Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AML3_LEIMU

TriTrypDb:

LmxM.09.0110

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AML3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AML3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.610
CLV_NRD_NRD_1	119	121	PF00675	0.636
CLV_NRD_NRD_1	136	138	PF00675	0.473
CLV_NRD_NRD_1	173	175	PF00675	0.496
CLV_NRD_NRD_1	189	191	PF00675	0.565
CLV_NRD_NRD_1	192	194	PF00675	0.543
CLV_NRD_NRD_1	215	217	PF00675	0.615
CLV_NRD_NRD_1	278	280	PF00675	0.629
CLV_NRD_NRD_1	305	307	PF00675	0.580
CLV_NRD_NRD_1	325	327	PF00675	0.522
CLV_NRD_NRD_1	332	334	PF00675	0.479
CLV_NRD_NRD_1	422	424	PF00675	0.495
CLV_NRD_NRD_1	427	429	PF00675	0.491
CLV_NRD_NRD_1	433	435	PF00675	0.512
CLV_NRD_NRD_1	441	443	PF00675	0.470
CLV_NRD_NRD_1	535	537	PF00675	0.453
CLV_NRD_NRD_1	582	584	PF00675	0.805
CLV_NRD_NRD_1	657	659	PF00675	0.717
CLV_NRD_NRD_1	689	691	PF00675	0.665
CLV_NRD_NRD_1	96	98	PF00675	0.554
CLV_PCSK_FUR_1	117	121	PF00082	0.577
CLV_PCSK_FUR_1	190	194	PF00082	0.620
CLV_PCSK_FUR_1	533	537	PF00082	0.428
CLV_PCSK_KEX2_1	119	121	PF00082	0.655
CLV_PCSK_KEX2_1	136	138	PF00082	0.444
CLV_PCSK_KEX2_1	173	175	PF00082	0.485
CLV_PCSK_KEX2_1	189	191	PF00082	0.538
CLV_PCSK_KEX2_1	192	194	PF00082	0.523
CLV_PCSK_KEX2_1	215	217	PF00082	0.615
CLV_PCSK_KEX2_1	278	280	PF00082	0.658
CLV_PCSK_KEX2_1	325	327	PF00082	0.516
CLV_PCSK_KEX2_1	331	333	PF00082	0.461
CLV_PCSK_KEX2_1	427	429	PF00082	0.507
CLV_PCSK_KEX2_1	440	442	PF00082	0.482
CLV_PCSK_KEX2_1	533	535	PF00082	0.449
CLV_PCSK_KEX2_1	57	59	PF00082	0.516
CLV_PCSK_KEX2_1	582	584	PF00082	0.805
CLV_PCSK_KEX2_1	657	659	PF00082	0.717
CLV_PCSK_KEX2_1	95	97	PF00082	0.521
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.522
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.363
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.539
CLV_PCSK_PC7_1	423	429	PF00082	0.585
CLV_PCSK_SKI1_1	366	370	PF00082	0.685
CLV_PCSK_SKI1_1	418	422	PF00082	0.438
CLV_PCSK_SKI1_1	82	86	PF00082	0.562
CLV_Separin_Metazoa	32	36	PF03568	0.445
DEG_APCC_DBOX_1	148	156	PF00400	0.556
DEG_APCC_DBOX_1	487	495	PF00400	0.617
DEG_COP1_1	623	633	PF00400	0.729
DEG_ODPH_VHL_1	248	261	PF01847	0.487
DEG_SCF_FBW7_1	384	391	PF00400	0.524
DEG_SPOP_SBC_1	203	207	PF00917	0.574
DEG_SPOP_SBC_1	612	616	PF00917	0.717
DOC_CYCLIN_RxL_1	330	338	PF00134	0.623
DOC_CYCLIN_RxL_1	76	89	PF00134	0.591
DOC_MAPK_gen_1	170	180	PF00069	0.662
DOC_MAPK_gen_1	26	33	PF00069	0.523
DOC_MAPK_gen_1	304	313	PF00069	0.655
DOC_MAPK_gen_1	331	337	PF00069	0.622
DOC_MAPK_JIP1_4	307	313	PF00069	0.578
DOC_MAPK_MEF2A_6	173	182	PF00069	0.584
