Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cdc2-related kinase 12

Species:

Leishmania mexicana

UniProt:

E9AMN0_LEIMU

TriTrypDb:

LmxM.09.0310

Length:

882

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AMN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMN0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.526
CLV_NRD_NRD_1	304	306	PF00675	0.701
CLV_NRD_NRD_1	429	431	PF00675	0.705
CLV_NRD_NRD_1	575	577	PF00675	0.524
CLV_NRD_NRD_1	596	598	PF00675	0.399
CLV_NRD_NRD_1	6	8	PF00675	0.729
CLV_NRD_NRD_1	801	803	PF00675	0.399
CLV_NRD_NRD_1	861	863	PF00675	0.495
CLV_NRD_NRD_1	878	880	PF00675	0.581
CLV_PCSK_KEX2_1	202	204	PF00082	0.715
CLV_PCSK_KEX2_1	429	431	PF00082	0.705
CLV_PCSK_KEX2_1	479	481	PF00082	0.399
CLV_PCSK_KEX2_1	488	490	PF00082	0.309
CLV_PCSK_KEX2_1	575	577	PF00082	0.524
CLV_PCSK_KEX2_1	6	8	PF00082	0.729
CLV_PCSK_KEX2_1	801	803	PF00082	0.397
CLV_PCSK_KEX2_1	861	863	PF00082	0.495
CLV_PCSK_KEX2_1	878	880	PF00082	0.581
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.715
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.399
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.309
CLV_PCSK_SKI1_1	241	245	PF00082	0.593
CLV_PCSK_SKI1_1	413	417	PF00082	0.608
CLV_PCSK_SKI1_1	453	457	PF00082	0.468
CLV_PCSK_SKI1_1	488	492	PF00082	0.399
CLV_PCSK_SKI1_1	590	594	PF00082	0.424
CLV_PCSK_SKI1_1	607	611	PF00082	0.229
CLV_Separin_Metazoa	827	831	PF03568	0.399
DEG_SCF_FBW7_2	850	857	PF00400	0.552
DEG_SPOP_SBC_1	157	161	PF00917	0.533
DEG_SPOP_SBC_1	243	247	PF00917	0.602
DEG_SPOP_SBC_1	62	66	PF00917	0.710
DEG_SPOP_SBC_1	83	87	PF00917	0.532
DOC_CDC14_PxL_1	837	845	PF14671	0.531
DOC_CKS1_1	117	122	PF01111	0.699
DOC_CKS1_1	645	650	PF01111	0.399
DOC_CKS1_1	851	856	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.528
DOC_MAPK_DCC_7	351	361	PF00069	0.530
DOC_MAPK_gen_1	429	438	PF00069	0.698
DOC_MAPK_gen_1	479	487	PF00069	0.399
DOC_MAPK_gen_1	554	563	PF00069	0.399
DOC_MAPK_gen_1	590	596	PF00069	0.399
DOC_MAPK_gen_1	597	604	PF00069	0.329
DOC_MAPK_gen_1	607	616	PF00069	0.229
DOC_MAPK_gen_1	861	868	PF00069	0.384
DOC_MAPK_HePTP_8	551	563	PF00069	0.399
DOC_MAPK_MEF2A_6	429	438	PF00069	0.648
DOC_MAPK_MEF2A_6	554	563	PF00069	0.399
DOC_MAPK_RevD_3	585	598	PF00069	0.349
DOC_PP2B_LxvP_1	686	689	PF13499	0.399
DOC_PP2B_LxvP_1	829	832	PF13499	0.399
DOC_USP7_MATH_1	157	161	PF00917	0.727
DOC_USP7_MATH_1	206	210	PF00917	0.640
DOC_USP7_MATH_1	243	247	PF00917	0.695
DOC_USP7_MATH_1	281	285	PF00917	0.583
DOC_USP7_MATH_1	500	504	PF00917	0.399
DOC_USP7_MATH_1	541	545	PF00917	0.399
DOC_USP7_MATH_1	566	570	PF00917	0.474
DOC_USP7_MATH_1	62	66	PF00917	0.710
DOC_USP7_MATH_1	634	638	PF00917	0.389
DOC_USP7_MATH_1	706	710	PF00917	0.399
