Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AMG7_LEIMU

TriTrypDb:

LmxM.08.0930

Length:

1160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.526
CLV_C14_Caspase3-7	372	376	PF00656	0.561
CLV_C14_Caspase3-7	794	798	PF00656	0.725
CLV_C14_Caspase3-7	858	862	PF00656	0.810
CLV_C14_Caspase3-7	966	970	PF00656	0.576
CLV_NRD_NRD_1	1012	1014	PF00675	0.658
CLV_NRD_NRD_1	123	125	PF00675	0.531
CLV_NRD_NRD_1	178	180	PF00675	0.526
CLV_NRD_NRD_1	24	26	PF00675	0.640
CLV_NRD_NRD_1	301	303	PF00675	0.526
CLV_NRD_NRD_1	462	464	PF00675	0.830
CLV_NRD_NRD_1	555	557	PF00675	0.753
CLV_NRD_NRD_1	612	614	PF00675	0.862
CLV_NRD_NRD_1	655	657	PF00675	0.582
CLV_NRD_NRD_1	777	779	PF00675	0.757
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.541
CLV_PCSK_KEX2_1	178	180	PF00082	0.526
CLV_PCSK_KEX2_1	300	302	PF00082	0.526
CLV_PCSK_KEX2_1	428	430	PF00082	0.776
CLV_PCSK_KEX2_1	461	463	PF00082	0.829
CLV_PCSK_KEX2_1	555	557	PF00082	0.753
CLV_PCSK_KEX2_1	612	614	PF00082	0.861
CLV_PCSK_KEX2_1	655	657	PF00082	0.559
CLV_PCSK_KEX2_1	777	779	PF00082	0.757
CLV_PCSK_PC1ET2_1	1012	1014	PF00082	0.541
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.776
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.829
CLV_PCSK_SKI1_1	178	182	PF00082	0.526
CLV_PCSK_SKI1_1	183	187	PF00082	0.444
CLV_PCSK_SKI1_1	534	538	PF00082	0.772
CLV_PCSK_SKI1_1	767	771	PF00082	0.638
CLV_PCSK_SKI1_1	914	918	PF00082	0.646
DEG_APCC_DBOX_1	918	926	PF00400	0.641
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SPOP_SBC_1	143	147	PF00917	0.246
DEG_SPOP_SBC_1	876	880	PF00917	0.517
DOC_ANK_TNKS_1	594	601	PF00023	0.581
DOC_CDC14_PxL_1	315	323	PF14671	0.648
DOC_CKS1_1	1085	1090	PF01111	0.677
DOC_CYCLIN_RxL_1	55	66	PF00134	0.433
DOC_CYCLIN_yCln2_LP_2	1080	1086	PF00134	0.851
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	765	771	PF00134	0.559
DOC_MAPK_gen_1	183	192	PF00069	0.526
DOC_MAPK_gen_1	25	32	PF00069	0.499
DOC_MAPK_MEF2A_6	17	24	PF00069	0.645
DOC_MAPK_RevD_3	11	26	PF00069	0.680
DOC_PP2B_LxvP_1	1127	1130	PF13499	0.611
DOC_PP2B_LxvP_1	399	402	PF13499	0.560
DOC_PP2B_LxvP_1	596	599	PF13499	0.825
DOC_PP2B_LxvP_1	823	826	PF13499	0.832
DOC_PP2B_LxvP_1	949	952	PF13499	0.749
DOC_PP4_FxxP_1	47	50	PF00568	0.526
DOC_PP4_FxxP_1	537	540	PF00568	0.826
DOC_PP4_FxxP_1	770	773	PF00568	0.742
DOC_PP4_FxxP_1	873	876	PF00568	0.631
DOC_PP4_MxPP_1	538	541	PF00568	0.810
DOC_USP7_MATH_1	143	147	PF00917	0.309
DOC_USP7_MATH_1	214	218	PF00917	0.368
