LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

SPX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SPX domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AMM1_LEIMU
TriTrypDb:
LmxM.09.0220
Length:
813

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0020022 acidocalcisome 5 1
GO:0032991 protein-containing complex 1 1
GO:0033254 vacuolar transporter chaperone complex 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0101031 protein folding chaperone complex 3 1
GO:0140535 intracellular protein-containing complex 2 1

Expansion

Sequence features

E9AMM1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM1

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006797 polyphosphate metabolic process 4 1
GO:0006799 polyphosphate biosynthetic process 4 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 427 431 PF00656 0.491
CLV_NRD_NRD_1 212 214 PF00675 0.260
CLV_NRD_NRD_1 275 277 PF00675 0.250
CLV_NRD_NRD_1 327 329 PF00675 0.250
CLV_NRD_NRD_1 355 357 PF00675 0.337
CLV_NRD_NRD_1 629 631 PF00675 0.454
CLV_NRD_NRD_1 764 766 PF00675 0.340
CLV_NRD_NRD_1 769 771 PF00675 0.377
CLV_NRD_NRD_1 801 803 PF00675 0.635
CLV_PCSK_FUR_1 762 766 PF00082 0.261
CLV_PCSK_KEX2_1 105 107 PF00082 0.471
CLV_PCSK_KEX2_1 212 214 PF00082 0.286
CLV_PCSK_KEX2_1 250 252 PF00082 0.147
CLV_PCSK_KEX2_1 275 277 PF00082 0.249
CLV_PCSK_KEX2_1 326 328 PF00082 0.250
CLV_PCSK_KEX2_1 354 356 PF00082 0.336
CLV_PCSK_KEX2_1 605 607 PF00082 0.522
CLV_PCSK_KEX2_1 629 631 PF00082 0.441
CLV_PCSK_KEX2_1 675 677 PF00082 0.441
CLV_PCSK_KEX2_1 764 766 PF00082 0.340
CLV_PCSK_KEX2_1 769 771 PF00082 0.377
CLV_PCSK_KEX2_1 801 803 PF00082 0.635
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.478
CLV_PCSK_PC1ET2_1 250 252 PF00082 0.147
CLV_PCSK_PC1ET2_1 326 328 PF00082 0.250
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.336
CLV_PCSK_PC1ET2_1 605 607 PF00082 0.522
CLV_PCSK_PC1ET2_1 675 677 PF00082 0.441
CLV_PCSK_PC7_1 323 329 PF00082 0.250
CLV_PCSK_PC7_1 765 771 PF00082 0.402
CLV_PCSK_SKI1_1 105 109 PF00082 0.378
CLV_PCSK_SKI1_1 213 217 PF00082 0.250
CLV_PCSK_SKI1_1 269 273 PF00082 0.265
CLV_PCSK_SKI1_1 28 32 PF00082 0.329
CLV_PCSK_SKI1_1 383 387 PF00082 0.260
CLV_PCSK_SKI1_1 392 396 PF00082 0.235
CLV_PCSK_SKI1_1 531 535 PF00082 0.448
CLV_PCSK_SKI1_1 630 634 PF00082 0.530
CLV_PCSK_SKI1_1 675 679 PF00082 0.473
CLV_PCSK_SKI1_1 686 690 PF00082 0.219
CLV_PCSK_SKI1_1 717 721 PF00082 0.518
CLV_PCSK_SKI1_1 81 85 PF00082 0.423
CLV_PCSK_SKI1_1 92 96 PF00082 0.486
CLV_Separin_Metazoa 122 126 PF03568 0.476
DEG_APCC_KENBOX_2 34 38 PF00400 0.646
DEG_SPOP_SBC_1 585 589 PF00917 0.756