DOC_USP7_MATH_1	84	88	PF00917	0.527
DOC_USP7_UBL2_3	475	479	PF12436	0.399
DOC_WW_Pin1_4	113	118	PF00397	0.701
DOC_WW_Pin1_4	158	163	PF00397	0.564
DOC_WW_Pin1_4	214	219	PF00397	0.679
DOC_WW_Pin1_4	254	259	PF00397	0.764
DOC_WW_Pin1_4	314	319	PF00397	0.672
DOC_WW_Pin1_4	323	328	PF00397	0.634
DOC_WW_Pin1_4	354	359	PF00397	0.649
DOC_WW_Pin1_4	374	379	PF00397	0.549
DOC_WW_Pin1_4	413	418	PF00397	0.575
DOC_WW_Pin1_4	423	428	PF00397	0.606
DOC_WW_Pin1_4	446	451	PF00397	0.458
DOC_WW_Pin1_4	578	583	PF00397	0.399
DOC_WW_Pin1_4	58	63	PF00397	0.715
DOC_WW_Pin1_4	644	649	PF00397	0.399
DOC_WW_Pin1_4	850	855	PF00397	0.524
LIG_14-3-3_CanoR_1	110	120	PF00244	0.665
LIG_14-3-3_CanoR_1	241	251	PF00244	0.602
LIG_14-3-3_CanoR_1	366	371	PF00244	0.704
LIG_14-3-3_CanoR_1	411	416	PF00244	0.553
LIG_14-3-3_CanoR_1	708	717	PF00244	0.399
LIG_14-3-3_CanoR_1	719	727	PF00244	0.289
LIG_14-3-3_CanoR_1	78	84	PF00244	0.676
LIG_BRCT_BRCA1_1	200	204	PF00533	0.527
LIG_BRCT_BRCA1_1	444	448	PF00533	0.659
LIG_deltaCOP1_diTrp_1	193	204	PF00928	0.531
LIG_EVH1_1	178	182	PF00568	0.525
LIG_FHA_1	130	136	PF00498	0.713
LIG_FHA_1	141	147	PF00498	0.600
LIG_FHA_1	167	173	PF00498	0.718
LIG_FHA_1	227	233	PF00498	0.683
LIG_FHA_1	302	308	PF00498	0.611
LIG_FHA_1	355	361	PF00498	0.683
LIG_FHA_1	378	384	PF00498	0.675
LIG_FHA_1	479	485	PF00498	0.224
LIG_FHA_1	53	59	PF00498	0.669
LIG_FHA_1	535	541	PF00498	0.389
LIG_FHA_1	565	571	PF00498	0.399
LIG_FHA_1	645	651	PF00498	0.399
LIG_FHA_1	719	725	PF00498	0.399
LIG_FHA_1	83	89	PF00498	0.639
LIG_FHA_2	315	321	PF00498	0.570
LIG_FHA_2	452	458	PF00498	0.527
LIG_FHA_2	467	473	PF00498	0.249
LIG_FHA_2	579	585	PF00498	0.506
LIG_FHA_2	663	669	PF00498	0.399
LIG_FHA_2	710	716	PF00498	0.399
LIG_FHA_2	768	774	PF00498	0.399
LIG_FHA_2	822	828	PF00498	0.372
LIG_FHA_2	833	839	PF00498	0.425
LIG_LIR_Apic_2	194	200	PF02991	0.651
LIG_LIR_Apic_2	642	648	PF02991	0.343
LIG_LIR_Apic_2	652	658	PF02991	0.356
LIG_LIR_Gen_1	217	227	PF02991	0.536
LIG_LIR_Gen_1	406	417	PF02991	0.569
LIG_LIR_Gen_1	775	784	PF02991	0.399
LIG_LIR_Gen_1	845	854	PF02991	0.538
LIG_LIR_Nem_3	201	207	PF02991	0.528
LIG_LIR_Nem_3	406	412	PF02991	0.627
LIG_LIR_Nem_3	445	451	PF02991	0.640
LIG_LIR_Nem_3	467	473	PF02991	0.399
LIG_LIR_Nem_3	775	781	PF02991	0.399
LIG_LIR_Nem_3	845	849	PF02991	0.572
LIG_MYND_1	122	126	PF01753	0.605
LIG_NRBOX	675	681	PF00104	0.399
LIG_PCNA_yPIPBox_3	452	464	PF02747	0.517
LIG_PCNA_yPIPBox_3	501	511	PF02747	0.349
LIG_Pex14_2	772	776	PF04695	0.399
LIG_Pex14_2	784	788	PF04695	0.279
LIG_SH2_CRK	846	850	PF00017	0.624
LIG_SH2_NCK_1	565	569	PF00017	0.399
LIG_SH2_STAP1	667	671	PF00017	0.399
LIG_SH2_STAT3	552	555	PF00017	0.399
LIG_SH2_STAT5	23	26	PF00017	0.662
LIG_SH2_STAT5	684	687	PF00017	0.337
