RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMH9_LEIMU

TriTrypDb:

LmxM.08.1091

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004842	ubiquitin-protein transferase activity	4	10
GO:0005488	binding	1	9
GO:0016740	transferase activity	2	10
GO:0019787	ubiquitin-like protein transferase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0061630	ubiquitin protein ligase activity	5	10
GO:0061659	ubiquitin-like protein ligase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:0008270	zinc ion binding	6	4
GO:0046914	transition metal ion binding	5	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.758
CLV_NRD_NRD_1	10	12	PF00675	0.552
CLV_NRD_NRD_1	263	265	PF00675	0.627
CLV_NRD_NRD_1	274	276	PF00675	0.476
CLV_NRD_NRD_1	311	313	PF00675	0.551
CLV_PCSK_KEX2_1	12	14	PF00082	0.545
CLV_PCSK_KEX2_1	242	244	PF00082	0.608
CLV_PCSK_KEX2_1	274	276	PF00082	0.484
CLV_PCSK_KEX2_1	97	99	PF00082	0.476
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.537
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.637
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.563
CLV_PCSK_SKI1_1	103	107	PF00082	0.503
CLV_PCSK_SKI1_1	12	16	PF00082	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DOC_MAPK_HePTP_8	81	93	PF00069	0.285
DOC_MAPK_MEF2A_6	84	93	PF00069	0.297
DOC_PP2B_LxvP_1	343	346	PF13499	0.687
DOC_SPAK_OSR1_1	32	36	PF12202	0.545
DOC_USP7_MATH_1	132	136	PF00917	0.613
DOC_USP7_MATH_1	193	197	PF00917	0.444
DOC_USP7_MATH_1	207	211	PF00917	0.658
DOC_USP7_MATH_1	215	219	PF00917	0.604
DOC_WW_Pin1_4	241	246	PF00397	0.380
LIG_14-3-3_CanoR_1	32	36	PF00244	0.265
LIG_BRCT_BRCA1_1	195	199	PF00533	0.592
LIG_BRCT_BRCA1_1	212	216	PF00533	0.500
LIG_Clathr_ClatBox_1	235	239	PF01394	0.509
LIG_FHA_1	109	115	PF00498	0.588
LIG_FHA_1	172	178	PF00498	0.498
LIG_FHA_1	242	248	PF00498	0.472
LIG_FHA_1	340	346	PF00498	0.739
LIG_FHA_1	62	68	PF00498	0.506
LIG_LIR_Gen_1	170	181	PF02991	0.585
LIG_LIR_Gen_1	213	224	PF02991	0.633
LIG_LIR_Gen_1	230	238	PF02991	0.472
LIG_LIR_Gen_1	301	309	PF02991	0.412
LIG_LIR_Gen_1	316	323	PF02991	0.441
LIG_LIR_Nem_3	170	176	PF02991	0.491
LIG_LIR_Nem_3	221	227	PF02991	0.555
LIG_LIR_Nem_3	230	235	PF02991	0.445
LIG_LIR_Nem_3	301	306	PF02991	0.412
LIG_LIR_Nem_3	316	320	PF02991	0.433
LIG_NRBOX	64	70	PF00104	0.518
LIG_Pex14_1	299	303	PF04695	0.430
LIG_REV1ctd_RIR_1	69	78	PF16727	0.523
LIG_SH2_CRK	173	177	PF00017	0.460
LIG_SH2_CRK	232	236	PF00017	0.572
LIG_SH2_GRB2like	85	88	PF00017	0.573
LIG_SH2_STAP1	173	177	PF00017	0.535
LIG_SH2_STAP1	232	236	PF00017	0.506
LIG_SH2_STAT5	173	176	PF00017	0.497
