Sperm-tail PG-rich repeat-containing protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania mexicana

UniProt:

E9AMM0_LEIMU

TriTrypDb:

LmxM.09.0210

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	21
GO:0005815	microtubule organizing center	2	21
GO:0110165	cellular anatomical entity	1	21

Expansion

Sequence features

E9AMM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.306
CLV_NRD_NRD_1	178	180	PF00675	0.309
CLV_NRD_NRD_1	236	238	PF00675	0.327
CLV_PCSK_KEX2_1	16	18	PF00082	0.266
CLV_PCSK_KEX2_1	173	175	PF00082	0.308
CLV_PCSK_KEX2_1	221	223	PF00082	0.296
CLV_PCSK_KEX2_1	34	36	PF00082	0.252
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.266
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.296
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.252
CLV_PCSK_SKI1_1	174	178	PF00082	0.291
DEG_Nend_Nbox_1	1	3	PF02207	0.440
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.505
DOC_PP4_FxxP_1	2	5	PF00568	0.465
DOC_PP4_FxxP_1	61	64	PF00568	0.502
DOC_USP7_MATH_1	190	194	PF00917	0.475
DOC_USP7_MATH_1	229	233	PF00917	0.544
DOC_USP7_MATH_1	46	50	PF00917	0.505
DOC_USP7_MATH_1	55	59	PF00917	0.505
DOC_USP7_MATH_1	67	71	PF00917	0.420
DOC_USP7_UBL2_3	95	99	PF12436	0.524
DOC_WW_Pin1_4	186	191	PF00397	0.509
DOC_WW_Pin1_4	220	225	PF00397	0.480
LIG_14-3-3_CanoR_1	222	230	PF00244	0.500
LIG_AP2alpha_2	45	47	PF02296	0.442
LIG_BRCT_BRCA1_1	57	61	PF00533	0.534
LIG_CSL_BTD_1	239	242	PF09270	0.505
LIG_CSL_BTD_1	280	283	PF09270	0.465
LIG_FHA_1	182	188	PF00498	0.511
LIG_FHA_1	213	219	PF00498	0.492
LIG_FHA_1	292	298	PF00498	0.517
LIG_FHA_2	103	109	PF00498	0.436
LIG_FHA_2	121	127	PF00498	0.440
LIG_LIR_Apic_2	58	64	PF02991	0.470
LIG_LIR_Gen_1	45	55	PF02991	0.475
LIG_LIR_Nem_3	101	106	PF02991	0.452
LIG_LIR_Nem_3	115	121	PF02991	0.442
LIG_LIR_Nem_3	147	153	PF02991	0.449
LIG_LIR_Nem_3	287	292	PF02991	0.485
LIG_LIR_Nem_3	41	47	PF02991	0.464
LIG_LIR_Nem_3	54	59	PF02991	0.384
LIG_Pex14_2	61	65	PF04695	0.505
LIG_SH2_CRK	150	154	PF00017	0.460
LIG_SH2_CRK	289	293	PF00017	0.538
LIG_SH2_CRK	299	303	PF00017	0.489
LIG_SH2_CRK	56	60	PF00017	0.534
LIG_SH2_NCK_1	299	303	PF00017	0.521
LIG_SH2_NCK_1	56	60	PF00017	0.415
LIG_SH2_SRC	299	302	PF00017	0.543
LIG_SH2_STAT5	150	153	PF00017	0.481
LIG_SH2_STAT5	163	166	PF00017	0.441
LIG_SH2_STAT5	291	294	PF00017	0.545
LIG_SH2_STAT5	56	59	PF00017	0.418
LIG_SH2_STAT5	7	10	PF00017	0.468
LIG_SH3_2	217	222	PF14604	0.440
LIG_SH3_3	137	143	PF00018	0.469
LIG_SH3_3	161	167	PF00018	0.486
