Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania mexicana

UniProt:

E9AMH8_LEIMU

TriTrypDb:

LmxM.08.1090

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AMH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMH8

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	43	49	PF00089	0.450
CLV_NRD_NRD_1	18	20	PF00675	0.477
CLV_NRD_NRD_1	31	33	PF00675	0.544
CLV_NRD_NRD_1	539	541	PF00675	0.439
CLV_NRD_NRD_1	545	547	PF00675	0.465
CLV_PCSK_FUR_1	147	151	PF00082	0.138
CLV_PCSK_FUR_1	537	541	PF00082	0.291
CLV_PCSK_FUR_1	585	589	PF00082	0.447
CLV_PCSK_KEX2_1	149	151	PF00082	0.138
CLV_PCSK_KEX2_1	18	20	PF00082	0.570
CLV_PCSK_KEX2_1	537	539	PF00082	0.427
CLV_PCSK_KEX2_1	587	589	PF00082	0.450
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.138
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.535
CLV_PCSK_PC7_1	534	540	PF00082	0.362
CLV_PCSK_SKI1_1	130	134	PF00082	0.372
CLV_PCSK_SKI1_1	204	208	PF00082	0.226
DEG_APCC_DBOX_1	435	443	PF00400	0.489
DEG_SCF_TRCP1_1	178	183	PF00400	0.338
DEG_SPOP_SBC_1	106	110	PF00917	0.373
DOC_CKS1_1	142	147	PF01111	0.429
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.533
DOC_MAPK_DCC_7	160	169	PF00069	0.467
DOC_MAPK_MEF2A_6	160	169	PF00069	0.467
DOC_MAPK_MEF2A_6	280	287	PF00069	0.390
DOC_MAPK_MEF2A_6	332	340	PF00069	0.413
DOC_MAPK_MEF2A_6	436	444	PF00069	0.406
DOC_MAPK_MEF2A_6	479	487	PF00069	0.472
DOC_MAPK_MEF2A_6	511	519	PF00069	0.221
DOC_PP2B_LxvP_1	169	172	PF13499	0.467
DOC_PP2B_LxvP_1	507	510	PF13499	0.406
DOC_PP2B_PxIxI_1	118	124	PF00149	0.387
DOC_PP2B_PxIxI_1	330	336	PF00149	0.413
DOC_PP4_FxxP_1	20	23	PF00568	0.491
DOC_PP4_FxxP_1	214	217	PF00568	0.507
DOC_PP4_FxxP_1	6	9	PF00568	0.680
DOC_PP4_MxPP_1	1	4	PF00568	0.559
DOC_USP7_MATH_1	105	109	PF00917	0.532
DOC_USP7_MATH_1	195	199	PF00917	0.508
DOC_USP7_MATH_1	268	272	PF00917	0.467
DOC_USP7_MATH_1	283	287	PF00917	0.357
DOC_USP7_MATH_1	51	55	PF00917	0.487
DOC_USP7_MATH_1	556	560	PF00917	0.618
DOC_USP7_UBL2_3	33	37	PF12436	0.468
DOC_USP7_UBL2_3	75	79	PF12436	0.467
DOC_WW_Pin1_4	138	143	PF00397	0.425
DOC_WW_Pin1_4	521	526	PF00397	0.373
DOC_WW_Pin1_4	54	59	PF00397	0.520
DOC_WW_Pin1_4	98	103	PF00397	0.717
LIG_14-3-3_CanoR_1	204	209	PF00244	0.426
LIG_14-3-3_CanoR_1	249	256	PF00244	0.469
LIG_14-3-3_CanoR_1	321	327	PF00244	0.467
LIG_14-3-3_CanoR_1	50	58	PF00244	0.534
LIG_Actin_WH2_2	502	520	PF00022	0.375
LIG_APCC_ABBA_1	173	178	PF00400	0.467
LIG_BIR_III_4	91	95	PF00653	0.469
LIG_BRCT_BRCA1_1	442	446	PF00533	0.413
