Thiopurine S-methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thiopurine S-methyltransferase (TPMT), putative

Species:

Leishmania mexicana

UniProt:

E9AMI6_LEIMU

TriTrypDb:

LmxM.08.1160

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AMI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMI6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	9
GO:0032259	methylation	2	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008168	methyltransferase activity	4	10
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0008119	thiopurine S-methyltransferase activity	6	1
GO:0008172	S-methyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.467
CLV_NRD_NRD_1	101	103	PF00675	0.616
CLV_NRD_NRD_1	198	200	PF00675	0.297
CLV_NRD_NRD_1	29	31	PF00675	0.389
CLV_NRD_NRD_1	8	10	PF00675	0.498
CLV_PCSK_FUR_1	6	10	PF00082	0.427
CLV_PCSK_KEX2_1	198	200	PF00082	0.428
CLV_PCSK_KEX2_1	310	312	PF00082	0.370
CLV_PCSK_KEX2_1	344	346	PF00082	0.310
CLV_PCSK_KEX2_1	379	381	PF00082	0.284
CLV_PCSK_KEX2_1	8	10	PF00082	0.474
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.288
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.359
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.288
CLV_PCSK_SKI1_1	123	127	PF00082	0.529
CLV_PCSK_SKI1_1	159	163	PF00082	0.646
CLV_PCSK_SKI1_1	166	170	PF00082	0.654
CLV_PCSK_SKI1_1	198	202	PF00082	0.297
CLV_PCSK_SKI1_1	268	272	PF00082	0.242
CLV_PCSK_SKI1_1	311	315	PF00082	0.264
CLV_PCSK_SKI1_1	35	39	PF00082	0.465
CLV_PCSK_SKI1_1	376	380	PF00082	0.288
CLV_PCSK_SKI1_1	396	400	PF00082	0.213
CLV_PCSK_SKI1_1	41	45	PF00082	0.406
DEG_APCC_DBOX_1	158	166	PF00400	0.406
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SCF_FBW7_2	415	422	PF00400	0.623
DEG_SPOP_SBC_1	173	177	PF00917	0.391
DOC_CKS1_1	386	391	PF01111	0.505
DOC_MAPK_gen_1	310	321	PF00069	0.584
DOC_MAPK_gen_1	379	387	PF00069	0.484
DOC_MAPK_gen_1	6	14	PF00069	0.663
DOC_PP2B_LxvP_1	417	420	PF13499	0.618
DOC_PP4_FxxP_1	118	121	PF00568	0.339
DOC_PP4_FxxP_1	270	273	PF00568	0.528
DOC_PP4_FxxP_1	64	67	PF00568	0.300
DOC_PP4_MxPP_1	336	339	PF00568	0.488
DOC_USP7_MATH_1	110	114	PF00917	0.499
DOC_USP7_MATH_1	144	148	PF00917	0.385
DOC_USP7_MATH_1	200	204	PF00917	0.433
DOC_USP7_MATH_1	236	240	PF00917	0.507
DOC_USP7_MATH_2	256	262	PF00917	0.418
DOC_USP7_UBL2_3	31	35	PF12436	0.641
DOC_USP7_UBL2_3	310	314	PF12436	0.484
DOC_USP7_UBL2_3	379	383	PF12436	0.488
DOC_WW_Pin1_4	140	145	PF00397	0.437
DOC_WW_Pin1_4	218	223	PF00397	0.434
DOC_WW_Pin1_4	269	274	PF00397	0.525
DOC_WW_Pin1_4	385	390	PF00397	0.533
DOC_WW_Pin1_4	415	420	PF00397	0.693
DOC_WW_Pin1_4	90	95	PF00397	0.433
LIG_14-3-3_CanoR_1	171	181	PF00244	0.501
LIG_14-3-3_CanoR_1	198	207	PF00244	0.396
LIG_14-3-3_CanoR_1	33	38	PF00244	0.712
LIG_14-3-3_CanoR_1	403	408	PF00244	0.621
LIG_14-3-3_CanoR_1	47	52	PF00244	0.586
LIG_Actin_WH2_2	17	32	PF00022	0.651
LIG_Actin_WH2_2	364	381	PF00022	0.528
LIG_BRCT_BRCA1_1	114	118	PF00533	0.369
LIG_CaM_IQ_9	365	381	PF13499	0.488
LIG_Clathr_ClatBox_1	318	322	PF01394	0.552
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.363
LIG_FHA_1	224	230	PF00498	0.525
LIG_FHA_1	325	331	PF00498	0.442
LIG_FHA_1	397	403	PF00498	0.571
LIG_FHA_1	404	410	PF00498	0.594
LIG_FHA_1	43	49	PF00498	0.627
LIG_FHA_2	127	133	PF00498	0.310
LIG_FHA_2	402	408	PF00498	0.651
LIG_FHA_2	90	96	PF00498	0.433
LIG_LIR_Apic_2	115	121	PF02991	0.326
LIG_LIR_Apic_2	274	279	PF02991	0.492
LIG_LIR_Apic_2	384	389	PF02991	0.443
LIG_LIR_Gen_1	258	265	PF02991	0.438
LIG_LIR_Gen_1	304	313	PF02991	0.454