LIG_SH3_3	184	190	PF00018	0.502
LIG_SH3_3	214	220	PF00018	0.436
LIG_SH3_3	236	242	PF00018	0.482
LIG_SH3_3	277	283	PF00018	0.466
LIG_SH3_3	83	89	PF00018	0.441
LIG_TRAF2_1	225	228	PF00917	0.346
LIG_WRC_WIRS_1	103	108	PF05994	0.440
LIG_WRPW_2	278	281	PF00400	0.465
LIG_WW_1	4	7	PF00397	0.524
MOD_CDC14_SPxK_1	189	192	PF00782	0.442
MOD_CDK_SPxK_1	186	192	PF00069	0.442
MOD_CK1_1	223	229	PF00069	0.511
MOD_CK1_1	231	237	PF00069	0.517
MOD_CK1_1	70	76	PF00069	0.338
MOD_CK1_1	93	99	PF00069	0.486
MOD_CK2_1	102	108	PF00069	0.433
MOD_CK2_1	222	228	PF00069	0.338
MOD_Cter_Amidation	235	238	PF01082	0.242
MOD_GlcNHglycan	192	195	PF01048	0.264
MOD_GlcNHglycan	196	199	PF01048	0.253
MOD_GlcNHglycan	231	234	PF01048	0.354
MOD_GlcNHglycan	275	278	PF01048	0.313
MOD_GlcNHglycan	31	34	PF01048	0.317
MOD_GlcNHglycan	69	72	PF01048	0.253
MOD_GlcNHglycan	79	82	PF01048	0.343
MOD_GlcNHglycan	96	99	PF01048	0.150
MOD_GSK3_1	144	151	PF00069	0.480
MOD_GSK3_1	186	193	PF00069	0.529
MOD_GSK3_1	66	73	PF00069	0.380
MOD_GSK3_1	90	97	PF00069	0.448
MOD_N-GLC_1	67	72	PF02516	0.335
MOD_NEK2_1	201	206	PF00069	0.493
MOD_NEK2_1	29	34	PF00069	0.530
MOD_PIKK_1	223	229	PF00454	0.513
MOD_PKA_1	144	150	PF00069	0.453
MOD_PKA_1	94	100	PF00069	0.529
MOD_Plk_1	40	46	PF00069	0.534
MOD_ProDKin_1	186	192	PF00069	0.509
MOD_ProDKin_1	220	226	PF00069	0.480
MOD_SUMO_rev_2	259	268	PF00179	0.483
TRG_ENDOCYTIC_2	103	106	PF00928	0.453
TRG_ENDOCYTIC_2	150	153	PF00928	0.474
TRG_ENDOCYTIC_2	289	292	PF00928	0.514
TRG_ENDOCYTIC_2	56	59	PF00928	0.465
TRG_ENDOCYTIC_2	7	10	PF00928	0.474
TRG_ER_diArg_1	172	174	PF00400	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4L7	Leptomonas seymouri	75%	100%
A0A0N1I8Z0	Leptomonas seymouri	32%	100%
A0A0S4IYY4	Bodo saltans	41%	100%
A0A0S4KM52	Bodo saltans	31%	100%
A0A1X0NMW4	Trypanosomatidae	50%	100%
A0A1X0NRI3	Trypanosomatidae	29%	100%
A0A3Q8IGT8	Leishmania donovani	31%	100%
A0A3S5H6B7	Leishmania donovani	94%	100%
A0A422NDP9	Trypanosoma rangeli	48%	100%
A0A422NZ19	Trypanosoma rangeli	28%	100%
A4H5J6	Leishmania braziliensis	86%	100%
A4HGN9	Leishmania braziliensis	30%	96%
A4HTT9	Leishmania infantum	94%	100%
A4I3R2	Leishmania infantum	31%	100%
D0A896	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A995	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q0P4C5	Danio rerio	27%	98%
Q2T9M0	Bos taurus	25%	99%
Q3U1D9	Mus musculus	28%	97%
Q4Q880	Leishmania major	31%	100%
Q4QI05	Leishmania major	96%	100%
Q5XHC1	Xenopus laevis	25%	99%
V5BSF6	Trypanosoma cruzi	47%	100%