DNA replication licensing factor MCM4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM4

Species:

Leishmania mexicana

UniProt:

E9AMM4_LEIMU

TriTrypDb:

LmxM.09.0250

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0032991	protein-containing complex	1	12
GO:0042555	MCM complex	2	12
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AMM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006270	DNA replication initiation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006268	DNA unwinding involved in DNA replication	9	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022616	DNA strand elongation	5	1
GO:0032392	DNA geometric change	7	1
GO:0032508	DNA duplex unwinding	8	1
GO:0033554	cellular response to stress	3	1
GO:0050896	response to stimulus	1	1
GO:0051276	chromosome organization	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071103	DNA conformation change	6	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1902292	cell cycle DNA replication initiation	3	1
GO:1902315	nuclear cell cycle DNA replication initiation	4	1
GO:1902975	mitotic DNA replication initiation	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.350
CLV_C14_Caspase3-7	671	675	PF00656	0.649
CLV_NRD_NRD_1	26	28	PF00675	0.318
CLV_NRD_NRD_1	325	327	PF00675	0.667
CLV_NRD_NRD_1	43	45	PF00675	0.337
CLV_NRD_NRD_1	595	597	PF00675	0.262
CLV_NRD_NRD_1	615	617	PF00675	0.441
CLV_NRD_NRD_1	821	823	PF00675	0.505
CLV_NRD_NRD_1	836	838	PF00675	0.418
CLV_PCSK_FUR_1	613	617	PF00082	0.733
CLV_PCSK_KEX2_1	26	28	PF00082	0.337
CLV_PCSK_KEX2_1	399	401	PF00082	0.251
CLV_PCSK_KEX2_1	43	45	PF00082	0.337
CLV_PCSK_KEX2_1	595	597	PF00082	0.262
CLV_PCSK_KEX2_1	615	617	PF00082	0.441
CLV_PCSK_KEX2_1	782	784	PF00082	0.312
CLV_PCSK_KEX2_1	821	823	PF00082	0.505
CLV_PCSK_KEX2_1	828	830	PF00082	0.451
CLV_PCSK_KEX2_1	836	838	PF00082	0.418
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.251
CLV_PCSK_PC1ET2_1	782	784	PF00082	0.312
CLV_PCSK_PC1ET2_1	828	830	PF00082	0.588
CLV_PCSK_PC7_1	22	28	PF00082	0.450
CLV_PCSK_SKI1_1	131	135	PF00082	0.288
CLV_PCSK_SKI1_1	297	301	PF00082	0.433
CLV_PCSK_SKI1_1	400	404	PF00082	0.251
CLV_PCSK_SKI1_1	519	523	PF00082	0.251
CLV_PCSK_SKI1_1	616	620	PF00082	0.672
CLV_PCSK_SKI1_1	791	795	PF00082	0.563
CLV_PCSK_SKI1_1	80	84	PF00082	0.289
CLV_PCSK_SKI1_1	845	849	PF00082	0.423
CLV_Separin_Metazoa	313	317	PF03568	0.568
DEG_APCC_DBOX_1	399	407	PF00400	0.451
DEG_APCC_DBOX_1	435	443	PF00400	0.537
DEG_APCC_DBOX_1	518	526	PF00400	0.451
DEG_APCC_DBOX_1	577	585	PF00400	0.451
DEG_Kelch_Keap1_1	485	490	PF01344	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.573
DEG_SPOP_SBC_1	425	429	PF00917	0.555
DOC_CKS1_1	606	611	PF01111	0.388
