Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMI0_LEIMU

TriTrypDb:

LmxM.08.1100

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	330	334	PF00656	0.605
CLV_NRD_NRD_1	2	4	PF00675	0.549
CLV_NRD_NRD_1	217	219	PF00675	0.455
CLV_NRD_NRD_1	292	294	PF00675	0.513
CLV_NRD_NRD_1	52	54	PF00675	0.525
CLV_NRD_NRD_1	63	65	PF00675	0.407
CLV_NRD_NRD_1	87	89	PF00675	0.507
CLV_PCSK_FUR_1	157	161	PF00082	0.473
CLV_PCSK_KEX2_1	144	146	PF00082	0.437
CLV_PCSK_KEX2_1	159	161	PF00082	0.487
CLV_PCSK_KEX2_1	191	193	PF00082	0.413
CLV_PCSK_KEX2_1	2	4	PF00082	0.551
CLV_PCSK_KEX2_1	224	226	PF00082	0.404
CLV_PCSK_KEX2_1	292	294	PF00082	0.490
CLV_PCSK_KEX2_1	52	54	PF00082	0.503
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.437
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.457
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.413
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.435
CLV_PCSK_SKI1_1	108	112	PF00082	0.281
CLV_PCSK_SKI1_1	2	6	PF00082	0.596
CLV_PCSK_SKI1_1	237	241	PF00082	0.385
CLV_PCSK_SKI1_1	292	296	PF00082	0.497
CLV_PCSK_SKI1_1	338	342	PF00082	0.445
CLV_PCSK_SKI1_1	88	92	PF00082	0.649
CLV_PCSK_SKI1_1	99	103	PF00082	0.430
DEG_Nend_UBRbox_1	1	4	PF02207	0.552
DEG_SCF_FBW7_2	130	137	PF00400	0.412
DOC_CKS1_1	131	136	PF01111	0.413
DOC_MAPK_gen_1	224	232	PF00069	0.367
DOC_MAPK_gen_1	271	280	PF00069	0.435
DOC_MAPK_gen_1	292	299	PF00069	0.494
DOC_MAPK_gen_1	338	346	PF00069	0.440
DOC_MAPK_gen_1	41	48	PF00069	0.413
DOC_MAPK_MEF2A_6	271	280	PF00069	0.435
DOC_MAPK_MEF2A_6	292	299	PF00069	0.494
DOC_MAPK_MEF2A_6	41	50	PF00069	0.405
DOC_PP1_RVXF_1	170	176	PF00149	0.347
DOC_PP2B_LxvP_1	4	7	PF13499	0.581
DOC_USP7_MATH_1	30	34	PF00917	0.602
DOC_USP7_MATH_1	327	331	PF00917	0.558
DOC_USP7_UBL2_3	116	120	PF12436	0.451
DOC_USP7_UBL2_3	41	45	PF12436	0.498
DOC_WW_Pin1_4	130	135	PF00397	0.413
DOC_WW_Pin1_4	284	289	PF00397	0.451
DOC_WW_Pin1_4	318	323	PF00397	0.631
LIG_14-3-3_CanoR_1	2	7	PF00244	0.678
LIG_14-3-3_CanoR_1	298	303	PF00244	0.474
LIG_14-3-3_CanoR_1	64	73	PF00244	0.438
LIG_14-3-3_CanoR_1	88	97	PF00244	0.519
LIG_Actin_WH2_2	93	110	PF00022	0.442
LIG_CSL_BTD_1	285	288	PF09270	0.440
LIG_EVH1_1	26	30	PF00568	0.591
LIG_EVH1_2	27	31	PF00568	0.595
LIG_FHA_1	65	71	PF00498	0.497
LIG_FHA_1	9	15	PF00498	0.577
LIG_FHA_2	131	137	PF00498	0.415
LIG_FHA_2	181	187	PF00498	0.577
LIG_FHA_2	67	73	PF00498	0.347
LIG_FHA_2	89	95	PF00498	0.537
LIG_LIR_Gen_1	122	131	PF02991	0.403
LIG_LIR_Gen_1	177	187	PF02991	0.485
LIG_LIR_Nem_3	122	126	PF02991	0.406
LIG_LIR_Nem_3	177	182	PF02991	0.480
LIG_LIR_Nem_3	234	239	PF02991	0.395
LIG_NRBOX	228	234	PF00104	0.367
LIG_PCNA_yPIPBox_3	252	264	PF02747	0.399