DOC_USP7_MATH_1	235	239	PF00917	0.526
DOC_USP7_MATH_1	258	262	PF00917	0.526
DOC_USP7_MATH_1	31	35	PF00917	0.526
DOC_USP7_MATH_1	349	353	PF00917	0.657
DOC_USP7_MATH_1	400	404	PF00917	0.747
DOC_USP7_MATH_1	406	410	PF00917	0.692
DOC_USP7_MATH_1	478	482	PF00917	0.869
DOC_USP7_MATH_1	530	534	PF00917	0.857
DOC_USP7_MATH_1	63	67	PF00917	0.433
DOC_USP7_MATH_1	698	702	PF00917	0.613
DOC_USP7_MATH_1	826	830	PF00917	0.632
DOC_USP7_MATH_1	915	919	PF00917	0.735
DOC_USP7_MATH_1	965	969	PF00917	0.765
DOC_WW_Pin1_4	1026	1031	PF00397	0.793
DOC_WW_Pin1_4	1084	1089	PF00397	0.679
DOC_WW_Pin1_4	219	224	PF00397	0.526
DOC_WW_Pin1_4	308	313	PF00397	0.526
DOC_WW_Pin1_4	367	372	PF00397	0.640
DOC_WW_Pin1_4	401	406	PF00397	0.788
DOC_WW_Pin1_4	417	422	PF00397	0.667
DOC_WW_Pin1_4	487	492	PF00397	0.853
DOC_WW_Pin1_4	521	526	PF00397	0.832
DOC_WW_Pin1_4	562	567	PF00397	0.835
DOC_WW_Pin1_4	690	695	PF00397	0.853
DOC_WW_Pin1_4	696	701	PF00397	0.750
DOC_WW_Pin1_4	769	774	PF00397	0.747
DOC_WW_Pin1_4	821	826	PF00397	0.754
DOC_WW_Pin1_4	961	966	PF00397	0.781
LIG_14-3-3_CanoR_1	350	358	PF00244	0.656
LIG_14-3-3_CanoR_1	429	433	PF00244	0.586
LIG_14-3-3_CanoR_1	595	599	PF00244	0.579
LIG_14-3-3_CanoR_1	721	729	PF00244	0.579
LIG_14-3-3_CanoR_1	874	882	PF00244	0.521
LIG_14-3-3_CanoR_1	905	911	PF00244	0.549
LIG_14-3-3_CanoR_1	914	922	PF00244	0.618
LIG_APCC_ABBA_1	44	49	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	178	184	PF00400	0.526
LIG_BIR_III_4	797	801	PF00653	0.817
LIG_BIR_III_4	969	973	PF00653	0.690
LIG_BRCT_BRCA1_1	187	191	PF00533	0.526
LIG_CSL_BTD_1	1032	1035	PF09270	0.740
LIG_CtBP_PxDLS_1	1034	1038	PF00389	0.555
LIG_EH1_1	440	448	PF00400	0.672
LIG_eIF4E_1	956	962	PF01652	0.603
LIG_EVH1_1	606	610	PF00568	0.585
LIG_FHA_1	1048	1054	PF00498	0.764
LIG_FHA_1	1146	1152	PF00498	0.559
LIG_FHA_1	150	156	PF00498	0.526
LIG_FHA_1	167	173	PF00498	0.299
LIG_FHA_1	472	478	PF00498	0.857
LIG_FHA_1	850	856	PF00498	0.721
LIG_FHA_1	877	883	PF00498	0.714
LIG_FHA_1	906	912	PF00498	0.723
LIG_FHA_1	938	944	PF00498	0.568
LIG_FHA_2	370	376	PF00498	0.564
LIG_FHA_2	465	471	PF00498	0.566
LIG_FHA_2	783	789	PF00498	0.780
LIG_FHA_2	799	805	PF00498	0.617
LIG_FHA_2	964	970	PF00498	0.756
LIG_LIR_Apic_2	222	228	PF02991	0.526
LIG_LIR_Apic_2	603	609	PF02991	0.609
LIG_LIR_Apic_2	871	876	PF02991	0.628
LIG_LIR_Apic_2	953	959	PF02991	0.599
LIG_LIR_Gen_1	112	120	PF02991	0.526
LIG_LIR_Gen_1	286	295	PF02991	0.521