DOC_CKS1_1 41 46 PF01111 0.543
DOC_CYCLIN_RxL_1 101 111 PF00134 0.687
DOC_CYCLIN_RxL_1 714 724 PF00134 0.336
DOC_MAPK_gen_1 212 221 PF00069 0.491
DOC_MAPK_gen_1 245 254 PF00069 0.458
DOC_MAPK_HePTP_8 501 513 PF00069 0.672
DOC_MAPK_MEF2A_6 230 237 PF00069 0.475
DOC_MAPK_MEF2A_6 504 513 PF00069 0.685
DOC_MAPK_MEF2A_6 65 74 PF00069 0.531
DOC_PP1_RVXF_1 529 535 PF00149 0.655
DOC_PP2B_LxvP_1 198 201 PF13499 0.740
DOC_PP2B_LxvP_1 719 722 PF13499 0.336
DOC_SPAK_OSR1_1 328 332 PF12202 0.511
DOC_USP7_MATH_1 204 208 PF00917 0.703
DOC_USP7_MATH_1 259 263 PF00917 0.461
DOC_USP7_MATH_1 365 369 PF00917 0.499
DOC_USP7_MATH_1 39 43 PF00917 0.602
DOC_USP7_MATH_1 576 580 PF00917 0.770
DOC_USP7_MATH_1 584 588 PF00917 0.670
DOC_USP7_MATH_1 6 10 PF00917 0.550
DOC_USP7_UBL2_3 101 105 PF12436 0.727
DOC_USP7_UBL2_3 241 245 PF12436 0.458
DOC_USP7_UBL2_3 678 682 PF12436 0.645
DOC_WW_Pin1_4 100 105 PF00397 0.633
DOC_WW_Pin1_4 255 260 PF00397 0.461
DOC_WW_Pin1_4 40 45 PF00397 0.545
DOC_WW_Pin1_4 428 433 PF00397 0.491
DOC_WW_Pin1_4 726 731 PF00397 0.311
LIG_14-3-3_CanoR_1 130 140 PF00244 0.538
LIG_14-3-3_CanoR_1 184 192 PF00244 0.557
LIG_14-3-3_CanoR_1 212 216 PF00244 0.461
LIG_14-3-3_CanoR_1 412 420 PF00244 0.469
LIG_14-3-3_CanoR_1 504 511 PF00244 0.616
LIG_14-3-3_CanoR_1 563 569 PF00244 0.581
LIG_14-3-3_CanoR_1 629 635 PF00244 0.523
LIG_14-3-3_CanoR_1 92 97 PF00244 0.663
LIG_Actin_WH2_2 112 127 PF00022 0.495
LIG_Actin_WH2_2 370 385 PF00022 0.461
LIG_APCC_ABBA_1 312 317 PF00400 0.450
LIG_APCC_ABBA_1 639 644 PF00400 0.639
LIG_APCC_ABBAyCdc20_2 8 14 PF00400 0.532
LIG_BIR_III_4 203 207 PF00653 0.524
LIG_BRCT_BRCA1_1 206 210 PF00533 0.619
LIG_BRCT_BRCA1_1 711 715 PF00533 0.423
LIG_BRCT_BRCA1_1 809 813 PF00533 0.429
LIG_BRCT_BRCA1_2 711 717 PF00533 0.423
LIG_EH1_1 225 233 PF00400 0.450
LIG_eIF4E_1 683 689 PF01652 0.556
LIG_FHA_1 132 138 PF00498 0.541
LIG_FHA_1 25 31 PF00498 0.541
LIG_FHA_1 369 375 PF00498 0.434
LIG_FHA_1 400 406 PF00498 0.401
LIG_FHA_1 484 490 PF00498 0.514
LIG_FHA_1 515 521 PF00498 0.585
LIG_FHA_1 539 545 PF00498 0.677
LIG_FHA_1 634 640 PF00498 0.687
LIG_FHA_1 645 651 PF00498 0.647
LIG_FHA_1 69 75 PF00498 0.535
LIG_FHA_1 782 788 PF00498 0.332
LIG_FHA_2 200 206 PF00498 0.735
LIG_FHA_2 237 243 PF00498 0.450
LIG_FHA_2 292 298 PF00498 0.536
LIG_FHA_2 41 47 PF00498 0.537
LIG_FHA_2 425 431 PF00498 0.526
LIG_FHA_2 505 511 PF00498 0.591
LIG_FHA_2 82 88 PF00498 0.601
LIG_GBD_Chelix_1 115 123 PF00786 0.289
LIG_LIR_Gen_1 163 174 PF02991 0.522
LIG_LIR_Gen_1 179 189 PF02991 0.465
LIG_LIR_Gen_1 297 306 PF02991 0.452
LIG_LIR_Gen_1 45 56 PF02991 0.505
