Stress-induced protein sti1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-induced protein sti1

Species:

Leishmania mexicana

UniProt:

E9AMI1_LEIMU

TriTrypDb:

LmxM.08.1110

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMI1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	460	464	PF00656	0.529
CLV_NRD_NRD_1	135	137	PF00675	0.371
CLV_NRD_NRD_1	209	211	PF00675	0.678
CLV_NRD_NRD_1	429	431	PF00675	0.353
CLV_NRD_NRD_1	488	490	PF00675	0.344
CLV_NRD_NRD_1	76	78	PF00675	0.398
CLV_NRD_NRD_1	85	87	PF00675	0.337
CLV_PCSK_KEX2_1	208	210	PF00082	0.690
CLV_PCSK_KEX2_1	321	323	PF00082	0.410
CLV_PCSK_KEX2_1	385	387	PF00082	0.455
CLV_PCSK_KEX2_1	488	490	PF00082	0.303
CLV_PCSK_KEX2_1	76	78	PF00082	0.395
CLV_PCSK_KEX2_1	85	87	PF00082	0.310
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.698
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.419
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.455
CLV_PCSK_SKI1_1	128	132	PF00082	0.560
CLV_PCSK_SKI1_1	175	179	PF00082	0.371
CLV_PCSK_SKI1_1	213	217	PF00082	0.621
CLV_PCSK_SKI1_1	220	224	PF00082	0.504
CLV_PCSK_SKI1_1	298	302	PF00082	0.355
CLV_PCSK_SKI1_1	321	325	PF00082	0.355
CLV_PCSK_SKI1_1	334	338	PF00082	0.465
CLV_PCSK_SKI1_1	54	58	PF00082	0.549
CLV_PCSK_SKI1_1	96	100	PF00082	0.423
DEG_APCC_DBOX_1	174	182	PF00400	0.608
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_CKS1_1	129	134	PF01111	0.586
DOC_MAPK_gen_1	251	259	PF00069	0.546
DOC_MAPK_gen_1	309	319	PF00069	0.355
DOC_MAPK_gen_1	462	472	PF00069	0.475
DOC_MAPK_MEF2A_6	137	146	PF00069	0.528
DOC_MAPK_MEF2A_6	311	319	PF00069	0.211
DOC_USP7_MATH_1	102	106	PF00917	0.445
DOC_USP7_MATH_2	388	394	PF00917	0.566
DOC_USP7_UBL2_3	341	345	PF12436	0.468
DOC_USP7_UBL2_3	412	416	PF12436	0.476
DOC_WW_Pin1_4	128	133	PF00397	0.565
LIG_14-3-3_CanoR_1	175	181	PF00244	0.503
LIG_BRCT_BRCA1_1	234	238	PF00533	0.586
LIG_BRCT_BRCA1_1	43	47	PF00533	0.513
LIG_FHA_1	254	260	PF00498	0.436
LIG_FHA_1	379	385	PF00498	0.446
LIG_FHA_2	214	220	PF00498	0.660
LIG_FHA_2	335	341	PF00498	0.508
LIG_LIR_Apic_2	326	330	PF02991	0.596
LIG_LIR_Apic_2	348	354	PF02991	0.490
LIG_LIR_Gen_1	152	161	PF02991	0.513
LIG_LIR_Gen_1	292	300	PF02991	0.342
LIG_LIR_Gen_1	44	53	PF02991	0.485
LIG_LIR_Gen_1	502	512	PF02991	0.503
LIG_LIR_Nem_3	133	138	PF02991	0.563
LIG_LIR_Nem_3	292	296	PF02991	0.342
LIG_LIR_Nem_3	463	469	PF02991	0.525
LIG_LIR_Nem_3	502	507	PF02991	0.514
LIG_Pex14_1	437	441	PF04695	0.355
LIG_Pex14_1	70	74	PF04695	0.371
LIG_SH2_CRK	293	297	PF00017	0.355
LIG_SH2_CRK	466	470	PF00017	0.536
LIG_SH2_CRK	504	508	PF00017	0.514
LIG_SH2_GRB2like	394	397	PF00017	0.355
LIG_SH2_GRB2like	40	43	PF00017	0.433
LIG_SH2_NCK_1	293	297	PF00017	0.412
LIG_SH2_PTP2	351	354	PF00017	0.495
LIG_SH2_PTP2	401	404	PF00017	0.502
LIG_SH2_SRC	19	22	PF00017	0.554
LIG_SH2_SRC	245	248	PF00017	0.483
LIG_SH2_SRC	351	354	PF00017	0.480
LIG_SH2_SRC	448	451	PF00017	0.390
LIG_SH2_SRC	87	90	PF00017	0.390
LIG_SH2_STAP1	272	276	PF00017	0.371
LIG_SH2_STAP1	293	297	PF00017	0.371
LIG_SH2_STAP1	313	317	PF00017	0.440
LIG_SH2_STAP1	380	384	PF00017	0.423
LIG_SH2_STAP1	394	398	PF00017	0.355
LIG_SH2_STAP1	87	91	PF00017	0.390
LIG_SH2_STAT3	266	269	PF00017	0.476
LIG_SH2_STAT5	153	156	PF00017	0.509
LIG_SH2_STAT5	182	185	PF00017	0.612
LIG_SH2_STAT5	19	22	PF00017	0.499
LIG_SH2_STAT5	233	236	PF00017	0.564
LIG_SH2_STAT5	25	28	PF00017	0.462
LIG_SH2_STAT5	258	261	PF00017	0.371
LIG_SH2_STAT5	266	269	PF00017	0.371
LIG_SH2_STAT5	293	296	PF00017	0.348
LIG_SH2_STAT5	351	354	PF00017	0.480
LIG_SH2_STAT5	367	370	PF00017	0.612
LIG_SH2_STAT5	380	383	PF00017	0.423
LIG_SH2_STAT5	401	404	PF00017	0.355
LIG_SH2_STAT5	435	438	PF00017	0.440
LIG_SH2_STAT5	74	77	PF00017	0.371
LIG_SH3_3	126	132	PF00018	0.521
LIG_TRAF2_1	346	349	PF00917	0.584
LIG_UBA3_1	180	187	PF00899	0.692
MOD_CK1_1	41	47	PF00069	0.410
MOD_CK1_1	477	483	PF00069	0.595
MOD_CK1_1	526	532	PF00069	0.552
MOD_CK2_1	213	219	PF00069	0.642
MOD_CK2_1	334	340	PF00069	0.508
MOD_DYRK1A_RPxSP_1	128	132	PF00069	0.595
MOD_GlcNHglycan	104	107	PF01048	0.504
MOD_GlcNHglycan	12	17	PF01048	0.488
MOD_GlcNHglycan	183	186	PF01048	0.475
MOD_GlcNHglycan	199	202	PF01048	0.638
MOD_GlcNHglycan	262	265	PF01048	0.502
MOD_GlcNHglycan	43	46	PF01048	0.407
MOD_GlcNHglycan	476	479	PF01048	0.533
MOD_GlcNHglycan	525	528	PF01048	0.328
MOD_GlcNHglycan	536	539	PF01048	0.428
MOD_GSK3_1	34	41	PF00069	0.561
MOD_N-GLC_1	260	265	PF02516	0.350
MOD_N-GLC_1	41	46	PF02516	0.409
MOD_N-GLC_2	289	291	PF02516	0.390
MOD_NEK2_1	176	181	PF00069	0.415
MOD_NEK2_1	232	237	PF00069	0.581
MOD_NEK2_1	260	265	PF00069	0.355
MOD_NEK2_1	500	505	PF00069	0.503
MOD_NEK2_1	523	528	PF00069	0.552
MOD_NEK2_2	253	258	PF00069	0.503
MOD_PIKK_1	162	168	PF00454	0.589
MOD_PK_1	62	68	PF00069	0.488
MOD_PKA_1	334	340	PF00069	0.578
MOD_PKA_2	197	203	PF00069	0.831
MOD_Plk_1	260	266	PF00069	0.362
MOD_Plk_1	291	297	PF00069	0.355
MOD_Plk_1	389	395	PF00069	0.435
MOD_Plk_4	142	148	PF00069	0.511
MOD_Plk_4	176	182	PF00069	0.423
MOD_Plk_4	253	259	PF00069	0.440
MOD_Plk_4	291	297	PF00069	0.355
MOD_Plk_4	34	40	PF00069	0.571
MOD_Plk_4	500	506	PF00069	0.505
MOD_ProDKin_1	128	134	PF00069	0.557
MOD_SUMO_for_1	225	228	PF00179	0.483
MOD_SUMO_rev_2	247	256	PF00179	0.561
MOD_SUMO_rev_2	413	422	PF00179	0.440
TRG_DiLeu_BaEn_4	227	233	PF01217	0.445
TRG_ENDOCYTIC_2	153	156	PF00928	0.503
TRG_ENDOCYTIC_2	293	296	PF00928	0.355
TRG_ENDOCYTIC_2	401	404	PF00928	0.355
TRG_ENDOCYTIC_2	466	469	PF00928	0.573
TRG_ENDOCYTIC_2	504	507	PF00928	0.503
TRG_ER_diArg_1	75	77	PF00400	0.407
TRG_ER_diArg_1	84	86	PF00400	0.327
TRG_Pf-PMV_PEXEL_1	136	140	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK79	Leptomonas seymouri	85%	100%
A0A0S4IP08	Bodo saltans	54%	93%
A0A0S4ITS9	Bodo saltans	20%	73%
A0A1X0NFP0	Trypanosomatidae	68%	100%
A0A1X0P1G8	Trypanosomatidae	23%	77%
A0A422NFX1	Trypanosoma rangeli	62%	98%
A4H5F0	Leishmania braziliensis	93%	100%
A4HTP4	Leishmania infantum	97%	100%
C9ZPE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
F8RP11	Triticum aestivum	42%	94%
O35814	Rattus norvegicus	40%	100%
O54981	Cricetulus griseus	40%	100%
P15705	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	93%
P31948	Homo sapiens	40%	100%
Q3ZBZ8	Bos taurus	40%	100%
Q43468	Glycine max	41%	95%
Q4JHN0	Leishmania donovani	97%	100%
Q4QI58	Leishmania major	97%	100%
Q4R8N7	Macaca fascicularis	40%	100%
Q54DA8	Dictyostelium discoideum	36%	97%
Q54IP0	Dictyostelium discoideum	24%	100%
Q5R8D8	Pongo abelii	24%	100%
Q5XEP2	Arabidopsis thaliana	41%	95%
Q60864	Mus musculus	40%	100%
Q75Q39	Rattus norvegicus	23%	89%
Q7ZWU1	Xenopus laevis	39%	100%
Q99615	Homo sapiens	24%	100%
Q9CZW5	Mus musculus	24%	89%
Q9LNB6	Arabidopsis thaliana	39%	95%
Q9QYI3	Mus musculus	24%	100%
Q9STH1	Arabidopsis thaliana	41%	98%
Q9USI5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	92%
V5AUF3	Trypanosoma cruzi	63%	98%
V5BSG3	Trypanosoma cruzi	23%	78%