LIG_LIR_Gen_1	947	956	PF02991	0.754
LIG_LIR_Nem_3	112	117	PF02991	0.526
LIG_LIR_Nem_3	27	32	PF02991	0.595
LIG_LIR_Nem_3	286	291	PF02991	0.500
LIG_LIR_Nem_3	923	929	PF02991	0.746
LIG_LIR_Nem_3	947	951	PF02991	0.743
LIG_MYND_1	487	491	PF01753	0.756
LIG_NBox_RRM_1	795	805	PF00076	0.811
LIG_NRBOX	244	250	PF00104	0.526
LIG_NRBOX	6	12	PF00104	0.721
LIG_OCRL_FandH_1	54	66	PF00620	0.526
LIG_SH2_CRK	1108	1112	PF00017	0.686
LIG_SH2_CRK	114	118	PF00017	0.526
LIG_SH2_CRK	956	960	PF00017	0.596
LIG_SH2_PTP2	29	32	PF00017	0.433
LIG_SH2_SRC	107	110	PF00017	0.330
LIG_SH2_SRC	132	135	PF00017	0.246
LIG_SH2_SRC	29	32	PF00017	0.526
LIG_SH2_SRC	95	98	PF00017	0.526
LIG_SH2_STAP1	250	254	PF00017	0.526
LIG_SH2_STAP1	283	287	PF00017	0.433
LIG_SH2_STAT5	102	105	PF00017	0.351
LIG_SH2_STAT5	1105	1108	PF00017	0.666
LIG_SH2_STAT5	225	228	PF00017	0.526
LIG_SH2_STAT5	29	32	PF00017	0.526
LIG_SH2_STAT5	54	57	PF00017	0.526
LIG_SH2_STAT5	91	94	PF00017	0.382
LIG_SH3_1	274	280	PF00018	0.368
LIG_SH3_1	416	422	PF00018	0.764
LIG_SH3_1	512	518	PF00018	0.720
LIG_SH3_2	357	362	PF14604	0.818
LIG_SH3_2	607	612	PF14604	0.581
LIG_SH3_3	1020	1026	PF00018	0.792
LIG_SH3_3	1029	1035	PF00018	0.681
LIG_SH3_3	1064	1070	PF00018	0.712
LIG_SH3_3	1082	1088	PF00018	0.542
LIG_SH3_3	12	18	PF00018	0.718
LIG_SH3_3	274	280	PF00018	0.368
LIG_SH3_3	353	359	PF00018	0.827
LIG_SH3_3	399	405	PF00018	0.636
LIG_SH3_3	416	422	PF00018	0.675
LIG_SH3_3	512	518	PF00018	0.813
LIG_SH3_3	537	543	PF00018	0.824
LIG_SH3_3	555	561	PF00018	0.557
LIG_SH3_3	604	610	PF00018	0.585
LIG_SH3_3	688	694	PF00018	0.738
LIG_SH3_3	716	722	PF00018	0.690
LIG_SH3_4	705	712	PF00018	0.562
LIG_SH3_CIN85_PxpxPR_1	357	362	PF14604	0.841
LIG_SUMO_SIM_anti_2	1138	1143	PF11976	0.700
LIG_SUMO_SIM_par_1	1068	1078	PF11976	0.549
LIG_SUMO_SIM_par_1	1147	1152	PF11976	0.533
LIG_SUMO_SIM_par_1	556	562	PF11976	0.643
LIG_TRAF2_1	442	445	PF00917	0.674
LIG_TRAF2_1	828	831	PF00917	0.622
LIG_TYR_ITIM	1106	1111	PF00017	0.674
LIG_UBA3_1	267	274	PF00899	0.526
LIG_UBA3_1	290	297	PF00899	0.526
LIG_WRC_WIRS_1	926	931	PF05994	0.745
LIG_WW_2	540	543	PF00397	0.816
LIG_WW_3	275	279	PF00397	0.433
LIG_WW_3	359	363	PF00397	0.818
MOD_CDC14_SPxK_1	370	373	PF00782	0.641
MOD_CDK_SPxK_1	367	373	PF00069	0.649
MOD_CDK_SPxxK_3	562	569	PF00069	0.728
MOD_CK1_1	1038	1044	PF00069	0.731
MOD_CK1_1	115	121	PF00069	0.526
MOD_CK1_1	136	142	PF00069	0.526
MOD_CK1_1	145	151	PF00069	0.379
MOD_CK1_1	404	410	PF00069	0.710
