Peroxisomal membrane protein PEX16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peroxisomal biogenesis factor 11 (PEX11), putative

Species:

Leishmania mexicana

UniProt:

E9AMK4_LEIMU

TriTrypDb:

LmxM.09.0030

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMK4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016559	peroxisome fission	6	11
GO:0048285	organelle fission	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0032535	regulation of cellular component size	4	1
GO:0044375	regulation of peroxisome size	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0090066	regulation of anatomical structure size	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.167
CLV_NRD_NRD_1	224	226	PF00675	0.268
CLV_NRD_NRD_1	85	87	PF00675	0.302
CLV_PCSK_KEX2_1	224	226	PF00082	0.267
CLV_PCSK_KEX2_1	85	87	PF00082	0.302
CLV_PCSK_SKI1_1	136	140	PF00082	0.411
CLV_PCSK_SKI1_1	142	146	PF00082	0.208
CLV_PCSK_SKI1_1	154	158	PF00082	0.248
CLV_PCSK_SKI1_1	279	283	PF00082	0.308
CLV_PCSK_SKI1_1	30	34	PF00082	0.273
CLV_PCSK_SKI1_1	41	45	PF00082	0.266
CLV_PCSK_SKI1_1	85	89	PF00082	0.266
DEG_APCC_DBOX_1	170	178	PF00400	0.360
DEG_APCC_DBOX_1	38	46	PF00400	0.281
DEG_MDM2_SWIB_1	268	275	PF02201	0.266
DOC_CYCLIN_RxL_1	133	143	PF00134	0.360
DOC_CYCLIN_RxL_1	26	35	PF00134	0.266
DOC_MAPK_DCC_7	171	179	PF00069	0.325
DOC_MAPK_gen_1	73	81	PF00069	0.411
DOC_MAPK_MEF2A_6	106	115	PF00069	0.290
DOC_MAPK_MEF2A_6	171	179	PF00069	0.275
DOC_MAPK_MEF2A_6	279	288	PF00069	0.266
DOC_PP1_RVXF_1	134	141	PF00149	0.411
DOC_PP1_RVXF_1	51	57	PF00149	0.411
DOC_USP7_MATH_1	197	201	PF00917	0.287
DOC_USP7_UBL2_3	222	226	PF12436	0.380
DOC_USP7_UBL2_3	237	241	PF12436	0.331
LIG_14-3-3_CanoR_1	314	319	PF00244	0.428
LIG_14-3-3_CanoR_1	99	105	PF00244	0.295
LIG_BRCT_BRCA1_1	57	61	PF00533	0.360
LIG_EH_1	17	21	PF12763	0.536
LIG_FHA_1	176	182	PF00498	0.291
LIG_FHA_1	183	189	PF00498	0.256
LIG_FHA_1	300	306	PF00498	0.462
LIG_FHA_2	228	234	PF00498	0.479
LIG_FHA_2	264	270	PF00498	0.423
LIG_GBD_Chelix_1	121	129	PF00786	0.300
LIG_LIR_Gen_1	209	217	PF02991	0.267
LIG_LIR_Gen_1	258	268	PF02991	0.267
LIG_LIR_Gen_1	269	280	PF02991	0.263
LIG_LIR_Gen_1	283	291	PF02991	0.266
LIG_LIR_Gen_1	96	105	PF02991	0.281
LIG_LIR_Nem_3	109	115	PF02991	0.311
LIG_LIR_Nem_3	209	214	PF02991	0.267
LIG_LIR_Nem_3	215	220	PF02991	0.299
LIG_LIR_Nem_3	258	263	PF02991	0.267
LIG_LIR_Nem_3	269	275	PF02991	0.263
LIG_LIR_Nem_3	283	288	PF02991	0.266
LIG_NRBOX	28	34	PF00104	0.300
LIG_PCNA_PIPBox_1	87	96	PF02747	0.411
LIG_Pex14_1	120	124	PF04695	0.281
