Suppressive immunomodulating factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

suppressive immunomodulating factor, putative

Species:

Leishmania mexicana

UniProt:

E9AMI4_LEIMU

TriTrypDb:

LmxM.08.1140

Length:

946

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMI4

Function

Biological processes
Term	Name	Level	Count
GO:0001775	cell activation	2	1
GO:0002274	myeloid leukocyte activation	3	1
GO:0002376	immune system process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0042116	macrophage activation	4	1
GO:0045321	leukocyte activation	2	1
GO:0045428	regulation of nitric oxide biosynthetic process	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080164	regulation of nitric oxide metabolic process	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	534	538	PF00656	0.569
CLV_MEL_PAP_1	256	262	PF00089	0.266
CLV_NRD_NRD_1	539	541	PF00675	0.770
CLV_NRD_NRD_1	582	584	PF00675	0.778
CLV_NRD_NRD_1	735	737	PF00675	0.701
CLV_NRD_NRD_1	739	741	PF00675	0.685
CLV_NRD_NRD_1	743	745	PF00675	0.669
CLV_NRD_NRD_1	889	891	PF00675	0.692
CLV_PCSK_KEX2_1	539	541	PF00082	0.770
CLV_PCSK_KEX2_1	567	569	PF00082	0.830
CLV_PCSK_KEX2_1	582	584	PF00082	0.589
CLV_PCSK_KEX2_1	723	725	PF00082	0.726
CLV_PCSK_KEX2_1	739	741	PF00082	0.568
CLV_PCSK_KEX2_1	789	791	PF00082	0.612
CLV_PCSK_KEX2_1	888	890	PF00082	0.735
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.753
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.762
CLV_PCSK_PC1ET2_1	789	791	PF00082	0.612
CLV_PCSK_SKI1_1	223	227	PF00082	0.293
CLV_PCSK_SKI1_1	575	579	PF00082	0.821
CLV_PCSK_SKI1_1	65	69	PF00082	0.437
CLV_PCSK_SKI1_1	723	727	PF00082	0.757
CLV_PCSK_SKI1_1	789	793	PF00082	0.614
CLV_PCSK_SKI1_1	869	873	PF00082	0.749
CLV_Separin_Metazoa	337	341	PF03568	0.497
DEG_APCC_DBOX_1	368	376	PF00400	0.497
DEG_APCC_DBOX_1	64	72	PF00400	0.474
DEG_COP1_1	639	648	PF00400	0.749
DEG_SCF_FBW7_2	457	464	PF00400	0.769
DOC_CDC14_PxL_1	83	91	PF14671	0.511
DOC_CKS1_1	430	435	PF01111	0.642
DOC_CKS1_1	496	501	PF01111	0.765
DOC_CYCLIN_RxL_1	720	729	PF00134	0.675
DOC_CYCLIN_yClb5_NLxxxL_5	101	109	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	179	182	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	933	939	PF00134	0.674
DOC_MAPK_MEF2A_6	223	230	PF00069	0.595
DOC_MAPK_MEF2A_6	29	37	PF00069	0.307
DOC_MAPK_MEF2A_6	723	732	PF00069	0.772
