Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMM7_LEIMU

TriTrypDb:

LmxM.09.0280

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.632
CLV_C14_Caspase3-7	40	44	PF00656	0.787
CLV_C14_Caspase3-7	60	64	PF00656	0.567
CLV_C14_Caspase3-7	601	605	PF00656	0.707
CLV_C14_Caspase3-7	656	660	PF00656	0.740
CLV_NRD_NRD_1	185	187	PF00675	0.519
CLV_NRD_NRD_1	188	190	PF00675	0.529
CLV_NRD_NRD_1	203	205	PF00675	0.485
CLV_NRD_NRD_1	294	296	PF00675	0.605
CLV_NRD_NRD_1	319	321	PF00675	0.537
CLV_NRD_NRD_1	346	348	PF00675	0.636
CLV_NRD_NRD_1	729	731	PF00675	0.478
CLV_NRD_NRD_1	748	750	PF00675	0.591
CLV_PCSK_FUR_1	186	190	PF00082	0.536
CLV_PCSK_KEX2_1	184	186	PF00082	0.521
CLV_PCSK_KEX2_1	188	190	PF00082	0.530
CLV_PCSK_KEX2_1	203	205	PF00082	0.485
CLV_PCSK_KEX2_1	319	321	PF00082	0.537
CLV_PCSK_KEX2_1	346	348	PF00082	0.636
CLV_PCSK_KEX2_1	729	731	PF00082	0.548
CLV_PCSK_KEX2_1	748	750	PF00082	0.591
CLV_PCSK_PC7_1	181	187	PF00082	0.534
CLV_PCSK_SKI1_1	103	107	PF00082	0.438
CLV_PCSK_SKI1_1	296	300	PF00082	0.608
CLV_PCSK_SKI1_1	395	399	PF00082	0.435
CLV_PCSK_SKI1_1	484	488	PF00082	0.404
CLV_PCSK_SKI1_1	670	674	PF00082	0.403
DEG_APCC_DBOX_1	294	302	PF00400	0.750
DEG_Nend_Nbox_1	1	3	PF02207	0.346
DEG_SCF_FBW7_1	485	491	PF00400	0.759
DEG_SPOP_SBC_1	489	493	PF00917	0.640
DEG_SPOP_SBC_1	58	62	PF00917	0.592
DOC_CKS1_1	198	203	PF01111	0.702
DOC_CKS1_1	485	490	PF01111	0.759
DOC_CYCLIN_RxL_1	392	401	PF00134	0.603
DOC_CYCLIN_RxL_1	667	677	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.652
DOC_CYCLIN_yCln2_LP_2	672	675	PF00134	0.604
DOC_MAPK_gen_1	295	303	PF00069	0.808
DOC_MAPK_gen_1	316	325	PF00069	0.763
DOC_MAPK_gen_1	768	778	PF00069	0.766
DOC_MAPK_MEF2A_6	295	303	PF00069	0.739
DOC_MAPK_MEF2A_6	316	325	PF00069	0.833
DOC_MAPK_MEF2A_6	719	728	PF00069	0.636
DOC_MAPK_MEF2A_6	771	780	PF00069	0.707
DOC_PP1_RVXF_1	564	570	PF00149	0.604
DOC_PP2B_LxvP_1	24	27	PF13499	0.650
DOC_PP2B_LxvP_1	291	294	PF13499	0.735
DOC_PP2B_LxvP_1	549	552	PF13499	0.665
DOC_PP2B_LxvP_1	672	675	PF13499	0.604
DOC_PP2B_LxvP_1	74	77	PF13499	0.752
DOC_PP4_FxxP_1	520	523	PF00568	0.595
DOC_SPAK_OSR1_1	530	534	PF12202	0.730
DOC_USP7_MATH_1	275	279	PF00917	0.709
DOC_USP7_MATH_1	332	336	PF00917	0.788
DOC_USP7_MATH_1	37	41	PF00917	0.766
DOC_USP7_MATH_1	384	388	PF00917	0.633
DOC_USP7_MATH_1	393	397	PF00917	0.631
DOC_USP7_MATH_1	412	416	PF00917	0.757
DOC_USP7_MATH_1	488	492	PF00917	0.776
DOC_USP7_MATH_1	501	505	PF00917	0.604
DOC_USP7_MATH_1	509	513	PF00917	0.667
DOC_USP7_MATH_1	51	55	PF00917	0.631
DOC_USP7_MATH_1	58	62	PF00917	0.802
DOC_USP7_MATH_1	600	604	PF00917	0.701
DOC_USP7_MATH_1	706	710	PF00917	0.819
DOC_USP7_UBL2_3	593	597	PF12436	0.496