MOD_CK1_1	565	571	PF00069	0.844
MOD_CK1_1	64	70	PF00069	0.433
MOD_CK1_1	644	650	PF00069	0.676
MOD_CK1_1	671	677	PF00069	0.711
MOD_CK1_1	836	842	PF00069	0.768
MOD_CK1_1	963	969	PF00069	0.750
MOD_CK2_1	439	445	PF00069	0.776
MOD_CK2_1	464	470	PF00069	0.581
MOD_CK2_1	645	651	PF00069	0.679
MOD_CK2_1	825	831	PF00069	0.818
MOD_GlcNHglycan	1037	1040	PF01048	0.744
MOD_GlcNHglycan	118	121	PF01048	0.420
MOD_GlcNHglycan	133	138	PF01048	0.281
MOD_GlcNHglycan	148	151	PF01048	0.298
MOD_GlcNHglycan	26	29	PF01048	0.616
MOD_GlcNHglycan	340	343	PF01048	0.776
MOD_GlcNHglycan	351	354	PF01048	0.630
MOD_GlcNHglycan	464	467	PF01048	0.841
MOD_GlcNHglycan	480	483	PF01048	0.562
MOD_GlcNHglycan	518	521	PF01048	0.850
MOD_GlcNHglycan	548	552	PF01048	0.584
MOD_GlcNHglycan	572	575	PF01048	0.754
MOD_GlcNHglycan	596	599	PF01048	0.711
MOD_GlcNHglycan	620	625	PF01048	0.868
MOD_GlcNHglycan	637	642	PF01048	0.405
MOD_GlcNHglycan	700	703	PF01048	0.866
MOD_GlcNHglycan	732	736	PF01048	0.570
MOD_GlcNHglycan	811	814	PF01048	0.726
MOD_GlcNHglycan	833	836	PF01048	0.783
MOD_GlcNHglycan	838	841	PF01048	0.702
MOD_GlcNHglycan	980	983	PF01048	0.824
MOD_GSK3_1	112	119	PF00069	0.501
MOD_GSK3_1	142	149	PF00069	0.357
MOD_GSK3_1	20	27	PF00069	0.594
MOD_GSK3_1	204	211	PF00069	0.526
MOD_GSK3_1	215	222	PF00069	0.347
MOD_GSK3_1	378	385	PF00069	0.742
MOD_GSK3_1	400	407	PF00069	0.833
MOD_GSK3_1	637	644	PF00069	0.503
MOD_GSK3_1	696	703	PF00069	0.789
MOD_GSK3_1	727	734	PF00069	0.569
MOD_GSK3_1	787	794	PF00069	0.839
MOD_GSK3_1	821	828	PF00069	0.751
MOD_GSK3_1	845	852	PF00069	0.798
MOD_GSK3_1	921	928	PF00069	0.687
MOD_GSK3_1	960	967	PF00069	0.674
MOD_N-GLC_2	1018	1020	PF02516	0.614
MOD_NEK2_1	116	121	PF00069	0.526
MOD_NEK2_1	165	170	PF00069	0.503
MOD_NEK2_1	203	208	PF00069	0.526
MOD_NEK2_1	209	214	PF00069	0.484
MOD_NEK2_1	215	220	PF00069	0.358
MOD_NEK2_1	24	29	PF00069	0.526
MOD_NEK2_1	259	264	PF00069	0.435
MOD_NEK2_1	845	850	PF00069	0.775
MOD_NEK2_1	868	873	PF00069	0.711
MOD_NEK2_1	877	882	PF00069	0.631
MOD_NEK2_1	906	911	PF00069	0.723
MOD_NEK2_1	939	944	PF00069	0.679
MOD_NEK2_2	921	926	PF00069	0.460
MOD_PIKK_1	1024	1030	PF00454	0.606
MOD_PIKK_1	1087	1093	PF00454	0.680
MOD_PIKK_1	281	287	PF00454	0.433
MOD_PIKK_1	406	412	PF00454	0.796
MOD_PIKK_1	464	470	PF00454	0.567
MOD_PIKK_1	789	795	PF00454	0.740
MOD_PK_1	650	656	PF00069	0.721
MOD_PKA_1	428	434	PF00069	0.588
MOD_PKA_1	462	468	PF00069	0.841
MOD_PKA_1	777	783	PF00069	0.763
