Pre-mRNA-splicing factor SLU7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMI8_LEIMU

TriTrypDb:

LmxM.08.1180

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

E9AMI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMI8

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000386	second spliceosomal transesterification activity	4	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0030628	pre-mRNA 3'-splice site binding	6	12
GO:0036002	pre-mRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.583
CLV_NRD_NRD_1	27	29	PF00675	0.435
CLV_NRD_NRD_1	282	284	PF00675	0.539
CLV_NRD_NRD_1	70	72	PF00675	0.563
CLV_PCSK_KEX2_1	151	153	PF00082	0.466
CLV_PCSK_KEX2_1	282	284	PF00082	0.519
CLV_PCSK_KEX2_1	404	406	PF00082	0.409
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.466
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.452
CLV_PCSK_SKI1_1	15	19	PF00082	0.596
CLV_PCSK_SKI1_1	263	267	PF00082	0.458
CLV_PCSK_SKI1_1	305	309	PF00082	0.700
CLV_PCSK_SKI1_1	408	412	PF00082	0.386
DEG_Nend_UBRbox_2	1	3	PF02207	0.757
DEG_SPOP_SBC_1	333	337	PF00917	0.733
DEG_SPOP_SBC_1	343	347	PF00917	0.726
DEG_SPOP_SBC_1	354	358	PF00917	0.616
DOC_AGCK_PIF_2	272	277	PF00069	0.564
DOC_CYCLIN_yClb3_PxF_3	47	55	PF00134	0.553
DOC_MAPK_DCC_7	28	37	PF00069	0.469
DOC_MAPK_gen_1	151	161	PF00069	0.542
DOC_MAPK_MEF2A_6	154	163	PF00069	0.579
DOC_PP4_FxxP_1	221	224	PF00568	0.506
DOC_USP7_MATH_1	235	239	PF00917	0.477
DOC_USP7_MATH_1	342	346	PF00917	0.598
DOC_USP7_MATH_1	365	369	PF00917	0.664
DOC_USP7_UBL2_3	205	209	PF12436	0.492
DOC_USP7_UBL2_3	404	408	PF12436	0.505
DOC_WW_Pin1_4	307	312	PF00397	0.663
DOC_WW_Pin1_4	344	349	PF00397	0.732
DOC_WW_Pin1_4	43	48	PF00397	0.442
LIG_14-3-3_CanoR_1	112	120	PF00244	0.488
LIG_APCC_ABBA_1	139	144	PF00400	0.537
LIG_BRCT_BRCA1_1	116	120	PF00533	0.570
LIG_BRCT_BRCA1_1	268	272	PF00533	0.484
LIG_FHA_1	129	135	PF00498	0.527
LIG_FHA_1	302	308	PF00498	0.723
LIG_FHA_1	9	15	PF00498	0.558
LIG_FHA_2	133	139	PF00498	0.460
LIG_FHA_2	308	314	PF00498	0.522
LIG_FHA_2	39	45	PF00498	0.507
LIG_Integrin_RGD_1	243	245	PF01839	0.484
LIG_LIR_Apic_2	218	224	PF02991	0.549
LIG_LIR_Apic_2	389	393	PF02991	0.510
LIG_LIR_Gen_1	253	262	PF02991	0.441
LIG_LIR_Gen_1	269	280	PF02991	0.456
LIG_LIR_Nem_3	251	257	PF02991	0.457
LIG_LIR_Nem_3	259	265	PF02991	0.428
LIG_LIR_Nem_3	269	275	PF02991	0.448
LIG_LIR_Nem_3	389	394	PF02991	0.478
LIG_PDZ_Class_1	413	418	PF00595	0.678
LIG_SH2_CRK	262	266	PF00017	0.525
LIG_SH2_GRB2like	130	133	PF00017	0.579
LIG_SH2_GRB2like	254	257	PF00017	0.580
LIG_SH2_SRC	257	260	PF00017	0.539
LIG_SH2_STAP1	130	134	PF00017	0.566
LIG_SH2_STAT5	130	133	PF00017	0.579
LIG_SH2_STAT5	210	213	PF00017	0.510
LIG_SH2_STAT5	257	260	PF00017	0.437
LIG_SH2_STAT5	390	393	PF00017	0.400
LIG_SH3_2	5	10	PF14604	0.431
LIG_SH3_3	175	181	PF00018	0.700
LIG_SH3_3	2	8	PF00018	0.447
LIG_SH3_3	345	351	PF00018	0.675
