Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMG8_LEIMU

TriTrypDb:

LmxM.08.0940

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.684
CLV_NRD_NRD_1	113	115	PF00675	0.711
CLV_NRD_NRD_1	50	52	PF00675	0.606
CLV_PCSK_KEX2_1	113	115	PF00082	0.747
CLV_PCSK_KEX2_1	135	137	PF00082	0.676
CLV_PCSK_KEX2_1	19	21	PF00082	0.657
CLV_PCSK_KEX2_1	50	52	PF00082	0.606
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.641
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.727
CLV_PCSK_SKI1_1	4	8	PF00082	0.710
CLV_PCSK_SKI1_1	76	80	PF00082	0.532
DEG_SCF_FBW7_1	139	146	PF00400	0.608
DEG_SCF_FBW7_2	230	237	PF00400	0.535
DEG_SPOP_SBC_1	138	142	PF00917	0.685
DEG_SPOP_SBC_1	22	26	PF00917	0.475
DOC_ANK_TNKS_1	115	122	PF00023	0.739
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.553
DOC_PP4_MxPP_1	70	73	PF00568	0.588
DOC_USP7_MATH_1	11	15	PF00917	0.499
DOC_USP7_MATH_1	128	132	PF00917	0.709
DOC_USP7_MATH_1	156	160	PF00917	0.709
DOC_USP7_MATH_1	161	165	PF00917	0.744
DOC_USP7_MATH_1	207	211	PF00917	0.739
DOC_USP7_MATH_1	55	59	PF00917	0.681
DOC_WW_Pin1_4	139	144	PF00397	0.768
DOC_WW_Pin1_4	154	159	PF00397	0.521
DOC_WW_Pin1_4	202	207	PF00397	0.804
DOC_WW_Pin1_4	223	228	PF00397	0.646
DOC_WW_Pin1_4	230	235	PF00397	0.752
DOC_WW_Pin1_4	79	84	PF00397	0.552
LIG_14-3-3_CanoR_1	253	263	PF00244	0.648
LIG_14-3-3_CanoR_1	59	65	PF00244	0.578
LIG_APCC_ABBA_1	64	69	PF00400	0.668
LIG_BIR_III_4	30	34	PF00653	0.681
LIG_BRCT_BRCA1_1	17	21	PF00533	0.471
LIG_BRCT_BRCA1_1	36	40	PF00533	0.632
LIG_BRCT_BRCA1_1	81	85	PF00533	0.468
LIG_CSL_BTD_1	80	83	PF09270	0.661
LIG_FHA_1	142	148	PF00498	0.794
LIG_FHA_1	155	161	PF00498	0.669
LIG_FHA_1	173	179	PF00498	0.551
LIG_FHA_1	255	261	PF00498	0.635
LIG_FHA_2	22	28	PF00498	0.771
LIG_LIR_Gen_1	210	219	PF02991	0.824
LIG_LIR_Gen_1	37	48	PF02991	0.624
LIG_LIR_Gen_1	5	15	PF02991	0.463
LIG_LIR_Gen_1	58	68	PF02991	0.538
LIG_LIR_Gen_1	82	90	PF02991	0.462
LIG_LIR_Nem_3	103	109	PF02991	0.584
LIG_LIR_Nem_3	210	214	PF02991	0.820
LIG_LIR_Nem_3	37	43	PF02991	0.621
LIG_LIR_Nem_3	5	10	PF02991	0.464
LIG_LIR_Nem_3	58	64	PF02991	0.558
LIG_LIR_Nem_3	82	88	PF02991	0.469
LIG_Pex14_1	81	85	PF04695	0.468
LIG_SH2_CRK	61	65	PF00017	0.576
LIG_SH2_PTP2	108	111	PF00017	0.627
LIG_SH2_STAP1	183	187	PF00017	0.653
LIG_SH2_STAT5	108	111	PF00017	0.709
LIG_SH2_STAT5	263	266	PF00017	0.739
LIG_SH2_STAT5	61	64	PF00017	0.576
LIG_SH2_STAT5	67	70	PF00017	0.506
LIG_SH2_STAT5	99	102	PF00017	0.665
LIG_SH3_3	106	112	PF00018	0.654
LIG_SH3_3	155	161	PF00018	0.525
LIG_SUMO_SIM_par_1	144	150	PF11976	0.523
LIG_TRAF2_1	235	238	PF00917	0.810
LIG_WRC_WIRS_1	208	213	PF05994	0.811
MOD_CK1_1	141	147	PF00069	0.699
MOD_CK1_1	169	175	PF00069	0.695
MOD_CK1_1	226	232	PF00069	0.642
MOD_CK1_1	23	29	PF00069	0.668
MOD_CK2_1	207	213	PF00069	0.810
MOD_GlcNHglycan	122	126	PF01048	0.762
MOD_GlcNHglycan	154	157	PF01048	0.727
MOD_GlcNHglycan	171	174	PF01048	0.576
MOD_GlcNHglycan	36	39	PF01048	0.622
MOD_GlcNHglycan	52	56	PF01048	0.602
MOD_GSK3_1	11	18	PF00069	0.537
MOD_GSK3_1	137	144	PF00069	0.766
MOD_GSK3_1	152	159	PF00069	0.793
MOD_GSK3_1	169	176	PF00069	0.709
MOD_GSK3_1	2	9	PF00069	0.557
MOD_GSK3_1	226	233	PF00069	0.704
MOD_GSK3_1	51	58	PF00069	0.676
MOD_N-GLC_1	161	166	PF02516	0.774
MOD_N-GLC_1	55	60	PF02516	0.653
MOD_NEK2_1	15	20	PF00069	0.641
MOD_NEK2_1	21	26	PF00069	0.766
MOD_NEK2_1	88	93	PF00069	0.423
MOD_NEK2_2	207	212	PF00069	0.808
MOD_PIKK_1	166	172	PF00454	0.707
MOD_PIKK_1	254	260	PF00454	0.732
MOD_PKA_2	31	37	PF00069	0.670
MOD_PKB_1	57	65	PF00069	0.539
MOD_Plk_1	236	242	PF00069	0.727
MOD_Plk_4	129	135	PF00069	0.695
MOD_Plk_4	143	149	PF00069	0.707
MOD_Plk_4	174	180	PF00069	0.703
MOD_Plk_4	62	68	PF00069	0.575
MOD_ProDKin_1	139	145	PF00069	0.769
MOD_ProDKin_1	154	160	PF00069	0.525
MOD_ProDKin_1	202	208	PF00069	0.803
MOD_ProDKin_1	223	229	PF00069	0.645
MOD_ProDKin_1	230	236	PF00069	0.750
MOD_ProDKin_1	79	85	PF00069	0.554
TRG_ENDOCYTIC_2	108	111	PF00928	0.713
TRG_ENDOCYTIC_2	46	49	PF00928	0.581
TRG_ENDOCYTIC_2	61	64	PF00928	0.597
TRG_ENDOCYTIC_2	67	70	PF00928	0.558
TRG_ER_diArg_1	112	114	PF00400	0.738
TRG_ER_diArg_1	115	118	PF00400	0.683
TRG_ER_diArg_1	49	51	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUT6	Leptomonas seymouri	36%	66%
A0A3S5H676	Leishmania donovani	88%	100%
A4H5D9	Leishmania braziliensis	68%	100%
A4HTN4	Leishmania infantum	87%	100%
Q4QI75	Leishmania major	87%	100%