Putative amastin-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMF0_LEIMU

TriTrypDb:

LmxM.08.0720

Length:

184

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 178
NetGPI	no	yes: 0, no: 188

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	167
GO:0110165	cellular anatomical entity	1	167

Expansion

Sequence features

E9AMF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMF0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.561
CLV_NRD_NRD_1	26	28	PF00675	0.553
DEG_Nend_UBRbox_1	1	3	PF02207	0.277
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.436
DOC_MAPK_gen_1	27	35	PF00069	0.218
DOC_MAPK_MEF2A_6	27	35	PF00069	0.203
DOC_MAPK_MEF2A_6	81	89	PF00069	0.568
DOC_MAPK_RevD_3	15	28	PF00069	0.199
DOC_PP2B_LxvP_1	143	146	PF13499	0.583
LIG_14-3-3_CanoR_1	14	20	PF00244	0.326
LIG_BRCT_BRCA1_1	116	120	PF00533	0.216
LIG_eIF4E_1	63	69	PF01652	0.283
LIG_FHA_1	103	109	PF00498	0.395
LIG_FHA_1	30	36	PF00498	0.334
LIG_FHA_2	8	14	PF00498	0.454
LIG_LIR_Gen_1	139	149	PF02991	0.443
LIG_LIR_Nem_3	117	122	PF02991	0.276
LIG_LIR_Nem_3	124	129	PF02991	0.352
LIG_LIR_Nem_3	139	145	PF02991	0.425
LIG_LIR_Nem_3	78	83	PF02991	0.584
LIG_MLH1_MIPbox_1	116	120	PF16413	0.197
LIG_NRBOX	139	145	PF00104	0.214
LIG_PCNA_yPIPBox_3	44	55	PF02747	0.214
LIG_Pex14_2	122	126	PF04695	0.475
LIG_Pex14_2	65	69	PF04695	0.374
LIG_SH2_PTP2	113	116	PF00017	0.198
LIG_SH2_PTP2	2	5	PF00017	0.281
LIG_SH2_SRC	2	5	PF00017	0.272
LIG_SH2_STAT5	113	116	PF00017	0.303
LIG_SH2_STAT5	129	132	PF00017	0.347
LIG_SH2_STAT5	2	5	PF00017	0.446
LIG_SH2_STAT5	75	78	PF00017	0.461
LIG_SH3_3	105	111	PF00018	0.339
LIG_SH3_3	37	43	PF00018	0.233
LIG_SUMO_SIM_anti_2	136	142	PF11976	0.411
LIG_SUMO_SIM_par_1	133	139	PF11976	0.444
LIG_SUMO_SIM_par_1	31	37	PF11976	0.206
LIG_TRAF2_1	172	175	PF00917	0.807
LIG_TRFH_1	142	146	PF08558	0.276
LIG_UBA3_1	101	107	PF00899	0.213
MOD_CK1_1	152	158	PF00069	0.791
MOD_CK2_1	167	173	PF00069	0.762
MOD_CK2_1	31	37	PF00069	0.395
MOD_GlcNHglycan	10	13	PF01048	0.628
MOD_GlcNHglycan	151	154	PF01048	0.401
MOD_GlcNHglycan	58	61	PF01048	0.363
MOD_GlcNHglycan	77	80	PF01048	0.223
MOD_GSK3_1	155	162	PF00069	0.784
MOD_NEK2_1	102	107	PF00069	0.471
MOD_Plk_1	114	120	PF00069	0.302
MOD_Plk_4	15	21	PF00069	0.316
MOD_SUMO_for_1	5	8	PF00179	0.318
MOD_SUMO_rev_2	163	172	PF00179	0.633
MOD_SUMO_rev_2	173	182	PF00179	0.634
TRG_ENDOCYTIC_2	113	116	PF00928	0.289
TRG_ENDOCYTIC_2	2	5	PF00928	0.470
TRG_ER_diArg_1	43	46	PF00400	0.373
TRG_NES_CRM1_1	136	148	PF08389	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	32%	100%
A0A0N0P547	Leptomonas seymouri	36%	100%
A0A0N0P993	Leptomonas seymouri	26%	82%
A0A0N1HWY5	Leptomonas seymouri	26%	94%
A0A0N1PDH0	Leptomonas seymouri	31%	91%
A0A1X0NQ58	Trypanosomatidae	30%	100%
A0A1X0P988	Trypanosomatidae	33%	100%
A0A381MTA7	Leishmania infantum	43%	96%
A0A381MTB8	Leishmania infantum	47%	95%
A0A381MTC7	Leishmania infantum	44%	90%