LIG_SH2_STAT5	181	184	PF00017	0.446
LIG_SH2_STAT5	258	261	PF00017	0.618
LIG_SH2_STAT5	85	88	PF00017	0.573
LIG_SH3_1	192	198	PF00018	0.550
LIG_SH3_3	147	153	PF00018	0.631
LIG_SH3_3	192	198	PF00018	0.601
LIG_SH3_3	349	355	PF00018	0.623
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.509
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.284
LIG_SUMO_SIM_par_1	233	239	PF11976	0.595
LIG_TRAF2_1	99	102	PF00917	0.323
LIG_TYR_ITIM	222	227	PF00017	0.524
LIG_UBA3_1	235	242	PF00899	0.624
MOD_CK1_1	20	26	PF00069	0.512
MOD_CK1_1	210	216	PF00069	0.637
MOD_CK1_1	252	258	PF00069	0.579
MOD_CK1_1	301	307	PF00069	0.443
MOD_CK1_1	347	353	PF00069	0.645
MOD_CK2_1	148	154	PF00069	0.640
MOD_CK2_1	322	328	PF00069	0.711
MOD_GlcNHglycan	134	137	PF01048	0.589
MOD_GlcNHglycan	259	262	PF01048	0.540
MOD_GSK3_1	148	155	PF00069	0.558
MOD_GSK3_1	15	22	PF00069	0.386
MOD_GSK3_1	167	174	PF00069	0.569
MOD_GSK3_1	193	200	PF00069	0.476
MOD_GSK3_1	329	336	PF00069	0.714
MOD_GSK3_1	344	351	PF00069	0.682
MOD_GSK3_1	51	58	PF00069	0.471
MOD_N-GLC_1	171	176	PF02516	0.510
MOD_N-GLC_1	252	257	PF02516	0.585
MOD_N-GLC_1	265	270	PF02516	0.455
MOD_N-GLC_1	43	48	PF02516	0.480
MOD_N-GLC_2	141	143	PF02516	0.571
MOD_NEK2_1	199	204	PF00069	0.565
MOD_NEK2_1	333	338	PF00069	0.695
MOD_OFUCOSY	168	175	PF10250	0.505
MOD_PIKK_1	55	61	PF00454	0.475
MOD_PK_1	348	354	PF00069	0.681
MOD_PKA_1	12	18	PF00069	0.541
MOD_PKA_2	107	113	PF00069	0.400
MOD_PKA_2	12	18	PF00069	0.541
MOD_PKA_2	20	26	PF00069	0.562
MOD_PKA_2	31	37	PF00069	0.224
MOD_Plk_1	171	177	PF00069	0.469
MOD_Plk_1	252	258	PF00069	0.500
MOD_Plk_1	43	49	PF00069	0.505
MOD_Plk_1	89	95	PF00069	0.458
MOD_Plk_2-3	322	328	PF00069	0.532
MOD_Plk_4	63	69	PF00069	0.508
MOD_Plk_4	89	95	PF00069	0.458
MOD_ProDKin_1	241	247	PF00069	0.380
MOD_SUMO_rev_2	148	157	PF00179	0.636
MOD_SUMO_rev_2	322	332	PF00179	0.682
MOD_SUMO_rev_2	96	105	PF00179	0.560
TRG_DiLeu_BaEn_1	90	95	PF01217	0.478
TRG_DiLeu_BaEn_4	249	255	PF01217	0.606
TRG_ENDOCYTIC_2	173	176	PF00928	0.449
TRG_ENDOCYTIC_2	224	227	PF00928	0.509
TRG_ENDOCYTIC_2	232	235	PF00928	0.477
TRG_ER_diArg_1	10	13	PF00400	0.525
TRG_ER_diArg_1	273	275	PF00400	0.429
TRG_NLS_MonoExtN_4	9	15	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H3	Leptomonas seymouri	43%	96%
A0A0S4KHN3	Bodo saltans	27%	67%
A0A1X0NP60	Trypanosomatidae	30%	79%
A0A3S7WQF3	Leishmania donovani	87%	100%
A4H5E8	Leishmania braziliensis	69%	100%
C9ZPE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	79%
E9ACQ5	Leishmania major	87%	100%
E9AG87	Leishmania infantum	88%	100%