Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMJ3_LEIMU

TriTrypDb:

LmxM.08.1218

Length:

510

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.711
CLV_NRD_NRD_1	274	276	PF00675	0.562
CLV_NRD_NRD_1	339	341	PF00675	0.575
CLV_NRD_NRD_1	474	476	PF00675	0.567
CLV_PCSK_KEX2_1	274	276	PF00082	0.562
CLV_PCSK_KEX2_1	339	341	PF00082	0.615
CLV_PCSK_KEX2_1	474	476	PF00082	0.516
CLV_PCSK_SKI1_1	257	261	PF00082	0.615
DEG_Nend_Nbox_1	1	3	PF02207	0.596
DEG_SPOP_SBC_1	285	289	PF00917	0.590
DOC_CYCLIN_yClb5_NLxxxL_5	60	69	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	36	39	PF00134	0.534
DOC_PP2B_LxvP_1	36	39	PF13499	0.534
DOC_PP4_FxxP_1	42	45	PF00568	0.660
DOC_USP7_MATH_1	220	224	PF00917	0.699
DOC_USP7_MATH_1	281	285	PF00917	0.703
DOC_USP7_MATH_1	330	334	PF00917	0.661
DOC_USP7_MATH_1	358	362	PF00917	0.633
DOC_USP7_MATH_1	424	428	PF00917	0.621
DOC_USP7_MATH_1	438	442	PF00917	0.769
DOC_USP7_MATH_1	482	486	PF00917	0.728
DOC_USP7_MATH_1	83	87	PF00917	0.787
DOC_USP7_MATH_1	97	101	PF00917	0.544
DOC_WW_Pin1_4	105	110	PF00397	0.749
DOC_WW_Pin1_4	146	151	PF00397	0.717
DOC_WW_Pin1_4	203	208	PF00397	0.714
DOC_WW_Pin1_4	291	296	PF00397	0.674
DOC_WW_Pin1_4	429	434	PF00397	0.617
LIG_14-3-3_CanoR_1	339	343	PF00244	0.620
LIG_14-3-3_CanoR_1	398	404	PF00244	0.617
LIG_14-3-3_CanoR_1	73	77	PF00244	0.774
LIG_Actin_WH2_2	124	140	PF00022	0.739
LIG_BIR_III_2	219	223	PF00653	0.476
LIG_BIR_III_2	413	417	PF00653	0.770
LIG_BIR_III_4	329	333	PF00653	0.616
LIG_BIR_III_4	96	100	PF00653	0.692
LIG_Clathr_ClatBox_1	363	367	PF01394	0.735
LIG_EVH1_2	38	42	PF00568	0.700
LIG_FHA_1	123	129	PF00498	0.745
LIG_FHA_1	206	212	PF00498	0.550
LIG_FHA_2	441	447	PF00498	0.505
LIG_FHA_2	459	465	PF00498	0.826
LIG_GBD_Chelix_1	395	403	PF00786	0.557
LIG_NRBOX	127	133	PF00104	0.772
LIG_NRBOX	297	303	PF00104	0.570
LIG_PTAP_UEV_1	115	120	PF05743	0.525
LIG_SH2_STAT5	311	314	PF00017	0.512
LIG_SH2_STAT5	391	394	PF00017	0.529
LIG_SH2_STAT5	486	489	PF00017	0.727
LIG_SH3_3	113	119	PF00018	0.724
LIG_SH3_3	444	450	PF00018	0.748
LIG_SUMO_SIM_par_1	299	305	PF11976	0.602
LIG_SUMO_SIM_par_1	360	368	PF11976	0.727
LIG_TRAF2_1	270	273	PF00917	0.701
LIG_WW_3	37	41	PF00397	0.698
MOD_CDK_SPK_2	146	151	PF00069	0.422
MOD_CK1_1	108	114	PF00069	0.766
MOD_CK1_1	127	133	PF00069	0.772
MOD_CK1_1	203	209	PF00069	0.745
MOD_CK1_1	223	229	PF00069	0.747
MOD_CK1_1	284	290	PF00069	0.550
MOD_CK1_1	294	300	PF00069	0.596
MOD_CK1_1	305	311	PF00069	0.450
MOD_CK1_1	402	408	PF00069	0.614
MOD_CK2_1	146	152	PF00069	0.628
