Putative cathepsin L-like protease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cathepsin L-like protease, putative

Species:

Leishmania mexicana

UniProt:

E9AMH6_LEIMU

TriTrypDb:

LmxM.08.1070

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 36, no: 5
NetGPI	no	yes: 0, no: 41

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

E9AMH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMH6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	42
GO:0006807	nitrogen compound metabolic process	2	42
GO:0008152	metabolic process	1	42
GO:0019538	protein metabolic process	3	42
GO:0043170	macromolecule metabolic process	3	42
GO:0044238	primary metabolic process	2	42
GO:0071704	organic substance metabolic process	2	42
GO:1901564	organonitrogen compound metabolic process	3	42
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	42
GO:0004175	endopeptidase activity	4	28
GO:0004197	cysteine-type endopeptidase activity	5	28
GO:0008233	peptidase activity	3	42
GO:0008234	cysteine-type peptidase activity	4	42
GO:0016787	hydrolase activity	2	42
GO:0140096	catalytic activity, acting on a protein	2	42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.449
CLV_NRD_NRD_1	116	118	PF00675	0.573
CLV_NRD_NRD_1	373	375	PF00675	0.294
CLV_NRD_NRD_1	376	378	PF00675	0.292
CLV_PCSK_KEX2_1	109	111	PF00082	0.421
CLV_PCSK_KEX2_1	373	375	PF00082	0.238
CLV_PCSK_KEX2_1	42	44	PF00082	0.517
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.429
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.517
CLV_PCSK_SKI1_1	5	9	PF00082	0.606
CLV_Separin_Metazoa	67	71	PF03568	0.458
DEG_APCC_DBOX_1	119	127	PF00400	0.574
DEG_APCC_DBOX_1	376	384	PF00400	0.206
DEG_APCC_DBOX_1	4	12	PF00400	0.646
DEG_SPOP_SBC_1	346	350	PF00917	0.484
DOC_CKS1_1	30	35	PF01111	0.667
DOC_CYCLIN_RxL_1	58	71	PF00134	0.458
DOC_MAPK_gen_1	373	383	PF00069	0.209
DOC_MAPK_MEF2A_6	257	265	PF00069	0.470
DOC_USP7_MATH_1	146	150	PF00917	0.546
DOC_USP7_MATH_1	215	219	PF00917	0.376
DOC_USP7_MATH_1	224	228	PF00917	0.376
DOC_USP7_MATH_1	346	350	PF00917	0.309
DOC_USP7_UBL2_3	378	382	PF12436	0.319
DOC_WW_Pin1_4	136	141	PF00397	0.431
DOC_WW_Pin1_4	29	34	PF00397	0.608
DOC_WW_Pin1_4	351	356	PF00397	0.402
DOC_WW_Pin1_4	397	402	PF00397	0.230
DOC_WW_Pin1_4	426	431	PF00397	0.615
LIG_14-3-3_CanoR_1	377	381	PF00244	0.451
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	409	413	PF00533	0.399
LIG_BRCT_BRCA1_1	428	432	PF00533	0.287
LIG_FHA_1	277	283	PF00498	0.401
LIG_FHA_1	296	302	PF00498	0.540
LIG_FHA_2	348	354	PF00498	0.349
LIG_FHA_2	49	55	PF00498	0.461
LIG_LIR_Gen_1	316	326	PF02991	0.427
LIG_LIR_LC3C_4	229	234	PF02991	0.259
LIG_LIR_Nem_3	211	217	PF02991	0.444
LIG_LIR_Nem_3	268	273	PF02991	0.368
LIG_LIR_Nem_3	300	306	PF02991	0.395
LIG_LIR_Nem_3	316	322	PF02991	0.358
LIG_LIR_Nem_3	84	89	PF02991	0.457
LIG_LYPXL_yS_3	214	217	PF13949	0.338
LIG_MLH1_MIPbox_1	428	432	PF16413	0.294
LIG_PCNA_PIPBox_1	80	89	PF02747	0.259
LIG_PCNA_yPIPBox_3	75	87	PF02747	0.259
LIG_SH2_GRB2like	409	412	PF00017	0.462
LIG_SH2_GRB2like	98	101	PF00017	0.481
LIG_SH2_PTP2	319	322	PF00017	0.376
LIG_SH2_SRC	98	101	PF00017	0.514
LIG_SH2_STAP1	409	413	PF00017	0.229
LIG_SH2_STAP1	49	53	PF00017	0.416
LIG_SH2_STAT5	104	107	PF00017	0.483