DOC_MAPK_MEF2A_6	304	313	PF00069	0.431
DOC_PP1_RVXF_1	225	231	PF00149	0.560
DOC_PP1_RVXF_1	416	423	PF00149	0.442
DOC_PP4_FxxP_1	509	512	PF00568	0.599
DOC_USP7_MATH_1	115	119	PF00917	0.626
DOC_USP7_MATH_1	202	206	PF00917	0.651
DOC_USP7_MATH_1	223	227	PF00917	0.629
DOC_USP7_MATH_1	250	254	PF00917	0.611
DOC_USP7_MATH_1	458	462	PF00917	0.704
DOC_USP7_MATH_1	50	54	PF00917	0.561
DOC_USP7_MATH_1	578	582	PF00917	0.808
DOC_USP7_MATH_1	585	589	PF00917	0.809
DOC_USP7_MATH_1	613	617	PF00917	0.606
DOC_USP7_MATH_1	65	69	PF00917	0.546
DOC_USP7_MATH_1	669	673	PF00917	0.802
DOC_USP7_UBL2_3	366	370	PF12436	0.689
DOC_USP7_UBL2_3	57	61	PF12436	0.541
DOC_WW_Pin1_4	105	110	PF00397	0.699
DOC_WW_Pin1_4	215	220	PF00397	0.589
DOC_WW_Pin1_4	344	349	PF00397	0.564
DOC_WW_Pin1_4	384	389	PF00397	0.603
DOC_WW_Pin1_4	560	565	PF00397	0.724
DOC_WW_Pin1_4	633	638	PF00397	0.680
LIG_14-3-3_CanoR_1	173	179	PF00244	0.706
LIG_14-3-3_CanoR_1	297	305	PF00244	0.645
LIG_14-3-3_CanoR_1	5	13	PF00244	0.645
LIG_14-3-3_CanoR_1	560	564	PF00244	0.602
LIG_14-3-3_CanoR_1	567	572	PF00244	0.688
LIG_14-3-3_CanoR_1	624	631	PF00244	0.664
LIG_14-3-3_CanoR_1	66	75	PF00244	0.664
LIG_14-3-3_CanoR_1	696	705	PF00244	0.728
LIG_14-3-3_CanoR_1	708	712	PF00244	0.477
LIG_APCC_ABBA_1	501	506	PF00400	0.636
LIG_APCC_ABBAyCdc20_2	251	257	PF00400	0.555
LIG_APCC_Cbox_2	481	487	PF00515	0.451
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_2	515	519	PF00653	0.589
LIG_BRCT_BRCA1_1	645	649	PF00533	0.717
LIG_FHA_1	124	130	PF00498	0.424
LIG_FHA_1	354	360	PF00498	0.551
LIG_FHA_1	385	391	PF00498	0.679
LIG_FHA_1	612	618	PF00498	0.462
LIG_FHA_1	650	656	PF00498	0.718
LIG_FHA_2	119	125	PF00498	0.655
LIG_FHA_2	146	152	PF00498	0.555
LIG_FHA_2	587	593	PF00498	0.754
LIG_Integrin_RGD_1	513	515	PF01839	0.496
LIG_LIR_Apic_2	303	308	PF02991	0.666
LIG_LIR_Apic_2	506	512	PF02991	0.570
LIG_LIR_Apic_2	605	611	PF02991	0.743
LIG_LIR_Apic_2	686	692	PF02991	0.630
LIG_LIR_Gen_1	18	27	PF02991	0.550
LIG_LIR_Gen_1	260	269	PF02991	0.379
LIG_LIR_Gen_1	461	471	PF02991	0.605
LIG_LIR_Gen_1	620	630	PF02991	0.666
LIG_LIR_Nem_3	18	22	PF02991	0.519
LIG_LIR_Nem_3	260	265	PF02991	0.470
LIG_LIR_Nem_3	620	625	PF02991	0.669
LIG_PDZ_Class_1	707	712	PF00595	0.524
LIG_Pex14_1	543	547	PF04695	0.660
LIG_Pex14_2	604	608	PF04695	0.748
LIG_SH2_CRK	305	309	PF00017	0.727
LIG_SH2_CRK	695	699	PF00017	0.640
LIG_SH2_NCK_1	547	551	PF00017	0.607
LIG_SH2_STAP1	224	228	PF00017	0.498
LIG_SH2_STAP1	255	259	PF00017	0.591
LIG_SH2_STAP1	55	59	PF00017	0.522
LIG_SH2_STAP1	651	655	PF00017	0.597
LIG_SH2_STAT3	639	642	PF00017	0.543
LIG_SH2_STAT5	19	22	PF00017	0.553
LIG_SH2_STAT5	262	265	PF00017	0.699
