Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMJ1_LEIMU

TriTrypDb:

LmxM.08.1210

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.665
CLV_PCSK_KEX2_1	7	9	PF00082	0.665
CLV_PCSK_SKI1_1	188	192	PF00082	0.561
CLV_Separin_Metazoa	130	134	PF03568	0.565
DEG_APCC_DBOX_1	352	360	PF00400	0.472
DEG_SPOP_SBC_1	271	275	PF00917	0.450
DEG_SPOP_SBC_1	32	36	PF00917	0.638
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.507
DOC_MAPK_gen_1	7	14	PF00069	0.594
DOC_MAPK_MEF2A_6	137	146	PF00069	0.508
DOC_MAPK_MEF2A_6	7	14	PF00069	0.644
DOC_MAPK_NFAT4_5	7	15	PF00069	0.642
DOC_PP2B_LxvP_1	12	15	PF13499	0.637
DOC_PP2B_LxvP_1	354	357	PF13499	0.575
DOC_PP4_FxxP_1	328	331	PF00568	0.421
DOC_USP7_MATH_1	115	119	PF00917	0.674
DOC_USP7_MATH_1	153	157	PF00917	0.546
DOC_USP7_MATH_1	173	177	PF00917	0.487
DOC_USP7_MATH_1	246	250	PF00917	0.589
DOC_USP7_MATH_1	269	273	PF00917	0.665
DOC_WW_Pin1_4	106	111	PF00397	0.407
DOC_WW_Pin1_4	181	186	PF00397	0.710
DOC_WW_Pin1_4	247	252	PF00397	0.605
DOC_WW_Pin1_4	272	277	PF00397	0.474
LIG_14-3-3_CanoR_1	314	321	PF00244	0.494
LIG_14-3-3_CanoR_1	378	387	PF00244	0.468
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	231	235	PF00533	0.375
LIG_BRCT_BRCA1_1	297	301	PF00533	0.426
LIG_Clathr_ClatBox_1	226	230	PF01394	0.464
LIG_FHA_1	273	279	PF00498	0.651
LIG_FHA_1	33	39	PF00498	0.638
LIG_FHA_1	80	86	PF00498	0.591
LIG_FHA_2	167	173	PF00498	0.750
LIG_FHA_2	65	71	PF00498	0.596
LIG_LIR_Apic_2	109	114	PF02991	0.483
LIG_LIR_Apic_2	325	331	PF02991	0.558
LIG_LIR_Apic_2	344	348	PF02991	0.335
LIG_LIR_Gen_1	92	100	PF02991	0.565
LIG_LIR_Nem_3	216	222	PF02991	0.336
LIG_LIR_Nem_3	92	97	PF02991	0.532
LIG_MYND_1	41	45	PF01753	0.563
LIG_Pex14_2	386	390	PF04695	0.466
LIG_REV1ctd_RIR_1	289	298	PF16727	0.459
LIG_REV1ctd_RIR_1	384	390	PF16727	0.472
LIG_SH2_CRK	111	115	PF00017	0.682
LIG_SH2_CRK	219	223	PF00017	0.313
LIG_SH2_CRK	25	29	PF00017	0.529
LIG_SH2_CRK	285	289	PF00017	0.459
LIG_SH2_CRK	345	349	PF00017	0.451
LIG_SH2_CRK	80	84	PF00017	0.761
LIG_SH2_NCK_1	193	197	PF00017	0.416
LIG_SH2_NCK_1	285	289	PF00017	0.459
LIG_SH2_STAT5	385	388	PF00017	0.335
LIG_SH2_STAT5	60	63	PF00017	0.479
LIG_SH3_3	275	281	PF00018	0.508
LIG_SH3_3	354	360	PF00018	0.590
LIG_TRFH_1	345	349	PF08558	0.584
LIG_TYR_ITIM	283	288	PF00017	0.463
LIG_TYR_ITIM	78	83	PF00017	0.552
MOD_CDK_SPxxK_3	181	188	PF00069	0.731
MOD_CDK_SPxxK_3	249	256	PF00069	0.527
MOD_CK1_1	106	112	PF00069	0.615