DOC_MAPK_DCC_7	181	191	PF00069	0.451
DOC_MAPK_gen_1	181	191	PF00069	0.451
DOC_MAPK_gen_1	766	775	PF00069	0.451
DOC_MAPK_gen_1	834	841	PF00069	0.287
DOC_MAPK_MEF2A_6	102	109	PF00069	0.466
DOC_MAPK_MEF2A_6	184	191	PF00069	0.451
DOC_MAPK_MEF2A_6	436	443	PF00069	0.451
DOC_MAPK_MEF2A_6	578	586	PF00069	0.451
DOC_MAPK_MEF2A_6	90	97	PF00069	0.461
DOC_PP2B_PxIxI_1	186	192	PF00149	0.462
DOC_USP7_MATH_1	39	43	PF00917	0.535
DOC_USP7_MATH_1	426	430	PF00917	0.537
DOC_USP7_MATH_1	517	521	PF00917	0.462
DOC_USP7_MATH_1	544	548	PF00917	0.451
DOC_USP7_MATH_1	554	558	PF00917	0.451
DOC_USP7_MATH_1	56	60	PF00917	0.555
DOC_USP7_MATH_1	631	635	PF00917	0.628
DOC_USP7_MATH_1	697	701	PF00917	0.586
DOC_USP7_MATH_1	740	744	PF00917	0.476
DOC_USP7_UBL2_3	240	244	PF12436	0.512
DOC_USP7_UBL2_3	76	80	PF12436	0.537
DOC_WW_Pin1_4	162	167	PF00397	0.512
DOC_WW_Pin1_4	245	250	PF00397	0.480
DOC_WW_Pin1_4	254	259	PF00397	0.419
DOC_WW_Pin1_4	285	290	PF00397	0.537
DOC_WW_Pin1_4	42	47	PF00397	0.537
DOC_WW_Pin1_4	605	610	PF00397	0.635
LIG_14-3-3_CanoR_1	650	658	PF00244	0.758
LIG_14-3-3_CanoR_1	759	767	PF00244	0.511
LIG_14-3-3_CanoR_1	768	775	PF00244	0.467
LIG_14-3-3_CanoR_1	836	842	PF00244	0.430
LIG_14-3-3_CanoR_1	90	94	PF00244	0.513
LIG_Actin_WH2_2	122	139	PF00022	0.556
LIG_AP2alpha_1	21	25	PF02296	0.424
LIG_APCC_ABBA_1	18	23	PF00400	0.478
LIG_APCC_ABBA_1	234	239	PF00400	0.451
LIG_APCC_ABBA_1	602	607	PF00400	0.451
LIG_APCC_ABBA_1	681	686	PF00400	0.564
LIG_APCC_ABBAyCdc20_2	412	418	PF00400	0.537
LIG_BIR_III_4	623	627	PF00653	0.487
LIG_BIR_III_4	664	668	PF00653	0.788
LIG_BRCT_BRCA1_1	431	435	PF00533	0.537
LIG_CaM_IQ_9	196	212	PF13499	0.476
LIG_Clathr_ClatBox_1	800	804	PF01394	0.542
LIG_eIF4E_1	130	136	PF01652	0.556
LIG_eIF4E_1	237	243	PF01652	0.537
LIG_FHA_1	114	120	PF00498	0.537
LIG_FHA_1	29	35	PF00498	0.492
LIG_FHA_1	294	300	PF00498	0.422
LIG_FHA_1	363	369	PF00498	0.577
LIG_FHA_1	477	483	PF00498	0.451
LIG_FHA_1	486	492	PF00498	0.451
LIG_FHA_1	516	522	PF00498	0.451
LIG_FHA_1	528	534	PF00498	0.451
LIG_FHA_1	544	550	PF00498	0.451
LIG_FHA_1	795	801	PF00498	0.510
LIG_FHA_1	882	888	PF00498	0.484
LIG_FHA_1	90	96	PF00498	0.537
LIG_FHA_2	303	309	PF00498	0.359
LIG_FHA_2	347	353	PF00498	0.597
LIG_FHA_2	638	644	PF00498	0.657
LIG_FHA_2	659	665	PF00498	0.677
LIG_FHA_2	669	675	PF00498	0.674
LIG_LIR_Gen_1	369	378	PF02991	0.484
LIG_LIR_Gen_1	379	389	PF02991	0.414
LIG_LIR_Gen_1	5	16	PF02991	0.533
LIG_LIR_Gen_1	509	517	PF02991	0.451
LIG_LIR_Gen_1	577	586	PF02991	0.451
LIG_LIR_Gen_1	708	718	PF02991	0.451
LIG_LIR_Gen_1	81	87	PF02991	0.516
LIG_LIR_Gen_1	94	105	PF02991	0.555
LIG_LIR_Nem_3	127	133	PF02991	0.512
LIG_LIR_Nem_3	23	28	PF02991	0.355
LIG_LIR_Nem_3	369	374	PF02991	0.457
LIG_LIR_Nem_3	379	384	PF02991	0.441
