LeishMANIAdb
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CHASE domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CHASE domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AMN1_LEIMU
TriTrypDb:
LmxM.09.0320
Length:
917

Annotations

LeishMANIAdb annotations

Appears to be an enzyme-linked receptor, putatively a receptor nucleotide cyclase (cAMP synthase).. Expanded on the Leishmaniid lineage. The first helical segment is very similar to a signal peptide.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9AMN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 4
GO:0006163 purine nucleotide metabolic process 5 4
GO:0006164 purine nucleotide biosynthetic process 6 4
GO:0006171 cAMP biosynthetic process 8 4
GO:0006725 cellular aromatic compound metabolic process 3 4
GO:0006753 nucleoside phosphate metabolic process 4 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009058 biosynthetic process 2 4
GO:0009117 nucleotide metabolic process 5 4
GO:0009150 purine ribonucleotide metabolic process 6 4
GO:0009152 purine ribonucleotide biosynthetic process 7 4
GO:0009165 nucleotide biosynthetic process 6 4
GO:0009187 cyclic nucleotide metabolic process 6 4
GO:0009190 cyclic nucleotide biosynthetic process 7 4
GO:0009259 ribonucleotide metabolic process 5 4
GO:0009260 ribonucleotide biosynthetic process 6 4
GO:0009987 cellular process 1 4
GO:0018130 heterocycle biosynthetic process 4 4
GO:0019438 aromatic compound biosynthetic process 4 4
GO:0019637 organophosphate metabolic process 3 4
GO:0019693 ribose phosphate metabolic process 4 4
GO:0034641 cellular nitrogen compound metabolic process 3 4
GO:0034654 nucleobase-containing compound biosynthetic process 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0044249 cellular biosynthetic process 3 4
GO:0044271 cellular nitrogen compound biosynthetic process 4 4
GO:0044281 small molecule metabolic process 2 4
GO:0046058 cAMP metabolic process 7 4
GO:0046390 ribose phosphate biosynthetic process 5 4
GO:0046483 heterocycle metabolic process 3 4
GO:0052652 cyclic purine nucleotide metabolic process 6 4
GO:0055086 nucleobase-containing small molecule metabolic process 3 4
GO:0071704 organic substance metabolic process 2 4
GO:0072521 purine-containing compound metabolic process 4 4
GO:0072522 purine-containing compound biosynthetic process 5 4
GO:0090407 organophosphate biosynthetic process 4 4
GO:1901135 carbohydrate derivative metabolic process 3 4
GO:1901137 carbohydrate derivative biosynthetic process 4 4
GO:1901293 nucleoside phosphate biosynthetic process 5 4
GO:1901360 organic cyclic compound metabolic process 3 4