LIG_SH2_STAT5	464	467	PF00017	0.611
LIG_SH2_STAT5	651	654	PF00017	0.596
LIG_SH3_1	103	109	PF00018	0.403
LIG_SH3_3	103	109	PF00018	0.656
LIG_SH3_3	44	50	PF00018	0.523
LIG_SH3_3	462	468	PF00018	0.670
LIG_SH3_3	504	510	PF00018	0.609
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.528
LIG_SUMO_SIM_par_1	651	656	PF11976	0.595
LIG_TRAF2_1	626	629	PF00917	0.610
LIG_TRAF2_1	675	678	PF00917	0.498
LIG_TRAF2_1	90	93	PF00917	0.596
LIG_TYR_ITIM	17	22	PF00017	0.554
LIG_TYR_ITIM	693	698	PF00017	0.645
LIG_WRC_WIRS_1	262	267	PF05994	0.525
MOD_CDK_SPxxK_3	344	351	PF00069	0.549
MOD_CDK_SPxxK_3	560	567	PF00069	0.791
MOD_CK1_1	118	124	PF00069	0.630
MOD_CK1_1	153	159	PF00069	0.622
MOD_CK1_1	206	212	PF00069	0.581
MOD_CK1_1	270	276	PF00069	0.532
MOD_CK1_1	312	318	PF00069	0.639
MOD_CK1_1	321	327	PF00069	0.455
MOD_CK1_1	347	353	PF00069	0.630
MOD_CK1_1	391	397	PF00069	0.518
MOD_CK1_1	556	562	PF00069	0.633
MOD_CK1_1	563	569	PF00069	0.683
MOD_CK1_1	570	576	PF00069	0.740
MOD_CK1_1	581	587	PF00069	0.787
MOD_CK1_1	588	594	PF00069	0.554
MOD_CK1_1	620	626	PF00069	0.661
MOD_CK1_1	632	638	PF00069	0.606
MOD_CK2_1	145	151	PF00069	0.623
MOD_CK2_1	223	229	PF00069	0.558
MOD_CK2_1	586	592	PF00069	0.770
MOD_CK2_1	623	629	PF00069	0.715
MOD_CK2_1	694	700	PF00069	0.618
MOD_DYRK1A_RPxSP_1	560	564	PF00069	0.737
MOD_GlcNHglycan	155	158	PF01048	0.687
MOD_GlcNHglycan	208	211	PF01048	0.661
MOD_GlcNHglycan	212	215	PF01048	0.669
MOD_GlcNHglycan	221	224	PF01048	0.502
MOD_GlcNHglycan	269	272	PF01048	0.534
MOD_GlcNHglycan	373	376	PF01048	0.672
MOD_GlcNHglycan	402	405	PF01048	0.566
MOD_GlcNHglycan	407	410	PF01048	0.634
MOD_GlcNHglycan	461	464	PF01048	0.665
MOD_GlcNHglycan	578	581	PF01048	0.788
MOD_GlcNHglycan	583	586	PF01048	0.802
MOD_GlcNHglycan	631	634	PF01048	0.687
MOD_GlcNHglycan	683	686	PF01048	0.709
MOD_GlcNHglycan	9	12	PF01048	0.463
MOD_GSK3_1	105	112	PF00069	0.722
MOD_GSK3_1	174	181	PF00069	0.533
MOD_GSK3_1	202	209	PF00069	0.565
MOD_GSK3_1	215	222	PF00069	0.584
MOD_GSK3_1	257	264	PF00069	0.575
MOD_GSK3_1	270	277	PF00069	0.498
MOD_GSK3_1	296	303	PF00069	0.678
MOD_GSK3_1	371	378	PF00069	0.699
MOD_GSK3_1	380	387	PF00069	0.551
MOD_GSK3_1	556	563	PF00069	0.732
MOD_GSK3_1	567	574	PF00069	0.574
MOD_GSK3_1	581	588	PF00069	0.793
MOD_GSK3_1	611	618	PF00069	0.659
MOD_GSK3_1	629	636	PF00069	0.477
MOD_GSK3_1	649	656	PF00069	0.633
MOD_GSK3_1	681	688	PF00069	0.635
MOD_GSK3_1	694	701	PF00069	0.598
MOD_GSK3_1	7	14	PF00069	0.606
MOD_N-GLC_1	586	591	PF02516	0.491
MOD_N-GLC_1	680	685	PF02516	0.530
MOD_NEK2_1	197	202	PF00069	0.519
MOD_NEK2_1	261	266	PF00069	0.614
MOD_NEK2_1	296	301	PF00069	0.727