LIG_LIR_Nem_3	5	11	PF02991	0.550
LIG_LIR_Nem_3	577	582	PF02991	0.451
LIG_LIR_Nem_3	708	713	PF02991	0.453
LIG_LIR_Nem_3	716	722	PF02991	0.455
LIG_LIR_Nem_3	94	100	PF02991	0.556
LIG_NRBOX	438	444	PF00104	0.537
LIG_NRBOX	580	586	PF00104	0.451
LIG_NRBOX	822	828	PF00104	0.561
LIG_NRBOX	866	872	PF00104	0.455
LIG_Pex14_1	197	201	PF04695	0.537
LIG_Pex14_2	21	25	PF04695	0.303
LIG_Pex14_2	579	583	PF04695	0.451
LIG_SH2_CRK	381	385	PF00017	0.450
LIG_SH2_PTP2	710	713	PF00017	0.476
LIG_SH2_PTP2	734	737	PF00017	0.512
LIG_SH2_STAP1	226	230	PF00017	0.451
LIG_SH2_STAP1	381	385	PF00017	0.476
LIG_SH2_STAP1	769	773	PF00017	0.394
LIG_SH2_STAP1	8	12	PF00017	0.546
LIG_SH2_STAT5	10	13	PF00017	0.427
LIG_SH2_STAT5	108	111	PF00017	0.537
LIG_SH2_STAT5	28	31	PF00017	0.451
LIG_SH2_STAT5	467	470	PF00017	0.451
LIG_SH2_STAT5	710	713	PF00017	0.461
LIG_SH2_STAT5	734	737	PF00017	0.451
LIG_SH2_STAT5	78	81	PF00017	0.474
LIG_SH2_STAT5	831	834	PF00017	0.492
LIG_SH3_3	109	115	PF00018	0.512
LIG_SH3_3	35	41	PF00018	0.554
LIG_SH3_3	489	495	PF00018	0.451
LIG_SH3_3	855	861	PF00018	0.566
LIG_SUMO_SIM_anti_2	132	137	PF11976	0.638
LIG_SUMO_SIM_anti_2	866	872	PF11976	0.411
LIG_SUMO_SIM_anti_2	883	889	PF11976	0.420
LIG_SUMO_SIM_par_1	866	872	PF11976	0.515
LIG_SUMO_SIM_par_1	91	96	PF11976	0.477
LIG_TRAF2_1	640	643	PF00917	0.724
LIG_UBA3_1	172	176	PF00899	0.537
LIG_WRC_WIRS_1	29	34	PF05994	0.505
LIG_WRC_WIRS_1	385	390	PF05994	0.451
LIG_WRC_WIRS_1	877	882	PF05994	0.433
MOD_CDK_SPK_2	605	610	PF00069	0.445
MOD_CDK_SPxK_1	285	291	PF00069	0.537
MOD_CK1_1	157	163	PF00069	0.552
MOD_CK1_1	42	48	PF00069	0.551
MOD_CK1_1	429	435	PF00069	0.520
MOD_CK1_1	611	617	PF00069	0.659
MOD_CK1_1	651	657	PF00069	0.740
MOD_CK1_1	705	711	PF00069	0.264
MOD_CK1_1	743	749	PF00069	0.476
MOD_CK1_1	771	777	PF00069	0.537
MOD_CK2_1	232	238	PF00069	0.474
MOD_CK2_1	631	637	PF00069	0.718
MOD_CK2_1	837	843	PF00069	0.409
MOD_CK2_1	88	94	PF00069	0.476
MOD_Cter_Amidation	834	837	PF01082	0.426
MOD_GlcNHglycan	122	125	PF01048	0.330
MOD_GlcNHglycan	206	209	PF01048	0.337
MOD_GlcNHglycan	346	349	PF01048	0.734
MOD_GlcNHglycan	358	361	PF01048	0.567
MOD_GlcNHglycan	421	424	PF01048	0.300
MOD_GlcNHglycan	431	434	PF01048	0.337
MOD_GlcNHglycan	468	471	PF01048	0.251
MOD_GlcNHglycan	58	61	PF01048	0.272
MOD_GlcNHglycan	590	593	PF01048	0.359
MOD_GlcNHglycan	610	613	PF01048	0.637
MOD_GlcNHglycan	653	656	PF01048	0.776
MOD_GlcNHglycan	747	750	PF01048	0.263
MOD_GlcNHglycan	785	788	PF01048	0.251
MOD_GlcNHglycan	852	855	PF01048	0.611
MOD_GlcNHglycan	871	874	PF01048	0.310
MOD_GSK3_1	2	9	PF00069	0.620
MOD_GSK3_1	298	305	PF00069	0.409
MOD_GSK3_1	340	347	PF00069	0.606
MOD_GSK3_1	384	391	PF00069	0.451
MOD_GSK3_1	410	417	PF00069	0.537