DOC_WW_Pin1_4	110	115	PF00397	0.687
DOC_WW_Pin1_4	197	202	PF00397	0.704
DOC_WW_Pin1_4	273	278	PF00397	0.776
DOC_WW_Pin1_4	335	340	PF00397	0.828
DOC_WW_Pin1_4	353	358	PF00397	0.817
DOC_WW_Pin1_4	484	489	PF00397	0.790
DOC_WW_Pin1_4	491	496	PF00397	0.725
DOC_WW_Pin1_4	503	508	PF00397	0.663
LIG_14-3-3_CanoR_1	157	166	PF00244	0.745
LIG_14-3-3_CanoR_1	281	290	PF00244	0.782
LIG_14-3-3_CanoR_1	320	326	PF00244	0.748
LIG_14-3-3_CanoR_1	382	392	PF00244	0.770
LIG_14-3-3_CanoR_1	395	405	PF00244	0.636
LIG_14-3-3_CanoR_1	566	570	PF00244	0.614
LIG_14-3-3_CanoR_1	771	777	PF00244	0.673
LIG_14-3-3_CanoR_1	88	93	PF00244	0.700
LIG_Actin_WH2_2	303	318	PF00022	0.757
LIG_BIR_III_4	331	335	PF00653	0.846
LIG_BRCT_BRCA1_1	511	515	PF00533	0.701
LIG_DCNL_PONY_1	1	4	PF03556	0.346
LIG_EH1_1	207	215	PF00400	0.716
LIG_eIF4E_1	208	214	PF01652	0.559
LIG_eIF4E_1	392	398	PF01652	0.689
LIG_FHA_1	231	237	PF00498	0.645
LIG_FHA_1	348	354	PF00498	0.706
LIG_FHA_1	408	414	PF00498	0.746
LIG_FHA_1	586	592	PF00498	0.583
LIG_FHA_1	771	777	PF00498	0.667
LIG_FHA_1	85	91	PF00498	0.719
LIG_FHA_1	95	101	PF00498	0.642
LIG_FHA_2	312	318	PF00498	0.697
LIG_FHA_2	474	480	PF00498	0.588
LIG_FHA_2	58	64	PF00498	0.745
LIG_FHA_2	654	660	PF00498	0.729
LIG_LIR_Gen_1	206	217	PF02991	0.643
LIG_LIR_Gen_1	87	93	PF02991	0.633
LIG_LIR_Nem_3	125	129	PF02991	0.673
LIG_LIR_Nem_3	206	212	PF02991	0.647
LIG_LIR_Nem_3	734	740	PF02991	0.683
LIG_LIR_Nem_3	87	92	PF02991	0.636
LIG_LYPXL_yS_3	737	740	PF13949	0.691
LIG_MYND_1	671	675	PF01753	0.719
LIG_MYND_1	73	77	PF01753	0.611
LIG_NRBOX	1	7	PF00104	0.346
LIG_PCNA_yPIPBox_3	717	730	PF02747	0.682
LIG_Pex14_1	126	130	PF04695	0.746
LIG_PTAP_UEV_1	586	591	PF05743	0.680
LIG_SH2_CRK	71	75	PF00017	0.759
LIG_SH2_CRK	83	87	PF00017	0.578
LIG_SH2_GRB2like	251	254	PF00017	0.708
LIG_SH2_NCK_1	665	669	PF00017	0.755
LIG_SH2_NCK_1	83	87	PF00017	0.689
LIG_SH2_PTP2	89	92	PF00017	0.636
LIG_SH2_STAP1	130	134	PF00017	0.804
LIG_SH2_STAP1	251	255	PF00017	0.678
LIG_SH2_STAT3	526	529	PF00017	0.613
LIG_SH2_STAT5	20	23	PF00017	0.513
LIG_SH2_STAT5	644	647	PF00017	0.737
LIG_SH2_STAT5	83	86	PF00017	0.643
LIG_SH2_STAT5	89	92	PF00017	0.652
LIG_SH3_2	198	203	PF14604	0.681
LIG_SH3_2	671	676	PF14604	0.727
LIG_SH3_3	195	201	PF00018	0.692
LIG_SH3_3	291	297	PF00018	0.735
LIG_SH3_3	315	321	PF00018	0.755
LIG_SH3_3	458	464	PF00018	0.684
LIG_SH3_3	482	488	PF00018	0.778
LIG_SH3_3	584	590	PF00018	0.603
LIG_SH3_3	668	674	PF00018	0.697
LIG_SH3_5	434	438	PF00018	0.748
LIG_Sin3_3	592	599	PF02671	0.618
LIG_SUMO_SIM_anti_2	722	727	PF11976	0.680
LIG_SUMO_SIM_par_1	302	308	PF11976	0.803
LIG_SUMO_SIM_par_1	469	474	PF11976	0.713