LIG_SH2_STAT5	833	836	PF00017	0.486
LIG_SH3_1	148	154	PF00018	0.742
LIG_SH3_1	324	330	PF00018	0.603
LIG_SH3_1	848	854	PF00018	0.535
LIG_SH3_2	851	856	PF14604	0.501
LIG_SH3_3	114	120	PF00018	0.722
LIG_SH3_3	148	154	PF00018	0.742
LIG_SH3_3	176	182	PF00018	0.631
LIG_SH3_3	280	286	PF00018	0.522
LIG_SH3_3	295	301	PF00018	0.530
LIG_SH3_3	324	330	PF00018	0.647
LIG_SH3_3	367	373	PF00018	0.687
LIG_SH3_3	433	439	PF00018	0.694
LIG_SH3_3	68	74	PF00018	0.555
LIG_SH3_3	723	729	PF00018	0.392
LIG_SH3_3	848	854	PF00018	0.535
LIG_SUMO_SIM_anti_2	558	563	PF11976	0.399
LIG_SUMO_SIM_par_1	357	362	PF11976	0.528
LIG_TRAF2_1	297	300	PF00917	0.727
LIG_TRFH_1	684	688	PF08558	0.399
LIG_WRPW_2	204	207	PF00400	0.525
LIG_WW_1	688	691	PF00397	0.399
LIG_WW_3	75	79	PF00397	0.662
MOD_CDC14_SPxK_1	426	429	PF00782	0.698
MOD_CDK_SPxK_1	423	429	PF00069	0.706
MOD_CDK_SPxK_1	850	856	PF00069	0.558
MOD_CDK_SPxxK_3	254	261	PF00069	0.548
MOD_CDK_SPxxK_3	423	430	PF00069	0.706
MOD_CDK_SPxxK_3	446	453	PF00069	0.449
MOD_CK1_1	116	122	PF00069	0.648
MOD_CK1_1	155	161	PF00069	0.709
MOD_CK1_1	246	252	PF00069	0.690
MOD_CK1_1	326	332	PF00069	0.663
MOD_CK1_1	354	360	PF00069	0.631
MOD_CK1_1	362	368	PF00069	0.690
MOD_CK1_1	377	383	PF00069	0.560
MOD_CK1_1	385	391	PF00069	0.667
MOD_CK1_1	407	413	PF00069	0.594
MOD_CK1_1	466	472	PF00069	0.399
MOD_CK1_1	56	62	PF00069	0.716
MOD_CK1_1	637	643	PF00069	0.373
MOD_CK1_1	649	655	PF00069	0.283
MOD_CK1_1	67	73	PF00069	0.622
MOD_CK1_1	709	715	PF00069	0.399
MOD_CK1_1	718	724	PF00069	0.309
MOD_CK2_1	333	339	PF00069	0.534
MOD_CK2_1	451	457	PF00069	0.503
MOD_CK2_1	466	472	PF00069	0.287
MOD_CK2_1	500	506	PF00069	0.399
MOD_CK2_1	578	584	PF00069	0.449
MOD_CK2_1	615	621	PF00069	0.412
MOD_CK2_1	67	73	PF00069	0.731
MOD_CK2_1	709	715	PF00069	0.349
MOD_CK2_1	767	773	PF00069	0.399
MOD_CK2_1	821	827	PF00069	0.399
MOD_DYRK1A_RPxSP_1	413	417	PF00069	0.608
MOD_GlcNHglycan	174	177	PF01048	0.623
MOD_GlcNHglycan	214	217	PF01048	0.738
MOD_GlcNHglycan	219	222	PF01048	0.714
MOD_GlcNHglycan	234	237	PF01048	0.607
MOD_GlcNHglycan	271	274	PF01048	0.609
MOD_GlcNHglycan	283	286	PF01048	0.562
MOD_GlcNHglycan	331	334	PF01048	0.640
MOD_GlcNHglycan	361	364	PF01048	0.571
MOD_GlcNHglycan	384	387	PF01048	0.716
MOD_GlcNHglycan	397	400	PF01048	0.581
MOD_GlcNHglycan	406	409	PF01048	0.524
MOD_GlcNHglycan	639	642	PF01048	0.346
MOD_GlcNHglycan	66	69	PF01048	0.727
MOD_GlcNHglycan	707	711	PF01048	0.399
MOD_GlcNHglycan	8	11	PF01048	0.595
MOD_GlcNHglycan	92	95	PF01048	0.695
MOD_GSK3_1	152	159	PF00069	0.660
MOD_GSK3_1	208	215	PF00069	0.586
MOD_GSK3_1	242	249	PF00069	0.636
MOD_GSK3_1	329	336	PF00069	0.570
MOD_GSK3_1	362	369	PF00069	0.640
MOD_GSK3_1	403	410	PF00069	0.626
MOD_GSK3_1	411	418	PF00069	0.507
