Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AMF7_LEIMU

TriTrypDb:

LmxM.08.0810

Length:

164

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 161
NetGPI	no	yes: 0, no: 170

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	152
GO:0110165	cellular anatomical entity	1	152

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Expansion

Sequence features

E9AMF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMF7

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	18	20	PF00082	0.538
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.411
CLV_PCSK_SKI1_1	21	25	PF00082	0.417
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.447
DOC_MAPK_gen_1	18	24	PF00069	0.246
DOC_MAPK_MEF2A_6	55	63	PF00069	0.559
DOC_MAPK_RevD_3	110	126	PF00069	0.199
DOC_PP2B_LxvP_1	118	121	PF13499	0.530
DOC_USP7_UBL2_3	14	18	PF12436	0.203
LIG_APCC_ABBA_1	22	27	PF00400	0.198

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P547	Leptomonas seymouri	32%	100%
A0A0N1HWY5	Leptomonas seymouri	26%	84%
A0A0N1PDH0	Leptomonas seymouri	31%	81%
A0A1X0P988	Trypanosomatidae	32%	94%
A0A381MTA7	Leishmania infantum	40%	85%
A0A381MTB8	Leishmania infantum	42%	85%
A0A381MTC7	Leishmania infantum	43%	80%
A0A381MTN2	Leishmania infantum	44%	84%
A0A381MVY0	Leishmania infantum	41%	85%
A0A3Q8IEC2	Leishmania donovani	39%	85%

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