LIG_EVH1_2	2	6	PF00568	0.598
LIG_FHA_1	12	18	PF00498	0.483
LIG_FHA_1	241	247	PF00498	0.455
LIG_FHA_1	379	385	PF00498	0.444
LIG_FHA_1	478	484	PF00498	0.433
LIG_FHA_1	510	516	PF00498	0.442
LIG_FHA_1	83	89	PF00498	0.453
LIG_FHA_2	205	211	PF00498	0.426
LIG_FHA_2	88	94	PF00498	0.475
LIG_Integrin_RGD_1	378	380	PF01839	0.244
LIG_LIR_Apic_2	213	217	PF02991	0.472
LIG_LIR_Apic_2	447	453	PF02991	0.426
LIG_LIR_Gen_1	207	214	PF02991	0.545
LIG_LIR_Gen_1	286	293	PF02991	0.476
LIG_LIR_Gen_1	303	313	PF02991	0.519
LIG_LIR_Gen_1	358	367	PF02991	0.507
LIG_LIR_Gen_1	422	432	PF02991	0.345
LIG_LIR_Gen_1	460	470	PF02991	0.469
LIG_LIR_Gen_1	541	550	PF02991	0.571
LIG_LIR_LC3C_4	480	485	PF02991	0.467
LIG_LIR_Nem_3	207	211	PF02991	0.477
LIG_LIR_Nem_3	286	290	PF02991	0.476
LIG_LIR_Nem_3	303	308	PF02991	0.519
LIG_LIR_Nem_3	358	364	PF02991	0.488
LIG_LIR_Nem_3	422	427	PF02991	0.345
LIG_LIR_Nem_3	460	466	PF02991	0.469
LIG_LIR_Nem_3	541	545	PF02991	0.486
LIG_Pex14_2	424	428	PF04695	0.338
LIG_PTB_Apo_2	418	425	PF02174	0.338
LIG_SH2_SRC	208	211	PF00017	0.467
LIG_SH2_STAP1	220	224	PF00017	0.518
LIG_SH2_STAT5	238	241	PF00017	0.426
LIG_SH2_STAT5	361	364	PF00017	0.413
LIG_SH2_STAT5	383	386	PF00017	0.426
LIG_SH2_STAT5	418	421	PF00017	0.338
LIG_SH2_STAT5	83	86	PF00017	0.574
LIG_SH3_2	142	147	PF14604	0.426
LIG_SH3_2	327	332	PF14604	0.424
LIG_SH3_3	113	119	PF00018	0.467
LIG_SH3_3	139	145	PF00018	0.268
LIG_SH3_3	185	191	PF00018	0.377
LIG_SH3_3	287	293	PF00018	0.426
LIG_SH3_3	324	330	PF00018	0.424
LIG_SUMO_SIM_anti_2	69	74	PF11976	0.500
LIG_SUMO_SIM_par_1	334	339	PF11976	0.413
LIG_SUMO_SIM_par_1	438	443	PF11976	0.413
LIG_SUMO_SIM_par_1	482	488	PF11976	0.426
LIG_TRAF2_1	569	572	PF00917	0.565
LIG_TYR_ITIM	359	364	PF00017	0.426
LIG_UBA3_1	515	523	PF00899	0.230
LIG_UBA3_1	72	79	PF00899	0.598
LIG_WRC_WIRS_1	211	216	PF05994	0.507
LIG_WRC_WIRS_1	284	289	PF05994	0.467
LIG_WW_3	2	6	PF00397	0.550
LIG_WW_3	329	333	PF00397	0.469
MOD_CDK_SPK_2	521	526	PF00069	0.373
MOD_CDK_SPK_2	98	103	PF00069	0.456
MOD_CDK_SPxK_1	141	147	PF00069	0.294
MOD_CK1_1	136	142	PF00069	0.612
MOD_CK1_1	300	306	PF00069	0.482
MOD_CK1_1	392	398	PF00069	0.455
MOD_CK1_1	465	471	PF00069	0.534
MOD_CK1_1	54	60	PF00069	0.667
MOD_CK1_1	565	571	PF00069	0.545
MOD_CK1_1	98	104	PF00069	0.599
MOD_CK2_1	204	210	PF00069	0.424
MOD_CK2_1	345	351	PF00069	0.426
MOD_CK2_1	419	425	PF00069	0.459
MOD_CK2_1	87	93	PF00069	0.650
MOD_GlcNHglycan	178	181	PF01048	0.354
MOD_GlcNHglycan	192	195	PF01048	0.250