A0A381MTN2	Leishmania infantum	45%	94%
A0A381MVY0	Leishmania infantum	44%	96%
A0A3Q8ID16	Leishmania donovani	33%	100%
A0A3Q8IEC2	Leishmania donovani	49%	95%
A0A3Q8IEI1	Leishmania donovani	46%	96%
A0A3Q8IF65	Leishmania donovani	60%	93%
A0A3Q8IFB9	Leishmania donovani	27%	91%
A0A3Q8IFH7	Leishmania donovani	44%	90%
A0A3Q8IH65	Leishmania donovani	46%	95%
A0A3Q8IHN2	Leishmania donovani	46%	96%
A0A3Q8IHW7	Leishmania donovani	48%	100%
A0A3Q8IHZ6	Leishmania donovani	46%	87%
A0A3Q8IIH1	Leishmania donovani	43%	95%
A0A3Q8IL03	Leishmania donovani	38%	96%
A0A3Q8IUK8	Leishmania donovani	39%	96%
A0A3Q8IUR5	Leishmania donovani	45%	94%
A0A3S5H662	Leishmania donovani	64%	91%
A0A3S5H663	Leishmania donovani	64%	91%
A0A3S5H665	Leishmania donovani	65%	91%
A0A3S5H666	Leishmania donovani	44%	95%
A0A3S5H667	Leishmania donovani	65%	91%
A0A3S5H7L2	Leishmania donovani	49%	90%
A0A3S5H7V9	Leishmania donovani	40%	93%
A0A3S5H7W2	Leishmania donovani	25%	95%
A0A3S5H7W6	Leishmania donovani	38%	92%
A0A3S7WQA0	Leishmania donovani	65%	91%
A0A3S7WQA8	Leishmania donovani	51%	100%
A0A3S7WQC1	Leishmania donovani	49%	95%
A0A3S7X2E6	Leishmania donovani	51%	95%
A0A3S7X357	Leishmania donovani	25%	83%
A0A3S7X453	Leishmania donovani	58%	93%
A0A3S7X472	Leishmania donovani	59%	92%
A0A3S7X7E5	Leishmania donovani	39%	74%
A0A3S7X7M4	Leishmania donovani	47%	87%
A0A3S7X7U1	Leishmania donovani	39%	88%
A0A3S7X7U4	Leishmania donovani	45%	71%
A0A3S7X7W2	Leishmania donovani	38%	88%
A0A3S7X7Y0	Leishmania donovani	42%	95%
A4H595	Leishmania braziliensis	45%	100%
A4H596	Leishmania braziliensis	45%	100%
A4H597	Leishmania braziliensis	45%	100%
A4H5D1	Leishmania braziliensis	47%	100%
A4H5D2	Leishmania braziliensis	40%	100%
A4H5G0	Leishmania braziliensis	43%	100%
A4H5G4	Leishmania braziliensis	39%	100%
A4H5G6	Leishmania braziliensis	41%	100%
A4H5G7	Leishmania braziliensis	44%	100%
A4H5G9	Leishmania braziliensis	51%	98%
A4H5H1	Leishmania braziliensis	49%	100%
A4H5H2	Leishmania braziliensis	49%	100%
A4H5H3	Leishmania braziliensis	38%	100%
A4H6C8	Leishmania braziliensis	45%	92%
A4H7D7	Leishmania braziliensis	45%	100%
A4H9E8	Leishmania braziliensis	50%	88%
A4H9E9	Leishmania braziliensis	42%	94%
A4HAJ4	Leishmania braziliensis	49%	100%
A4HAJ5	Leishmania braziliensis	39%	100%
A4HAJ6	Leishmania braziliensis	45%	100%
A4HAL1	Leishmania braziliensis	44%	100%
A4HAL2	Leishmania braziliensis	27%	95%
A4HAM2	Leishmania braziliensis	46%	96%
A4HAM4	Leishmania braziliensis	45%	96%
A4HAR1	Leishmania braziliensis	44%	96%
A4HAZ8	Leishmania braziliensis	48%	100%
A4HB00	Leishmania braziliensis	41%	96%
A4HB02	Leishmania braziliensis	39%	95%
A4HB47	Leishmania braziliensis	29%	100%
A4HBJ0	Leishmania braziliensis	46%	100%
A4HBJ1	Leishmania braziliensis	46%	96%
A4HBJ2	Leishmania braziliensis	40%	88%
A4HDL3	Leishmania braziliensis	32%	100%
A4HTM3	Leishmania infantum	47%	95%
A4HTM4	Leishmania infantum	51%	100%