MOD_PKA_2	24	30	PF00069	0.524
MOD_PKA_2	349	355	PF00069	0.659
MOD_PKA_2	428	434	PF00069	0.588
MOD_PKA_2	462	468	PF00069	0.841
MOD_PKA_2	504	510	PF00069	0.704
MOD_PKA_2	516	522	PF00069	0.838
MOD_PKA_2	570	576	PF00069	0.849
MOD_PKA_2	594	600	PF00069	0.580
MOD_PKA_2	777	783	PF00069	0.763
MOD_PKA_2	904	910	PF00069	0.524
MOD_PKA_2	937	943	PF00069	0.733
MOD_PKA_2	978	984	PF00069	0.738
MOD_Plk_1	259	265	PF00069	0.526
MOD_Plk_1	547	553	PF00069	0.581
MOD_Plk_1	637	643	PF00069	0.646
MOD_Plk_1	644	650	PF00069	0.595
MOD_Plk_1	996	1002	PF00069	0.540
MOD_Plk_2-3	1135	1141	PF00069	0.704
MOD_Plk_2-3	645	651	PF00069	0.679
MOD_Plk_4	1112	1118	PF00069	0.611
MOD_Plk_4	112	118	PF00069	0.526
MOD_Plk_4	204	210	PF00069	0.526
MOD_Plk_4	791	797	PF00069	0.833
MOD_Plk_4	863	869	PF00069	0.808
MOD_Plk_4	877	883	PF00069	0.579
MOD_Plk_4	921	927	PF00069	0.725
MOD_ProDKin_1	1026	1032	PF00069	0.798
MOD_ProDKin_1	1084	1090	PF00069	0.679
MOD_ProDKin_1	219	225	PF00069	0.526
MOD_ProDKin_1	308	314	PF00069	0.526
MOD_ProDKin_1	367	373	PF00069	0.638
MOD_ProDKin_1	401	407	PF00069	0.790
MOD_ProDKin_1	417	423	PF00069	0.671
MOD_ProDKin_1	487	493	PF00069	0.853
MOD_ProDKin_1	521	527	PF00069	0.833
MOD_ProDKin_1	562	568	PF00069	0.834
MOD_ProDKin_1	690	696	PF00069	0.847
MOD_ProDKin_1	769	775	PF00069	0.747
MOD_ProDKin_1	821	827	PF00069	0.754
MOD_ProDKin_1	961	967	PF00069	0.784
MOD_SUMO_for_1	994	997	PF00179	0.712
MOD_SUMO_rev_2	1041	1050	PF00179	0.525
MOD_SUMO_rev_2	784	792	PF00179	0.566
TRG_DiLeu_BaEn_1	1152	1157	PF01217	0.670
TRG_DiLeu_BaEn_1	286	291	PF01217	0.433
TRG_DiLeu_BaEn_1	6	11	PF01217	0.718
TRG_DiLeu_BaEn_4	1075	1081	PF01217	0.574
TRG_DiLeu_BaEn_4	96	102	PF01217	0.526
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.526
TRG_ENDOCYTIC_2	102	105	PF00928	0.526
TRG_ENDOCYTIC_2	1108	1111	PF00928	0.674
TRG_ENDOCYTIC_2	114	117	PF00928	0.330
TRG_ENDOCYTIC_2	29	32	PF00928	0.526
TRG_ENDOCYTIC_2	54	57	PF00928	0.526
TRG_ENDOCYTIC_2	926	929	PF00928	0.729
TRG_ER_diArg_1	178	180	PF00400	0.526
TRG_ER_diArg_1	300	302	PF00400	0.526
TRG_ER_diArg_1	486	489	PF00400	0.765
TRG_ER_diArg_1	555	557	PF00400	0.753
TRG_ER_diArg_1	654	656	PF00400	0.554
TRG_NLS_MonoCore_2	460	465	PF00514	0.829
TRG_Pf-PMV_PEXEL_1	179	184	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	613	618	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H675	Leishmania donovani	87%	100%
A4H5D8	Leishmania braziliensis	68%	97%
Q4QI76	Leishmania major	86%	99%