LIG_LIR_Gen_1 486 496 PF02991 0.513
LIG_LIR_Gen_1 555 565 PF02991 0.545
LIG_LIR_Gen_1 633 642 PF02991 0.531
LIG_LIR_Gen_1 734 744 PF02991 0.301
LIG_LIR_Gen_1 751 761 PF02991 0.200
LIG_LIR_Gen_1 781 789 PF02991 0.324
LIG_LIR_Gen_1 790 799 PF02991 0.309
LIG_LIR_Nem_3 155 160 PF02991 0.526
LIG_LIR_Nem_3 163 169 PF02991 0.499
LIG_LIR_Nem_3 172 178 PF02991 0.452
LIG_LIR_Nem_3 179 185 PF02991 0.485
LIG_LIR_Nem_3 297 302 PF02991 0.452
LIG_LIR_Nem_3 306 312 PF02991 0.449
LIG_LIR_Nem_3 364 369 PF02991 0.475
LIG_LIR_Nem_3 45 51 PF02991 0.516
LIG_LIR_Nem_3 555 560 PF02991 0.558
LIG_LIR_Nem_3 633 637 PF02991 0.613
LIG_LIR_Nem_3 703 708 PF02991 0.401
LIG_LIR_Nem_3 734 739 PF02991 0.304
LIG_LIR_Nem_3 751 757 PF02991 0.224
LIG_LIR_Nem_3 781 785 PF02991 0.324
LIG_LIR_Nem_3 790 794 PF02991 0.309
LIG_LIR_Nem_3 9 15 PF02991 0.532
LIG_LYPXL_S_1 11 15 PF13949 0.323
LIG_LYPXL_SIV_4 437 445 PF13949 0.450
LIG_MYND_1 617 621 PF01753 0.699
LIG_PCNA_yPIPBox_3 168 180 PF02747 0.585
LIG_Pex14_1 157 161 PF04695 0.602
LIG_Pex14_1 732 736 PF04695 0.261
LIG_Pex14_1 782 786 PF04695 0.407
LIG_PTB_Apo_2 264 271 PF02174 0.491
LIG_Rb_LxCxE_1 442 459 PF01857 0.450
LIG_RPA_C_Fungi 760 772 PF08784 0.465
LIG_SH2_CRK 147 151 PF00017 0.430
LIG_SH2_CRK 166 170 PF00017 0.373
LIG_SH2_CRK 182 186 PF00017 0.325
LIG_SH2_CRK 48 52 PF00017 0.379
LIG_SH2_CRK 557 561 PF00017 0.407
LIG_SH2_CRK 666 670 PF00017 0.629
LIG_SH2_CRK 754 758 PF00017 0.318
LIG_SH2_GRB2like 265 268 PF00017 0.387
LIG_SH2_NCK_1 166 170 PF00017 0.472
LIG_SH2_NCK_1 438 442 PF00017 0.302
LIG_SH2_NCK_1 557 561 PF00017 0.455
LIG_SH2_SRC 475 478 PF00017 0.318
LIG_SH2_SRC 754 757 PF00017 0.337
LIG_SH2_SRC 774 777 PF00017 0.260
LIG_SH2_STAP1 291 295 PF00017 0.359
LIG_SH2_STAP1 3 7 PF00017 0.538
LIG_SH2_STAP1 48 52 PF00017 0.499
LIG_SH2_STAP1 557 561 PF00017 0.432
LIG_SH2_STAP1 774 778 PF00017 0.507
LIG_SH2_STAT5 161 164 PF00017 0.492
LIG_SH2_STAT5 21 24 PF00017 0.367
LIG_SH2_STAT5 426 429 PF00017 0.348
LIG_SH2_STAT5 634 637 PF00017 0.554
LIG_SH2_STAT5 756 759 PF00017 0.337
LIG_SH2_STAT5 82 85 PF00017 0.442
LIG_SH3_1 230 236 PF00018 0.318
LIG_SH3_3 146 152 PF00018 0.443
LIG_SH3_3 230 236 PF00018 0.318
LIG_SH3_3 38 44 PF00018 0.452
LIG_SH3_3 774 780 PF00018 0.510
LIG_SH3_5 553 557 PF00018 0.536
LIG_Sin3_3 746 753 PF02671 0.274
LIG_SUMO_SIM_par_1 68 73 PF11976 0.379
LIG_TRAF2_1 170 173 PF00917 0.474
LIG_TRAF2_1 301 304 PF00917 0.449
LIG_TRAF2_1 361 364 PF00917 0.387
LIG_TRAF2_1 84 87 PF00917 0.518
LIG_TRFH_1 380 384 PF08558 0.318
LIG_TRFH_1 637 641 PF08558 0.588
LIG_TYR_ITIM 664 669 PF00017 0.630
LIG_TYR_ITIM 752 757 PF00017 0.314