LIG_Pex14_1	175	179	PF04695	0.416
LIG_SH2_CRK	179	183	PF00017	0.467
LIG_SH2_CRK	195	199	PF00017	0.421
LIG_SH2_CRK	217	221	PF00017	0.407
LIG_SH2_NCK_1	179	183	PF00017	0.631
LIG_SH2_NCK_1	195	199	PF00017	0.511
LIG_SH2_STAP1	195	199	PF00017	0.560
LIG_SH2_STAT5	132	135	PF00017	0.425
LIG_SH2_STAT5	25	28	PF00017	0.522
LIG_SH2_STAT5	62	65	PF00017	0.461
LIG_SH3_3	128	134	PF00018	0.414
LIG_SH3_3	163	169	PF00018	0.553
LIG_SH3_3	24	30	PF00018	0.596
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.398
LIG_SUMO_SIM_anti_2	98	104	PF11976	0.395
LIG_SUMO_SIM_par_1	227	234	PF11976	0.363
LIG_TRAF2_1	288	291	PF00917	0.482
LIG_TRAF2_1	35	38	PF00917	0.544
LIG_TRAF2_1	357	360	PF00917	0.701
LIG_TRAF2_1	69	72	PF00917	0.404
LIG_TYR_ITIM	193	198	PF00017	0.514
LIG_UBA3_1	245	252	PF00899	0.399
MOD_CK1_1	321	327	PF00069	0.672
MOD_CK2_1	180	186	PF00069	0.644
MOD_CK2_1	284	290	PF00069	0.456
MOD_CK2_1	298	304	PF00069	0.465
MOD_CK2_1	30	36	PF00069	0.502
MOD_CK2_1	66	72	PF00069	0.336
MOD_GlcNHglycan	279	283	PF01048	0.547
MOD_GlcNHglycan	329	332	PF01048	0.570
MOD_GSK3_1	321	328	PF00069	0.735
MOD_GSK3_1	60	67	PF00069	0.483
MOD_N-GLC_1	180	185	PF02516	0.613
MOD_NEK2_1	309	314	PF00069	0.500
MOD_PIKK_1	309	315	PF00454	0.526
MOD_PIKK_1	321	327	PF00454	0.646
MOD_PIKK_1	8	14	PF00454	0.528
MOD_PK_1	298	304	PF00069	0.486
MOD_PKA_1	2	8	PF00069	0.673
MOD_PKA_1	41	47	PF00069	0.417
MOD_PKA_1	64	70	PF00069	0.463
MOD_PKA_1	88	94	PF00069	0.521
MOD_PKA_2	2	8	PF00069	0.673
MOD_PKA_2	247	253	PF00069	0.401
MOD_PKB_1	192	200	PF00069	0.496
MOD_ProDKin_1	130	136	PF00069	0.410
MOD_ProDKin_1	284	290	PF00069	0.461
MOD_ProDKin_1	318	324	PF00069	0.638
MOD_SUMO_rev_2	135	141	PF00179	0.438
MOD_SUMO_rev_2	354	364	PF00179	0.704
TRG_DiLeu_BaEn_1	290	295	PF01217	0.493
TRG_DiLeu_BaEn_1	76	81	PF01217	0.411
TRG_DiLeu_BaEn_4	290	296	PF01217	0.495
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.477
TRG_DiLeu_LyEn_5	290	295	PF01217	0.493
TRG_ENDOCYTIC_2	179	182	PF00928	0.461
TRG_ENDOCYTIC_2	195	198	PF00928	0.468
TRG_ER_diArg_1	1	3	PF00400	0.553
TRG_ER_diArg_1	192	195	PF00400	0.438
TRG_ER_diArg_1	292	294	PF00400	0.490
TRG_ER_diArg_1	297	300	PF00400	0.481
TRG_ER_diArg_1	51	53	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W5	Leptomonas seymouri	84%	100%
A0A0S4IPK0	Bodo saltans	64%	99%
A0A1X0NPG5	Trypanosomatidae	75%	99%
A0A3S5H687	Leishmania donovani	98%	100%
A0A422NFX7	Trypanosoma rangeli	67%	99%
A4H5E9	Leishmania braziliensis	92%	100%
A4HTP3	Leishmania infantum	98%	100%
C9ZPE5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	99%
Q4QI59	Leishmania major	96%	100%
V5DAE9	Trypanosoma cruzi	70%	99%