LIG_SH3_3	44	50	PF00018	0.435
LIG_SUMO_SIM_anti_2	328	338	PF11976	0.448
LIG_SUMO_SIM_par_1	33	41	PF11976	0.448
LIG_TRAF2_1	41	44	PF00917	0.495
LIG_TRFH_1	30	34	PF08558	0.449
MOD_CK1_1	128	134	PF00069	0.550
MOD_CK1_1	334	340	PF00069	0.655
MOD_CK1_1	375	381	PF00069	0.563
MOD_CK1_1	99	105	PF00069	0.577
MOD_CK2_1	134	140	PF00069	0.542
MOD_CK2_1	332	338	PF00069	0.643
MOD_CK2_1	38	44	PF00069	0.464
MOD_CK2_1	73	79	PF00069	0.492
MOD_GlcNHglycan	412	416	PF01048	0.574
MOD_GlcNHglycan	75	78	PF01048	0.677
MOD_GSK3_1	110	117	PF00069	0.486
MOD_GSK3_1	128	135	PF00069	0.427
MOD_GSK3_1	301	308	PF00069	0.661
MOD_GSK3_1	315	322	PF00069	0.429
MOD_GSK3_1	332	339	PF00069	0.576
MOD_GSK3_1	353	360	PF00069	0.584
MOD_GSK3_1	361	368	PF00069	0.538
MOD_GSK3_1	372	379	PF00069	0.619
MOD_NEK2_1	315	320	PF00069	0.489
MOD_NEK2_1	355	360	PF00069	0.719
MOD_PIKK_1	146	152	PF00454	0.603
MOD_PIKK_1	257	263	PF00454	0.532
MOD_PIKK_1	320	326	PF00454	0.663
MOD_PK_1	10	16	PF00069	0.633
MOD_PK_1	125	131	PF00069	0.495
MOD_PKA_1	9	15	PF00069	0.689
MOD_PKA_2	132	138	PF00069	0.559
MOD_PKA_2	99	105	PF00069	0.542
MOD_Plk_1	172	178	PF00069	0.504
MOD_Plk_2-3	172	178	PF00069	0.504
MOD_Plk_4	125	131	PF00069	0.529
MOD_Plk_4	372	378	PF00069	0.647
MOD_Plk_4	386	392	PF00069	0.323
MOD_Plk_4	63	69	PF00069	0.579
MOD_ProDKin_1	307	313	PF00069	0.658
MOD_ProDKin_1	344	350	PF00069	0.728
MOD_ProDKin_1	43	49	PF00069	0.438
MOD_SUMO_rev_2	138	147	PF00179	0.577
MOD_SUMO_rev_2	2	11	PF00179	0.655
MOD_SUMO_rev_2	218	226	PF00179	0.522
MOD_SUMO_rev_2	334	342	PF00179	0.755
MOD_SUMO_rev_2	81	89	PF00179	0.629
TRG_ENDOCYTIC_2	255	258	PF00928	0.447
TRG_ENDOCYTIC_2	262	265	PF00928	0.434
TRG_ER_diArg_1	185	188	PF00400	0.623
TRG_ER_diArg_1	281	283	PF00400	0.594
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	263	268	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD09	Leptomonas seymouri	68%	98%
A0A0S4IP46	Bodo saltans	37%	97%
A0A1X0NEY6	Trypanosomatidae	48%	92%
A0A3R7NLB9	Trypanosoma rangeli	46%	99%
A0A3S5H692	Leishmania donovani	96%	100%
A4H5F6	Leishmania braziliensis	84%	100%
A4HTQ1	Leishmania infantum	95%	100%
C9ZPF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	87%
O23174	Arabidopsis thaliana	26%	78%
P0CR52	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	73%
P0CR53	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	73%
Q3KQD1	Xenopus laevis	27%	72%
Q3ZBE5	Bos taurus	25%	71%
Q4QI51	Leishmania major	96%	100%
Q4R4P2	Macaca fascicularis	25%	71%
Q4WWR2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	26%	88%
Q51LA6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	88%
Q54TA0	Dictyostelium discoideum	27%	75%
Q5B3U2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	90%
Q5U3F2	Danio rerio	27%	73%
Q5ZIG2	Gallus gallus	31%	74%
Q7SDY6	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
Q9SHY8	Arabidopsis thaliana	26%	78%
V5DAD7	Trypanosoma cruzi	46%	90%