Amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AMF7_LEIMU

TriTrypDb:

LmxM.08.0810

Length:

164

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 161
NetGPI	no	yes: 0, no: 170

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	152
GO:0110165	cellular anatomical entity	1	152

Expansion

Sequence features

E9AMF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMF7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	18	20	PF00082	0.538
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.411
CLV_PCSK_SKI1_1	21	25	PF00082	0.417
DOC_CYCLIN_yCln2_LP_2	118	124	PF00134	0.447
DOC_MAPK_gen_1	18	24	PF00069	0.246
DOC_MAPK_MEF2A_6	55	63	PF00069	0.559
DOC_MAPK_RevD_3	110	126	PF00069	0.199
DOC_PP2B_LxvP_1	118	121	PF13499	0.530
DOC_USP7_UBL2_3	14	18	PF12436	0.203
LIG_APCC_ABBA_1	22	27	PF00400	0.198
LIG_APCC_ABBAyCdc20_2	21	27	PF00400	0.198
LIG_Clathr_ClatBox_1	119	123	PF01394	0.345
LIG_eIF4E_1	37	43	PF01652	0.290
LIG_FHA_1	1	7	PF00498	0.403
LIG_FHA_1	100	106	PF00498	0.284
LIG_FHA_1	58	64	PF00498	0.391
LIG_FHA_1	66	72	PF00498	0.424
LIG_FHA_2	129	135	PF00498	0.612
LIG_FHA_2	145	151	PF00498	0.609
LIG_LIR_Gen_1	27	37	PF02991	0.288
LIG_LIR_Nem_3	27	32	PF02991	0.285
LIG_LIR_Nem_3	52	57	PF02991	0.470
LIG_Pex14_2	25	29	PF04695	0.211
LIG_Pex14_2	41	45	PF04695	0.330
LIG_Pex14_2	97	101	PF04695	0.373
LIG_SH2_NCK_1	37	41	PF00017	0.222
LIG_SH2_STAP1	37	41	PF00017	0.225
LIG_SH2_STAT3	160	163	PF00017	0.594
LIG_SH2_STAT5	160	163	PF00017	0.595
LIG_SH2_STAT5	5	8	PF00017	0.425
LIG_SUMO_SIM_anti_2	102	107	PF11976	0.384
LIG_TRFH_1	117	121	PF08558	0.282
LIG_UBA3_1	118	126	PF00899	0.354
MOD_CK1_1	128	134	PF00069	0.638
MOD_CK2_1	144	150	PF00069	0.650
MOD_GlcNHglycan	127	130	PF01048	0.417
MOD_GlcNHglycan	51	54	PF01048	0.228
MOD_GlcNHglycan	83	86	PF01048	0.407
MOD_NEK2_1	43	48	PF00069	0.351
MOD_PKA_1	125	131	PF00069	0.555
MOD_Plk_4	30	36	PF00069	0.286
MOD_SUMO_rev_2	152	161	PF00179	0.602
TRG_NES_CRM1_1	111	123	PF08389	0.310
TRG_NLS_MonoExtN_4	17	22	PF00514	0.201

