Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMG6_LEIMU

TriTrypDb:

LmxM.08.0920

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG6

PDB structure(s): 7aih_D , 7ane_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.486
CLV_NRD_NRD_1	40	42	PF00675	0.457
CLV_NRD_NRD_1	83	85	PF00675	0.434
CLV_PCSK_KEX2_1	32	34	PF00082	0.486
CLV_PCSK_KEX2_1	40	42	PF00082	0.458
CLV_PCSK_KEX2_1	83	85	PF00082	0.419
CLV_PCSK_PC7_1	36	42	PF00082	0.390
CLV_PCSK_SKI1_1	123	127	PF00082	0.465
CLV_PCSK_SKI1_1	130	134	PF00082	0.425
CLV_Separin_Metazoa	112	116	PF03568	0.563
DOC_CDC14_PxL_1	131	139	PF14671	0.431
DOC_MAPK_gen_1	40	46	PF00069	0.416
DOC_MAPK_MEF2A_6	123	131	PF00069	0.423
DOC_MAPK_MEF2A_6	136	145	PF00069	0.460
DOC_MAPK_MEF2A_6	16	24	PF00069	0.566
DOC_PP2B_LxvP_1	143	146	PF13499	0.506
DOC_USP7_MATH_1	12	16	PF00917	0.636
DOC_USP7_MATH_1	193	197	PF00917	0.558
DOC_USP7_MATH_1	91	95	PF00917	0.574
DOC_WW_Pin1_4	16	21	PF00397	0.537
DOC_WW_Pin1_4	46	51	PF00397	0.545
LIG_14-3-3_CanoR_1	123	128	PF00244	0.508
LIG_14-3-3_CanoR_1	40	48	PF00244	0.550
LIG_Actin_WH2_2	7	25	PF00022	0.620
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_FHA_1	108	114	PF00498	0.448
LIG_FHA_1	124	130	PF00498	0.510
LIG_LIR_Gen_1	147	156	PF02991	0.625
LIG_LIR_Nem_3	119	125	PF02991	0.511
LIG_LIR_Nem_3	51	56	PF02991	0.517
LIG_SH2_STAT5	29	32	PF00017	0.572
LIG_SH2_STAT5	48	51	PF00017	0.532
LIG_SH2_STAT5	52	55	PF00017	0.528
LIG_SH3_1	111	117	PF00018	0.444
LIG_SH3_3	111	117	PF00018	0.444
LIG_SH3_3	178	184	PF00018	0.453
LIG_SUMO_SIM_par_1	105	110	PF11976	0.410
LIG_UBA3_1	124	130	PF00899	0.491
MOD_CDK_SPK_2	16	21	PF00069	0.589
MOD_CDK_SPxxK_3	16	23	PF00069	0.571
MOD_CK1_1	147	153	PF00069	0.613
MOD_CK1_1	186	192	PF00069	0.750
MOD_GlcNHglycan	185	188	PF01048	0.764
MOD_GlcNHglycan	197	200	PF01048	0.739
MOD_GlcNHglycan	41	44	PF01048	0.483
MOD_GlcNHglycan	80	83	PF01048	0.521
MOD_GSK3_1	12	19	PF00069	0.555
MOD_GSK3_1	183	190	PF00069	0.677
MOD_GSK3_1	48	55	PF00069	0.536
MOD_GSK3_1	91	98	PF00069	0.464
MOD_NEK2_1	185	190	PF00069	0.514
MOD_PKA_2	39	45	PF00069	0.560
MOD_Plk_4	144	150	PF00069	0.532
MOD_Plk_4	152	158	PF00069	0.554
MOD_Plk_4	48	54	PF00069	0.515
MOD_ProDKin_1	16	22	PF00069	0.528
MOD_ProDKin_1	46	52	PF00069	0.540
MOD_SUMO_rev_2	159	166	PF00179	0.617
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.518
TRG_ER_diArg_1	20	23	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU7	Leptomonas seymouri	73%	100%
A0A0S4J9I7	Bodo saltans	42%	100%
A0A1X0NP61	Trypanosomatidae	58%	100%
A0A3R7NPP0	Trypanosoma rangeli	54%	100%
A0A3S5H674	Leishmania donovani	92%	100%
A4H5D7	Leishmania braziliensis	80%	100%
A4HTN2	Leishmania infantum	92%	100%
C9ZPD1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4QI77	Leishmania major	91%	100%
V5BGW6	Trypanosoma cruzi	55%	97%