SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMG2_LEIMU

TriTrypDb:

LmxM.08.0880

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG2

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	3
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	382	386	PF00656	0.557
CLV_NRD_NRD_1	169	171	PF00675	0.788
CLV_NRD_NRD_1	28	30	PF00675	0.654
CLV_NRD_NRD_1	32	34	PF00675	0.519
CLV_NRD_NRD_1	414	416	PF00675	0.401
CLV_PCSK_KEX2_1	169	171	PF00082	0.732
CLV_PCSK_KEX2_1	174	176	PF00082	0.645
CLV_PCSK_KEX2_1	28	30	PF00082	0.652
CLV_PCSK_KEX2_1	32	34	PF00082	0.522
CLV_PCSK_KEX2_1	414	416	PF00082	0.357
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.715
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.701
CLV_PCSK_PC7_1	170	176	PF00082	0.723
CLV_PCSK_SKI1_1	480	484	PF00082	0.466
DEG_APCC_DBOX_1	182	190	PF00400	0.545
DEG_SCF_TRCP1_1	146	152	PF00400	0.527
DEG_SPOP_SBC_1	107	111	PF00917	0.690
DEG_SPOP_SBC_1	427	431	PF00917	0.563
DEG_SPOP_SBC_1	434	438	PF00917	0.524
DOC_CYCLIN_RxL_1	477	484	PF00134	0.457
DOC_MAPK_gen_1	28	40	PF00069	0.607
DOC_MAPK_gen_1	340	348	PF00069	0.459
DOC_PP2B_LxvP_1	135	138	PF13499	0.502
DOC_USP7_MATH_1	107	111	PF00917	0.769
DOC_USP7_MATH_1	297	301	PF00917	0.654
DOC_USP7_MATH_1	428	432	PF00917	0.589
DOC_WW_Pin1_4	103	108	PF00397	0.698
DOC_WW_Pin1_4	430	435	PF00397	0.551
DOC_WW_Pin1_4	437	442	PF00397	0.553
DOC_WW_Pin1_4	47	52	PF00397	0.396
DOC_WW_Pin1_4	55	60	PF00397	0.389
LIG_14-3-3_CanoR_1	175	180	PF00244	0.560
LIG_14-3-3_CanoR_1	236	242	PF00244	0.592
LIG_14-3-3_CanoR_1	263	269	PF00244	0.477
LIG_14-3-3_CanoR_1	326	332	PF00244	0.568
LIG_14-3-3_CanoR_1	33	39	PF00244	0.549
LIG_14-3-3_CanoR_1	396	405	PF00244	0.578
LIG_14-3-3_CanoR_1	414	424	PF00244	0.587
LIG_14-3-3_CanoR_1	425	435	PF00244	0.446
LIG_14-3-3_CanoR_1	487	496	PF00244	0.514
LIG_BIR_II_1	1	5	PF00653	0.743
LIG_BRCT_BRCA1_1	344	348	PF00533	0.500
LIG_FHA_1	155	161	PF00498	0.688
LIG_FHA_1	212	218	PF00498	0.386
LIG_FHA_1	35	41	PF00498	0.527
LIG_FHA_1	450	456	PF00498	0.578
LIG_FHA_1	489	495	PF00498	0.489
LIG_FHA_2	427	433	PF00498	0.557
LIG_LIR_Apic_2	2	7	PF02991	0.658
LIG_LIR_Gen_1	213	223	PF02991	0.377
LIG_LIR_Gen_1	330	339	PF02991	0.525
LIG_LIR_Gen_1	462	471	PF02991	0.541
LIG_LIR_Nem_3	213	219	PF02991	0.389
LIG_LIR_Nem_3	330	334	PF02991	0.539
LIG_LIR_Nem_3	462	468	PF02991	0.467
LIG_LIR_Nem_3	484	489	PF02991	0.409
LIG_NRP_CendR_1	502	503	PF00754	0.564
LIG_RPA_C_Fungi	391	403	PF08784	0.188
LIG_SH2_CRK	125	129	PF00017	0.503
LIG_SH2_CRK	200	204	PF00017	0.495
LIG_SH2_CRK	486	490	PF00017	0.413
LIG_SH2_PTP2	4	7	PF00017	0.662
LIG_SH2_PTP2	465	468	PF00017	0.412
LIG_SH2_SRC	4	7	PF00017	0.662
LIG_SH2_STAP1	435	439	PF00017	0.372
LIG_SH2_STAT5	125	128	PF00017	0.498
LIG_SH2_STAT5	200	203	PF00017	0.453
LIG_SH2_STAT5	228	231	PF00017	0.415
LIG_SH2_STAT5	4	7	PF00017	0.662
LIG_SH2_STAT5	465	468	PF00017	0.421
LIG_SH3_3	118	124	PF00018	0.436
LIG_SH3_3	318	324	PF00018	0.623
LIG_SUMO_SIM_par_1	376	383	PF11976	0.422
LIG_TRAF2_1	19	22	PF00917	0.594
LIG_TRAF2_1	457	460	PF00917	0.312
LIG_TYR_ITIM	463	468	PF00017	0.425
LIG_WRC_WIRS_1	265	270	PF05994	0.460
LIG_WW_1	324	327	PF00397	0.497
LIG_WW_3	323	327	PF00397	0.523
MOD_CDK_SPxxK_3	55	62	PF00069	0.405
MOD_CK1_1	105	111	PF00069	0.729
MOD_CK1_1	112	118	PF00069	0.708
MOD_CK1_1	154	160	PF00069	0.744
MOD_CK1_1	246	252	PF00069	0.589
MOD_CK1_1	430	436	PF00069	0.395
MOD_CK2_1	426	432	PF00069	0.454
MOD_Cter_Amidation	172	175	PF01082	0.624
MOD_Cter_Amidation	30	33	PF01082	0.596
MOD_GlcNHglycan	146	149	PF01048	0.513
MOD_GlcNHglycan	153	156	PF01048	0.606
MOD_GlcNHglycan	280	283	PF01048	0.732
MOD_GlcNHglycan	299	302	PF01048	0.772
MOD_GlcNHglycan	316	319	PF01048	0.473
MOD_GlcNHglycan	382	385	PF01048	0.429
MOD_GSK3_1	101	108	PF00069	0.655
MOD_GSK3_1	150	157	PF00069	0.575
MOD_GSK3_1	199	206	PF00069	0.415
MOD_GSK3_1	271	278	PF00069	0.635
MOD_GSK3_1	334	341	PF00069	0.354
MOD_GSK3_1	349	356	PF00069	0.464
MOD_GSK3_1	426	433	PF00069	0.458
MOD_GSK3_1	435	442	PF00069	0.342
MOD_N-GLC_1	211	216	PF02516	0.521
MOD_N-GLC_1	243	248	PF02516	0.554
MOD_N-GLC_1	367	372	PF02516	0.312
MOD_NEK2_1	144	149	PF00069	0.510
MOD_NEK2_1	229	234	PF00069	0.398
MOD_NEK2_1	334	339	PF00069	0.382
MOD_NEK2_1	360	365	PF00069	0.380
MOD_NEK2_1	367	372	PF00069	0.446
MOD_OFUCOSY	365	371	PF10250	0.312
MOD_PIKK_1	406	412	PF00454	0.372
MOD_PIKK_1	497	503	PF00454	0.478
MOD_PIKK_1	5	11	PF00454	0.728
MOD_PK_1	175	181	PF00069	0.652
MOD_PK_1	342	348	PF00069	0.432
MOD_PKA_1	174	180	PF00069	0.420
MOD_PKA_1	415	421	PF00069	0.438
MOD_PKA_2	174	180	PF00069	0.460
MOD_PKA_2	314	320	PF00069	0.681
MOD_PKA_2	334	340	PF00069	0.213
MOD_PKB_1	340	348	PF00069	0.510
MOD_Plk_1	243	249	PF00069	0.565
MOD_Plk_1	367	373	PF00069	0.337
MOD_Plk_1	459	465	PF00069	0.324
MOD_Plk_2-3	467	473	PF00069	0.580
MOD_Plk_4	175	181	PF00069	0.633
MOD_Plk_4	334	340	PF00069	0.430
MOD_ProDKin_1	103	109	PF00069	0.697
MOD_ProDKin_1	430	436	PF00069	0.429
MOD_ProDKin_1	437	443	PF00069	0.432
MOD_ProDKin_1	47	53	PF00069	0.391
MOD_ProDKin_1	55	61	PF00069	0.385
TRG_DiLeu_BaEn_2	483	489	PF01217	0.410
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.568
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.429
TRG_ENDOCYTIC_2	200	203	PF00928	0.453
TRG_ENDOCYTIC_2	465	468	PF00928	0.421
TRG_ENDOCYTIC_2	486	489	PF00928	0.399
TRG_ENDOCYTIC_2	57	60	PF00928	0.384
TRG_ER_diArg_1	312	315	PF00400	0.606
TRG_ER_diArg_1	32	34	PF00400	0.538
TRG_ER_diArg_1	339	342	PF00400	0.492
TRG_ER_diArg_1	496	499	PF00400	0.519
TRG_NLS_MonoExtC_3	27	32	PF00514	0.677
TRG_NLS_MonoExtN_4	25	32	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I8	Leptomonas seymouri	49%	91%
A0A1X0NPE5	Trypanosomatidae	26%	100%
A0A3S5H671	Leishmania donovani	91%	78%
A0A3S5IRB9	Trypanosoma rangeli	27%	100%
A4H6C5	Leishmania braziliensis	87%	100%
A4HTM8	Leishmania infantum	91%	99%
C9ZPC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QI81	Leishmania major	93%	100%