Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AMF6_LEIMU

TriTrypDb:

LmxM.08.0801

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AMF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.379
CLV_NRD_NRD_1	349	351	PF00675	0.678
CLV_NRD_NRD_1	39	41	PF00675	0.485
CLV_NRD_NRD_1	68	70	PF00675	0.384
CLV_NRD_NRD_1	7	9	PF00675	0.419
CLV_PCSK_FUR_1	263	267	PF00082	0.326
CLV_PCSK_KEX2_1	265	267	PF00082	0.375
CLV_PCSK_KEX2_1	349	351	PF00082	0.678
CLV_PCSK_KEX2_1	39	41	PF00082	0.476
CLV_PCSK_KEX2_1	67	69	PF00082	0.392
CLV_PCSK_KEX2_1	7	9	PF00082	0.419
CLV_PCSK_SKI1_1	131	135	PF00082	0.315
CLV_PCSK_SKI1_1	8	12	PF00082	0.407
DEG_APCC_DBOX_1	44	52	PF00400	0.546
DEG_APCC_DBOX_1	7	15	PF00400	0.614
DEG_Nend_Nbox_1	1	3	PF02207	0.621
DEG_SPOP_SBC_1	17	21	PF00917	0.619
DEG_SPOP_SBC_1	333	337	PF00917	0.433
DOC_CYCLIN_RxL_1	4	15	PF00134	0.615
DOC_MAPK_gen_1	209	218	PF00069	0.487
DOC_MAPK_gen_1	67	74	PF00069	0.560
DOC_MAPK_MEF2A_6	67	74	PF00069	0.560
DOC_PP1_RVXF_1	181	188	PF00149	0.456
DOC_PP2B_LxvP_1	159	162	PF13499	0.535
DOC_PP4_FxxP_1	43	46	PF00568	0.559
DOC_SPAK_OSR1_1	306	310	PF12202	0.314
DOC_USP7_MATH_1	13	17	PF00917	0.695
DOC_USP7_MATH_1	22	26	PF00917	0.665
DOC_USP7_MATH_1	234	238	PF00917	0.499
DOC_USP7_MATH_1	333	337	PF00917	0.441
DOC_USP7_MATH_1	97	101	PF00917	0.532
DOC_USP7_UBL2_3	310	314	PF12436	0.343
DOC_WW_Pin1_4	90	95	PF00397	0.574
LIG_14-3-3_CanoR_1	235	239	PF00244	0.532
LIG_14-3-3_CanoR_1	265	275	PF00244	0.520
LIG_14-3-3_CanoR_1	294	303	PF00244	0.303
LIG_14-3-3_CanoR_1	39	44	PF00244	0.645
LIG_14-3-3_CanoR_1	8	18	PF00244	0.673
LIG_Actin_WH2_2	169	185	PF00022	0.477
LIG_BRCT_BRCA1_1	129	133	PF00533	0.547
LIG_BRCT_BRCA1_1	278	282	PF00533	0.227
LIG_BRCT_BRCA1_1	82	86	PF00533	0.516
LIG_EH1_1	132	140	PF00400	0.550
LIG_FHA_1	145	151	PF00498	0.578
LIG_FHA_1	194	200	PF00498	0.505
LIG_FHA_2	329	335	PF00498	0.465
LIG_LIR_Apic_2	41	46	PF02991	0.566
LIG_LIR_Nem_3	103	109	PF02991	0.485
LIG_LIR_Nem_3	269	275	PF02991	0.511
LIG_NRBOX	147	153	PF00104	0.470
LIG_Pex14_2	282	286	PF04695	0.332
LIG_Pex14_2	86	90	PF04695	0.512
LIG_SH2_CRK	272	276	PF00017	0.440
LIG_SH2_STAT5	106	109	PF00017	0.588
LIG_SH2_STAT5	181	184	PF00017	0.457
LIG_SH2_STAT5	217	220	PF00017	0.588
LIG_SH2_STAT5	296	299	PF00017	0.394
LIG_SH3_3	55	61	PF00018	0.651
LIG_SH3_3	91	97	PF00018	0.568
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.550
MOD_CK1_1	100	106	PF00069	0.489
MOD_CK1_1	16	22	PF00069	0.630
MOD_CK1_1	3	9	PF00069	0.698
MOD_CK1_1	30	36	PF00069	0.615
MOD_CK1_1	320	326	PF00069	0.423
MOD_CK1_1	336	342	PF00069	0.416
MOD_CK1_1	79	85	PF00069	0.586
MOD_CK2_1	234	240	PF00069	0.520
MOD_CK2_1	328	334	PF00069	0.479
MOD_GlcNHglycan	189	192	PF01048	0.326
MOD_GlcNHglycan	268	271	PF01048	0.315
MOD_GlcNHglycan	276	279	PF01048	0.238
MOD_GlcNHglycan	319	322	PF01048	0.709
MOD_GlcNHglycan	339	342	PF01048	0.614
MOD_GlcNHglycan	34	38	PF01048	0.423
MOD_GSK3_1	17	24	PF00069	0.618
MOD_GSK3_1	187	194	PF00069	0.477
MOD_GSK3_1	219	226	PF00069	0.524
MOD_GSK3_1	295	302	PF00069	0.326
MOD_GSK3_1	328	335	PF00069	0.431
MOD_GSK3_1	76	83	PF00069	0.498
MOD_GSK3_1	9	16	PF00069	0.611
MOD_N-GLC_1	144	149	PF02516	0.314
MOD_NEK2_1	276	281	PF00069	0.240
MOD_NEK2_2	284	289	PF00069	0.295
MOD_PIKK_1	115	121	PF00454	0.625
MOD_PIKK_1	228	234	PF00454	0.485
MOD_PIKK_1	76	82	PF00454	0.492
MOD_PKA_1	39	45	PF00069	0.582
MOD_PKA_2	234	240	PF00069	0.506
MOD_PKA_2	3	9	PF00069	0.698
MOD_PKA_2	38	44	PF00069	0.590
MOD_Plk_1	33	39	PF00069	0.624
MOD_Plk_4	146	152	PF00069	0.515
MOD_Plk_4	234	240	PF00069	0.594
MOD_Plk_4	39	45	PF00069	0.582
MOD_Plk_4	80	86	PF00069	0.507
MOD_ProDKin_1	90	96	PF00069	0.578
TRG_DiLeu_BaEn_1	214	219	PF01217	0.490
TRG_ENDOCYTIC_2	181	184	PF00928	0.477
TRG_ENDOCYTIC_2	272	275	PF00928	0.440
TRG_ER_diArg_1	265	267	PF00400	0.570
TRG_ER_diArg_1	348	350	PF00400	0.443
TRG_ER_diArg_1	38	40	PF00400	0.691
TRG_ER_diArg_1	67	69	PF00400	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HAZ7	Leishmania braziliensis	42%	76%
E8NHF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E8NHR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%