A4HTM5	Leishmania infantum	44%	95%
A4I0W5	Leishmania infantum	33%	100%
A4I4J2	Leishmania infantum	44%	90%
A4I4J3	Leishmania infantum	53%	71%
A4I5B9	Leishmania infantum	25%	83%
A4I6E5	Leishmania infantum	58%	92%
A4I9Q4	Leishmania infantum	46%	100%
A4I9R4	Leishmania infantum	25%	95%
A4I9R5	Leishmania infantum	27%	91%
A4I9R7	Leishmania infantum	45%	93%
A4I9W8	Leishmania infantum	46%	71%
A4I9X0	Leishmania infantum	38%	88%
A4IA59	Leishmania infantum	45%	71%
A4IAL7	Leishmania infantum	47%	100%
A4IAM1	Leishmania infantum	44%	96%
A4IAM2	Leishmania infantum	45%	96%
E8NHC3	Leishmania infantum	65%	92%
E8NHD3	Leishmania infantum	48%	90%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	95%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AG81	Leishmania infantum	62%	90%
E9AG82	Leishmania infantum	61%	90%
E9AG83	Leishmania infantum	43%	92%
E9AG85	Leishmania infantum	61%	91%
E9AHI9	Leishmania infantum	50%	95%
E9AHT2	Leishmania infantum	47%	87%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	88%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	94%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	94%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	72%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	88%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	95%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	88%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	83%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	94%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	88%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	87%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	93%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	93%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	94%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	89%
Q4Q1U9	Leishmania major	42%	100%
Q4Q305	Leishmania major	49%	100%
Q4Q309	Leishmania major	49%	100%
Q4Q313	Leishmania major	49%	100%
Q4Q317	Leishmania major	38%	91%
Q4Q325	Leishmania major	52%	100%
Q4Q327	Leishmania major	46%	100%
Q4Q329	Leishmania major	48%	100%
Q4Q333	Leishmania major	48%	100%
Q4Q335	Leishmania major	49%	100%
Q4Q337	Leishmania major	45%	100%
Q4Q339	Leishmania major	49%	100%
Q4Q341	Leishmania major	52%	100%
Q4Q397	Leishmania major	48%	70%
Q4Q3A7	Leishmania major	28%	100%
Q4Q3A8	Leishmania major	26%	100%
Q4Q3A9	Leishmania major	48%	93%
Q4Q3F7	Leishmania major	46%	87%
Q4Q6L8	Leishmania major	56%	100%
Q4Q7L6	Leishmania major	24%	83%
Q4QAK5	Leishmania major	31%	100%
Q4QI84	Leishmania major	44%	100%
Q4QI85	Leishmania major	44%	100%
Q4QI86	Leishmania major	45%	100%
Q4QI87	Leishmania major	49%	100%
Q4QI88	Leishmania major	45%	100%
Q4QI92	Leishmania major	66%	100%
Q4QI93	Leishmania major	66%	100%
Q4QI95	Leishmania major	63%	100%
Q4QI97	Leishmania major	67%	100%
Q4QIA0	Leishmania major	65%	100%
Q4QIA1	Leishmania major	65%	100%