DOC_MAPK_NFAT4_5	223	231	PF00069	0.593
DOC_PP1_RVXF_1	873	879	PF00149	0.785
DOC_PP2B_LxvP_1	179	182	PF13499	0.538
DOC_PP2B_LxvP_1	239	242	PF13499	0.574
DOC_PP2B_LxvP_1	407	410	PF13499	0.836
DOC_PP2B_LxvP_1	549	552	PF13499	0.728
DOC_PP2B_LxvP_1	933	936	PF13499	0.677
DOC_PP2B_LxvP_1	937	940	PF13499	0.667
DOC_PP4_FxxP_1	178	181	PF00568	0.349
DOC_SPAK_OSR1_1	340	344	PF12202	0.507
DOC_USP7_MATH_1	170	174	PF00917	0.648
DOC_USP7_MATH_1	305	309	PF00917	0.556
DOC_USP7_MATH_1	330	334	PF00917	0.523
DOC_USP7_MATH_1	379	383	PF00917	0.697
DOC_USP7_MATH_1	482	486	PF00917	0.522
DOC_USP7_MATH_1	506	510	PF00917	0.831
DOC_USP7_MATH_1	544	548	PF00917	0.814
DOC_USP7_MATH_1	558	562	PF00917	0.612
DOC_USP7_MATH_1	577	581	PF00917	0.574
DOC_USP7_MATH_1	588	592	PF00917	0.800
DOC_USP7_MATH_1	607	611	PF00917	0.781
DOC_USP7_MATH_1	650	654	PF00917	0.621
DOC_USP7_MATH_1	759	763	PF00917	0.521
DOC_USP7_MATH_1	834	838	PF00917	0.714
DOC_USP7_MATH_1	941	945	PF00917	0.664
DOC_USP7_UBL2_3	563	567	PF12436	0.752
DOC_WW_Pin1_4	275	280	PF00397	0.613
DOC_WW_Pin1_4	429	434	PF00397	0.640
DOC_WW_Pin1_4	457	462	PF00397	0.769
DOC_WW_Pin1_4	495	500	PF00397	0.841
DOC_WW_Pin1_4	554	559	PF00397	0.760
DOC_WW_Pin1_4	620	625	PF00397	0.731
DOC_WW_Pin1_4	693	698	PF00397	0.749
LIG_14-3-3_CanoR_1	126	135	PF00244	0.450
LIG_14-3-3_CanoR_1	158	162	PF00244	0.638
LIG_14-3-3_CanoR_1	168	178	PF00244	0.553
LIG_14-3-3_CanoR_1	211	221	PF00244	0.469
LIG_14-3-3_CanoR_1	259	263	PF00244	0.365
LIG_14-3-3_CanoR_1	582	586	PF00244	0.817
LIG_14-3-3_CanoR_1	65	71	PF00244	0.447
LIG_14-3-3_CanoR_1	790	794	PF00244	0.607
LIG_14-3-3_CanoR_1	81	86	PF00244	0.315
LIG_deltaCOP1_diTrp_1	366	370	PF00928	0.484
LIG_EH1_1	719	727	PF00400	0.665
LIG_eIF4E_1	111	117	PF01652	0.471
LIG_EVH1_1	549	553	PF00568	0.831
LIG_EVH1_1	937	941	PF00568	0.643
LIG_FHA_1	10	16	PF00498	0.591
LIG_FHA_1	120	126	PF00498	0.489
LIG_FHA_1	149	155	PF00498	0.496
LIG_FHA_1	175	181	PF00498	0.664
LIG_FHA_1	242	248	PF00498	0.465
LIG_FHA_1	255	261	PF00498	0.447
LIG_FHA_1	355	361	PF00498	0.485
LIG_FHA_1	452	458	PF00498	0.851
LIG_FHA_1	466	472	PF00498	0.606
LIG_FHA_1	496	502	PF00498	0.815
LIG_FHA_1	590	596	PF00498	0.664
LIG_FHA_1	683	689	PF00498	0.833
LIG_FHA_1	781	787	PF00498	0.666
LIG_FHA_1	822	828	PF00498	0.673
LIG_FHA_1	836	842	PF00498	0.690
LIG_FHA_1	911	917	PF00498	0.628
LIG_FHA_2	157	163	PF00498	0.556