MOD_CK2_1	267	273	PF00069	0.709
MOD_CK2_1	440	446	PF00069	0.536
MOD_CK2_1	83	89	PF00069	0.668
MOD_DYRK1A_RPxSP_1	429	433	PF00069	0.495
MOD_GlcNHglycan	116	119	PF01048	0.710
MOD_GlcNHglycan	142	146	PF01048	0.768
MOD_GlcNHglycan	202	205	PF01048	0.650
MOD_GlcNHglycan	212	215	PF01048	0.709
MOD_GlcNHglycan	269	272	PF01048	0.679
MOD_GlcNHglycan	283	286	PF01048	0.597
MOD_GlcNHglycan	332	335	PF01048	0.701
MOD_GlcNHglycan	407	411	PF01048	0.579
MOD_GlcNHglycan	436	439	PF01048	0.735
MOD_GlcNHglycan	46	49	PF01048	0.786
MOD_GlcNHglycan	84	88	PF01048	0.813
MOD_GSK3_1	137	144	PF00069	0.739
MOD_GSK3_1	16	23	PF00069	0.797
MOD_GSK3_1	206	213	PF00069	0.624
MOD_GSK3_1	281	288	PF00069	0.677
MOD_GSK3_1	289	296	PF00069	0.569
MOD_GSK3_1	402	409	PF00069	0.581
MOD_GSK3_1	434	441	PF00069	0.666
MOD_GSK3_1	59	66	PF00069	0.730
MOD_GSK3_1	79	86	PF00069	0.709
MOD_N-GLC_1	371	376	PF02516	0.687
MOD_N-GLC_1	63	68	PF02516	0.638
MOD_NEK2_1	185	190	PF00069	0.627
MOD_NEK2_1	210	215	PF00069	0.688
MOD_NEK2_1	260	265	PF00069	0.683
MOD_NEK2_1	302	307	PF00069	0.510
MOD_NEK2_1	399	404	PF00069	0.598
MOD_NEK2_1	59	64	PF00069	0.750
MOD_NEK2_1	65	70	PF00069	0.721
MOD_NEK2_1	71	76	PF00069	0.728
MOD_NEK2_2	338	343	PF00069	0.603
MOD_PIKK_1	108	114	PF00454	0.614
MOD_PIKK_1	16	22	PF00454	0.682
MOD_PKA_2	137	143	PF00069	0.715
MOD_PKA_2	200	206	PF00069	0.595
MOD_PKA_2	338	344	PF00069	0.613
MOD_PKA_2	473	479	PF00069	0.595
MOD_PKA_2	495	501	PF00069	0.713
MOD_PKA_2	72	78	PF00069	0.696
MOD_PKA_2	79	85	PF00069	0.801
MOD_Plk_1	231	237	PF00069	0.634
MOD_Plk_2-3	473	479	PF00069	0.727
MOD_Plk_4	127	133	PF00069	0.772
MOD_Plk_4	206	212	PF00069	0.745
MOD_Plk_4	399	405	PF00069	0.621
MOD_Plk_4	482	488	PF00069	0.695
MOD_Plk_4	65	71	PF00069	0.730
MOD_Plk_4	72	78	PF00069	0.711
MOD_ProDKin_1	105	111	PF00069	0.753
MOD_ProDKin_1	146	152	PF00069	0.710
MOD_ProDKin_1	203	209	PF00069	0.720
MOD_ProDKin_1	291	297	PF00069	0.665
MOD_ProDKin_1	429	435	PF00069	0.615
MOD_SUMO_rev_2	341	347	PF00179	0.508
TRG_DiLeu_BaEn_1	152	157	PF01217	0.599
TRG_DiLeu_LyEn_5	152	157	PF01217	0.645
TRG_ER_diArg_1	11	14	PF00400	0.683
TRG_ER_diArg_1	493	496	PF00400	0.760
TRG_ER_diArg_1	499	502	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	340	344	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK83	Leptomonas seymouri	43%	100%
A0A3S5H6A2	Leishmania donovani	89%	100%
A0A422NFT6	Trypanosoma rangeli	32%	100%
A4HC43	Leishmania braziliensis	73%	99%
E9AG89	Leishmania infantum	86%	100%
Q4QI40	Leishmania major	87%	100%
V5AUD8	Trypanosoma cruzi	32%	100%