GO:1901362 organic cyclic compound biosynthetic process 4 4
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 124 126 PF00675 0.343
CLV_NRD_NRD_1 265 267 PF00675 0.358
CLV_NRD_NRD_1 848 850 PF00675 0.725
CLV_NRD_NRD_1 877 879 PF00675 0.630
CLV_PCSK_KEX2_1 124 126 PF00082 0.343
CLV_PCSK_KEX2_1 265 267 PF00082 0.358
CLV_PCSK_KEX2_1 273 275 PF00082 0.409
CLV_PCSK_KEX2_1 719 721 PF00082 0.642
CLV_PCSK_KEX2_1 848 850 PF00082 0.725
CLV_PCSK_PC1ET2_1 273 275 PF00082 0.303
CLV_PCSK_PC1ET2_1 719 721 PF00082 0.617
CLV_PCSK_SKI1_1 320 324 PF00082 0.303
CLV_PCSK_SKI1_1 518 522 PF00082 0.615
CLV_PCSK_SKI1_1 526 530 PF00082 0.550
CLV_PCSK_SKI1_1 776 780 PF00082 0.679
CLV_PCSK_SKI1_1 787 791 PF00082 0.663
CLV_PCSK_SKI1_1 803 807 PF00082 0.493
CLV_PCSK_SKI1_1 832 836 PF00082 0.634
CLV_PCSK_SKI1_1 849 853 PF00082 0.538
DEG_APCC_DBOX_1 583 591 PF00400 0.367
DEG_APCC_DBOX_1 786 794 PF00400 0.434
DEG_MDM2_SWIB_1 86 94 PF02201 0.425
DEG_SCF_FBW7_1 173 180 PF00400 0.541
DEG_SPOP_SBC_1 484 488 PF00917 0.425
DEG_SPOP_SBC_1 896 900 PF00917 0.427
DOC_CKS1_1 174 179 PF01111 0.597
DOC_CYCLIN_yClb1_LxF_4 324 330 PF00134 0.454
DOC_CYCLIN_yClb5_NLxxxL_5 323 331 PF00134 0.508
DOC_CYCLIN_yCln2_LP_2 789 795 PF00134 0.425
DOC_CYCLIN_yCln2_LP_2 834 840 PF00134 0.460
DOC_MAPK_gen_1 206 212 PF00069 0.520
DOC_MAPK_gen_1 273 279 PF00069 0.488
DOC_MAPK_gen_1 320 329 PF00069 0.461
DOC_MAPK_gen_1 381 389 PF00069 0.553
DOC_MAPK_gen_1 719 727 PF00069 0.407
DOC_MAPK_MEF2A_6 796 804 PF00069 0.403
DOC_MAPK_MEF2A_6 816 824 PF00069 0.298
DOC_MAPK_RevD_3 110 125 PF00069 0.268
DOC_PP1_RVXF_1 801 807 PF00149 0.389
DOC_PP1_RVXF_1 830 836 PF00149 0.425
DOC_PP2B_LxvP_1 566 569 PF13499 0.272
DOC_PP2B_LxvP_1 838 841 PF13499 0.470
DOC_PP4_FxxP_1 854 857 PF00568 0.445
DOC_USP7_MATH_1 14 18 PF00917 0.493
DOC_USP7_MATH_1 144 148 PF00917 0.525
DOC_USP7_MATH_1 372 376 PF00917 0.561
DOC_USP7_MATH_1 379 383 PF00917 0.494
DOC_USP7_MATH_1 668 672 PF00917 0.591
DOC_USP7_MATH_1 690 694 PF00917 0.447
DOC_USP7_MATH_1 707 711 PF00917 0.510
DOC_USP7_MATH_1 896 900 PF00917 0.444
DOC_USP7_MATH_1 905 909 PF00917 0.444
DOC_WW_Pin1_4 173 178 PF00397 0.586
DOC_WW_Pin1_4 235 240 PF00397 0.630
DOC_WW_Pin1_4 387 392 PF00397 0.569
DOC_WW_Pin1_4 47 52 PF00397 0.491
DOC_WW_Pin1_4 698 703 PF00397 0.519
DOC_WW_Pin1_4 76 81 PF00397 0.479
DOC_WW_Pin1_4 768 773 PF00397 0.468
DOC_WW_Pin1_4 901 906 PF00397 0.508
LIG_14-3-3_CanoR_1 15 19 PF00244 0.496
LIG_14-3-3_CanoR_1 198 203 PF00244 0.590
LIG_14-3-3_CanoR_1 265 272 PF00244 0.659
LIG_14-3-3_CanoR_1 286 294 PF00244 0.561
LIG_14-3-3_CanoR_1 526 532 PF00244 0.349
LIG_14-3-3_CanoR_1 593 599 PF00244 0.403
LIG_14-3-3_CanoR_1 605 611 PF00244 0.493