LIG_Pex14_2	268	272	PF04695	0.269
LIG_Pex14_2	93	97	PF04695	0.281
LIG_SH2_CRK	189	193	PF00017	0.411
LIG_SH2_CRK	260	264	PF00017	0.302
LIG_SH2_NCK_1	217	221	PF00017	0.266
LIG_SH2_PTP2	112	115	PF00017	0.277
LIG_SH2_SRC	112	115	PF00017	0.259
LIG_SH2_SRC	256	259	PF00017	0.331
LIG_SH2_SRC	65	68	PF00017	0.308
LIG_SH2_STAP1	260	264	PF00017	0.360
LIG_SH2_STAT5	112	115	PF00017	0.246
LIG_SH2_STAT5	167	170	PF00017	0.411
LIG_SH2_STAT5	256	259	PF00017	0.411
LIG_SH2_STAT5	48	51	PF00017	0.281
LIG_SH2_STAT5	65	68	PF00017	0.281
LIG_SH3_3	108	114	PF00018	0.281
LIG_SUMO_SIM_par_1	175	180	PF11976	0.296
LIG_TRAF2_1	231	234	PF00917	0.401
LIG_TYR_ITIM	110	115	PF00017	0.277
MOD_CK1_1	207	213	PF00069	0.325
MOD_CK2_1	140	146	PF00069	0.266
MOD_CK2_1	197	203	PF00069	0.338
MOD_CK2_1	227	233	PF00069	0.462
MOD_CK2_1	263	269	PF00069	0.337
MOD_CK2_1	69	75	PF00069	0.267
MOD_GlcNHglycan	194	198	PF01048	0.447
MOD_GlcNHglycan	288	291	PF01048	0.439
MOD_GlcNHglycan	306	309	PF01048	0.154
MOD_GSK3_1	193	200	PF00069	0.393
MOD_GSK3_1	304	311	PF00069	0.285
MOD_GSK3_1	77	84	PF00069	0.293
MOD_N-GLC_1	69	74	PF02516	0.287
MOD_NEK2_1	100	105	PF00069	0.269
MOD_NEK2_1	140	145	PF00069	0.360
MOD_NEK2_1	156	161	PF00069	0.266
MOD_NEK2_1	182	187	PF00069	0.314
MOD_NEK2_1	193	198	PF00069	0.366
MOD_NEK2_1	32	37	PF00069	0.266
MOD_NEK2_2	308	313	PF00069	0.266
MOD_PKA_2	100	106	PF00069	0.281
MOD_Plk_1	69	75	PF00069	0.328
MOD_Plk_4	100	106	PF00069	0.270
MOD_Plk_4	140	146	PF00069	0.411
MOD_Plk_4	308	314	PF00069	0.266
MOD_Plk_4	77	83	PF00069	0.309
MOD_SUMO_rev_2	229	236	PF00179	0.411
TRG_AP2beta_CARGO_1	283	292	PF09066	0.411
TRG_DiLeu_BaEn_1	277	282	PF01217	0.266
TRG_DiLeu_BaEn_2	145	151	PF01217	0.281
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.360
TRG_ENDOCYTIC_2	112	115	PF00928	0.277
TRG_ENDOCYTIC_2	189	192	PF00928	0.411
TRG_ENDOCYTIC_2	217	220	PF00928	0.266
TRG_ENDOCYTIC_2	260	263	PF00928	0.266
TRG_ER_diArg_1	223	225	PF00400	0.266
TRG_ER_diArg_1	50	53	PF00400	0.369
TRG_ER_diArg_1	85	87	PF00400	0.266
TRG_ER_diArg_1	98	101	PF00400	0.266
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.209
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS3	Leptomonas seymouri	83%	99%
A0A0S4JT81	Bodo saltans	46%	84%
A0A1X0NNH2	Trypanosomatidae	69%	100%
A0A3S5H6A5	Leishmania donovani	95%	100%
A0A422NE20	Trypanosoma rangeli	66%	100%
A4H5I0	Leishmania braziliensis	90%	100%
A4HTS1	Leishmania infantum	95%	100%
D0A980	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
Q4QI32	Leishmania major	96%	100%
V5B2S3	Trypanosoma cruzi	64%	100%