Dimethylargininase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dimethylargininase

Gene product:

amidinotransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AMJ6_LEIMU

TriTrypDb:

LmxM.08.1225

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMJ6

Function

Biological processes
Term	Name	Level	Count
GO:0000052	citrulline metabolic process	5	2
GO:0006082	organic acid metabolic process	3	2
GO:0006520	amino acid metabolic process	3	2
GO:0006525	arginine metabolic process	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009064	glutamine family amino acid metabolic process	5	2
GO:0009889	regulation of biosynthetic process	4	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019222	regulation of metabolic process	3	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0045428	regulation of nitric oxide biosynthetic process	6	2
GO:0045429	positive regulation of nitric oxide biosynthetic process	7	2
GO:0048518	positive regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	2
GO:0080164	regulation of nitric oxide metabolic process	5	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901605	alpha-amino acid metabolic process	4	2
GO:1904407	positive regulation of nitric oxide metabolic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016403	dimethylargininase activity	5	8
GO:0016787	hydrolase activity	2	8
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	8
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	8
GO:0005488	binding	1	2
GO:0016597	amino acid binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043177	organic acid binding	3	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.315
CLV_NRD_NRD_1	46	48	PF00675	0.323
CLV_PCSK_KEX2_1	46	48	PF00082	0.323
CLV_PCSK_SKI1_1	152	156	PF00082	0.625
CLV_PCSK_SKI1_1	85	89	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DOC_CDC14_PxL_1	10	18	PF14671	0.546
DOC_USP7_MATH_1	224	228	PF00917	0.623
DOC_WW_Pin1_4	137	142	PF00397	0.554
LIG_14-3-3_CanoR_1	182	191	PF00244	0.633
LIG_Actin_WH2_2	111	128	PF00022	0.523
LIG_BRCT_BRCA1_1	150	154	PF00533	0.619
LIG_CaM_IQ_9	112	128	PF13499	0.491
LIG_FHA_1	134	140	PF00498	0.497
LIG_FHA_1	209	215	PF00498	0.662
LIG_FHA_1	32	38	PF00498	0.525
LIG_FHA_2	184	190	PF00498	0.635
LIG_LIR_Apic_2	140	146	PF02991	0.506
LIG_LIR_Gen_1	97	107	PF02991	0.508
LIG_LIR_Nem_3	151	157	PF02991	0.650
LIG_LIR_Nem_3	84	89	PF02991	0.529
LIG_LIR_Nem_3	97	103	PF02991	0.475
LIG_PDZ_Class_2	233	238	PF00595	0.614
LIG_PTB_Apo_2	80	87	PF02174	0.523
LIG_PTB_Phospho_1	80	86	PF10480	0.523
LIG_SH2_PTP2	86	89	PF00017	0.523
LIG_SH2_STAP1	6	10	PF00017	0.604
LIG_SH2_STAT5	106	109	PF00017	0.523
LIG_SH2_STAT5	86	89	PF00017	0.561
LIG_SH3_2	41	46	PF14604	0.523
LIG_SH3_3	38	44	PF00018	0.523
LIG_SUMO_SIM_anti_2	7	12	PF11976	0.757
LIG_SUMO_SIM_par_1	133	140	PF11976	0.472
LIG_SUMO_SIM_par_1	155	161	PF11976	0.641
LIG_TRAF2_1	201	204	PF00917	0.657
LIG_WRC_WIRS_1	169	174	PF05994	0.648
MOD_CDK_SPK_2	137	142	PF00069	0.517
MOD_CK1_1	133	139	PF00069	0.496
MOD_CK1_1	232	238	PF00069	0.615
MOD_CK1_1	92	98	PF00069	0.481
MOD_CK2_1	183	189	PF00069	0.639
MOD_CK2_1	192	198	PF00069	0.522
MOD_CK2_1	95	101	PF00069	0.536
MOD_GlcNHglycan	165	168	PF01048	0.548
MOD_GlcNHglycan	172	175	PF01048	0.603
MOD_GlcNHglycan	97	100	PF01048	0.325
MOD_GSK3_1	133	140	PF00069	0.511
MOD_N-GLC_1	95	100	PF02516	0.325
MOD_N-GLC_2	33	35	PF02516	0.323
MOD_PKA_2	208	214	PF00069	0.660
MOD_Plk_1	133	139	PF00069	0.500
MOD_Plk_1	26	32	PF00069	0.525
MOD_Plk_2-3	69	75	PF00069	0.481
MOD_Plk_4	127	133	PF00069	0.498
MOD_Plk_4	19	25	PF00069	0.481
MOD_Plk_4	229	235	PF00069	0.555
MOD_Plk_4	26	32	PF00069	0.481
MOD_ProDKin_1	137	143	PF00069	0.554
MOD_SUMO_for_1	222	225	PF00179	0.547
TRG_DiLeu_BaEn_1	134	139	PF01217	0.523
TRG_ENDOCYTIC_2	100	103	PF00928	0.551
TRG_ENDOCYTIC_2	86	89	PF00928	0.548
TRG_ER_diArg_1	46	48	PF00400	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6E5	Leptomonas seymouri	74%	83%
A0A0S4J9U5	Bodo saltans	47%	81%
A0A3S7WQF2	Leishmania donovani	95%	83%
E9AG92	Leishmania infantum	95%	83%
O08557	Rattus norvegicus	29%	84%
O34497	Bacillus subtilis (strain 168)	25%	83%
O94760	Homo sapiens	30%	84%
P56965	Bos taurus	29%	84%
Q4QI38	Leishmania major	90%	100%
Q4QI44	Leishmania major	91%	100%
Q9CWS0	Mus musculus	29%	84%
Q9I4E3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	94%
Q9X7M4	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	32%	92%
Q9Y8N2	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	33%	88%