MOD_GSK3_1	425	432	PF00069	0.537
MOD_GSK3_1	449	456	PF00069	0.451
MOD_GSK3_1	466	473	PF00069	0.451
MOD_GSK3_1	56	63	PF00069	0.541
MOD_GSK3_1	644	651	PF00069	0.763
MOD_GSK3_1	741	748	PF00069	0.453
MOD_GSK3_1	767	774	PF00069	0.394
MOD_GSK3_1	791	798	PF00069	0.480
MOD_GSK3_1	876	883	PF00069	0.431
MOD_N-GLC_1	232	237	PF02516	0.267
MOD_N-GLC_1	333	338	PF02516	0.723
MOD_N-GLC_1	619	624	PF02516	0.710
MOD_NEK2_1	269	274	PF00069	0.447
MOD_NEK2_1	340	345	PF00069	0.714
MOD_NEK2_1	362	367	PF00069	0.585
MOD_NEK2_1	370	375	PF00069	0.489
MOD_NEK2_1	384	389	PF00069	0.384
MOD_NEK2_1	407	412	PF00069	0.462
MOD_NEK2_1	880	885	PF00069	0.433
MOD_NEK2_2	108	113	PF00069	0.537
MOD_NEK2_2	714	719	PF00069	0.462
MOD_PIKK_1	449	455	PF00454	0.451
MOD_PIKK_1	554	560	PF00454	0.451
MOD_PIKK_1	644	650	PF00454	0.788
MOD_PK_1	837	843	PF00069	0.346
MOD_PKA_1	326	332	PF00069	0.529
MOD_PKA_2	180	186	PF00069	0.451
MOD_PKA_2	315	321	PF00069	0.589
MOD_PKA_2	544	550	PF00069	0.451
MOD_PKA_2	56	62	PF00069	0.539
MOD_PKA_2	649	655	PF00069	0.750
MOD_PKA_2	714	720	PF00069	0.466
MOD_PKA_2	740	746	PF00069	0.492
MOD_PKA_2	758	764	PF00069	0.476
MOD_PKA_2	767	773	PF00069	0.537
MOD_PKA_2	835	841	PF00069	0.460
MOD_PKA_2	89	95	PF00069	0.494
MOD_Plk_1	202	208	PF00069	0.512
MOD_Plk_1	232	238	PF00069	0.467
MOD_Plk_1	6	12	PF00069	0.460
MOD_Plk_1	644	650	PF00069	0.788
MOD_Plk_1	697	703	PF00069	0.312
MOD_Plk_1	771	777	PF00069	0.492
MOD_Plk_1	95	101	PF00069	0.506
MOD_Plk_4	154	160	PF00069	0.548
MOD_Plk_4	232	238	PF00069	0.462
MOD_Plk_4	269	275	PF00069	0.518
MOD_Plk_4	298	304	PF00069	0.527
MOD_Plk_4	340	346	PF00069	0.453
MOD_Plk_4	410	416	PF00069	0.537
MOD_Plk_4	544	550	PF00069	0.451
MOD_Plk_4	571	577	PF00069	0.451
MOD_Plk_4	6	12	PF00069	0.460
MOD_Plk_4	600	606	PF00069	0.451
MOD_Plk_4	697	703	PF00069	0.588
MOD_Plk_4	714	720	PF00069	0.501
MOD_Plk_4	753	759	PF00069	0.451
MOD_ProDKin_1	162	168	PF00069	0.512
MOD_ProDKin_1	245	251	PF00069	0.480
MOD_ProDKin_1	254	260	PF00069	0.419
MOD_ProDKin_1	285	291	PF00069	0.537
MOD_ProDKin_1	42	48	PF00069	0.537
MOD_ProDKin_1	605	611	PF00069	0.643
MOD_SUMO_rev_2	235	242	PF00179	0.454
MOD_SUMO_rev_2	774	784	PF00179	0.453
TRG_DiLeu_BaEn_1	238	243	PF01217	0.476
TRG_DiLeu_BaEn_1	438	443	PF01217	0.512
TRG_DiLeu_BaEn_1	494	499	PF01217	0.467
TRG_DiLeu_BaEn_1	866	871	PF01217	0.407
TRG_ENDOCYTIC_2	130	133	PF00928	0.532
TRG_ENDOCYTIC_2	266	269	PF00928	0.492
TRG_ENDOCYTIC_2	381	384	PF00928	0.462
TRG_ENDOCYTIC_2	710	713	PF00928	0.451
TRG_ENDOCYTIC_2	734	737	PF00928	0.451
TRG_ENDOCYTIC_2	8	11	PF00928	0.521
TRG_ER_diArg_1	25	27	PF00400	0.537
TRG_ER_diArg_1	595	597	PF00400	0.462
TRG_ER_diArg_1	613	616	PF00400	0.632
TRG_ER_diArg_1	820	822	PF00400	0.532
TRG_NES_CRM1_1	562	572	PF08389	0.537
