Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AML2_LEIMU

TriTrypDb:

LmxM.09.0105

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AML2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AML2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.628
CLV_C14_Caspase3-7	88	92	PF00656	0.666
CLV_NRD_NRD_1	131	133	PF00675	0.352
CLV_NRD_NRD_1	204	206	PF00675	0.580
CLV_NRD_NRD_1	209	211	PF00675	0.620
CLV_NRD_NRD_1	22	24	PF00675	0.536
CLV_NRD_NRD_1	68	70	PF00675	0.362
CLV_PCSK_KEX2_1	123	125	PF00082	0.376
CLV_PCSK_KEX2_1	131	133	PF00082	0.332
CLV_PCSK_KEX2_1	206	208	PF00082	0.571
CLV_PCSK_KEX2_1	22	24	PF00082	0.536
CLV_PCSK_KEX2_1	68	70	PF00082	0.355
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.440
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.633
CLV_PCSK_PC7_1	64	70	PF00082	0.395
CLV_PCSK_SKI1_1	104	108	PF00082	0.413
CLV_PCSK_SKI1_1	120	124	PF00082	0.356
CLV_PCSK_SKI1_1	23	27	PF00082	0.508
CLV_PCSK_SKI1_1	68	72	PF00082	0.419
DEG_SPOP_SBC_1	37	41	PF00917	0.748
DOC_CKS1_1	114	119	PF01111	0.686
DOC_CYCLIN_RxL_1	64	75	PF00134	0.642
DOC_MAPK_FxFP_2	5	8	PF00069	0.554
DOC_MAPK_gen_1	101	111	PF00069	0.644
DOC_MAPK_gen_1	184	192	PF00069	0.407
DOC_MAPK_MEF2A_6	184	192	PF00069	0.366
DOC_PP2B_LxvP_1	188	191	PF13499	0.387
DOC_PP4_FxxP_1	5	8	PF00568	0.554
DOC_USP7_MATH_1	35	39	PF00917	0.747
DOC_USP7_MATH_1	62	66	PF00917	0.576
DOC_USP7_MATH_1	8	12	PF00917	0.727
DOC_USP7_UBL2_3	211	215	PF12436	0.429
DOC_WW_Pin1_4	11	16	PF00397	0.592
DOC_WW_Pin1_4	113	118	PF00397	0.676
DOC_WW_Pin1_4	31	36	PF00397	0.743
LIG_14-3-3_CanoR_1	10	18	PF00244	0.709
LIG_14-3-3_CanoR_1	184	189	PF00244	0.386
LIG_14-3-3_CanoR_1	22	26	PF00244	0.713
LIG_Actin_WH2_2	59	74	PF00022	0.617
LIG_APCC_ABBA_1	100	105	PF00400	0.582
LIG_eIF4E_1	133	139	PF01652	0.611
LIG_FHA_1	106	112	PF00498	0.508
LIG_FHA_1	185	191	PF00498	0.390
LIG_FHA_1	92	98	PF00498	0.594
LIG_FHA_2	105	111	PF00498	0.628
LIG_FHA_2	39	45	PF00498	0.632
LIG_GBD_Chelix_1	151	159	PF00786	0.475
LIG_LIR_Apic_2	3	8	PF02991	0.551
LIG_LIR_Nem_3	162	168	PF02991	0.372
LIG_LIR_Nem_3	182	188	PF02991	0.389
LIG_LIR_Nem_3	65	70	PF02991	0.535
LIG_NRBOX	154	160	PF00104	0.449
LIG_NRP_CendR_1	219	221	PF00754	0.608
LIG_SH2_CRK	185	189	PF00017	0.407
LIG_SH2_CRK	67	71	PF00017	0.547
LIG_SH2_STAP1	134	138	PF00017	0.589
LIG_SH2_STAT5	157	160	PF00017	0.363
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.445
LIG_TRAF2_1	125	128	PF00917	0.452
LIG_TRAF2_1	73	76	PF00917	0.642
MOD_CDK_SPK_2	113	118	PF00069	0.317
MOD_CDK_SPxxK_3	113	120	PF00069	0.615
MOD_CK1_1	137	143	PF00069	0.453
MOD_CK1_1	36	42	PF00069	0.742
MOD_CK1_1	6	12	PF00069	0.739
MOD_GlcNHglycan	11	14	PF01048	0.675
MOD_GlcNHglycan	35	38	PF01048	0.666
MOD_GlcNHglycan	41	44	PF01048	0.498
MOD_GlcNHglycan	56	60	PF01048	0.495
MOD_GSK3_1	31	38	PF00069	0.644
MOD_GSK3_1	85	92	PF00069	0.501
MOD_NEK2_1	159	164	PF00069	0.427
MOD_NEK2_1	89	94	PF00069	0.506
MOD_NEK2_2	62	67	PF00069	0.412
MOD_PK_1	186	192	PF00069	0.522
MOD_PKA_2	21	27	PF00069	0.691
MOD_PKA_2	9	15	PF00069	0.682
MOD_PKB_1	184	192	PF00069	0.524
MOD_Plk_1	104	110	PF00069	0.555
MOD_Plk_2-3	105	111	PF00069	0.490
MOD_ProDKin_1	11	17	PF00069	0.493
MOD_ProDKin_1	113	119	PF00069	0.615
MOD_ProDKin_1	31	37	PF00069	0.700
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.517
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.515
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.439
TRG_ENDOCYTIC_2	157	160	PF00928	0.344
TRG_ENDOCYTIC_2	185	188	PF00928	0.461
TRG_ENDOCYTIC_2	67	70	PF00928	0.421
TRG_ER_diArg_1	131	133	PF00400	0.434
TRG_ER_diArg_1	145	148	PF00400	0.419
TRG_ER_diArg_1	204	207	PF00400	0.368
TRG_ER_diArg_1	67	69	PF00400	0.459
TRG_NES_CRM1_1	91	105	PF08389	0.382
TRG_NLS_MonoExtC_3	122	128	PF00514	0.303
TRG_NLS_MonoExtN_4	120	127	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	207	212	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG1	Leptomonas seymouri	74%	100%
A0A0S4JU75	Bodo saltans	36%	100%
A0A1X0NNG1	Trypanosomatidae	49%	100%
A0A3S7WQI9	Leishmania donovani	91%	100%
A0A422NED0	Trypanosoma rangeli	47%	100%
A4H5I8	Leishmania braziliensis	89%	100%
A4HTS9	Leishmania infantum	91%	100%
D0A990	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QI24	Leishmania major	88%	100%
V5B321	Trypanosoma cruzi	52%	100%