LIG_FHA_2	213	219	PF00498	0.262
LIG_FHA_2	3	9	PF00498	0.608
LIG_FHA_2	390	396	PF00498	0.842
LIG_FHA_2	430	436	PF00498	0.701
LIG_FHA_2	532	538	PF00498	0.839
LIG_FHA_2	582	588	PF00498	0.765
LIG_FHA_2	67	73	PF00498	0.485
LIG_FHA_2	824	830	PF00498	0.673
LIG_FHA_2	925	931	PF00498	0.765
LIG_LIR_Apic_2	176	181	PF02991	0.374
LIG_LIR_Apic_2	366	371	PF02991	0.486
LIG_LIR_Gen_1	829	836	PF02991	0.771
LIG_LIR_Gen_1	926	937	PF02991	0.657
LIG_LIR_LC3C_4	251	254	PF02991	0.468
LIG_LIR_LC3C_4	356	361	PF02991	0.475
LIG_LIR_Nem_3	207	213	PF02991	0.459
LIG_LIR_Nem_3	61	67	PF02991	0.491
LIG_LIR_Nem_3	799	803	PF02991	0.555
LIG_LIR_Nem_3	829	835	PF02991	0.667
LIG_LIR_Nem_3	870	876	PF02991	0.679
LIG_LIR_Nem_3	926	932	PF02991	0.650
LIG_PCNA_yPIPBox_3	29	41	PF02747	0.313
LIG_PDZ_Class_1	941	946	PF00595	0.674
LIG_Pex14_1	165	169	PF04695	0.699
LIG_Rb_LxCxE_1	141	163	PF01857	0.482
LIG_SH2_CRK	210	214	PF00017	0.393
LIG_SH2_CRK	873	877	PF00017	0.685
LIG_SH2_GRB2like	111	114	PF00017	0.490
LIG_SH2_STAP1	107	111	PF00017	0.486
LIG_SH2_STAP1	326	330	PF00017	0.451
LIG_SH2_STAT3	199	202	PF00017	0.305
LIG_SH2_STAT3	825	828	PF00017	0.677
LIG_SH2_STAT5	144	147	PF00017	0.445
LIG_SH2_STAT5	313	316	PF00017	0.545
LIG_SH2_STAT5	438	441	PF00017	0.738
LIG_SH2_STAT5	70	73	PF00017	0.512
LIG_SH2_STAT5	825	828	PF00017	0.677
LIG_SH3_3	400	406	PF00018	0.727
LIG_SH3_3	407	413	PF00018	0.735
LIG_SH3_3	424	430	PF00018	0.561
LIG_SH3_3	547	553	PF00018	0.781
LIG_SH3_3	597	603	PF00018	0.545
LIG_SH3_3	619	625	PF00018	0.733
LIG_SH3_3	768	774	PF00018	0.839
LIG_SH3_3	817	823	PF00018	0.700
LIG_SH3_3	855	861	PF00018	0.704
LIG_SH3_3	935	941	PF00018	0.697
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.759
LIG_SUMO_SIM_anti_2	320	327	PF11976	0.450
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.478
LIG_SUMO_SIM_anti_2	483	488	PF11976	0.531
LIG_SUMO_SIM_anti_2	591	599	PF11976	0.548
LIG_SUMO_SIM_anti_2	930	936	PF11976	0.675
LIG_SUMO_SIM_par_1	320	327	PF11976	0.454
LIG_SUMO_SIM_par_1	356	363	PF11976	0.478
LIG_SUMO_SIM_par_1	684	689	PF11976	0.541
LIG_TRAF2_1	160	163	PF00917	0.523
LIG_TRAF2_1	591	594	PF00917	0.760
LIG_TRFH_1	178	182	PF08558	0.339
LIG_TRFH_1	83	87	PF08558	0.464
LIG_TYR_ITIM	871	876	PF00017	0.780
LIG_UBA3_1	179	185	PF00899	0.518
LIG_UBA3_1	904	912	PF00899	0.469
LIG_WRC_WIRS_1	672	677	PF05994	0.604
LIG_WW_2	403	406	PF00397	0.826
MOD_CDK_SPxK_1	457	463	PF00069	0.770