LIG_TYR_ITIM 772 777 PF00017 0.346
LIG_TYR_ITSM 553 560 PF00017 0.509
LIG_UBA3_1 30 35 PF00899 0.424
LIG_WRC_WIRS_1 237 242 PF05994 0.337
LIG_WRC_WIRS_1 634 639 PF05994 0.646
MOD_CDK_SPK_2 100 105 PF00069 0.401
MOD_CDK_SPxK_1 100 106 PF00069 0.395
MOD_CK1_1 199 205 PF00069 0.707
MOD_CK1_1 258 264 PF00069 0.328
MOD_CK1_1 368 374 PF00069 0.357
MOD_CK1_1 406 412 PF00069 0.302
MOD_CK1_1 431 437 PF00069 0.359
MOD_CK1_1 579 585 PF00069 0.594
MOD_CK2_1 167 173 PF00069 0.368
MOD_CK2_1 199 205 PF00069 0.706
MOD_CK2_1 240 246 PF00069 0.394
MOD_CK2_1 291 297 PF00069 0.423
MOD_CK2_1 356 362 PF00069 0.359
MOD_CK2_1 40 46 PF00069 0.436
MOD_CK2_1 47 53 PF00069 0.381
MOD_CK2_1 504 510 PF00069 0.480
MOD_CK2_1 81 87 PF00069 0.501
MOD_Cter_Amidation 673 676 PF01082 0.563
MOD_GlcNHglycan 192 195 PF01048 0.526
MOD_GlcNHglycan 319 322 PF01048 0.302
MOD_GlcNHglycan 413 416 PF01048 0.351
MOD_GlcNHglycan 578 581 PF01048 0.714
MOD_GlcNHglycan 582 585 PF01048 0.707
MOD_GlcNHglycan 8 11 PF01048 0.444
MOD_GSK3_1 236 243 PF00069 0.318
MOD_GSK3_1 255 262 PF00069 0.318
MOD_GSK3_1 317 324 PF00069 0.304
MOD_GSK3_1 368 375 PF00069 0.275
MOD_GSK3_1 399 406 PF00069 0.158
MOD_GSK3_1 424 431 PF00069 0.387
MOD_GSK3_1 540 547 PF00069 0.570
MOD_GSK3_1 572 579 PF00069 0.633
MOD_GSK3_1 580 587 PF00069 0.660
MOD_GSK3_1 640 647 PF00069 0.622
MOD_GSK3_1 684 691 PF00069 0.302
MOD_GSK3_1 77 84 PF00069 0.410
MOD_GSK3_1 805 812 PF00069 0.540
MOD_GSK3_1 90 97 PF00069 0.515
MOD_N-GLC_1 356 361 PF02516 0.359
MOD_N-GLC_1 580 585 PF02516 0.629
MOD_N-GLC_1 644 649 PF02516 0.523
MOD_N-GLC_1 726 731 PF02516 0.236
MOD_N-GLC_1 90 95 PF02516 0.558
MOD_NEK2_1 240 245 PF00069 0.318
MOD_NEK2_1 47 52 PF00069 0.393
MOD_NEK2_1 632 637 PF00069 0.711
MOD_NEK2_1 654 659 PF00069 0.523
MOD_NEK2_1 70 75 PF00069 0.478
MOD_NEK2_1 701 706 PF00069 0.411
MOD_NEK2_1 708 713 PF00069 0.342
MOD_NEK2_1 807 812 PF00069 0.555
MOD_NEK2_2 236 241 PF00069 0.318
MOD_NEK2_2 259 264 PF00069 0.318
MOD_NEK2_2 399 404 PF00069 0.272
MOD_NEK2_2 478 483 PF00069 0.318
MOD_NEK2_2 709 714 PF00069 0.411
MOD_PIKK_1 204 210 PF00454 0.521
MOD_PIKK_1 385 391 PF00454 0.302
MOD_PIKK_1 538 544 PF00454 0.580
MOD_PIKK_1 95 101 PF00454 0.504
MOD_PKA_2 190 196 PF00069 0.530
MOD_PKA_2 211 217 PF00069 0.332
MOD_PKA_2 403 409 PF00069 0.302
MOD_PKA_2 411 417 PF00069 0.302
MOD_PKA_2 424 430 PF00069 0.335
MOD_PKA_2 503 509 PF00069 0.462
MOD_PKB_1 287 295 PF00069 0.344
MOD_Plk_1 399 405 PF00069 0.159
MOD_Plk_1 90 96 PF00069 0.542
MOD_Plk_2-3 167 173 PF00069 0.473
MOD_Plk_4 259 265 PF00069 0.302
MOD_Plk_4 281 287 PF00069 0.302
MOD_Plk_4 342 348 PF00069 0.378
