Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMJ5_LEIMU

TriTrypDb:

LmxM.08.1223

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.499
CLV_C14_Caspase3-7	458	462	PF00656	0.798
CLV_NRD_NRD_1	100	102	PF00675	0.482
CLV_NRD_NRD_1	199	201	PF00675	0.707
CLV_NRD_NRD_1	382	384	PF00675	0.611
CLV_NRD_NRD_1	449	451	PF00675	0.778
CLV_PCSK_KEX2_1	100	102	PF00082	0.482
CLV_PCSK_KEX2_1	199	201	PF00082	0.707
CLV_PCSK_KEX2_1	382	384	PF00082	0.611
CLV_PCSK_KEX2_1	449	451	PF00082	0.778
CLV_PCSK_SKI1_1	199	203	PF00082	0.706
CLV_PCSK_SKI1_1	346	350	PF00082	0.759
CLV_PCSK_SKI1_1	437	441	PF00082	0.498
CLV_PCSK_SKI1_1	49	53	PF00082	0.521
DEG_APCC_DBOX_1	436	444	PF00400	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.477
DEG_SCF_FBW7_1	18	25	PF00400	0.514
DEG_SPOP_SBC_1	131	135	PF00917	0.758
DEG_SPOP_SBC_1	353	357	PF00917	0.465
DEG_SPOP_SBC_1	60	64	PF00917	0.486
DOC_MAPK_DCC_7	27	37	PF00069	0.516
DOC_MAPK_gen_1	199	207	PF00069	0.712
DOC_MAPK_gen_1	302	311	PF00069	0.497
DOC_MAPK_gen_1	382	388	PF00069	0.539
DOC_MAPK_MEF2A_6	369	377	PF00069	0.651
DOC_MAPK_MEF2A_6	89	97	PF00069	0.485
DOC_MAPK_RevD_3	185	200	PF00069	0.526
DOC_PP2B_LxvP_1	30	33	PF13499	0.510
DOC_PP2B_LxvP_1	409	412	PF13499	0.649
DOC_PP4_FxxP_1	407	410	PF00568	0.666
DOC_USP7_MATH_1	116	120	PF00917	0.719
DOC_USP7_MATH_1	141	145	PF00917	0.706
DOC_USP7_MATH_1	169	173	PF00917	0.791
DOC_USP7_MATH_1	175	179	PF00917	0.702
DOC_USP7_MATH_1	222	226	PF00917	0.560
DOC_USP7_MATH_1	26	30	PF00917	0.517
DOC_USP7_MATH_1	271	275	PF00917	0.450
DOC_USP7_MATH_1	353	357	PF00917	0.751
DOC_USP7_MATH_1	410	414	PF00917	0.708
DOC_USP7_MATH_1	417	421	PF00917	0.687
DOC_USP7_MATH_1	540	544	PF00917	0.694
DOC_USP7_MATH_1	60	64	PF00917	0.486
DOC_WW_Pin1_4	123	128	PF00397	0.742
DOC_WW_Pin1_4	18	23	PF00397	0.505
DOC_WW_Pin1_4	207	212	PF00397	0.744
DOC_WW_Pin1_4	234	239	PF00397	0.523
DOC_WW_Pin1_4	252	257	PF00397	0.699
DOC_WW_Pin1_4	368	373	PF00397	0.743
DOC_WW_Pin1_4	388	393	PF00397	0.417
DOC_WW_Pin1_4	420	425	PF00397	0.776
DOC_WW_Pin1_4	531	536	PF00397	0.777
LIG_14-3-3_CanoR_1	416	425	PF00244	0.699
LIG_14-3-3_CanoR_1	441	447	PF00244	0.694
LIG_14-3-3_CanoR_1	6	12	PF00244	0.483
LIG_14-3-3_CterR_2	542	546	PF00244	0.504
LIG_APCC_ABBA_1	501	506	PF00400	0.714
LIG_CSL_BTD_1	535	538	PF09270	0.698
LIG_FHA_1	165	171	PF00498	0.767
LIG_FHA_1	234	240	PF00498	0.779
LIG_FHA_1	241	247	PF00498	0.663
LIG_FHA_1	293	299	PF00498	0.646
LIG_FHA_1	304	310	PF00498	0.626
LIG_FHA_1	406	412	PF00498	0.560
LIG_FHA_1	524	530	PF00498	0.675
LIG_FHA_1	60	66	PF00498	0.492
LIG_FHA_2	50	56	PF00498	0.517
LIG_FHA_2	523	529	PF00498	0.637
LIG_GBD_Chelix_1	373	381	PF00786	0.711
LIG_LIR_Gen_1	148	158	PF02991	0.711
LIG_LIR_Gen_1	495	503	PF02991	0.781
LIG_LIR_Nem_3	148	154	PF02991	0.711
LIG_LIR_Nem_3	255	261	PF02991	0.729
LIG_LIR_Nem_3	495	501	PF02991	0.777
LIG_LIR_Nem_3	90	95	PF02991	0.485
LIG_SH2_CRK	498	502	PF00017	0.787
LIG_SH2_PTP2	151	154	PF00017	0.716
LIG_SH2_PTP2	260	263	PF00017	0.709
LIG_SH2_SRC	151	154	PF00017	0.716
LIG_SH2_STAP1	164	168	PF00017	0.754
LIG_SH2_STAP1	430	434	PF00017	0.744
LIG_SH2_STAT5	151	154	PF00017	0.716
LIG_SH2_STAT5	260	263	PF00017	0.709
LIG_SH2_STAT5	406	409	PF00017	0.741
LIG_SH2_STAT5	520	523	PF00017	0.766
LIG_SH3_3	260	266	PF00018	0.721