MOD_CK1_1	133	139	PF00069	0.458
MOD_CK1_1	173	179	PF00069	0.701
MOD_CK1_1	243	249	PF00069	0.713
MOD_CK1_1	258	264	PF00069	0.389
MOD_CK1_1	265	271	PF00069	0.608
MOD_CK1_1	278	284	PF00069	0.689
MOD_CK1_1	504	510	PF00069	0.832
MOD_CK1_1	514	520	PF00069	0.683
MOD_CK1_1	561	567	PF00069	0.647
MOD_CK1_1	623	629	PF00069	0.745
MOD_CK1_1	674	680	PF00069	0.531
MOD_CK2_1	133	139	PF00069	0.293
MOD_CK2_1	156	162	PF00069	0.516
MOD_CK2_1	2	8	PF00069	0.623
MOD_CK2_1	212	218	PF00069	0.251
MOD_CK2_1	379	385	PF00069	0.692
MOD_CK2_1	389	395	PF00069	0.674
MOD_CK2_1	429	435	PF00069	0.700
MOD_CK2_1	488	494	PF00069	0.762
MOD_CK2_1	588	594	PF00069	0.761
MOD_CK2_1	924	930	PF00069	0.763
MOD_GlcNHglycan	172	175	PF01048	0.694
MOD_GlcNHglycan	206	209	PF01048	0.452
MOD_GlcNHglycan	273	276	PF01048	0.762
MOD_GlcNHglycan	319	322	PF01048	0.470
MOD_GlcNHglycan	381	384	PF01048	0.789
MOD_GlcNHglycan	449	452	PF01048	0.825
MOD_GlcNHglycan	506	509	PF01048	0.784
MOD_GlcNHglycan	513	516	PF01048	0.733
MOD_GlcNHglycan	604	607	PF01048	0.810
MOD_GlcNHglycan	609	612	PF01048	0.842
MOD_GlcNHglycan	639	643	PF01048	0.834
MOD_GlcNHglycan	652	655	PF01048	0.551
MOD_GlcNHglycan	667	670	PF01048	0.581
MOD_GlcNHglycan	761	764	PF01048	0.541
MOD_GSK3_1	105	112	PF00069	0.466
MOD_GSK3_1	148	155	PF00069	0.472
MOD_GSK3_1	169	176	PF00069	0.719
MOD_GSK3_1	237	244	PF00069	0.444
MOD_GSK3_1	254	261	PF00069	0.476
MOD_GSK3_1	271	278	PF00069	0.624
MOD_GSK3_1	441	448	PF00069	0.787
MOD_GSK3_1	453	460	PF00069	0.685
MOD_GSK3_1	497	504	PF00069	0.850
MOD_GSK3_1	554	561	PF00069	0.820
MOD_GSK3_1	577	584	PF00069	0.677
MOD_GSK3_1	607	614	PF00069	0.735
MOD_GSK3_1	620	627	PF00069	0.695
MOD_GSK3_1	682	689	PF00069	0.695
MOD_GSK3_1	698	705	PF00069	0.719
MOD_GSK3_1	81	88	PF00069	0.443
MOD_N-GLC_1	354	359	PF02516	0.530
MOD_N-GLC_1	379	384	PF02516	0.545
MOD_N-GLC_1	452	457	PF02516	0.600
MOD_N-GLC_1	628	633	PF02516	0.557
MOD_N-GLC_1	751	756	PF02516	0.737
MOD_N-GLC_1	780	785	PF02516	0.679
MOD_NEK2_1	105	110	PF00069	0.456
MOD_NEK2_1	188	193	PF00069	0.452
MOD_NEK2_1	237	242	PF00069	0.523
MOD_NEK2_1	248	253	PF00069	0.401
MOD_NEK2_1	359	364	PF00069	0.467
MOD_NEK2_1	56	61	PF00069	0.467
MOD_NEK2_1	638	643	PF00069	0.836
MOD_NEK2_1	66	71	PF00069	0.377
MOD_NEK2_1	682	687	PF00069	0.658
MOD_NEK2_1	76	81	PF00069	0.254
MOD_NEK2_1	903	908	PF00069	0.767
MOD_NEK2_2	506	511	PF00069	0.774