MOD_GlcNHglycan	225	228	PF01048	0.367
MOD_GlcNHglycan	250	253	PF01048	0.312
MOD_GlcNHglycan	270	273	PF01048	0.121
MOD_GlcNHglycan	275	278	PF01048	0.335
MOD_GlcNHglycan	302	305	PF01048	0.271
MOD_GlcNHglycan	327	330	PF01048	0.250
MOD_GlcNHglycan	58	61	PF01048	0.597
MOD_GSK3_1	176	183	PF00069	0.502
MOD_GSK3_1	266	273	PF00069	0.438
MOD_GSK3_1	321	328	PF00069	0.516
MOD_GSK3_1	505	512	PF00069	0.425
MOD_GSK3_1	52	59	PF00069	0.537
MOD_GSK3_1	556	563	PF00069	0.584
MOD_GSK3_1	94	101	PF00069	0.615
MOD_N-GLC_1	11	16	PF02516	0.325
MOD_N-GLC_1	195	200	PF02516	0.301
MOD_NEK2_1	11	16	PF00069	0.557
MOD_NEK2_1	223	228	PF00069	0.467
MOD_NEK2_1	360	365	PF00069	0.413
MOD_NEK2_1	419	424	PF00069	0.507
MOD_NEK2_1	505	510	PF00069	0.407
MOD_NEK2_2	13	18	PF00069	0.400
MOD_PIKK_1	195	201	PF00454	0.433
MOD_PIKK_1	297	303	PF00454	0.507
MOD_PIKK_1	567	573	PF00454	0.413
MOD_PIKK_1	96	102	PF00454	0.539
MOD_PKA_2	248	254	PF00069	0.469
MOD_PKA_2	51	57	PF00069	0.690
MOD_PKA_2	560	566	PF00069	0.548
MOD_PKA_2	94	100	PF00069	0.558
MOD_PKB_1	319	327	PF00069	0.467
MOD_PKB_1	50	58	PF00069	0.538
MOD_Plk_1	119	125	PF00069	0.375
MOD_Plk_1	195	201	PF00069	0.486
MOD_Plk_1	241	247	PF00069	0.503
MOD_Plk_1	256	262	PF00069	0.552
MOD_Plk_2-3	210	216	PF00069	0.467
MOD_Plk_4	345	351	PF00069	0.426
MOD_Plk_4	355	361	PF00069	0.426
MOD_Plk_4	419	425	PF00069	0.507
MOD_Plk_4	462	468	PF00069	0.507
MOD_ProDKin_1	138	144	PF00069	0.417
MOD_ProDKin_1	521	527	PF00069	0.370
MOD_ProDKin_1	54	60	PF00069	0.519
MOD_ProDKin_1	98	104	PF00069	0.716
MOD_SUMO_rev_2	559	568	PF00179	0.688
TRG_DiLeu_BaEn_1	578	583	PF01217	0.401
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.390
TRG_ENDOCYTIC_2	208	211	PF00928	0.503
TRG_ENDOCYTIC_2	220	223	PF00928	0.403
TRG_ENDOCYTIC_2	361	364	PF00928	0.426
TRG_ER_diArg_1	17	19	PF00400	0.462
TRG_ER_diArg_1	318	321	PF00400	0.467
TRG_ER_diArg_1	49	52	PF00400	0.657
TRG_ER_diArg_1	531	534	PF00400	0.377
TRG_ER_diArg_1	537	540	PF00400	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD56	Leptomonas seymouri	65%	100%
A0A0S4J6F0	Bodo saltans	37%	90%
A0A1X0NP71	Trypanosomatidae	44%	97%
A0A3S5H686	Leishmania donovani	92%	100%
A0A422NJU7	Trypanosoma rangeli	46%	100%
A4HTP2	Leishmania infantum	91%	93%
E9AI33	Leishmania braziliensis	80%	100%
P53973	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	86%
Q4QI60	Leishmania major	90%	100%
Q5A960	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	73%
V5BR24	Trypanosoma cruzi	45%	100%