MOD_Plk_4 47 53 PF00069 0.397
MOD_Plk_4 478 484 PF00069 0.318
MOD_Plk_4 588 594 PF00069 0.467
MOD_Plk_4 615 621 PF00069 0.733
MOD_Plk_4 684 690 PF00069 0.302
MOD_Plk_4 778 784 PF00069 0.309
MOD_Plk_4 787 793 PF00069 0.291
MOD_ProDKin_1 100 106 PF00069 0.554
MOD_ProDKin_1 255 261 PF00069 0.318
MOD_ProDKin_1 40 46 PF00069 0.436
MOD_ProDKin_1 428 434 PF00069 0.359
MOD_ProDKin_1 726 732 PF00069 0.387
MOD_SUMO_rev_2 17 27 PF00179 0.484
MOD_SUMO_rev_2 306 314 PF00179 0.299
MOD_SUMO_rev_2 375 385 PF00179 0.340
MOD_SUMO_rev_2 50 56 PF00179 0.430
MOD_SUMO_rev_2 596 603 PF00179 0.724
TRG_DiLeu_BaEn_1 173 178 PF01217 0.268
TRG_DiLeu_BaEn_1 281 286 PF01217 0.318
TRG_DiLeu_BaEn_2 334 340 PF01217 0.423
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.598
TRG_DiLeu_BaLyEn_6 110 115 PF01217 0.453
TRG_DiLeu_BaLyEn_6 528 533 PF01217 0.652
TRG_ENDOCYTIC_2 12 15 PF00928 0.389
TRG_ENDOCYTIC_2 147 150 PF00928 0.430
TRG_ENDOCYTIC_2 166 169 PF00928 0.373
TRG_ENDOCYTIC_2 182 185 PF00928 0.284
TRG_ENDOCYTIC_2 438 441 PF00928 0.331
TRG_ENDOCYTIC_2 48 51 PF00928 0.381
TRG_ENDOCYTIC_2 557 560 PF00928 0.416
TRG_ENDOCYTIC_2 561 564 PF00928 0.381
TRG_ENDOCYTIC_2 634 637 PF00928 0.554
TRG_ENDOCYTIC_2 666 669 PF00928 0.633
TRG_ENDOCYTIC_2 728 731 PF00928 0.236
TRG_ENDOCYTIC_2 754 757 PF00928 0.302
TRG_ENDOCYTIC_2 774 777 PF00928 0.260
TRG_ENDOCYTIC_2 803 806 PF00928 0.422
TRG_ER_diArg_1 275 277 PF00400 0.302
TRG_ER_diArg_1 286 289 PF00400 0.285
TRG_ER_diArg_1 327 329 PF00400 0.302
TRG_ER_diArg_1 762 765 PF00400 0.318
TRG_ER_diArg_1 801 803 PF00400 0.561
TRG_NLS_MonoExtC_3 769 775 PF00514 0.478
TRG_NLS_MonoExtN_4 323 330 PF00514 0.302
TRG_NLS_MonoExtN_4 352 358 PF00514 0.423
TRG_NLS_MonoExtN_4 769 774 PF00514 0.479
TRG_Pf-PMV_PEXEL_1 106 111 PF00026 0.549
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.406
TRG_Pf-PMV_PEXEL_1 130 135 PF00026 0.257
TRG_Pf-PMV_PEXEL_1 566 571 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 81 85 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5C3 Leptomonas seymouri 80% 99%
A0A0S4J2S6 Bodo saltans 57% 100%
A0A0S4JCW1 Bodo saltans 25% 83%
A0A1X0NMU3 Trypanosomatidae 69% 100%
A0A3S7WQI7 Leishmania donovani 95% 100%
A0A422NDG2 Trypanosoma rangeli 68% 100%
A4H5J7 Leishmania braziliensis 87% 100%
A4HTX5 Leishmania infantum 95% 100%
D0A996 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
P47075 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
P78810 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 100%
Q4QI04 Leishmania major 95% 100%
V5BIC5 Trypanosoma cruzi 67% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS