Glutamine amidotransferase type-2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NRDE protein, putative

Species:

Leishmania mexicana

UniProt:

E9AML9_LEIMU

TriTrypDb:

LmxM.09.0200

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AML9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AML9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.430
CLV_NRD_NRD_1	220	222	PF00675	0.427
CLV_NRD_NRD_1	70	72	PF00675	0.328
CLV_PCSK_KEX2_1	220	222	PF00082	0.427
CLV_PCSK_KEX2_1	70	72	PF00082	0.328
CLV_PCSK_SKI1_1	172	176	PF00082	0.373
DEG_Nend_UBRbox_4	1	3	PF02207	0.269
DEG_SCF_FBW7_1	436	443	PF00400	0.413
DEG_SPOP_SBC_1	306	310	PF00917	0.568
DEG_SPOP_SBC_1	442	446	PF00917	0.388
DOC_PP1_RVXF_1	451	458	PF00149	0.399
DOC_PP2B_LxvP_1	202	205	PF13499	0.440
DOC_PP2B_PxIxI_1	14	20	PF00149	0.386
DOC_PP4_FxxP_1	336	339	PF00568	0.455
DOC_PP4_FxxP_1	408	411	PF00568	0.391
DOC_SPAK_OSR1_1	62	66	PF12202	0.269
DOC_USP7_MATH_1	142	146	PF00917	0.598
DOC_USP7_MATH_1	184	188	PF00917	0.446
DOC_USP7_MATH_1	226	230	PF00917	0.677
DOC_USP7_MATH_1	306	310	PF00917	0.474
DOC_USP7_MATH_1	430	434	PF00917	0.535
DOC_USP7_MATH_1	440	444	PF00917	0.446
DOC_USP7_MATH_1	460	464	PF00917	0.535
DOC_USP7_MATH_1	49	53	PF00917	0.274
DOC_WW_Pin1_4	311	316	PF00397	0.530
DOC_WW_Pin1_4	436	441	PF00397	0.427
DOC_WW_Pin1_4	69	74	PF00397	0.328
LIG_14-3-3_CanoR_1	100	110	PF00244	0.496
LIG_14-3-3_CanoR_1	418	423	PF00244	0.276
LIG_BRCT_BRCA1_1	387	391	PF00533	0.475
LIG_BRCT_BRCA1_1	404	408	PF00533	0.228
LIG_BRCT_BRCA1_1	59	63	PF00533	0.328
LIG_DLG_GKlike_1	453	461	PF00625	0.341
LIG_eIF4E_1	208	214	PF01652	0.450
LIG_FHA_1	121	127	PF00498	0.461
LIG_FHA_1	175	181	PF00498	0.426
LIG_FHA_1	28	34	PF00498	0.300
LIG_FHA_1	281	287	PF00498	0.459
LIG_FHA_1	289	295	PF00498	0.444
LIG_FHA_1	308	314	PF00498	0.396
LIG_FHA_1	37	43	PF00498	0.341
LIG_FHA_1	442	448	PF00498	0.441
LIG_FHA_1	459	465	PF00498	0.393
LIG_FHA_2	138	144	PF00498	0.699
LIG_FHA_2	366	372	PF00498	0.481
LIG_HP1_1	127	131	PF01393	0.353
LIG_LIR_Apic_2	158	164	PF02991	0.538
LIG_LIR_Apic_2	405	411	PF02991	0.389
LIG_LIR_Nem_3	12	17	PF02991	0.272
LIG_LIR_Nem_3	470	475	PF02991	0.225
LIG_LIR_Nem_3	52	56	PF02991	0.269
LIG_LIR_Nem_3	60	66	PF02991	0.269
LIG_PAM2_1	101	113	PF00658	0.472
LIG_Pex14_2	408	412	PF04695	0.541
LIG_SH2_CRK	161	165	PF00017	0.494
LIG_SH2_CRK	472	476	PF00017	0.392
LIG_SH2_NCK_1	161	165	PF00017	0.548
LIG_SH2_SRC	161	164	PF00017	0.546
LIG_SH2_STAT5	10	13	PF00017	0.234
LIG_SH2_STAT5	248	251	PF00017	0.418
LIG_SH2_STAT5	273	276	PF00017	0.503
LIG_SH2_STAT5	375	378	PF00017	0.600
LIG_SH2_STAT5	402	405	PF00017	0.393