LIG_TYR_ITIM	100	105	PF00017	0.639
LIG_TYR_ITIM	735	740	PF00017	0.669
LIG_UBA3_1	731	739	PF00899	0.694
LIG_WW_3	673	677	PF00397	0.730
MOD_CDK_SPK_2	110	115	PF00069	0.687
MOD_CDK_SPK_2	335	340	PF00069	0.740
MOD_CDK_SPxK_1	197	203	PF00069	0.704
MOD_CDK_SPxK_1	491	497	PF00069	0.756
MOD_CDK_SPxxK_3	197	204	PF00069	0.775
MOD_CK1_1	155	161	PF00069	0.721
MOD_CK1_1	165	171	PF00069	0.725
MOD_CK1_1	176	182	PF00069	0.769
MOD_CK1_1	283	289	PF00069	0.745
MOD_CK1_1	333	339	PF00069	0.842
MOD_CK1_1	373	379	PF00069	0.760
MOD_CK1_1	386	392	PF00069	0.607
MOD_CK1_1	396	402	PF00069	0.742
MOD_CK1_1	414	420	PF00069	0.740
MOD_CK1_1	491	497	PF00069	0.752
MOD_CK1_1	585	591	PF00069	0.678
MOD_CK1_1	630	636	PF00069	0.635
MOD_CK1_1	681	687	PF00069	0.825
MOD_CK1_1	692	698	PF00069	0.703
MOD_CK2_1	110	116	PF00069	0.691
MOD_CK2_1	473	479	PF00069	0.584
MOD_CK2_1	608	614	PF00069	0.722
MOD_CK2_1	88	94	PF00069	0.648
MOD_DYRK1A_RPxSP_1	484	488	PF00069	0.757
MOD_GlcNHglycan	154	157	PF01048	0.450
MOD_GlcNHglycan	159	162	PF01048	0.590
MOD_GlcNHglycan	167	170	PF01048	0.492
MOD_GlcNHglycan	205	208	PF01048	0.530
MOD_GlcNHglycan	270	273	PF01048	0.526
MOD_GlcNHglycan	285	288	PF01048	0.618
MOD_GlcNHglycan	307	310	PF01048	0.595
MOD_GlcNHglycan	331	335	PF01048	0.579
MOD_GlcNHglycan	361	364	PF01048	0.627
MOD_GlcNHglycan	378	381	PF01048	0.486
MOD_GlcNHglycan	39	42	PF01048	0.590
MOD_GlcNHglycan	422	425	PF01048	0.622
MOD_GlcNHglycan	430	433	PF01048	0.529
MOD_GlcNHglycan	45	48	PF01048	0.519
MOD_GlcNHglycan	453	456	PF01048	0.512
MOD_GlcNHglycan	499	502	PF01048	0.568
MOD_GlcNHglycan	503	506	PF01048	0.470
MOD_GlcNHglycan	511	514	PF01048	0.396
MOD_GlcNHglycan	53	56	PF01048	0.432
MOD_GlcNHglycan	569	572	PF01048	0.258
MOD_GlcNHglycan	606	609	PF01048	0.532
MOD_GlcNHglycan	632	635	PF01048	0.595
MOD_GlcNHglycan	676	679	PF01048	0.616
MOD_GlcNHglycan	691	694	PF01048	0.508
MOD_GlcNHglycan	695	698	PF01048	0.424
MOD_GlcNHglycan	699	702	PF01048	0.489
MOD_GlcNHglycan	708	711	PF01048	0.527
MOD_GlcNHglycan	751	754	PF01048	0.589
MOD_GSK3_1	130	137	PF00069	0.797
MOD_GSK3_1	152	159	PF00069	0.792
MOD_GSK3_1	164	171	PF00069	0.714
MOD_GSK3_1	173	180	PF00069	0.770
MOD_GSK3_1	193	200	PF00069	0.557
MOD_GSK3_1	33	40	PF00069	0.724
MOD_GSK3_1	349	356	PF00069	0.661
MOD_GSK3_1	372	379	PF00069	0.793
MOD_GSK3_1	382	389	PF00069	0.720
MOD_GSK3_1	393	400	PF00069	0.775
MOD_GSK3_1	403	410	PF00069	0.714
MOD_GSK3_1	411	418	PF00069	0.685
MOD_GSK3_1	469	476	PF00069	0.693
MOD_GSK3_1	484	491	PF00069	0.734
MOD_GSK3_1	497	504	PF00069	0.647
MOD_GSK3_1	600	607	PF00069	0.766
MOD_GSK3_1	638	645	PF00069	0.702
MOD_GSK3_1	674	681	PF00069	0.711
MOD_GSK3_1	689	696	PF00069	0.701