LIG_SH2_STAT5	164	167	PF00017	0.289
LIG_SH2_STAT5	216	219	PF00017	0.373
LIG_SH2_STAT5	222	225	PF00017	0.374
LIG_SH2_STAT5	319	322	PF00017	0.376
LIG_SH2_STAT5	431	434	PF00017	0.554
LIG_SH2_STAT5	98	101	PF00017	0.474
LIG_SH3_3	27	33	PF00018	0.617
LIG_SUMO_SIM_par_1	169	175	PF11976	0.408
LIG_SUMO_SIM_par_1	358	363	PF11976	0.255
LIG_TYR_ITIM	301	306	PF00017	0.465
MOD_CDC14_SPxK_1	400	403	PF00782	0.229
MOD_CDK_SPxK_1	136	142	PF00069	0.431
MOD_CDK_SPxK_1	397	403	PF00069	0.229
MOD_CDK_SPxxK_3	351	358	PF00069	0.229
MOD_CK1_1	227	233	PF00069	0.412
MOD_CK1_1	269	275	PF00069	0.369
MOD_CK1_1	349	355	PF00069	0.463
MOD_CK2_1	169	175	PF00069	0.353
MOD_CK2_1	347	353	PF00069	0.330
MOD_CK2_1	48	54	PF00069	0.442
MOD_CK2_1	87	93	PF00069	0.367
MOD_GlcNHglycan	122	126	PF01048	0.619
MOD_GlcNHglycan	153	156	PF01048	0.484
MOD_GlcNHglycan	217	220	PF01048	0.382
MOD_GlcNHglycan	274	277	PF01048	0.474
MOD_GlcNHglycan	336	339	PF01048	0.415
MOD_GlcNHglycan	342	345	PF01048	0.372
MOD_GSK3_1	265	272	PF00069	0.388
MOD_GSK3_1	345	352	PF00069	0.402
MOD_GSK3_1	432	439	PF00069	0.488
MOD_N-GLC_1	227	232	PF02516	0.475
MOD_N-GLC_2	327	329	PF02516	0.407
MOD_N-GLC_2	384	386	PF02516	0.413
MOD_N-GLC_2	438	440	PF02516	0.439
MOD_NEK2_1	1	6	PF00069	0.602
MOD_NEK2_1	201	206	PF00069	0.485
MOD_NEK2_1	265	270	PF00069	0.478
MOD_NEK2_1	41	46	PF00069	0.490
MOD_NEK2_1	432	437	PF00069	0.497
MOD_NEK2_1	81	86	PF00069	0.475
MOD_PKA_2	340	346	PF00069	0.251
MOD_PKA_2	376	382	PF00069	0.245
MOD_Plk_1	121	127	PF00069	0.661
MOD_Plk_1	210	216	PF00069	0.359
MOD_Plk_1	265	271	PF00069	0.341
MOD_Plk_2-3	169	175	PF00069	0.259
MOD_Plk_4	266	272	PF00069	0.352
MOD_Plk_4	376	382	PF00069	0.461
MOD_Plk_4	392	398	PF00069	0.271
MOD_Plk_4	432	438	PF00069	0.472
MOD_ProDKin_1	136	142	PF00069	0.431
MOD_ProDKin_1	29	35	PF00069	0.601
MOD_ProDKin_1	351	357	PF00069	0.402
MOD_ProDKin_1	397	403	PF00069	0.230
MOD_ProDKin_1	426	432	PF00069	0.623
MOD_SUMO_rev_2	39	44	PF00179	0.513
MOD_SUMO_rev_2	422	429	PF00179	0.380
TRG_DiLeu_BaEn_4	54	60	PF01217	0.454
TRG_ENDOCYTIC_2	214	217	PF00928	0.359
TRG_ENDOCYTIC_2	303	306	PF00928	0.367
TRG_ENDOCYTIC_2	319	322	PF00928	0.367
TRG_ENDOCYTIC_2	49	52	PF00928	0.433
TRG_NES_CRM1_1	57	71	PF08389	0.458
TRG_NLS_MonoExtC_3	116	122	PF00514	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	38%	100%
A0A0N0P293	Leptomonas seymouri	33%	100%
A0A0N0P8D1	Leptomonas seymouri	26%	100%
A0A0N1PA65	Leptomonas seymouri	43%	95%
A0A0S4IMD3	Bodo saltans	46%	100%
A0A0S4ISD8	Bodo saltans	42%	83%
A0A0S4IWQ5	Bodo saltans	35%	100%
A0A0S4IY45	Bodo saltans	35%	100%
A0A0S4J328	Bodo saltans	50%	100%
A0A0S4J3Q7	Bodo saltans	30%	100%
A0A0S4J628	Bodo saltans	45%	81%
A0A0S4J918	Bodo saltans	39%	100%
A0A0S4J9K9	Bodo saltans	48%	100%
A0A0S4JPQ2	Bodo saltans	32%	100%
A0A0S4JSZ3	Bodo saltans	33%	100%
A0A0S4JV57	Bodo saltans	31%	100%
A0A0S4JXJ3	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	46%	95%
A0A1X0NIG8	Trypanosomatidae	32%	100%
A0A1X0NM52	Trypanosomatidae	54%	100%
A0A1X0NXC8	Trypanosomatidae	32%	100%
A0A3R7L7E7	Trypanosoma rangeli	47%	84%
A0A3S5H682	Leishmania donovani	83%	100%
A0A3S5H683	Leishmania donovani	80%	100%
A0A3S5H684	Leishmania donovani	79%	100%
A0A3S5H685	Leishmania donovani	79%	100%
A0A3S7WQD0	Leishmania donovani	79%	100%