LIG_SH3_1	70	76	PF00018	0.386
LIG_SH3_3	257	263	PF00018	0.491
LIG_SH3_3	294	300	PF00018	0.469
LIG_SH3_3	462	468	PF00018	0.436
LIG_SH3_3	70	76	PF00018	0.293
LIG_SUMO_SIM_par_1	127	133	PF11976	0.380
LIG_SUMO_SIM_par_1	421	426	PF11976	0.330
LIG_WRC_WIRS_1	3	8	PF05994	0.178
LIG_WW_1	205	208	PF00397	0.515
MOD_CK1_1	187	193	PF00069	0.547
MOD_CK1_1	236	242	PF00069	0.606
MOD_CK1_1	307	313	PF00069	0.635
MOD_CK1_1	441	447	PF00069	0.440
MOD_CK2_1	137	143	PF00069	0.693
MOD_CK2_1	344	350	PF00069	0.445
MOD_CK2_1	365	371	PF00069	0.548
MOD_GlcNHglycan	189	192	PF01048	0.470
MOD_GlcNHglycan	239	242	PF01048	0.560
MOD_GlcNHglycan	310	313	PF01048	0.657
MOD_GlcNHglycan	346	349	PF01048	0.593
MOD_GlcNHglycan	378	381	PF01048	0.579
MOD_GlcNHglycan	440	443	PF01048	0.551
MOD_GlcNHglycan	483	486	PF01048	0.661
MOD_GlcNHglycan	59	62	PF01048	0.328
MOD_GlcNHglycan	79	82	PF01048	0.410
MOD_GSK3_1	153	160	PF00069	0.410
MOD_GSK3_1	233	240	PF00069	0.745
MOD_GSK3_1	304	311	PF00069	0.567
MOD_GSK3_1	316	323	PF00069	0.407
MOD_GSK3_1	414	421	PF00069	0.325
MOD_GSK3_1	436	443	PF00069	0.709
MOD_LATS_1	231	237	PF00433	0.630
MOD_N-GLC_1	385	390	PF02516	0.349
MOD_N-GLC_1	436	441	PF02516	0.427
MOD_NEK2_1	174	179	PF00069	0.526
MOD_NEK2_1	247	252	PF00069	0.361
MOD_NEK2_1	269	274	PF00069	0.387
MOD_NEK2_1	341	346	PF00069	0.551
MOD_NEK2_1	35	40	PF00069	0.331
MOD_NEK2_1	376	381	PF00069	0.549
MOD_NEK2_1	403	408	PF00069	0.408
MOD_NEK2_1	77	82	PF00069	0.636
MOD_PIKK_1	458	464	PF00454	0.450
MOD_PIKK_1	487	493	PF00454	0.463
MOD_PKA_2	27	33	PF00069	0.322
MOD_PKA_2	481	487	PF00069	0.574
MOD_Plk_1	184	190	PF00069	0.480
MOD_Plk_1	341	347	PF00069	0.505
MOD_Plk_1	385	391	PF00069	0.494
MOD_Plk_1	453	459	PF00069	0.369
MOD_Plk_4	2	8	PF00069	0.178
MOD_Plk_4	269	275	PF00069	0.404
MOD_Plk_4	403	409	PF00069	0.405
MOD_Plk_4	418	424	PF00069	0.255
MOD_Plk_4	443	449	PF00069	0.380
MOD_Plk_4	460	466	PF00069	0.384
MOD_Plk_4	49	55	PF00069	0.272
MOD_ProDKin_1	311	317	PF00069	0.524
MOD_ProDKin_1	436	442	PF00069	0.423
MOD_ProDKin_1	69	75	PF00069	0.328
MOD_SUMO_for_1	339	342	PF00179	0.483
TRG_DiLeu_BaEn_2	11	17	PF01217	0.386
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.548
TRG_ENDOCYTIC_2	208	211	PF00928	0.370
TRG_ENDOCYTIC_2	472	475	PF00928	0.522
TRG_ER_diArg_1	219	221	PF00400	0.405
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R3	Leptomonas seymouri	46%	100%
A0A1X0NNG0	Trypanosomatidae	34%	100%
A0A3R7K8K9	Trypanosoma rangeli	33%	100%
A0A3S5H6B6	Leishmania donovani	87%	98%
A4HTT8	Leishmania infantum	87%	98%
Q4QI06	Leishmania major	86%	100%
V5BMV9	Trypanosoma cruzi	32%	100%