LIG_14-3-3_CanoR_1 848 857 PF00244 0.462
LIG_14-3-3_CanoR_1 85 91 PF00244 0.490
LIG_Actin_RPEL_3 376 395 PF02755 0.521
LIG_Actin_WH2_2 115 132 PF00022 0.326
LIG_Clathr_ClatBox_1 777 781 PF01394 0.454
LIG_deltaCOP1_diTrp_1 297 302 PF00928 0.500
LIG_FHA_1 100 106 PF00498 0.283
LIG_FHA_1 109 115 PF00498 0.254
LIG_FHA_1 188 194 PF00498 0.636
LIG_FHA_1 308 314 PF00498 0.553
LIG_FHA_1 339 345 PF00498 0.612
LIG_FHA_1 350 356 PF00498 0.503
LIG_FHA_1 365 371 PF00498 0.560
LIG_FHA_1 390 396 PF00498 0.489
LIG_FHA_1 458 464 PF00498 0.444
LIG_FHA_1 485 491 PF00498 0.410
LIG_FHA_1 595 601 PF00498 0.380
LIG_FHA_1 628 634 PF00498 0.369
LIG_FHA_1 784 790 PF00498 0.417
LIG_FHA_1 810 816 PF00498 0.432
LIG_FHA_2 332 338 PF00498 0.565
LIG_FHA_2 351 357 PF00498 0.526
LIG_FHA_2 363 369 PF00498 0.529
LIG_FHA_2 502 508 PF00498 0.382
LIG_FHA_2 571 577 PF00498 0.420
LIG_FHA_2 607 613 PF00498 0.418
LIG_FHA_2 8 14 PF00498 0.481
LIG_GBD_Chelix_1 398 406 PF00786 0.257
LIG_LIR_Apic_2 852 857 PF02991 0.460
LIG_LIR_Gen_1 143 153 PF02991 0.520
LIG_LIR_Gen_1 256 264 PF02991 0.576
LIG_LIR_Gen_1 356 362 PF02991 0.602
LIG_LIR_Gen_1 384 394 PF02991 0.551
LIG_LIR_Gen_1 592 601 PF02991 0.371
LIG_LIR_Gen_1 629 640 PF02991 0.347
LIG_LIR_Gen_1 807 815 PF02991 0.511
LIG_LIR_Nem_3 143 148 PF02991 0.554
LIG_LIR_Nem_3 169 174 PF02991 0.541
LIG_LIR_Nem_3 256 262 PF02991 0.576
LIG_LIR_Nem_3 297 303 PF02991 0.585
LIG_LIR_Nem_3 356 360 PF02991 0.620
LIG_LIR_Nem_3 384 389 PF02991 0.545
LIG_LIR_Nem_3 401 406 PF02991 0.220
LIG_LIR_Nem_3 592 598 PF02991 0.364
LIG_LIR_Nem_3 629 635 PF02991 0.319
LIG_LIR_Nem_3 670 676 PF02991 0.439
LIG_LIR_Nem_3 807 811 PF02991 0.501
LIG_LIR_Nem_3 814 820 PF02991 0.416
LIG_LIR_Nem_3 829 834 PF02991 0.324
LIG_PCNA_PIPBox_1 858 867 PF02747 0.432
LIG_PCNA_yPIPBox_3 756 765 PF02747 0.419
LIG_PDZ_Class_2 912 917 PF00595 0.443
LIG_Pex14_2 86 90 PF04695 0.450
LIG_SH2_CRK 259 263 PF00017 0.553
LIG_SH2_CRK 595 599 PF00017 0.334
LIG_SH2_CRK 673 677 PF00017 0.463
LIG_SH2_CRK 808 812 PF00017 0.463
LIG_SH2_CRK 831 835 PF00017 0.398
LIG_SH2_NCK_1 259 263 PF00017 0.553
LIG_SH2_NCK_1 423 427 PF00017 0.384
LIG_SH2_PTP2 386 389 PF00017 0.520
LIG_SH2_SRC 259 262 PF00017 0.531
LIG_SH2_SRC 817 820 PF00017 0.415
LIG_SH2_STAP1 357 361 PF00017 0.535
LIG_SH2_STAP1 423 427 PF00017 0.384
LIG_SH2_STAP1 531 535 PF00017 0.399
LIG_SH2_STAT3 477 480 PF00017 0.442
LIG_SH2_STAT5 192 195 PF00017 0.558
LIG_SH2_STAT5 386 389 PF00017 0.520
LIG_SH2_STAT5 489 492 PF00017 0.413
LIG_SH2_STAT5 586 589 PF00017 0.322
LIG_SH2_STAT5 632 635 PF00017 0.369
LIG_SH2_STAT5 673 676 PF00017 0.465
LIG_SH2_STAT5 826 829 PF00017 0.417
LIG_SH2_STAT5 99 102 PF00017 0.428
LIG_SH3_3 223 229 PF00018 0.574