A0A6L0WJ22	Leishmania infantum	80%	100%
A0E358	Paramecium tetraurelia	34%	100%
A1KXI0	Blomia tropicalis	29%	100%
A2XQE8	Oryza sativa subsp. indica	37%	100%
A4H5E4	Leishmania braziliensis	67%	100%
A4H5E5	Leishmania braziliensis	65%	100%
A4H5E6	Leishmania braziliensis	65%	100%
A4HA92	Leishmania braziliensis	44%	100%
A4HH90	Leishmania braziliensis	30%	100%
A4HTP0	Leishmania infantum	81%	100%
A4HYH2	Leishmania infantum	45%	100%
A4I4D6	Leishmania infantum	32%	100%
A5HII1	Actinidia deliciosa	31%	100%
A8DS38	Tabernaemontana divaricata	38%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D3ZZ07	Rattus norvegicus	33%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9ADT5	Leishmania major	30%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
F4JNL3	Arabidopsis thaliana	31%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	36%	100%
O17473	Brugia pahangi	34%	100%
O23791	Ananas comosus	34%	100%
O35186	Rattus norvegicus	35%	100%
O45734	Caenorhabditis elegans	39%	100%
O46427	Sus scrofa	34%	100%
O60911	Homo sapiens	39%	100%
O65039	Ricinus communis	35%	100%
O65493	Arabidopsis thaliana	36%	100%
O70370	Mus musculus	36%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	35%	100%
O97397	Phaedon cochleariae	32%	100%
P00785	Actinidia chinensis var. chinensis	31%	100%
P00786	Rattus norvegicus	34%	100%
P04988	Dictyostelium discoideum	36%	100%
P04989	Dictyostelium discoideum	34%	100%
P05167	Hordeum vulgare	38%	100%
P06797	Mus musculus	41%	100%
P07154	Rattus norvegicus	41%	100%
P07711	Homo sapiens	37%	100%
P08176	Dermatophagoides pteronyssinus	27%	100%
P09668	Homo sapiens	35%	100%
P12412	Vigna mungo	35%	100%
P13277	Homarus americanus	41%	100%
P14658	Trypanosoma brucei brucei	45%	98%
P15242	Rattus norvegicus	36%	100%
P16311	Dermatophagoides farinae	30%	100%
P22497	Theileria parva	35%	100%
P22895	Glycine max	36%	100%
P25250	Hordeum vulgare	38%	100%
P25251	Brassica napus	37%	100%
P25326	Bos taurus	36%	100%
P25773	Felis catus	37%	100%
P25774	Homo sapiens	34%	100%
P25775	Leishmania mexicana	46%	100%
P25776	Oryza sativa subsp. japonica	38%	97%
P25777	Oryza sativa subsp. japonica	38%	95%
P25778	Oryza sativa subsp. japonica	40%	100%
P25779	Trypanosoma cruzi	46%	95%
P25780	Euroglyphus maynei	28%	100%
P25781	Theileria annulata	31%	100%
P25782	Homarus americanus	37%	100%
P25783	Autographa californica nuclear polyhedrosis virus	36%	100%
P25784	Homarus americanus	40%	100%
P25803	Phaseolus vulgaris	36%	100%
P25804	Pisum sativum	43%	100%
P25805	Plasmodium falciparum	28%	78%
P25975	Bos taurus	38%	100%
P35591	Leishmania pifanoi	46%	100%
P36184	Entamoeba histolytica	33%	100%
P36400	Leishmania mexicana	98%	100%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	37%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	36%	100%
P42666	Plasmodium vivax (strain Salvador I)	28%	76%
P43156	Hemerocallis sp.	36%	100%
P43234	Homo sapiens	35%	100%
P43235	Homo sapiens	34%	100%
P43236	Oryctolagus cuniculus	33%	100%
P43295	Arabidopsis thaliana	41%	100%
P43296	Arabidopsis thaliana	41%	100%
P43297	Arabidopsis thaliana	37%	96%
P43508	Caenorhabditis elegans	24%	100%
P46102	Plasmodium vinckei	30%	88%
P49935	Mus musculus	34%	100%
P54639	Dictyostelium discoideum	33%	100%