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	30%	90%
A0A0N1I383	Leptomonas seymouri	75%	88%
A0A0S4IK09	Bodo saltans	29%	91%
A0A0S4IW18	Bodo saltans	57%	100%
A0A0S4IYQ3	Bodo saltans	29%	100%
A0A1X0NNF6	Trypanosomatidae	58%	98%
A0A1X0NZT6	Trypanosomatidae	30%	95%
A0A3Q8IAX4	Leishmania donovani	31%	92%
A0A3R7K9K0	Trypanosoma rangeli	30%	100%
A0A3R7NBN0	Trypanosoma rangeli	31%	94%
A0A3S7WQI8	Leishmania donovani	95%	100%
A0A3S7WY81	Leishmania donovani	30%	100%
A0A422NDD9	Trypanosoma rangeli	57%	100%
A4FUD9	Bos taurus	32%	100%
A4H5K0	Leishmania braziliensis	87%	100%
A4HDE7	Leishmania braziliensis	29%	100%
A4HGC9	Leishmania braziliensis	31%	92%
A4HTX2	Leishmania infantum	95%	100%
A4I0T0	Leishmania infantum	30%	100%
A4I3G2	Leishmania infantum	31%	92%
B8AZ14	Oryza sativa subsp. indica	30%	100%
B8AZ99	Oryza sativa subsp. indica	30%	100%
B8BKI8	Oryza sativa subsp. indica	28%	93%
B9FKM7	Oryza sativa subsp. japonica	30%	100%
D0A7X6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	94%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D3ZVK1	Rattus norvegicus	31%	100%
E1BPX4	Bos taurus	30%	100%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
I0IUP3	Gallus gallus	28%	100%
P24279	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
P25205	Homo sapiens	32%	100%
P25206	Mus musculus	32%	100%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P30664	Xenopus laevis	43%	100%
P30665	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	96%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P33991	Homo sapiens	43%	100%
P49717	Mus musculus	43%	100%
P49739	Xenopus laevis	31%	100%
P55861	Xenopus laevis	29%	100%
Q0DHC4	Oryza sativa subsp. japonica	30%	100%
Q0V9Q6	Xenopus tropicalis	30%	100%
Q0WVF5	Arabidopsis thaliana	39%	100%
Q21902	Caenorhabditis elegans	28%	100%
Q26454	Drosophila melanogaster	41%	100%
Q28BS0	Xenopus tropicalis	32%	100%
Q2R482	Oryza sativa subsp. japonica	29%	93%
Q43704	Zea mays	30%	100%
Q4Q8I2	Leishmania major	31%	92%
Q4QAP2	Leishmania major	30%	100%
Q4QI01	Leishmania major	94%	100%
Q4QJG9	Leishmania major	25%	100%
Q5F310	Xenopus laevis	29%	100%
Q5JKB0	Oryza sativa subsp. japonica	42%	100%
Q5R8G6	Pongo abelii	32%	100%
Q5XK83	Xenopus laevis	42%	100%
Q6GL41	Xenopus tropicalis	43%	100%
Q7ZXZ0	Xenopus laevis	32%	100%
Q95XQ8	Caenorhabditis elegans	41%	100%
Q9CWV1	Mus musculus	30%	100%
Q9FL33	Arabidopsis thaliana	30%	100%
Q9LPD9	Arabidopsis thaliana	28%	96%
Q9SF37	Arabidopsis thaliana	30%	100%
Q9SX03	Zea mays	30%	100%
Q9SX04	Zea mays	30%	100%
Q9UJA3	Homo sapiens	29%	100%
Q9VF30	Drosophila melanogaster	25%	100%
Q9XYU1	Drosophila melanogaster	31%	100%
V5BQA9	Trypanosoma cruzi	29%	100%
V5BSG2	Trypanosoma cruzi	58%	100%