MOD_PIKK_1	436	442	PF00454	0.839
MOD_PIKK_1	577	583	PF00454	0.643
MOD_PIKK_1	686	692	PF00454	0.578
MOD_PIKK_1	769	775	PF00454	0.764
MOD_PIKK_1	90	96	PF00454	0.557
MOD_PKA_1	789	795	PF00069	0.713
MOD_PKA_2	133	139	PF00069	0.458
MOD_PKA_2	157	163	PF00069	0.532
MOD_PKA_2	258	264	PF00069	0.461
MOD_PKA_2	265	271	PF00069	0.608
MOD_PKA_2	28	34	PF00069	0.533
MOD_PKA_2	581	587	PF00069	0.798
MOD_PKA_2	650	656	PF00069	0.619
MOD_PKA_2	682	688	PF00069	0.658
MOD_PKA_2	789	795	PF00069	0.713
MOD_PKA_2	847	853	PF00069	0.728
MOD_PKB_1	463	471	PF00069	0.843
MOD_Plk_1	189	195	PF00069	0.444
MOD_Plk_1	354	360	PF00069	0.476
MOD_Plk_1	434	440	PF00069	0.653
MOD_Plk_1	445	451	PF00069	0.739
MOD_Plk_1	452	458	PF00069	0.749
MOD_Plk_1	482	488	PF00069	0.563
MOD_Plk_1	76	82	PF00069	0.477
MOD_Plk_1	869	875	PF00069	0.682
MOD_Plk_2-3	389	395	PF00069	0.848
MOD_Plk_2-3	441	447	PF00069	0.761
MOD_Plk_2-3	589	595	PF00069	0.762
MOD_Plk_4	133	139	PF00069	0.458
MOD_Plk_4	152	158	PF00069	0.455
MOD_Plk_4	174	180	PF00069	0.572
MOD_Plk_4	189	195	PF00069	0.350
MOD_Plk_4	243	249	PF00069	0.705
MOD_Plk_4	258	264	PF00069	0.315
MOD_Plk_4	28	34	PF00069	0.533
MOD_Plk_4	330	336	PF00069	0.513
MOD_Plk_4	354	360	PF00069	0.499
MOD_Plk_4	482	488	PF00069	0.563
MOD_Plk_4	66	72	PF00069	0.467
MOD_Plk_4	85	91	PF00069	0.528
MOD_Plk_4	904	910	PF00069	0.590
MOD_Plk_4	924	930	PF00069	0.659
MOD_ProDKin_1	275	281	PF00069	0.610
MOD_ProDKin_1	429	435	PF00069	0.644
MOD_ProDKin_1	457	463	PF00069	0.770
MOD_ProDKin_1	495	501	PF00069	0.842
MOD_ProDKin_1	554	560	PF00069	0.762
MOD_ProDKin_1	620	626	PF00069	0.731
MOD_ProDKin_1	693	699	PF00069	0.748
MOD_SUMO_for_1	469	472	PF00179	0.542
MOD_SUMO_rev_2	782	791	PF00179	0.642
TRG_DiLeu_BaEn_1	919	924	PF01217	0.682
TRG_DiLeu_BaEn_1	930	935	PF01217	0.670
TRG_DiLeu_BaEn_2	62	68	PF01217	0.481
TRG_DiLeu_BaEn_4	930	936	PF01217	0.675
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.743
TRG_ENDOCYTIC_2	210	213	PF00928	0.398
TRG_ENDOCYTIC_2	873	876	PF00928	0.684
TRG_ER_diArg_1	739	741	PF00400	0.706
TRG_ER_diArg_1	888	890	PF00400	0.783
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.767
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP7	Leptomonas seymouri	49%	100%
A0A3S7WQE7	Leishmania donovani	90%	100%
A4H5F2	Leishmania braziliensis	76%	100%
A4HTP7	Leishmania infantum	90%	100%
Q4QI55	Leishmania major	90%	100%