P54640	Dictyostelium discoideum	34%	100%
P55097	Mus musculus	34%	100%
P56202	Homo sapiens	32%	100%
P56203	Mus musculus	33%	100%
P61276	Macaca fascicularis	36%	100%
P61277	Macaca mulatta	36%	100%
P80884	Ananas comosus	33%	100%
Q01957	Entamoeba histolytica	31%	100%
Q02765	Rattus norvegicus	34%	100%
Q05094	Leishmania pifanoi	98%	100%
Q10716	Zea mays	40%	100%
Q10717	Zea mays	39%	100%
Q1EIQ3	Psoroptes ovis	29%	100%
Q23894	Dictyostelium discoideum	33%	100%
Q24940	Fasciola hepatica	40%	100%
Q26534	Schistosoma mansoni	36%	100%
Q26636	Sarcophaga peregrina	37%	100%
Q28944	Sus scrofa	39%	100%
Q3T0I2	Bos taurus	35%	100%
Q3ZKN1	Canis lupus familiaris	36%	100%
Q40143	Solanum lycopersicum	37%	100%
Q4QD68	Leishmania major	48%	100%
Q4QI61	Leishmania major	75%	100%
Q4QI62	Leishmania major	85%	100%
Q4QI64	Leishmania major	85%	100%
Q4QI65	Leishmania major	85%	100%
Q4QI66	Leishmania major	74%	100%
Q4QI67	Leishmania major	85%	100%
Q4QI68	Leishmania major	84%	100%
Q54TR1	Dictyostelium discoideum	37%	83%
Q5E968	Bos taurus	36%	100%
Q5E998	Bos taurus	38%	100%
Q63088	Rattus norvegicus	36%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	37%	100%
Q6YD92	Petrosia ficiformis	38%	100%
Q7GDU7	Oryza sativa subsp. japonica	36%	100%
Q7XR52	Oryza sativa subsp. japonica	39%	90%
Q7XWK5	Oryza sativa subsp. japonica	37%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	38%	100%
Q80UB0	Mus musculus	35%	100%
Q86GF7	Pandalus borealis	37%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	36%	100%
Q8H166	Arabidopsis thaliana	40%	100%
Q8HY81	Canis lupus familiaris	36%	100%
Q8HY82	Saimiri boliviensis boliviensis	36%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	36%	100%
Q8RWQ9	Arabidopsis thaliana	39%	100%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	37%	100%
Q8VYS0	Arabidopsis thaliana	39%	100%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	36%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	37%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	37%	100%
Q91ZF2	Mus musculus	34%	100%
Q93VC9	Arabidopsis thaliana	27%	100%
Q94714	Paramecium tetraurelia	35%	100%
Q94715	Paramecium tetraurelia	29%	100%
Q95029	Drosophila melanogaster	39%	100%
Q9BIE1	Leishmania donovani	45%	100%
Q9FGR9	Arabidopsis thaliana	35%	100%
Q9GKL8	Chlorocebus aethiops	37%	100%
Q9GL24	Canis lupus familiaris	38%	100%
Q9GLE3	Sus scrofa	34%	100%
Q9GQM5	Leishmania donovani	32%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	36%	100%
Q9JI81	Mus musculus	34%	100%
Q9JIA9	Mus musculus	35%	100%
Q9JL96	Mus musculus	32%	100%
Q9LT77	Arabidopsis thaliana	37%	100%
Q9LT78	Arabidopsis thaliana	36%	98%
Q9PYY5	Xestia c-nigrum granulosis virus	38%	100%
Q9QZE3	Rattus norvegicus	33%	100%
Q9R013	Mus musculus	42%	96%
Q9R014	Mus musculus	36%	100%
Q9STL4	Arabidopsis thaliana	33%	100%
Q9SUL1	Arabidopsis thaliana	40%	100%
Q9SUS9	Arabidopsis thaliana	35%	100%
Q9SUT0	Arabidopsis thaliana	34%	100%
Q9TST1	Felis catus	32%	100%
Q9UBX1	Homo sapiens	42%	92%
Q9VN93	Drosophila melanogaster	39%	72%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	34%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	37%	100%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	34%	100%
V5B261	Trypanosoma cruzi	33%	100%