Calmodulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

flagellar pocket cytoskeletal protein bilbo1

Species:

Leishmania mexicana

UniProt:

E9AML1_LEIMU

TriTrypDb:

LmxM.09.0100

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AML1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AML1

Function

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Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.645
CLV_C14_Caspase3-7	375	379	PF00656	0.473
CLV_C14_Caspase3-7	45	49	PF00656	0.621
CLV_C14_Caspase3-7	473	477	PF00656	0.686
CLV_C14_Caspase3-7	543	547	PF00656	0.470
CLV_NRD_NRD_1	152	154	PF00675	0.658
CLV_NRD_NRD_1	261	263	PF00675	0.485
CLV_NRD_NRD_1	324	326	PF00675	0.613
CLV_NRD_NRD_1	352	354	PF00675	0.483
CLV_NRD_NRD_1	368	370	PF00675	0.518

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II86	Leptomonas seymouri	82%	99%
A0A0S4JFD7	Bodo saltans	34%	95%
A0A0S4JWH7	Bodo saltans	50%	98%
A0A0S4KKB4	Bodo saltans	24%	85%
A0A1X0NMV7	Trypanosomatidae	58%	98%
A0A3R7KQJ5	Trypanosoma rangeli	24%	100%
A0A3S5H6A9	Leishmania donovani	97%	100%
A0A3S7X1F4	Leishmania donovani	24%	100%
A0A422NE50	Trypanosoma rangeli	56%	100%
A4H5I7	Leishmania braziliensis	92%	100%

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