Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMM9_LEIMU

TriTrypDb:

LmxM.09.0300

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.638
CLV_NRD_NRD_1	167	169	PF00675	0.734
CLV_PCSK_KEX2_1	167	169	PF00082	0.650
CLV_PCSK_SKI1_1	167	171	PF00082	0.721
CLV_PCSK_SKI1_1	40	44	PF00082	0.351
DEG_APCC_DBOX_1	39	47	PF00400	0.414
DOC_CDC14_PxL_1	108	116	PF14671	0.526
DOC_CDC14_PxL_1	191	199	PF14671	0.450
DOC_PP2B_LxvP_1	155	158	PF13499	0.465
DOC_PP4_FxxP_1	170	173	PF00568	0.636
DOC_USP7_MATH_1	11	15	PF00917	0.559
DOC_USP7_MATH_1	158	162	PF00917	0.734
DOC_USP7_MATH_1	198	202	PF00917	0.508
DOC_USP7_MATH_1	60	64	PF00917	0.609
DOC_USP7_MATH_1	84	88	PF00917	0.587
DOC_USP7_UBL2_3	171	175	PF12436	0.565
DOC_WW_Pin1_4	102	107	PF00397	0.689
DOC_WW_Pin1_4	58	63	PF00397	0.431
LIG_14-3-3_CanoR_1	68	74	PF00244	0.615
LIG_FHA_1	116	122	PF00498	0.464
LIG_FHA_1	228	234	PF00498	0.418
LIG_FHA_2	138	144	PF00498	0.511
LIG_FHA_2	174	180	PF00498	0.486
LIG_FHA_2	205	211	PF00498	0.603
LIG_GBD_Chelix_1	119	127	PF00786	0.356
LIG_LIR_Apic_2	17	22	PF02991	0.330
LIG_LIR_Nem_3	14	19	PF02991	0.323
LIG_LIR_Nem_3	188	194	PF02991	0.408
LIG_SH2_CRK	19	23	PF00017	0.316
LIG_SH2_STAP1	134	138	PF00017	0.443
LIG_SH2_STAP1	16	20	PF00017	0.444
LIG_SH3_1	19	25	PF00018	0.324
LIG_SH3_3	19	25	PF00018	0.509
LIG_SH3_3	192	198	PF00018	0.561
LIG_SH3_3	63	69	PF00018	0.627
LIG_SUMO_SIM_anti_2	128	137	PF11976	0.471
LIG_SUMO_SIM_par_1	115	122	PF11976	0.408
LIG_SUMO_SIM_par_1	69	74	PF11976	0.505
LIG_TRAF2_1	176	179	PF00917	0.474
LIG_UBA3_1	26	34	PF00899	0.264
MOD_CK1_1	136	142	PF00069	0.514
MOD_CK1_1	87	93	PF00069	0.645
MOD_CK2_1	11	17	PF00069	0.524
MOD_CK2_1	137	143	PF00069	0.501
MOD_CK2_1	158	164	PF00069	0.665
MOD_CK2_1	173	179	PF00069	0.435
MOD_CK2_1	197	203	PF00069	0.599
MOD_CK2_1	204	210	PF00069	0.540
MOD_GSK3_1	115	122	PF00069	0.366
MOD_GSK3_1	133	140	PF00069	0.477
MOD_GSK3_1	205	212	PF00069	0.650
MOD_GSK3_1	58	65	PF00069	0.588
MOD_GSK3_1	84	91	PF00069	0.491
MOD_N-GLC_1	102	107	PF02516	0.610
MOD_NEK2_1	119	124	PF00069	0.452
MOD_NEK2_1	217	222	PF00069	0.458
MOD_NEK2_1	88	93	PF00069	0.465
MOD_NEK2_2	11	16	PF00069	0.263
MOD_Plk_1	115	121	PF00069	0.333
MOD_Plk_1	134	140	PF00069	0.346
MOD_Plk_1	205	211	PF00069	0.505
MOD_Plk_1	84	90	PF00069	0.464
MOD_Plk_4	11	17	PF00069	0.360
MOD_Plk_4	119	125	PF00069	0.384
MOD_Plk_4	62	68	PF00069	0.554
MOD_ProDKin_1	102	108	PF00069	0.683
MOD_ProDKin_1	58	64	PF00069	0.434
MOD_SUMO_for_1	221	224	PF00179	0.467
TRG_ER_diArg_1	166	168	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R6	Leptomonas seymouri	45%	96%
A0A3S7WQM1	Leishmania donovani	84%	100%
A4H5K4	Leishmania braziliensis	66%	98%
A4HTU2	Leishmania infantum	84%	100%
D0A9A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4QHZ6	Leishmania major	80%	98%
V5B2V2	Trypanosoma cruzi	29%	100%