MOD_GSK3_1	704	711	PF00069	0.747
MOD_GSK3_1	749	756	PF00069	0.591
MOD_GSK3_1	84	91	PF00069	0.646
MOD_N-GLC_1	373	378	PF02516	0.574
MOD_N-GLC_1	684	689	PF02516	0.568
MOD_NEK2_1	152	157	PF00069	0.597
MOD_NEK2_1	177	182	PF00069	0.745
MOD_NEK2_1	311	316	PF00069	0.694
MOD_NEK2_1	397	402	PF00069	0.729
MOD_NEK2_1	640	645	PF00069	0.698
MOD_NEK2_1	679	684	PF00069	0.827
MOD_NEK2_1	731	736	PF00069	0.639
MOD_NEK2_1	767	772	PF00069	0.731
MOD_NEK2_1	8	13	PF00069	0.411
MOD_NEK2_1	82	87	PF00069	0.662
MOD_NEK2_2	223	228	PF00069	0.642
MOD_NEK2_2	627	632	PF00069	0.677
MOD_PIKK_1	642	648	PF00454	0.738
MOD_PKA_1	203	209	PF00069	0.742
MOD_PKA_1	748	754	PF00069	0.796
MOD_PKA_2	152	158	PF00069	0.748
MOD_PKA_2	180	186	PF00069	0.733
MOD_PKA_2	203	209	PF00069	0.725
MOD_PKA_2	280	286	PF00069	0.811
MOD_PKA_2	565	571	PF00069	0.615
MOD_PKA_2	661	667	PF00069	0.821
MOD_PKA_2	748	754	PF00069	0.786
MOD_PKA_2	767	773	PF00069	0.531
MOD_Plk_1	373	379	PF00069	0.783
MOD_Plk_1	473	479	PF00069	0.584
MOD_Plk_1	582	588	PF00069	0.601
MOD_Plk_1	648	654	PF00069	0.749
MOD_Plk_1	684	690	PF00069	0.769
MOD_Plk_1	93	99	PF00069	0.712
MOD_Plk_2-3	469	475	PF00069	0.713
MOD_Plk_4	648	654	PF00069	0.697
MOD_ProDKin_1	110	116	PF00069	0.691
MOD_ProDKin_1	197	203	PF00069	0.704
MOD_ProDKin_1	273	279	PF00069	0.781
MOD_ProDKin_1	335	341	PF00069	0.828
MOD_ProDKin_1	353	359	PF00069	0.816
MOD_ProDKin_1	484	490	PF00069	0.791
MOD_ProDKin_1	491	497	PF00069	0.728
MOD_ProDKin_1	503	509	PF00069	0.661
MOD_SUMO_for_1	227	230	PF00179	0.642
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.791
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.735
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.607
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.607
TRG_DiLeu_BaLyEn_6	70	75	PF01217	0.788
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.666
TRG_ENDOCYTIC_2	102	105	PF00928	0.638
TRG_ENDOCYTIC_2	20	23	PF00928	0.513
TRG_ENDOCYTIC_2	574	577	PF00928	0.591
TRG_ENDOCYTIC_2	71	74	PF00928	0.762
TRG_ENDOCYTIC_2	737	740	PF00928	0.688
TRG_ENDOCYTIC_2	83	86	PF00928	0.568
TRG_ENDOCYTIC_2	89	92	PF00928	0.518
TRG_ER_diArg_1	184	186	PF00400	0.730
TRG_ER_diArg_1	187	189	PF00400	0.739
TRG_ER_diArg_1	202	204	PF00400	0.674
TRG_ER_diArg_1	255	258	PF00400	0.631
TRG_ER_diArg_1	318	320	PF00400	0.738
TRG_ER_diArg_1	728	730	PF00400	0.753
TRG_ER_diArg_1	748	750	PF00400	0.791
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	729	733	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK26	Leptomonas seymouri	43%	93%
A0A3S5H6C2	Leishmania donovani	86%	100%
A4H5K2	Leishmania braziliensis	67%	96%
A4HTU0	Leishmania infantum	86%	100%
Q4QHZ8	Leishmania major	85%	100%