J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMK3_LEIMU

TriTrypDb:

LmxM.09.0020

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMK3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0031123	RNA 3'-end processing	7	3
GO:0031124	mRNA 3'-end processing	8	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.510
CLV_C14_Caspase3-7	263	267	PF00656	0.409
CLV_NRD_NRD_1	117	119	PF00675	0.434
CLV_NRD_NRD_1	189	191	PF00675	0.309
CLV_NRD_NRD_1	227	229	PF00675	0.537
CLV_NRD_NRD_1	278	280	PF00675	0.494
CLV_NRD_NRD_1	414	416	PF00675	0.391
CLV_NRD_NRD_1	567	569	PF00675	0.675
CLV_NRD_NRD_1	93	95	PF00675	0.331
CLV_PCSK_KEX2_1	117	119	PF00082	0.542
CLV_PCSK_KEX2_1	189	191	PF00082	0.309
CLV_PCSK_KEX2_1	227	229	PF00082	0.350
CLV_PCSK_KEX2_1	278	280	PF00082	0.477
CLV_PCSK_KEX2_1	413	415	PF00082	0.397
CLV_PCSK_KEX2_1	479	481	PF00082	0.721
CLV_PCSK_KEX2_1	567	569	PF00082	0.623
CLV_PCSK_KEX2_1	580	582	PF00082	0.476
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.481
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.616
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.654
CLV_PCSK_SKI1_1	12	16	PF00082	0.398
CLV_PCSK_SKI1_1	149	153	PF00082	0.480
CLV_PCSK_SKI1_1	18	22	PF00082	0.394
CLV_PCSK_SKI1_1	368	372	PF00082	0.442
CLV_PCSK_SKI1_1	410	414	PF00082	0.458
CLV_PCSK_SKI1_1	603	607	PF00082	0.666
DEG_Nend_UBRbox_2	1	3	PF02207	0.497
DOC_CYCLIN_yCln2_LP_2	76	82	PF00134	0.367
DOC_MAPK_gen_1	522	531	PF00069	0.497
DOC_MAPK_gen_1	567	574	PF00069	0.544
DOC_MAPK_MEF2A_6	399	408	PF00069	0.539
DOC_PP2B_LxvP_1	102	105	PF13499	0.313
DOC_PP2B_LxvP_1	76	79	PF13499	0.375
DOC_PP4_FxxP_1	497	500	PF00568	0.558
DOC_USP7_MATH_1	237	241	PF00917	0.362
DOC_USP7_MATH_1	296	300	PF00917	0.490
DOC_USP7_MATH_1	489	493	PF00917	0.585
DOC_USP7_UBL2_3	330	334	PF12436	0.489
DOC_USP7_UBL2_3	550	554	PF12436	0.724
DOC_WW_Pin1_4	343	348	PF00397	0.449
DOC_WW_Pin1_4	460	465	PF00397	0.578
DOC_WW_Pin1_4	485	490	PF00397	0.581
LIG_14-3-3_CanoR_1	227	231	PF00244	0.504
LIG_14-3-3_CanoR_1	295	301	PF00244	0.564
LIG_14-3-3_CanoR_1	423	428	PF00244	0.503
LIG_14-3-3_CanoR_1	567	573	PF00244	0.497
LIG_14-3-3_CanoR_1	581	586	PF00244	0.516
LIG_14-3-3_CanoR_1	9	19	PF00244	0.417
LIG_14-3-3_CanoR_1	94	98	PF00244	0.529
LIG_Actin_WH2_2	174	191	PF00022	0.374
LIG_Clathr_ClatBox_1	397	401	PF01394	0.432
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.310