MOD_CK1_1	177	183	PF00069	0.647
MOD_CK1_1	249	255	PF00069	0.787
MOD_CK1_1	257	263	PF00069	0.687
MOD_CK1_1	272	278	PF00069	0.447
MOD_CK1_1	96	102	PF00069	0.607
MOD_CK2_1	115	121	PF00069	0.574
MOD_CK2_1	257	263	PF00069	0.713
MOD_CK2_1	64	70	PF00069	0.470
MOD_GlcNHglycan	105	108	PF01048	0.632
MOD_GlcNHglycan	202	205	PF01048	0.676
MOD_GlcNHglycan	208	211	PF01048	0.574
MOD_GlcNHglycan	230	234	PF01048	0.406
MOD_GlcNHglycan	259	262	PF01048	0.655
MOD_GlcNHglycan	297	300	PF01048	0.550
MOD_GlcNHglycan	315	318	PF01048	0.491
MOD_GSK3_1	153	160	PF00069	0.457
MOD_GSK3_1	173	180	PF00069	0.484
MOD_GSK3_1	195	202	PF00069	0.543
MOD_GSK3_1	267	274	PF00069	0.710
MOD_GSK3_1	60	67	PF00069	0.458
MOD_N-GLC_1	147	152	PF02516	0.600
MOD_NEK2_1	103	108	PF00069	0.555
MOD_NEK2_1	147	152	PF00069	0.536
MOD_NEK2_1	157	162	PF00069	0.504
MOD_NEK2_1	229	234	PF00069	0.403
MOD_NEK2_1	295	300	PF00069	0.446
MOD_NEK2_1	33	38	PF00069	0.610
MOD_NEK2_1	379	384	PF00069	0.441
MOD_NEK2_1	49	54	PF00069	0.453
MOD_NEK2_1	64	69	PF00069	0.353
MOD_NEK2_1	93	98	PF00069	0.567
MOD_PIKK_1	174	180	PF00454	0.689
MOD_PKA_2	166	172	PF00069	0.558
MOD_PKA_2	257	263	PF00069	0.784
MOD_PKA_2	313	319	PF00069	0.526
MOD_Plk_1	115	121	PF00069	0.665
MOD_Plk_1	8	14	PF00069	0.643
MOD_Plk_4	115	121	PF00069	0.697
MOD_Plk_4	142	148	PF00069	0.464
MOD_Plk_4	153	159	PF00069	0.430
MOD_Plk_4	274	280	PF00069	0.629
MOD_Plk_4	33	39	PF00069	0.630
MOD_Plk_4	60	66	PF00069	0.441
MOD_ProDKin_1	106	112	PF00069	0.409
MOD_ProDKin_1	181	187	PF00069	0.706
MOD_ProDKin_1	247	253	PF00069	0.608
MOD_ProDKin_1	272	278	PF00069	0.461
MOD_SUMO_for_1	162	165	PF00179	0.446
MOD_SUMO_rev_2	139	145	PF00179	0.600
TRG_DiLeu_BaEn_1	13	18	PF01217	0.636
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.334
TRG_ENDOCYTIC_2	219	222	PF00928	0.493
TRG_ENDOCYTIC_2	223	226	PF00928	0.509
TRG_ENDOCYTIC_2	25	28	PF00928	0.533
TRG_ENDOCYTIC_2	285	288	PF00928	0.459
TRG_ENDOCYTIC_2	80	83	PF00928	0.759
TRG_ER_diArg_1	256	259	PF00400	0.612
TRG_ER_diArg_1	350	353	PF00400	0.527
TRG_ER_diArg_1	6	8	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE21	Leptomonas seymouri	59%	86%
A0A0S4INY1	Bodo saltans	33%	85%
A0A1X0NGS9	Trypanosomatidae	37%	100%
A0A3S5H694	Leishmania donovani	91%	99%
A4HC41	Leishmania braziliensis	82%	100%
A4HTQ4	Leishmania infantum	92%	99%
C9ZPG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QI48	Leishmania major	91%	100%
V5BEE3	Trypanosoma cruzi	34%	100%