G10 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

G10 protein

Gene product:

G10 protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMM5_LEIMU

TriTrypDb:

LmxM.09.0260

Length:

272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AMM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.724
CLV_C14_Caspase3-7	64	68	PF00656	0.391
CLV_NRD_NRD_1	156	158	PF00675	0.329
CLV_NRD_NRD_1	195	197	PF00675	0.329
CLV_NRD_NRD_1	220	222	PF00675	0.348
CLV_NRD_NRD_1	58	60	PF00675	0.443
CLV_PCSK_KEX2_1	156	158	PF00082	0.329
CLV_PCSK_KEX2_1	195	197	PF00082	0.329
CLV_PCSK_KEX2_1	60	62	PF00082	0.410
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.397
CLV_PCSK_SKI1_1	124	128	PF00082	0.362
CLV_PCSK_SKI1_1	186	190	PF00082	0.428
CLV_PCSK_SKI1_1	224	228	PF00082	0.227
CLV_PCSK_SKI1_1	30	34	PF00082	0.348
DOC_MAPK_gen_1	120	128	PF00069	0.470
DOC_PP4_MxPP_1	74	77	PF00568	0.190
DOC_USP7_MATH_1	47	51	PF00917	0.287
DOC_USP7_MATH_1	86	90	PF00917	0.365
LIG_14-3-3_CanoR_1	165	174	PF00244	0.358
LIG_14-3-3_CanoR_1	196	206	PF00244	0.443
LIG_BRCT_BRCA1_1	222	226	PF00533	0.447
LIG_Clathr_ClatBox_1	19	23	PF01394	0.330
LIG_EVH1_2	11	15	PF00568	0.329
LIG_FHA_1	121	127	PF00498	0.322
LIG_FHA_2	245	251	PF00498	0.766
LIG_FHA_2	256	262	PF00498	0.771
LIG_FHA_2	31	37	PF00498	0.441
LIG_FHA_2	60	66	PF00498	0.346
LIG_FHA_2	83	89	PF00498	0.467
LIG_FHA_2	93	99	PF00498	0.445
LIG_LIR_Gen_1	123	131	PF02991	0.432
LIG_LIR_Nem_3	123	128	PF02991	0.432
LIG_MLH1_MIPbox_1	222	226	PF16413	0.330
LIG_SH2_PTP2	125	128	PF00017	0.441
LIG_SH2_STAP1	141	145	PF00017	0.416
LIG_SH2_STAP1	25	29	PF00017	0.348
LIG_SH2_STAT3	130	133	PF00017	0.441
LIG_SH2_STAT3	25	28	PF00017	0.470
LIG_SH2_STAT5	125	128	PF00017	0.325
LIG_SH2_STAT5	143	146	PF00017	0.299
LIG_SH2_STAT5	225	228	PF00017	0.480
LIG_SH3_3	105	111	PF00018	0.327
LIG_SH3_3	261	267	PF00018	0.748
LIG_SH3_3	3	9	PF00018	0.470
LIG_TRAF2_1	103	106	PF00917	0.447
LIG_TRAF2_1	258	261	PF00917	0.760
LIG_TRAF2_1	32	35	PF00917	0.441
MOD_CK1_1	50	56	PF00069	0.349
MOD_CK1_1	82	88	PF00069	0.284
MOD_CK1_1	89	95	PF00069	0.265
MOD_CK2_1	255	261	PF00069	0.784
MOD_CK2_1	30	36	PF00069	0.436
MOD_CK2_1	82	88	PF00069	0.348
MOD_CK2_1	92	98	PF00069	0.259
MOD_GlcNHglycan	199	202	PF01048	0.405
MOD_GlcNHglycan	238	241	PF01048	0.389
MOD_GlcNHglycan	49	52	PF01048	0.409
MOD_GlcNHglycan	90	94	PF01048	0.344
MOD_GSK3_1	195	202	PF00069	0.465
MOD_GSK3_1	236	243	PF00069	0.297
MOD_GSK3_1	30	37	PF00069	0.403
MOD_GSK3_1	82	89	PF00069	0.434
MOD_NEK2_1	166	171	PF00069	0.364
MOD_NEK2_1	197	202	PF00069	0.468
MOD_PIKK_1	199	205	PF00454	0.470
MOD_PIKK_1	30	36	PF00454	0.436
MOD_PKA_1	195	201	PF00069	0.441
MOD_PKA_1	59	65	PF00069	0.447
MOD_PKA_2	195	201	PF00069	0.381
MOD_PKA_2	220	226	PF00069	0.447
MOD_PKA_2	47	53	PF00069	0.449
MOD_SUMO_for_1	20	23	PF00179	0.441
MOD_SUMO_rev_2	35	40	PF00179	0.441
TRG_DiLeu_BaEn_4	26	32	PF01217	0.190
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.470
TRG_ENDOCYTIC_2	125	128	PF00928	0.405
TRG_ENDOCYTIC_2	163	166	PF00928	0.313
TRG_ER_diArg_1	122	125	PF00400	0.329
TRG_ER_diArg_1	156	158	PF00400	0.332
TRG_ER_diArg_1	195	197	PF00400	0.402
TRG_NLS_MonoExtC_3	58	63	PF00514	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF7	Leptomonas seymouri	64%	100%
A0A1X0P8N9	Trypanosomatidae	44%	100%
A0A3S5H6C0	Leishmania donovani	89%	100%
A0A422NIY1	Trypanosoma rangeli	41%	100%
A4HTX3	Leishmania infantum	89%	100%
D0A382	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4QI00	Leishmania major	87%	99%
V5AWF3	Trypanosoma cruzi	42%	83%