Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AML8_LEIMU

TriTrypDb:

LmxM.09.0190

Length:

126

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AML8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AML8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.586
CLV_NRD_NRD_1	35	37	PF00675	0.334
CLV_NRD_NRD_1	7	9	PF00675	0.370
CLV_PCSK_FUR_1	33	37	PF00082	0.328
CLV_PCSK_KEX2_1	35	37	PF00082	0.321
DEG_SPOP_SBC_1	91	95	PF00917	0.400
DOC_USP7_MATH_1	106	110	PF00917	0.411
DOC_USP7_MATH_1	91	95	PF00917	0.410
DOC_USP7_UBL2_3	119	123	PF12436	0.384
DOC_WW_Pin1_4	102	107	PF00397	0.480
DOC_WW_Pin1_4	19	24	PF00397	0.525
DOC_WW_Pin1_4	25	30	PF00397	0.503
LIG_BIR_II_1	1	5	PF00653	0.650
LIG_BRCT_BRCA1_1	1	5	PF00533	0.569
LIG_FHA_1	12	18	PF00498	0.555
LIG_FHA_1	73	79	PF00498	0.313
LIG_FHA_2	93	99	PF00498	0.425
LIG_LIR_Nem_3	60	66	PF02991	0.422
LIG_LIR_Nem_3	76	82	PF02991	0.357
LIG_NRBOX	16	22	PF00104	0.521
LIG_PTB_Apo_2	53	60	PF02174	0.329
LIG_PTB_Phospho_1	53	59	PF10480	0.332
LIG_SH2_CRK	63	67	PF00017	0.307
LIG_SH2_STAP1	59	63	PF00017	0.306
LIG_SH2_STAT5	19	22	PF00017	0.544
LIG_SH2_STAT5	39	42	PF00017	0.283
LIG_SH2_STAT5	51	54	PF00017	0.262
LIG_SH2_STAT5	61	64	PF00017	0.431
LIG_SH2_STAT5	82	85	PF00017	0.387
LIG_SH3_3	100	106	PF00018	0.494
LIG_SH3_3	23	29	PF00018	0.512
LIG_SH3_3	74	80	PF00018	0.324
LIG_SxIP_EBH_1	83	97	PF03271	0.387
LIG_TRFH_1	19	23	PF08558	0.550
MOD_CDC14_SPxK_1	22	25	PF00782	0.514
MOD_CDK_SPxK_1	19	25	PF00069	0.518
MOD_CK1_1	105	111	PF00069	0.461
MOD_CK1_1	92	98	PF00069	0.434
MOD_CK2_1	25	31	PF00069	0.584
MOD_CK2_1	92	98	PF00069	0.421
MOD_Cter_Amidation	6	9	PF01082	0.347
MOD_DYRK1A_RPxSP_1	25	29	PF00069	0.520
MOD_GlcNHglycan	111	114	PF01048	0.624
MOD_GSK3_1	102	109	PF00069	0.419
MOD_GSK3_1	11	18	PF00069	0.516
MOD_GSK3_1	21	28	PF00069	0.530
MOD_GSK3_1	57	64	PF00069	0.313
MOD_GSK3_1	81	88	PF00069	0.364
MOD_PKA_2	109	115	PF00069	0.394
MOD_PKA_2	12	18	PF00069	0.529
MOD_Plk_1	57	63	PF00069	0.309
MOD_Plk_4	15	21	PF00069	0.501
MOD_ProDKin_1	102	108	PF00069	0.481
MOD_ProDKin_1	19	25	PF00069	0.518
MOD_SUMO_rev_2	111	120	PF00179	0.386
TRG_ENDOCYTIC_2	63	66	PF00928	0.393
TRG_ENDOCYTIC_2	82	85	PF00928	0.394
TRG_ER_diArg_1	34	36	PF00400	0.531
TRG_ER_diArg_1	66	69	PF00400	0.331
TRG_ER_diLys_1	122	126	PF00400	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B9	Leptomonas seymouri	60%	100%
A0A3S7WQJ7	Leishmania donovani	87%	100%
A4H5J4	Leishmania braziliensis	77%	100%
A4HTT7	Leishmania infantum	87%	100%
D0A994	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QI07	Leishmania major	88%	100%