LIG_SH3_3	30	36	PF00018	0.514
LIG_SH3_3	421	427	PF00018	0.774
LIG_SH3_3	532	538	PF00018	0.697
LIG_SUMO_SIM_par_1	204	210	PF11976	0.725
LIG_TYR_ITIM	496	501	PF00017	0.571
LIG_ULM_U2AF65_1	100	105	PF00076	0.483
LIG_WRC_WIRS_1	443	448	PF05994	0.652
LIG_WW_1	256	259	PF00397	0.739
LIG_WW_3	31	35	PF00397	0.514
MOD_CDK_SPK_2	207	212	PF00069	0.457
MOD_CDK_SPK_2	22	27	PF00069	0.527
MOD_CK1_1	133	139	PF00069	0.766
MOD_CK1_1	145	151	PF00069	0.600
MOD_CK1_1	173	179	PF00069	0.758
MOD_CK1_1	181	187	PF00069	0.677
MOD_CK1_1	292	298	PF00069	0.689
MOD_CK1_1	352	358	PF00069	0.462
MOD_CK1_1	391	397	PF00069	0.733
MOD_CK1_1	420	426	PF00069	0.774
MOD_CK1_1	445	451	PF00069	0.677
MOD_CK1_1	58	64	PF00069	0.488
MOD_CK1_1	81	87	PF00069	0.525
MOD_CK2_1	522	528	PF00069	0.643
MOD_CK2_1	74	80	PF00069	0.525
MOD_GlcNHglycan	145	148	PF01048	0.759
MOD_GlcNHglycan	172	175	PF01048	0.757
MOD_GlcNHglycan	178	181	PF01048	0.714
MOD_GlcNHglycan	183	186	PF01048	0.634
MOD_GlcNHglycan	351	354	PF01048	0.755
MOD_GlcNHglycan	419	422	PF01048	0.720
MOD_GlcNHglycan	432	435	PF01048	0.502
MOD_GlcNHglycan	458	461	PF01048	0.775
MOD_GlcNHglycan	474	477	PF01048	0.588
MOD_GSK3_1	131	138	PF00069	0.727
MOD_GSK3_1	139	146	PF00069	0.621
MOD_GSK3_1	14	21	PF00069	0.490
MOD_GSK3_1	169	176	PF00069	0.758
MOD_GSK3_1	207	214	PF00069	0.682
MOD_GSK3_1	22	29	PF00069	0.510
MOD_GSK3_1	224	231	PF00069	0.583
MOD_GSK3_1	303	310	PF00069	0.704
MOD_GSK3_1	349	356	PF00069	0.757
MOD_GSK3_1	388	395	PF00069	0.719
MOD_GSK3_1	416	423	PF00069	0.700
MOD_GSK3_1	55	62	PF00069	0.497
MOD_GSK3_1	70	77	PF00069	0.500
MOD_NEK2_1	240	245	PF00069	0.781
MOD_NEK2_1	280	285	PF00069	0.690
MOD_NEK2_1	349	354	PF00069	0.757
MOD_NEK2_1	399	404	PF00069	0.730
MOD_NEK2_1	415	420	PF00069	0.528
MOD_NEK2_1	442	447	PF00069	0.646
MOD_NEK2_1	470	475	PF00069	0.616
MOD_NEK2_1	88	93	PF00069	0.492
MOD_OFUCOSY	223	228	PF10250	0.706
MOD_PIKK_1	271	277	PF00454	0.447
MOD_PIKK_1	317	323	PF00454	0.710
MOD_PKA_2	211	217	PF00069	0.484
MOD_PKA_2	233	239	PF00069	0.667
MOD_PKA_2	26	32	PF00069	0.513
MOD_PKA_2	303	309	PF00069	0.594
MOD_PKA_2	415	421	PF00069	0.702
MOD_PKA_2	5	11	PF00069	0.482
MOD_PKA_2	506	512	PF00069	0.713
MOD_PKA_2	88	94	PF00069	0.489
MOD_PKB_1	72	80	PF00069	0.524
MOD_Plk_1	49	55	PF00069	0.518
MOD_Plk_4	280	286	PF00069	0.688
MOD_Plk_4	376	382	PF00069	0.704
MOD_Plk_4	425	431	PF00069	0.695
MOD_Plk_4	492	498	PF00069	0.559
MOD_Plk_4	88	94	PF00069	0.489
MOD_ProDKin_1	123	129	PF00069	0.744
MOD_ProDKin_1	18	24	PF00069	0.511
MOD_ProDKin_1	207	213	PF00069	0.748
MOD_ProDKin_1	234	240	PF00069	0.525
MOD_ProDKin_1	252	258	PF00069	0.701
MOD_ProDKin_1	368	374	PF00069	0.740
MOD_ProDKin_1	388	394	PF00069	0.410
MOD_ProDKin_1	420	426	PF00069	0.774
MOD_ProDKin_1	531	537	PF00069	0.776
TRG_DiLeu_BaEn_1	438	443	PF01217	0.705
TRG_DiLeu_LyEn_5	438	443	PF01217	0.705
TRG_ENDOCYTIC_2	151	154	PF00928	0.716
TRG_ENDOCYTIC_2	258	261	PF00928	0.724
TRG_ENDOCYTIC_2	406	409	PF00928	0.741
TRG_ENDOCYTIC_2	498	501	PF00928	0.784
TRG_ER_diArg_1	198	200	PF00400	0.715
TRG_ER_diArg_1	381	383	PF00400	0.613
TRG_ER_diArg_1	99	101	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H698	Leishmania donovani	90%	100%
A4HC45	Leishmania braziliensis	71%	98%
E9ACQ6	Leishmania major	90%	100%
E9AG91	Leishmania infantum	90%	100%