MOD_NEK2_1	405	410	PF00069	0.569
MOD_NEK2_1	617	622	PF00069	0.699
MOD_NEK2_2	250	255	PF00069	0.427
MOD_NEK2_2	364	369	PF00069	0.531
MOD_NEK2_2	446	451	PF00069	0.603
MOD_NEK2_2	50	55	PF00069	0.522
MOD_PIKK_1	567	573	PF00454	0.776
MOD_PIKK_1	623	629	PF00454	0.669
MOD_PK_1	174	180	PF00069	0.494
MOD_PK_1	694	700	PF00069	0.447
MOD_PKA_2	118	124	PF00069	0.697
MOD_PKA_2	159	165	PF00069	0.565
MOD_PKA_2	250	256	PF00069	0.518
MOD_PKA_2	296	302	PF00069	0.658
MOD_PKA_2	375	381	PF00069	0.620
MOD_PKA_2	400	406	PF00069	0.528
MOD_PKA_2	459	465	PF00069	0.655
MOD_PKA_2	556	562	PF00069	0.635
MOD_PKA_2	581	587	PF00069	0.803
MOD_PKA_2	623	629	PF00069	0.731
MOD_PKA_2	65	71	PF00069	0.555
MOD_PKA_2	663	669	PF00069	0.777
MOD_PKB_1	694	702	PF00069	0.590
MOD_Plk_1	178	184	PF00069	0.620
MOD_Plk_1	197	203	PF00069	0.403
MOD_Plk_1	257	263	PF00069	0.438
MOD_Plk_1	446	452	PF00069	0.562
MOD_Plk_1	497	503	PF00069	0.517
MOD_Plk_4	250	256	PF00069	0.582
MOD_Plk_4	257	263	PF00069	0.460
MOD_Plk_4	309	315	PF00069	0.693
MOD_Plk_4	50	56	PF00069	0.518
MOD_Plk_4	644	650	PF00069	0.663
MOD_ProDKin_1	105	111	PF00069	0.698
MOD_ProDKin_1	215	221	PF00069	0.585
MOD_ProDKin_1	344	350	PF00069	0.562
MOD_ProDKin_1	384	390	PF00069	0.593
MOD_ProDKin_1	560	566	PF00069	0.724
MOD_ProDKin_1	633	639	PF00069	0.682
TRG_DiLeu_BaEn_1	29	34	PF01217	0.446
TRG_DiLeu_BaEn_1	416	421	PF01217	0.511
TRG_DiLeu_BaEn_4	431	437	PF01217	0.531
TRG_ENDOCYTIC_2	19	22	PF00928	0.552
TRG_ENDOCYTIC_2	262	265	PF00928	0.672
TRG_ENDOCYTIC_2	464	467	PF00928	0.572
TRG_ENDOCYTIC_2	695	698	PF00928	0.645
TRG_ER_diArg_1	117	120	PF00400	0.678
TRG_ER_diArg_1	136	139	PF00400	0.512
TRG_ER_diArg_1	189	192	PF00400	0.572
TRG_ER_diArg_1	215	217	PF00400	0.629
TRG_ER_diArg_1	278	280	PF00400	0.609
TRG_ER_diArg_1	325	327	PF00400	0.628
TRG_ER_diArg_1	331	333	PF00400	0.624
TRG_ER_diArg_1	398	401	PF00400	0.542
TRG_ER_diArg_1	440	442	PF00400	0.567
TRG_ER_diArg_1	533	536	PF00400	0.480
TRG_NES_CRM1_1	486	498	PF08389	0.321
TRG_NLS_Bipartite_1	81	99	PF00514	0.533
TRG_NLS_MonoExtN_4	366	373	PF00514	0.579
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	333	338	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	434	438	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHI3	Leptomonas seymouri	56%	97%
A0A0S4JTQ5	Bodo saltans	29%	94%
A0A1X0NN57	Trypanosomatidae	35%	100%
A0A3R7NK16	Trypanosoma rangeli	36%	100%
A0A3S5H6B0	Leishmania donovani	90%	100%
A4H5I9	Leishmania braziliensis	74%	98%
A4HTT0	Leishmania infantum	90%	100%
D0A991	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QI23	Leishmania major	90%	100%
V5BSF1	Trypanosoma cruzi	37%	100%