LIG_LIR_Gen_1	388	398	PF02991	0.595
LIG_LIR_Nem_3	258	263	PF02991	0.428
LIG_LIR_Nem_3	304	308	PF02991	0.454
LIG_LIR_Nem_3	388	393	PF02991	0.545
LIG_LIR_Nem_3	79	84	PF02991	0.510
LIG_MLH1_MIPbox_1	114	118	PF16413	0.369
LIG_MYND_1	415	419	PF01753	0.672
LIG_Pex14_1	267	271	PF04695	0.459
LIG_Pex14_2	64	68	PF04695	0.300
LIG_SH2_CRK	122	126	PF00017	0.334
LIG_SH2_CRK	260	264	PF00017	0.522
LIG_SH2_CRK	285	289	PF00017	0.484
LIG_SH2_CRK	305	309	PF00017	0.442
LIG_SH2_NCK_1	285	289	PF00017	0.525
LIG_SH2_PTP2	386	389	PF00017	0.522
LIG_SH2_PTP2	81	84	PF00017	0.475
LIG_SH2_SRC	320	323	PF00017	0.442
LIG_SH2_STAP1	285	289	PF00017	0.484
LIG_SH2_STAP1	305	309	PF00017	0.442
LIG_SH2_STAT3	289	292	PF00017	0.442
LIG_SH2_STAT5	307	310	PF00017	0.452
LIG_SH2_STAT5	320	323	PF00017	0.469
LIG_SH2_STAT5	358	361	PF00017	0.465
LIG_SH2_STAT5	386	389	PF00017	0.522
LIG_SH2_STAT5	81	84	PF00017	0.475
LIG_SH3_1	80	86	PF00018	0.447
LIG_SH3_3	202	208	PF00018	0.393
LIG_SH3_3	409	415	PF00018	0.677
LIG_SH3_3	80	86	PF00018	0.469
LIG_TRAF2_1	419	422	PF00917	0.671
LIG_UBA3_1	161	167	PF00899	0.323
LIG_UBA3_1	25	31	PF00899	0.640
LIG_WRC_WIRS_1	148	153	PF05994	0.422
LIG_WRC_WIRS_1	48	53	PF05994	0.371
MOD_CDK_SPxxK_3	218	225	PF00069	0.442
MOD_CK1_1	143	149	PF00069	0.454
MOD_CK1_1	172	178	PF00069	0.505
MOD_CK1_1	239	245	PF00069	0.539
MOD_CK1_1	36	42	PF00069	0.666
MOD_CK2_1	13	19	PF00069	0.609
MOD_CK2_1	183	189	PF00069	0.407
MOD_CK2_1	340	346	PF00069	0.459
MOD_CK2_1	401	407	PF00069	0.599
MOD_CK2_1	89	95	PF00069	0.501
MOD_Cter_Amidation	281	284	PF01082	0.284
MOD_GlcNHglycan	134	137	PF01048	0.595
MOD_GlcNHglycan	15	18	PF01048	0.407
MOD_GlcNHglycan	171	174	PF01048	0.723
MOD_GlcNHglycan	185	188	PF01048	0.678
MOD_GlcNHglycan	202	205	PF01048	0.394
MOD_GSK3_1	139	146	PF00069	0.423
MOD_GSK3_1	169	176	PF00069	0.505
MOD_GSK3_1	179	186	PF00069	0.532
MOD_GSK3_1	194	201	PF00069	0.352
MOD_GSK3_1	239	246	PF00069	0.476
MOD_GSK3_1	29	36	PF00069	0.706
MOD_NEK2_1	1	6	PF00069	0.624
MOD_NEK2_1	139	144	PF00069	0.362
MOD_NEK2_1	169	174	PF00069	0.461
MOD_NEK2_1	29	34	PF00069	0.672
MOD_NEK2_1	76	81	PF00069	0.542
MOD_PIKK_1	237	243	PF00454	0.542
MOD_PIKK_1	84	90	PF00454	0.535
MOD_PK_1	33	39	PF00069	0.646
MOD_PKA_1	198	204	PF00069	0.297
MOD_PKA_2	198	204	PF00069	0.341
MOD_PKA_2	29	35	PF00069	0.662
MOD_Plk_1	396	402	PF00069	0.570
MOD_Plk_4	33	39	PF00069	0.646
MOD_Plk_4	47	53	PF00069	0.472
MOD_ProDKin_1	140	146	PF00069	0.442
MOD_ProDKin_1	218	224	PF00069	0.434
MOD_ProDKin_1	269	275	PF00069	0.525
MOD_ProDKin_1	385	391	PF00069	0.526
MOD_ProDKin_1	415	421	PF00069	0.696
MOD_ProDKin_1	90	96	PF00069	0.429
TRG_DiLeu_BaEn_1	72	77	PF01217	0.409
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.436
TRG_ENDOCYTIC_2	122	125	PF00928	0.330
TRG_ENDOCYTIC_2	260	263	PF00928	0.512
TRG_ENDOCYTIC_2	285	288	PF00928	0.520
TRG_ENDOCYTIC_2	305	308	PF00928	0.442
TRG_ENDOCYTIC_2	81	84	PF00928	0.477
TRG_ER_diArg_1	402	405	PF00400	0.652
TRG_ER_diArg_1	6	9	PF00400	0.663
TRG_NLS_MonoExtC_3	29	34	PF00514	0.635
TRG_NLS_MonoExtN_4	28	34	PF00514	0.671
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.289
TRG_PTS2	1	14	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4U9	Leptomonas seymouri	67%	100%
A0A0S4INW4	Bodo saltans	39%	100%
A0A1X0NF48	Trypanosomatidae	49%	100%
A0A3S5H690	Leishmania donovani	94%	100%
A4H5F4	Leishmania braziliensis	84%	99%
A4HTP9	Leishmania infantum	94%	100%
C9ZPF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QI53	Leishmania major	91%	100%