF01048 0.272
MOD_GlcNHglycan 326 329 PF01048 0.447
MOD_GlcNHglycan 542 545 PF01048 0.586
MOD_GlcNHglycan 617 620 PF01048 0.691
MOD_GlcNHglycan 628 631 PF01048 0.677
MOD_GlcNHglycan 665 668 PF01048 0.603
MOD_GlcNHglycan 681 684 PF01048 0.730
MOD_GSK3_1 148 155 PF00069 0.334
MOD_GSK3_1 170 177 PF00069 0.513
MOD_GSK3_1 209 216 PF00069 0.629
MOD_GSK3_1 241 248 PF00069 0.523
MOD_GSK3_1 261 268 PF00069 0.531
MOD_GSK3_1 288 295 PF00069 0.388
MOD_GSK3_1 320 327 PF00069 0.403
MOD_GSK3_1 408 415 PF00069 0.425
MOD_GSK3_1 466 473 PF00069 0.563
MOD_GSK3_1 526 533 PF00069 0.644
MOD_GSK3_1 548 555 PF00069 0.636
MOD_GSK3_1 566 573 PF00069 0.731
MOD_GSK3_1 591 598 PF00069 0.366
MOD_GSK3_1 613 620 PF00069 0.517
MOD_GSK3_1 622 629 PF00069 0.582
MOD_GSK3_1 641 648 PF00069 0.560
MOD_GSK3_1 658 665 PF00069 0.740
MOD_GSK3_1 666 673 PF00069 0.694
MOD_GSK3_1 690 697 PF00069 0.706
MOD_GSK3_1 829 836 PF00069 0.615
MOD_N-GLC_1 102 107 PF02516 0.584
MOD_N-GLC_1 115 120 PF02516 0.577
MOD_N-GLC_1 151 156 PF02516 0.611
MOD_N-GLC_1 209 214 PF02516 0.505
MOD_N-GLC_1 230 235 PF02516 0.437
MOD_N-GLC_1 244 249 PF02516 0.573
MOD_N-GLC_1 260 265 PF02516 0.495
MOD_N-GLC_1 311 316 PF02516 0.489
MOD_NEK2_1 225 230 PF00069 0.382
MOD_NEK2_1 241 246 PF00069 0.520
MOD_NEK2_1 270 275 PF00069 0.557
MOD_NEK2_1 288 293 PF00069 0.267
MOD_NEK2_1 300 305 PF00069 0.400
MOD_NEK2_1 409 414 PF00069 0.450
MOD_NEK2_1 424 429 PF00069 0.442
MOD_NEK2_1 451 456 PF00069 0.401
MOD_NEK2_1 470 475 PF00069 0.646
MOD_NEK2_1 530 535 PF00069 0.639
MOD_NEK2_1 595 600 PF00069 0.457
MOD_NEK2_1 617 622 PF00069 0.525
MOD_NEK2_1 766 771 PF00069 0.469
MOD_NEK2_1 84 89 PF00069 0.492
MOD_NEK2_2 174 179 PF00069 0.310
MOD_NEK2_2 255 260 PF00069 0.383
MOD_PIKK_1 277 283 PF00454 0.455
MOD_PIKK_1 836 842 PF00454 0.539
MOD_PIKK_1 84 90 PF00454 0.428
MOD_PKA_1 128 134 PF00069 0.381
MOD_PKA_1 249 255 PF00069 0.312
MOD_PKA_2 128 134 PF00069 0.381
MOD_PKA_2 157 163 PF00069 0.503
MOD_PKA_2 189 195 PF00069 0.554
MOD_PKA_2 210 216 PF00069 0.602
MOD_PKA_2 249 255 PF00069 0.312
MOD_PKA_2 663 669 PF00069 0.623
MOD_Plk_1 151 157 PF00069 0.349
MOD_Plk_1 209 215 PF00069 0.516
MOD_Plk_1 217 223 PF00069 0.368
MOD_Plk_1 53 59 PF00069 0.448
MOD_Plk_1 64 70 PF00069 0.529
MOD_Plk_4 218 224 PF00069 0.445
MOD_Plk_4 321 327 PF00069 0.336
MOD_Plk_4 409 415 PF00069 0.389
MOD_ProDKin_1 146 152 PF00069 0.503
MOD_ProDKin_1 170 176 PF00069 0.510
MOD_ProDKin_1 292 298 PF00069 0.571
MOD_ProDKin_1 311 317 PF00069 0.607
MOD_ProDKin_1 42 48 PF00069 0.342
MOD_ProDKin_1 548 554 PF00069 0.578
MOD_ProDKin_1 566 572 PF00069 0.615
MOD_ProDKin_1 653 659 PF00069 0.780
MOD_ProDKin_1 829 835 PF00069 0.630
TRG_DiLeu_BaEn_1 448 453 PF01217 0.572
TRG_DiLeu_BaEn_1 758 763 PF01217 0.521
TRG_DiLeu_BaEn_2 236 242 PF01217 0.301
TRG_DiLeu_BaEn_4 370 376 PF01217 0.512
TRG_DiLeu_BaLyEn_6 43 48 PF01217 0.328
TRG_DiLeu_BaLyEn_6 447 452 PF01217 0.491
TRG_DiLeu_BaLyEn_6 728 733 PF01217 0.574
TRG_ENDOCYTIC_2 145 148 PF00928 0.501
TRG_ENDOCYTIC_2 26 29 PF00928 0.365
TRG_ENDOCYTIC_2 747 750 PF00928 0.447
TRG_ENDOCYTIC_2 756 759 PF00928 0.417
TRG_ENDOCYTIC_2 76 79 PF00928 0.414
TRG_ENDOCYTIC_2 770 773 PF00928 0.462
TRG_ENDOCYTIC_2 843 846 PF00928 0.595
TRG_ER_diArg_1 12 15 PF00400 0.638
TRG_ER_diArg_1 127 129 PF00400 0.432
TRG_ER_diArg_1 204 206 PF00400 0.395
TRG_ER_diArg_1 525 528 PF00400 0.576
TRG_ER_diArg_1 599 601 PF00400 0.512
TRG_ER_diArg_1 712 714 PF00400 0.468
TRG_ER_diArg_1 786 788 PF00400 0.518
TRG_ER_diArg_1 820 822 PF00400 0.393
TRG_ER_diArg_1 97 100 PF00400 0.306
TRG_NLS_MonoExtC_3 248 254 PF00514 0.395
TRG_Pf-PMV_PEXEL_1 726 730 PF00026 0.650
TRG_Pf-PMV_PEXEL_1 820 825 PF00026 0.459

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C6 Leptomonas seymouri 50% 99%
A0A3S5H6C4 Leishmania donovani 86% 100%
A4H5K7 Leishmania braziliensis 68% 100%
A4HTU4 Leishmania infantum 48% 100%
A4HTU5 Leishmania infantum 86% 100%
D0A9A6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 99%
E9AMN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 93%
Q4QHZ3 Leishmania major 82% 99%
Q4QHZ4 Leishmania major 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS