BAR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMG1_LEIMU

TriTrypDb:

LmxM.08.0870

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.562
CLV_C14_Caspase3-7	339	343	PF00656	0.547
CLV_NRD_NRD_1	131	133	PF00675	0.421
CLV_NRD_NRD_1	142	144	PF00675	0.408
CLV_NRD_NRD_1	233	235	PF00675	0.389
CLV_NRD_NRD_1	35	37	PF00675	0.425
CLV_PCSK_FUR_1	129	133	PF00082	0.330
CLV_PCSK_FUR_1	179	183	PF00082	0.384
CLV_PCSK_KEX2_1	10	12	PF00082	0.503
CLV_PCSK_KEX2_1	131	133	PF00082	0.410
CLV_PCSK_KEX2_1	142	144	PF00082	0.391
CLV_PCSK_KEX2_1	181	183	PF00082	0.377
CLV_PCSK_KEX2_1	222	224	PF00082	0.420
CLV_PCSK_KEX2_1	232	234	PF00082	0.510
CLV_PCSK_KEX2_1	319	321	PF00082	0.511
CLV_PCSK_KEX2_1	325	327	PF00082	0.552
CLV_PCSK_KEX2_1	35	37	PF00082	0.423
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.485
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.377
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.398
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.385
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.511
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.552
CLV_PCSK_SKI1_1	132	136	PF00082	0.407
DEG_Nend_UBRbox_3	1	3	PF02207	0.586
DOC_CYCLIN_RxL_1	255	265	PF00134	0.379
DOC_USP7_MATH_1	149	153	PF00917	0.434
DOC_USP7_MATH_1	347	351	PF00917	0.564
DOC_USP7_MATH_1	353	357	PF00917	0.574
DOC_USP7_MATH_1	364	368	PF00917	0.568
DOC_USP7_MATH_1	384	388	PF00917	0.535
DOC_USP7_MATH_1	394	398	PF00917	0.552
DOC_USP7_MATH_1	411	415	PF00917	0.496
DOC_USP7_MATH_2	123	129	PF00917	0.439
DOC_USP7_UBL2_3	201	205	PF12436	0.429
DOC_USP7_UBL2_3	214	218	PF12436	0.422
DOC_USP7_UBL2_3	232	236	PF12436	0.404
DOC_USP7_UBL2_3	315	319	PF12436	0.549
LIG_14-3-3_CanoR_1	132	138	PF00244	0.412
LIG_14-3-3_CanoR_1	179	189	PF00244	0.384
LIG_14-3-3_CanoR_1	35	44	PF00244	0.382
LIG_Actin_WH2_2	158	175	PF00022	0.394
LIG_BRCT_BRCA1_1	313	317	PF00533	0.447
LIG_BRCT_BRCA1_2	313	319	PF00533	0.448
LIG_FHA_1	181	187	PF00498	0.338
LIG_FHA_1	295	301	PF00498	0.456
LIG_FHA_2	134	140	PF00498	0.462
LIG_FHA_2	381	387	PF00498	0.593
LIG_FHA_2	410	416	PF00498	0.554
LIG_FHA_2	92	98	PF00498	0.539
LIG_IBAR_NPY_1	90	92	PF08397	0.559
LIG_LIR_Gen_1	240	247	PF02991	0.373
LIG_LIR_Gen_1	290	299	PF02991	0.467
LIG_LIR_Gen_1	60	69	PF02991	0.418
LIG_LIR_Nem_3	20	25	PF02991	0.457
LIG_LIR_Nem_3	224	230	PF02991	0.391
LIG_LIR_Nem_3	240	244	PF02991	0.410
LIG_LIR_Nem_3	290	294	PF02991	0.479
LIG_LIR_Nem_3	60	65	PF02991	0.391
LIG_MYND_3	166	170	PF01753	0.404
LIG_PCNA_PIPBox_1	338	347	PF02747	0.587
LIG_Pex14_2	237	241	PF04695	0.408
LIG_Pex14_2	8	12	PF04695	0.463
LIG_PTB_Apo_2	260	267	PF02174	0.368
LIG_PTB_Phospho_1	260	266	PF10480	0.364
LIG_SH2_CRK	291	295	PF00017	0.462
LIG_SH2_NCK_1	291	295	PF00017	0.401
LIG_SH2_NCK_1	62	66	PF00017	0.375
LIG_SH2_STAP1	113	117	PF00017	0.545
LIG_SH2_STAP1	375	379	PF00017	0.604
LIG_SH2_STAT3	100	103	PF00017	0.504
LIG_SH2_STAT3	266	269	PF00017	0.362
LIG_SH2_STAT3	345	348	PF00017	0.571
LIG_SH2_STAT5	203	206	PF00017	0.407
LIG_SH2_STAT5	219	222	PF00017	0.419
LIG_SH2_STAT5	230	233	PF00017	0.337
LIG_SH2_STAT5	259	262	PF00017	0.398
LIG_SH2_STAT5	266	269	PF00017	0.406
LIG_SH3_3	77	83	PF00018	0.539
LIG_SUMO_SIM_par_1	296	301	PF11976	0.458
LIG_TRAF2_1	226	229	PF00917	0.310
LIG_UBA3_1	165	173	PF00899	0.399
LIG_UBA3_1	52	56	PF00899	0.456
MOD_CK1_1	116	122	PF00069	0.496
MOD_CK1_1	14	20	PF00069	0.516
MOD_CK2_1	133	139	PF00069	0.506
MOD_CK2_1	171	177	PF00069	0.513
MOD_CK2_1	380	386	PF00069	0.628
MOD_CK2_1	409	415	PF00069	0.594
MOD_CK2_1	57	63	PF00069	0.410
MOD_GlcNHglycan	327	330	PF01048	0.516
MOD_GlcNHglycan	364	367	PF01048	0.599
MOD_GlcNHglycan	38	41	PF01048	0.449
MOD_GlcNHglycan	396	399	PF01048	0.538
MOD_GlcNHglycan	59	62	PF01048	0.387
MOD_GlcNHglycan	80	83	PF01048	0.477
MOD_GSK3_1	113	120	PF00069	0.507
MOD_GSK3_1	290	297	PF00069	0.512
MOD_GSK3_1	311	318	PF00069	0.608
MOD_GSK3_1	347	354	PF00069	0.581
MOD_GSK3_1	358	365	PF00069	0.642
MOD_GSK3_1	380	387	PF00069	0.612
MOD_LATS_1	313	319	PF00433	0.571
MOD_LATS_1	323	329	PF00433	0.559
MOD_LATS_1	378	384	PF00433	0.569
MOD_N-GLC_1	17	22	PF02516	0.490
MOD_N-GLC_1	237	242	PF02516	0.373
MOD_N-GLC_2	190	192	PF02516	0.322
MOD_NEK2_1	133	138	PF00069	0.415
MOD_NEK2_1	237	242	PF00069	0.356
MOD_NEK2_1	369	374	PF00069	0.624
MOD_NEK2_1	72	77	PF00069	0.526
MOD_PIKK_1	99	105	PF00454	0.548
MOD_PKA_1	217	223	PF00069	0.393
MOD_PKA_1	325	331	PF00069	0.513
MOD_PKA_2	325	331	PF00069	0.513
MOD_Plk_1	17	23	PF00069	0.478
MOD_Plk_1	237	243	PF00069	0.360
MOD_Plk_1	70	76	PF00069	0.439
MOD_Plk_2-3	371	377	PF00069	0.616
MOD_Plk_4	294	300	PF00069	0.476
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.413
TRG_ENDOCYTIC_2	259	262	PF00928	0.398
TRG_ENDOCYTIC_2	291	294	PF00928	0.469
TRG_ENDOCYTIC_2	62	65	PF00928	0.383
TRG_ER_diArg_1	129	132	PF00400	0.424
TRG_ER_diArg_1	142	144	PF00400	0.390
TRG_ER_diArg_1	34	36	PF00400	0.396
TRG_NLS_MonoExtC_3	204	209	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	65%	96%
A0A3Q8IIE7	Leishmania donovani	25%	100%
A0A3S7WQB3	Leishmania donovani	87%	100%
A4H6C6	Leishmania braziliensis	74%	100%
A4HTM7	Leishmania infantum	87%	100%
E9AHL0	Leishmania infantum	24%	100%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q6I6	Leishmania major	24%	100%
Q4QI82	Leishmania major	87%	100%