MOD_GSK3_1	442	449	PF00069	0.649
MOD_GSK3_1	52	59	PF00069	0.722
MOD_GSK3_1	6	13	PF00069	0.700
MOD_GSK3_1	63	70	PF00069	0.612
MOD_GSK3_1	635	642	PF00069	0.361
MOD_GSK3_1	79	86	PF00069	0.559
MOD_N-GLC_1	281	286	PF02516	0.693
MOD_NEK2_1	212	217	PF00069	0.589
MOD_NEK2_1	227	232	PF00069	0.604
MOD_NEK2_1	242	247	PF00069	0.650
MOD_NEK2_1	379	384	PF00069	0.544
MOD_NEK2_1	404	409	PF00069	0.598
MOD_NEK2_1	492	497	PF00069	0.287
MOD_NEK2_1	63	68	PF00069	0.716
MOD_NEK2_1	661	666	PF00069	0.399
MOD_NEK2_1	792	797	PF00069	0.399
MOD_NEK2_1	842	847	PF00069	0.568
MOD_NEK2_1	90	95	PF00069	0.693
MOD_NEK2_2	166	171	PF00069	0.649
MOD_NEK2_2	500	505	PF00069	0.399
MOD_PIKK_1	385	391	PF00454	0.672
MOD_PIKK_1	541	547	PF00454	0.399
MOD_PIKK_1	801	807	PF00454	0.399
MOD_PIKK_1	873	879	PF00454	0.682
MOD_PK_1	261	267	PF00069	0.544
MOD_PK_1	366	372	PF00069	0.653
MOD_PK_1	44	50	PF00069	0.726
MOD_PK_1	646	652	PF00069	0.399
MOD_PKA_1	6	12	PF00069	0.728
MOD_PKA_1	801	807	PF00069	0.399
MOD_PKA_2	111	117	PF00069	0.730
MOD_PKA_2	172	178	PF00069	0.608
MOD_PKA_2	312	318	PF00069	0.632
MOD_PKA_2	6	12	PF00069	0.728
MOD_PKA_2	718	724	PF00069	0.399
MOD_PKA_2	801	807	PF00069	0.399
MOD_PKA_2	821	827	PF00069	0.199
MOD_Plk_1	541	547	PF00069	0.487
MOD_Plk_4	646	652	PF00069	0.354
MOD_Plk_4	728	734	PF00069	0.349
MOD_Plk_4	767	773	PF00069	0.430
MOD_ProDKin_1	113	119	PF00069	0.700
MOD_ProDKin_1	158	164	PF00069	0.564
MOD_ProDKin_1	214	220	PF00069	0.681
MOD_ProDKin_1	254	260	PF00069	0.763
MOD_ProDKin_1	314	320	PF00069	0.676
MOD_ProDKin_1	323	329	PF00069	0.633
MOD_ProDKin_1	354	360	PF00069	0.651
MOD_ProDKin_1	374	380	PF00069	0.552
MOD_ProDKin_1	413	419	PF00069	0.587
MOD_ProDKin_1	423	429	PF00069	0.606
MOD_ProDKin_1	446	452	PF00069	0.456
MOD_ProDKin_1	578	584	PF00069	0.399
MOD_ProDKin_1	58	64	PF00069	0.716
MOD_ProDKin_1	644	650	PF00069	0.399
MOD_ProDKin_1	850	856	PF00069	0.517
MOD_SUMO_rev_2	664	671	PF00179	0.399
TRG_DiLeu_BaEn_1	584	589	PF01217	0.399
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.660
TRG_DiLeu_BaLyEn_6	838	843	PF01217	0.596
TRG_ENDOCYTIC_2	470	473	PF00928	0.399
TRG_ENDOCYTIC_2	778	781	PF00928	0.399
TRG_ENDOCYTIC_2	846	849	PF00928	0.631
TRG_ER_diArg_1	170	173	PF00400	0.678
TRG_ER_diArg_1	429	432	PF00400	0.654
TRG_ER_diArg_1	5	7	PF00400	0.713
TRG_ER_diArg_1	691	694	PF00400	0.399
TRG_ER_diArg_1	801	803	PF00400	0.394
TRG_ER_diArg_1	860	862	PF00400	0.481
TRG_ER_diArg_1	878	880	PF00400	0.571
TRG_NLS_MonoExtC_3	201	206	PF00514	0.699
TRG_NLS_MonoExtN_4	199	206	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	742	746	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQK2	Leishmania donovani	88%	100%
A4H5K5	Leishmania braziliensis	77%	100%
Q4QHZ5	Leishmania major	89%	100%