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.334
LIG_deltaCOP1_diTrp_1	43	51	PF00928	0.316
LIG_deltaCOP1_diTrp_1	490	497	PF00928	0.607
LIG_DLG_GKlike_1	399	406	PF00625	0.475
LIG_FHA_1	269	275	PF00498	0.435
LIG_FHA_1	346	352	PF00498	0.489
LIG_FHA_1	577	583	PF00498	0.618
LIG_FHA_1	58	64	PF00498	0.407
LIG_FHA_2	153	159	PF00498	0.468
LIG_FHA_2	424	430	PF00498	0.526
LIG_FHA_2	486	492	PF00498	0.597
LIG_FHA_2	593	599	PF00498	0.506
LIG_FHA_2	602	608	PF00498	0.520
LIG_LIR_Apic_2	495	500	PF02991	0.690
LIG_LIR_Gen_1	148	157	PF02991	0.447
LIG_LIR_Gen_1	168	178	PF02991	0.421
LIG_LIR_Gen_1	393	400	PF02991	0.361
LIG_LIR_Gen_1	442	450	PF02991	0.463
LIG_LIR_Nem_3	148	153	PF02991	0.411
LIG_LIR_Nem_3	206	212	PF02991	0.334
LIG_LIR_Nem_3	311	315	PF02991	0.341
LIG_LIR_Nem_3	393	397	PF02991	0.360
LIG_LIR_Nem_3	43	48	PF02991	0.363
LIG_LIR_Nem_3	442	447	PF02991	0.397
LIG_LIR_Nem_3	462	468	PF02991	0.522
LIG_LIR_Nem_3	491	497	PF02991	0.549
LIG_PCNA_yPIPBox_3	414	428	PF02747	0.541
LIG_PCNA_yPIPBox_3	430	441	PF02747	0.621
LIG_Pex14_1	109	113	PF04695	0.466
LIG_Pex14_1	146	150	PF04695	0.361
LIG_Pex14_1	166	170	PF04695	0.325
LIG_Pex14_1	45	49	PF04695	0.316
LIG_Pex14_2	6	10	PF04695	0.523
LIG_SH2_CRK	360	364	PF00017	0.504
LIG_SH2_STAT3	373	376	PF00017	0.524
LIG_SH2_STAT5	41	44	PF00017	0.372
LIG_SH2_STAT5	436	439	PF00017	0.428
LIG_SH2_STAT5	48	51	PF00017	0.353
LIG_SH3_3	493	499	PF00018	0.620
LIG_SUMO_SIM_par_1	19	27	PF11976	0.545
LIG_SUMO_SIM_par_1	30	38	PF11976	0.456
LIG_SUMO_SIM_par_1	592	598	PF11976	0.537
LIG_TRAF2_1	280	283	PF00917	0.462
LIG_TRAF2_1	459	462	PF00917	0.593
LIG_TRAF2_1	506	509	PF00917	0.628
LIG_UBA3_1	403	410	PF00899	0.429
LIG_WRC_WIRS_1	424	429	PF05994	0.498
LIG_WW_3	469	473	PF00397	0.607
MOD_CK1_1	13	19	PF00069	0.351
MOD_CK1_1	22	28	PF00069	0.406
MOD_CK1_1	257	263	PF00069	0.620
MOD_CK1_1	393	399	PF00069	0.493
MOD_CK1_1	90	96	PF00069	0.494
MOD_CK2_1	127	133	PF00069	0.479
MOD_CK2_1	152	158	PF00069	0.550
MOD_CK2_1	423	429	PF00069	0.409
MOD_CK2_1	456	462	PF00069	0.568
MOD_CK2_1	489	495	PF00069	0.604
MOD_CK2_1	503	509	PF00069	0.601
MOD_CK2_1	592	598	PF00069	0.504
MOD_CK2_1	601	607	PF00069	0.516
MOD_CK2_1	93	99	PF00069	0.424
MOD_GlcNHglycan	12	15	PF01048	0.339
MOD_GlcNHglycan	231	234	PF01048	0.452
MOD_GlcNHglycan	263	266	PF01048	0.692
MOD_GlcNHglycan	268	271	PF01048	0.613