LIG_SH3_3 236 242 PF00018 0.577
LIG_SH3_3 45 51 PF00018 0.488
LIG_SH3_3 69 75 PF00018 0.522
LIG_SH3_3 789 795 PF00018 0.425
LIG_SUMO_SIM_anti_2 392 398 PF11976 0.508
LIG_SUMO_SIM_anti_2 405 410 PF11976 0.237
LIG_SUMO_SIM_par_1 776 781 PF11976 0.457
LIG_TRAF2_1 10 13 PF00917 0.488
LIG_TRAF2_1 42 45 PF00917 0.484
LIG_TRAF2_1 504 507 PF00917 0.423
LIG_TYR_ITIM 815 820 PF00017 0.420
LIG_TYR_ITSM 628 635 PF00017 0.308
LIG_WRC_WIRS_1 296 301 PF05994 0.570
MOD_CK1_1 167 173 PF00069 0.584
MOD_CK1_1 17 23 PF00069 0.502
MOD_CK1_1 205 211 PF00069 0.475
MOD_CK1_1 240 246 PF00069 0.610
MOD_CK1_1 295 301 PF00069 0.577
MOD_CK1_1 335 341 PF00069 0.596
MOD_CK1_1 347 353 PF00069 0.533
MOD_CK1_1 364 370 PF00069 0.484
MOD_CK1_1 382 388 PF00069 0.574
MOD_CK1_1 488 494 PF00069 0.411
MOD_CK1_1 50 56 PF00069 0.468
MOD_CK1_1 698 704 PF00069 0.505
MOD_CK1_1 714 720 PF00069 0.495
MOD_CK1_1 899 905 PF00069 0.461
MOD_CK2_1 246 252 PF00069 0.661
MOD_CK2_1 31 37 PF00069 0.486
MOD_CK2_1 331 337 PF00069 0.549
MOD_CK2_1 39 45 PF00069 0.521
MOD_CK2_1 500 506 PF00069 0.446
MOD_CK2_1 570 576 PF00069 0.469
MOD_CK2_1 7 13 PF00069 0.481
MOD_CK2_1 76 82 PF00069 0.421
MOD_GlcNHglycan 125 128 PF01048 0.375
MOD_GlcNHglycan 142 145 PF01048 0.260
MOD_GlcNHglycan 207 210 PF01048 0.312
MOD_GlcNHglycan 217 220 PF01048 0.297
MOD_GlcNHglycan 255 258 PF01048 0.472
MOD_GlcNHglycan 337 340 PF01048 0.456
MOD_GlcNHglycan 349 352 PF01048 0.347
MOD_GlcNHglycan 41 44 PF01048 0.700
MOD_GlcNHglycan 587 590 PF01048 0.597
MOD_GlcNHglycan 696 700 PF01048 0.752
MOD_GlcNHglycan 705 708 PF01048 0.689
MOD_GlcNHglycan 891 895 PF01048 0.604
MOD_GlcNHglycan 899 902 PF01048 0.606
MOD_GSK3_1 140 147 PF00069 0.512
MOD_GSK3_1 173 180 PF00069 0.643
MOD_GSK3_1 198 205 PF00069 0.503
MOD_GSK3_1 246 253 PF00069 0.675
MOD_GSK3_1 264 271 PF00069 0.562
MOD_GSK3_1 331 338 PF00069 0.661
MOD_GSK3_1 343 350 PF00069 0.573
MOD_GSK3_1 385 392 PF00069 0.626
MOD_GSK3_1 398 405 PF00069 0.327
MOD_GSK3_1 484 491 PF00069 0.416
MOD_GSK3_1 542 549 PF00069 0.491
MOD_GSK3_1 585 592 PF00069 0.404
MOD_GSK3_1 600 607 PF00069 0.471
MOD_GSK3_1 675 682 PF00069 0.468
MOD_GSK3_1 703 710 PF00069 0.549
MOD_GSK3_1 711 718 PF00069 0.506
MOD_GSK3_1 76 83 PF00069 0.450
MOD_GSK3_1 895 902 PF00069 0.476
MOD_N-GLC_1 178 183 PF02516 0.530
MOD_N-GLC_1 286 291 PF02516 0.458
MOD_N-GLC_1 307 312 PF02516 0.404
MOD_N-GLC_1 680 685 PF02516 0.627
MOD_NEK2_1 202 207 PF00069 0.547
MOD_NEK2_1 331 336 PF00069 0.535
MOD_NEK2_1 402 407 PF00069 0.353
MOD_NEK2_1 417 422 PF00069 0.545
MOD_NEK2_1 485 490 PF00069 0.440
MOD_NEK2_1 500 505 PF00069 0.265
MOD_NEK2_1 527 532 PF00069 0.345
MOD_NEK2_1 546 551 PF00069 0.368