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P547	Leptomonas seymouri	32%	100%
A0A0N1HWY5	Leptomonas seymouri	26%	84%
A0A0N1PDH0	Leptomonas seymouri	31%	81%
A0A1X0P988	Trypanosomatidae	32%	94%
A0A381MTA7	Leishmania infantum	40%	85%
A0A381MTB8	Leishmania infantum	42%	85%
A0A381MTC7	Leishmania infantum	43%	80%
A0A381MTN2	Leishmania infantum	44%	84%
A0A381MVY0	Leishmania infantum	41%	85%
A0A3Q8IEC2	Leishmania donovani	39%	85%
A0A3Q8IEI1	Leishmania donovani	42%	85%
A0A3Q8IF65	Leishmania donovani	42%	83%
A0A3Q8IFB9	Leishmania donovani	34%	81%
A0A3Q8IFH7	Leishmania donovani	43%	80%
A0A3Q8IH65	Leishmania donovani	42%	85%
A0A3Q8IHN2	Leishmania donovani	43%	85%
A0A3Q8IHW7	Leishmania donovani	43%	89%
A0A3Q8IHZ6	Leishmania donovani	45%	78%
A0A3Q8IIH1	Leishmania donovani	47%	85%
A0A3Q8IL03	Leishmania donovani	41%	85%
A0A3Q8IUK8	Leishmania donovani	41%	86%
A0A3Q8IUR5	Leishmania donovani	44%	84%
A0A3S5H662	Leishmania donovani	42%	81%
A0A3S5H663	Leishmania donovani	47%	81%
A0A3S5H665	Leishmania donovani	45%	81%
A0A3S5H666	Leishmania donovani	47%	85%
A0A3S5H667	Leishmania donovani	45%	81%
A0A3S5H7L2	Leishmania donovani	69%	80%
A0A3S5H7V9	Leishmania donovani	47%	83%
A0A3S5H7W2	Leishmania donovani	29%	100%
A0A3S7WQA0	Leishmania donovani	45%	81%
A0A3S7WQA8	Leishmania donovani	47%	94%
A0A3S7WQC1	Leishmania donovani	43%	85%
A0A3S7X2E6	Leishmania donovani	67%	85%
A0A3S7X453	Leishmania donovani	41%	83%
A0A3S7X472	Leishmania donovani	44%	82%
A0A3S7X7M4	Leishmania donovani	45%	78%
A0A3S7X7U1	Leishmania donovani	35%	100%
A0A3S7X7W2	Leishmania donovani	38%	78%
A0A3S7X7Y0	Leishmania donovani	40%	85%
A4H595	Leishmania braziliensis	41%	100%
A4H596	Leishmania braziliensis	41%	100%
A4H597	Leishmania braziliensis	41%	100%
A4H5D1	Leishmania braziliensis	42%	100%
A4H5D2	Leishmania braziliensis	40%	88%
A4H5G0	Leishmania braziliensis	46%	100%
A4H5G4	Leishmania braziliensis	35%	100%
A4H5G6	Leishmania braziliensis	36%	100%
A4H5G7	Leishmania braziliensis	42%	100%
A4H5G9	Leishmania braziliensis	46%	88%
A4H5H0	Leishmania braziliensis	46%	87%
A4H5H1	Leishmania braziliensis	46%	100%
A4H5H2	Leishmania braziliensis	46%	88%
A4H5H3	Leishmania braziliensis	36%	100%
A4H6C8	Leishmania braziliensis	42%	100%
A4H7D7	Leishmania braziliensis	41%	100%
A4H9E8	Leishmania braziliensis	46%	78%
A4H9E9	Leishmania braziliensis	36%	100%
A4HAJ4	Leishmania braziliensis	46%	78%
A4HAJ5	Leishmania braziliensis	39%	74%
A4HAJ6	Leishmania braziliensis	41%	100%
A4HAL1	Leishmania braziliensis	46%	100%
A4HAL2	Leishmania braziliensis	25%	100%
A4HAM2	Leishmania braziliensis	40%	100%
A4HAM4	Leishmania braziliensis	40%	100%
A4HAR1	Leishmania braziliensis	36%	100%
A4HAZ8	Leishmania braziliensis	40%	100%
A4HB00	Leishmania braziliensis	34%	100%
A4HB02	Leishmania braziliensis	37%	85%
A4HB47	Leishmania braziliensis	32%	100%
A4HBJ0	Leishmania braziliensis	41%	100%
A4HBJ1	Leishmania braziliensis	41%	100%
A4HBJ2	Leishmania braziliensis	40%	100%
A4HTM3	Leishmania infantum	43%	85%
A4HTM4	Leishmania infantum	47%	94%
A4HTM5	Leishmania infantum	42%	85%
A4I4J2	Leishmania infantum	61%	80%
A4I6E5	Leishmania infantum	44%	82%
A4I9Q4	Leishmania infantum	44%	97%
A4I9R4	Leishmania infantum	29%	100%
A4I9R5	Leishmania infantum	34%	81%
A4I9R7	Leishmania infantum	46%	83%
A4I9X0	Leishmania infantum	38%	78%
A4IAL7	Leishmania infantum	44%	89%
A4IAM1	Leishmania infantum	46%	85%
A4IAM2	Leishmania infantum	42%	85%
E8NHC3	Leishmania infantum	42%	82%
E8NHD3	Leishmania infantum	68%	80%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	90%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	85%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	78%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	80%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	78%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AG81	Leishmania infantum	47%	80%
E9AG82	Leishmania infantum	47%	80%
E9AG83	Leishmania infantum	41%	82%
E9AG85	Leishmania infantum	47%	81%
E9AHI9	Leishmania infantum	66%	85%
E9AHT2	Leishmania infantum	45%	78%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	85%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	85%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	78%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	84%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	78%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	83%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	83%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	84%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	81%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	80%
Q4Q1U9	Leishmania major	41%	100%
Q4Q305	Leishmania major	42%	100%
Q4Q309	Leishmania major	41%	100%
Q4Q313	Leishmania major	42%	100%
Q4Q317	Leishmania major	40%	100%
Q4Q325	Leishmania major	42%	100%
Q4Q327	Leishmania major	38%	100%
Q4Q329	Leishmania major	42%	100%
Q4Q333	Leishmania major	42%	100%
Q4Q335	Leishmania major	42%	100%
Q4Q337	Leishmania major	40%	100%
Q4Q339	Leishmania major	42%	100%
Q4Q341	Leishmania major	48%	100%
Q4Q3A7	Leishmania major	28%	100%
Q4Q3A8	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	42%	100%
Q4Q3F7	Leishmania major	42%	100%
Q4Q6L8	Leishmania major	41%	100%
Q4Q7L6	Leishmania major	32%	74%
Q4QI84	Leishmania major	48%	100%
Q4QI85	Leishmania major	44%	100%
Q4QI86	Leishmania major	47%	100%
Q4QI87	Leishmania major	48%	100%
Q4QI88	Leishmania major	44%	100%
Q4QI92	Leishmania major	42%	100%
Q4QI93	Leishmania major	42%	100%
Q4QI95	Leishmania major	41%	100%
Q4QI97	Leishmania major	42%	100%
Q4QIA0	Leishmania major	40%	100%
Q4QIA1	Leishmania major	40%	100%