DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA polymerase

Gene product:

mitochondrial DNA polymerase beta-PAK, putative

Species:

Leishmania mexicana

UniProt:

E9AMG4_LEIMU

TriTrypDb:

LmxM.08.0900

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

E9AMG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006259	DNA metabolic process	4	4
GO:0006281	DNA repair	5	4
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006396	RNA processing	6	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	4
GO:0006974	DNA damage response	4	4

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003824	catalytic activity	1	4
GO:0003887	DNA-directed DNA polymerase activity	5	4
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	4
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	4
GO:0016779	nucleotidyltransferase activity	4	4
GO:0034061	DNA polymerase activity	4	4
GO:0043167	ion binding	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.426
CLV_NRD_NRD_1	372	374	PF00675	0.205
CLV_NRD_NRD_1	389	391	PF00675	0.208
CLV_NRD_NRD_1	491	493	PF00675	0.205
CLV_NRD_NRD_1	537	539	PF00675	0.226
CLV_NRD_NRD_1	541	543	PF00675	0.209
CLV_PCSK_FUR_1	176	180	PF00082	0.351
CLV_PCSK_FUR_1	227	231	PF00082	0.428
CLV_PCSK_FUR_1	489	493	PF00082	0.226
CLV_PCSK_KEX2_1	178	180	PF00082	0.388

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
C9ZPC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	83%
Q4QI79	Leishmania major	92%	100%
Q67VC8	Oryza sativa subsp. japonica	23%	100%

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