MOD_GlcNHglycan	585	588	PF01048	0.540
MOD_GlcNHglycan	76	79	PF01048	0.325
MOD_GSK3_1	135	142	PF00069	0.461
MOD_GSK3_1	168	175	PF00069	0.414
MOD_GSK3_1	19	26	PF00069	0.480
MOD_GSK3_1	254	261	PF00069	0.564
MOD_GSK3_1	283	290	PF00069	0.447
MOD_GSK3_1	341	348	PF00069	0.596
MOD_GSK3_1	456	463	PF00069	0.618
MOD_GSK3_1	485	492	PF00069	0.598
MOD_GSK3_1	499	506	PF00069	0.572
MOD_GSK3_1	542	549	PF00069	0.692
MOD_GSK3_1	568	575	PF00069	0.553
MOD_GSK3_1	611	618	PF00069	0.605
MOD_N-GLC_1	572	577	PF02516	0.525
MOD_NEK2_1	100	105	PF00069	0.436
MOD_NEK2_1	177	182	PF00069	0.416
MOD_NEK2_1	268	273	PF00069	0.600
MOD_NEK2_1	404	409	PF00069	0.513
MOD_NEK2_1	601	606	PF00069	0.550
MOD_PIKK_1	197	203	PF00454	0.293
MOD_PIKK_1	313	319	PF00454	0.510
MOD_PIKK_1	489	495	PF00454	0.596
MOD_PK_1	568	574	PF00069	0.528
MOD_PK_1	581	587	PF00069	0.605
MOD_PKA_1	117	123	PF00069	0.472
MOD_PKA_2	117	123	PF00069	0.472
MOD_PKA_2	226	232	PF00069	0.508
MOD_PKA_2	422	428	PF00069	0.482
MOD_PKA_2	93	99	PF00069	0.325
MOD_PKB_1	546	554	PF00069	0.547
MOD_Plk_1	204	210	PF00069	0.470
MOD_Plk_1	439	445	PF00069	0.573
MOD_Plk_1	489	495	PF00069	0.651
MOD_Plk_1	601	607	PF00069	0.697
MOD_Plk_2-3	456	462	PF00069	0.622
MOD_Plk_4	177	183	PF00069	0.448
MOD_Plk_4	245	251	PF00069	0.364
MOD_Plk_4	31	37	PF00069	0.395
MOD_Plk_4	393	399	PF00069	0.386
MOD_Plk_4	423	429	PF00069	0.392
MOD_Plk_4	93	99	PF00069	0.526
MOD_ProDKin_1	343	349	PF00069	0.447
MOD_ProDKin_1	460	466	PF00069	0.583
MOD_ProDKin_1	485	491	PF00069	0.578
MOD_SUMO_rev_2	322	332	PF00179	0.448
TRG_ENDOCYTIC_2	150	153	PF00928	0.502
TRG_ENDOCYTIC_2	360	363	PF00928	0.453
TRG_ENDOCYTIC_2	48	51	PF00928	0.453
TRG_ER_diArg_1	116	118	PF00400	0.420
TRG_ER_diArg_1	188	190	PF00400	0.313
TRG_ER_diArg_1	566	568	PF00400	0.685
TRG_NES_CRM1_1	244	258	PF08389	0.369
TRG_NES_CRM1_1	520	532	PF08389	0.654
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	603	607	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9R7	Leptomonas seymouri	65%	99%
A0A0S4IQN5	Bodo saltans	29%	100%
A0A1X0NMW7	Trypanosomatidae	33%	98%
A0A3S7WQJ2	Leishmania donovani	95%	100%
A0A422NEC5	Trypanosoma rangeli	35%	99%
A4H5H9	Leishmania braziliensis	86%	100%
A4HTS0	Leishmania infantum	95%	100%
D0A979	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
Q4QI33	Leishmania major	94%	100%
V5BN50	Trypanosoma cruzi	36%	100%