MOD_NEK2_1 585 590 PF00069 0.386
MOD_NEK2_1 601 606 PF00069 0.419
MOD_NEK2_1 827 832 PF00069 0.447
MOD_NEK2_1 86 91 PF00069 0.465
MOD_NEK2_1 890 895 PF00069 0.452
MOD_NEK2_2 372 377 PF00069 0.554
MOD_NEK2_2 627 632 PF00069 0.342
MOD_NEK2_2 668 673 PF00069 0.402
MOD_PIKK_1 286 292 PF00454 0.522
MOD_PIKK_1 350 356 PF00454 0.579
MOD_PIKK_1 7 13 PF00454 0.481
MOD_PIKK_1 80 86 PF00454 0.479
MOD_PIKK_1 872 878 PF00454 0.363
MOD_PKA_1 265 271 PF00069 0.535
MOD_PKA_1 719 725 PF00069 0.409
MOD_PKA_2 123 129 PF00069 0.580
MOD_PKA_2 14 20 PF00069 0.493
MOD_PKA_2 264 270 PF00069 0.646
MOD_PKA_2 285 291 PF00069 0.544
MOD_PKA_2 382 388 PF00069 0.557
MOD_PKA_2 601 607 PF00069 0.459
MOD_PKA_2 719 725 PF00069 0.457
MOD_PKA_2 84 90 PF00069 0.416
MOD_Plk_1 362 368 PF00069 0.537
MOD_Plk_1 680 686 PF00069 0.443
MOD_Plk_4 108 114 PF00069 0.295
MOD_Plk_4 14 20 PF00069 0.493
MOD_Plk_4 144 150 PF00069 0.529
MOD_Plk_4 198 204 PF00069 0.564
MOD_Plk_4 295 301 PF00069 0.570
MOD_Plk_4 382 388 PF00069 0.548
MOD_Plk_4 402 408 PF00069 0.387
MOD_Plk_4 485 491 PF00069 0.408
MOD_Plk_4 627 633 PF00069 0.348
MOD_Plk_4 668 674 PF00069 0.457
MOD_ProDKin_1 173 179 PF00069 0.594
MOD_ProDKin_1 235 241 PF00069 0.625
MOD_ProDKin_1 387 393 PF00069 0.568
MOD_ProDKin_1 47 53 PF00069 0.488
MOD_ProDKin_1 698 704 PF00069 0.519
MOD_ProDKin_1 76 82 PF00069 0.478
MOD_ProDKin_1 768 774 PF00069 0.469
MOD_ProDKin_1 901 907 PF00069 0.507
TRG_DiLeu_BaEn_1 524 529 PF01217 0.433
TRG_DiLeu_BaEn_1 754 759 PF01217 0.471
TRG_DiLeu_BaEn_1 773 778 PF01217 0.403
TRG_DiLeu_BaEn_1 819 824 PF01217 0.404
TRG_DiLeu_BaEn_4 446 452 PF01217 0.456
TRG_DiLeu_BaLyEn_6 523 528 PF01217 0.448
TRG_DiLeu_BaLyEn_6 789 794 PF01217 0.428
TRG_ENDOCYTIC_2 259 262 PF00928 0.557
TRG_ENDOCYTIC_2 357 360 PF00928 0.539
TRG_ENDOCYTIC_2 386 389 PF00928 0.520
TRG_ENDOCYTIC_2 595 598 PF00928 0.379
TRG_ENDOCYTIC_2 632 635 PF00928 0.319
TRG_ENDOCYTIC_2 673 676 PF00928 0.463
TRG_ENDOCYTIC_2 808 811 PF00928 0.459
TRG_ENDOCYTIC_2 817 820 PF00928 0.389
TRG_ENDOCYTIC_2 831 834 PF00928 0.374
TRG_ER_diArg_1 123 125 PF00400 0.537
TRG_ER_diArg_1 264 266 PF00400 0.584
TRG_ER_diArg_1 380 383 PF00400 0.622
TRG_ER_diArg_1 847 849 PF00400 0.518
TRG_Pf-PMV_PEXEL_1 787 791 PF00026 0.693

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H6C4 Leishmania donovani 49% 100%
A0A3S7WQJ6 Leishmania donovani 86% 100%
A4H5K6 Leishmania braziliensis 68% 98%
A4H5K7 Leishmania braziliensis 44% 100%
A4HTU4 Leishmania infantum 86% 100%
A4HTU5 Leishmania infantum 49% 100%
E9AMN2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
Q4QHZ3 Leishmania major 47% 100%
Q4QHZ4 Leishmania major 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS