Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania mexicana

UniProt:

E9AME7_LEIMU

TriTrypDb:

LmxM.08.0790

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

E9AME7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AME7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.455
CLV_NRD_NRD_1	350	352	PF00675	0.606
CLV_NRD_NRD_1	39	41	PF00675	0.419
CLV_NRD_NRD_1	474	476	PF00675	0.511
CLV_NRD_NRD_1	565	567	PF00675	0.617
CLV_NRD_NRD_1	68	70	PF00675	0.388
CLV_NRD_NRD_1	7	9	PF00675	0.511
CLV_PCSK_FUR_1	263	267	PF00082	0.381
CLV_PCSK_KEX2_1	265	267	PF00082	0.435
CLV_PCSK_KEX2_1	350	352	PF00082	0.606
CLV_PCSK_KEX2_1	39	41	PF00082	0.418
CLV_PCSK_KEX2_1	474	476	PF00082	0.511
CLV_PCSK_KEX2_1	565	567	PF00082	0.638
CLV_PCSK_KEX2_1	582	584	PF00082	0.578
CLV_PCSK_KEX2_1	67	69	PF00082	0.393
CLV_PCSK_KEX2_1	7	9	PF00082	0.518
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.601
CLV_PCSK_SKI1_1	131	135	PF00082	0.322
CLV_PCSK_SKI1_1	225	229	PF00082	0.389
CLV_PCSK_SKI1_1	359	363	PF00082	0.593
CLV_PCSK_SKI1_1	440	444	PF00082	0.641
CLV_PCSK_SKI1_1	559	563	PF00082	0.496
CLV_PCSK_SKI1_1	8	12	PF00082	0.457
DEG_APCC_DBOX_1	7	15	PF00400	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.631
DEG_SPOP_SBC_1	17	21	PF00917	0.624
DEG_SPOP_SBC_1	22	26	PF00917	0.647
DEG_SPOP_SBC_1	333	337	PF00917	0.509
DOC_CYCLIN_RxL_1	4	15	PF00134	0.611
DOC_MAPK_gen_1	209	218	PF00069	0.553
DOC_MAPK_gen_1	474	481	PF00069	0.281
DOC_MAPK_gen_1	67	74	PF00069	0.559
DOC_MAPK_MEF2A_6	446	454	PF00069	0.339
DOC_MAPK_MEF2A_6	474	483	PF00069	0.293
DOC_MAPK_MEF2A_6	67	74	PF00069	0.530
DOC_PP1_RVXF_1	181	188	PF00149	0.446
DOC_PP1_RVXF_1	495	501	PF00149	0.342
DOC_PP1_RVXF_1	606	613	PF00149	0.318
DOC_PP2B_LxvP_1	159	162	PF13499	0.523
DOC_PP2B_LxvP_1	417	420	PF13499	0.372
DOC_PP2B_PxIxI_1	369	375	PF00149	0.301
DOC_PP4_FxxP_1	43	46	PF00568	0.660
DOC_PP4_FxxP_1	602	605	PF00568	0.376
DOC_SPAK_OSR1_1	306	310	PF12202	0.381
DOC_USP7_MATH_1	13	17	PF00917	0.643
DOC_USP7_MATH_1	22	26	PF00917	0.721
DOC_USP7_MATH_1	234	238	PF00917	0.563
DOC_USP7_MATH_1	333	337	PF00917	0.419
DOC_USP7_MATH_1	484	488	PF00917	0.309
DOC_USP7_MATH_1	97	101	PF00917	0.695
DOC_USP7_UBL2_3	310	314	PF12436	0.374
DOC_USP7_UBL2_3	578	582	PF12436	0.372
DOC_WW_Pin1_4	444	449	PF00397	0.291
DOC_WW_Pin1_4	548	553	PF00397	0.372
DOC_WW_Pin1_4	90	95	PF00397	0.585
LIG_14-3-3_CanoR_1	235	239	PF00244	0.512
LIG_14-3-3_CanoR_1	265	275	PF00244	0.616
LIG_14-3-3_CanoR_1	294	303	PF00244	0.439
LIG_14-3-3_CanoR_1	39	44	PF00244	0.689
LIG_14-3-3_CanoR_1	8	18	PF00244	0.661
LIG_Actin_WH2_2	169	185	PF00022	0.474
LIG_Actin_WH2_2	396	413	PF00022	0.366
LIG_BIR_III_4	520	524	PF00653	0.279
LIG_BRCT_BRCA1_1	129	133	PF00533	0.535
LIG_BRCT_BRCA1_1	278	282	PF00533	0.275
LIG_BRCT_BRCA1_1	82	86	PF00533	0.622
LIG_deltaCOP1_diTrp_1	355	362	PF00928	0.363
LIG_deltaCOP1_diTrp_1	618	622	PF00928	0.321
LIG_EH1_1	132	140	PF00400	0.481
LIG_eIF4E_1	555	561	PF01652	0.319
LIG_FHA_1	145	151	PF00498	0.572
LIG_FHA_1	194	200	PF00498	0.513
LIG_FHA_1	445	451	PF00498	0.286
LIG_FHA_1	489	495	PF00498	0.433
LIG_FHA_2	329	335	PF00498	0.622
LIG_LIR_Apic_2	41	46	PF02991	0.672
LIG_LIR_Apic_2	499	504	PF02991	0.357
LIG_LIR_Apic_2	599	605	PF02991	0.287
LIG_LIR_Gen_1	509	519	PF02991	0.368
LIG_LIR_Nem_3	103	109	PF02991	0.575
LIG_LIR_Nem_3	269	275	PF02991	0.460
LIG_LIR_Nem_3	499	503	PF02991	0.335
LIG_LIR_Nem_3	509	515	PF02991	0.347
LIG_NRBOX	147	153	PF00104	0.468
LIG_NRBOX	537	543	PF00104	0.339
LIG_Pex14_2	282	286	PF04695	0.315
LIG_Pex14_2	86	90	PF04695	0.623
LIG_SH2_CRK	179	183	PF00017	0.435
LIG_SH2_CRK	272	276	PF00017	0.283
LIG_SH2_CRK	501	505	PF00017	0.366
LIG_SH2_CRK	613	617	PF00017	0.356
LIG_SH2_GRB2like	555	558	PF00017	0.295
LIG_SH2_NCK_1	501	505	PF00017	0.318
LIG_SH2_NCK_1	613	617	PF00017	0.352
LIG_SH2_SRC	512	515	PF00017	0.416
LIG_SH2_SRC	589	592	PF00017	0.327
LIG_SH2_STAT5	106	109	PF00017	0.556
LIG_SH2_STAT5	181	184	PF00017	0.531
LIG_SH2_STAT5	217	220	PF00017	0.556
LIG_SH2_STAT5	296	299	PF00017	0.385
LIG_SH2_STAT5	378	381	PF00017	0.344
LIG_SH2_STAT5	501	504	PF00017	0.366
LIG_SH2_STAT5	514	517	PF00017	0.343
LIG_SH2_STAT5	555	558	PF00017	0.369
LIG_SH3_3	478	484	PF00018	0.318
LIG_SH3_3	55	61	PF00018	0.673
LIG_SH3_3	91	97	PF00018	0.544
LIG_SUMO_SIM_anti_2	447	453	PF11976	0.290
LIG_SUMO_SIM_par_1	371	376	PF11976	0.296
LIG_TYR_ITIM	611	616	PF00017	0.328
MOD_CK1_1	100	106	PF00069	0.680
MOD_CK1_1	16	22	PF00069	0.701
MOD_CK1_1	3	9	PF00069	0.610
MOD_CK1_1	30	36	PF00069	0.666
MOD_CK1_1	320	326	PF00069	0.496
MOD_CK1_1	336	342	PF00069	0.539
MOD_CK1_1	385	391	PF00069	0.252
MOD_CK1_1	487	493	PF00069	0.428
MOD_CK1_1	600	606	PF00069	0.387
MOD_CK1_1	79	85	PF00069	0.687
MOD_CK2_1	234	240	PF00069	0.541
MOD_CK2_1	328	334	PF00069	0.639
MOD_CK2_1	548	554	PF00069	0.394
MOD_GlcNHglycan	189	192	PF01048	0.355
MOD_GlcNHglycan	25	28	PF01048	0.557
MOD_GlcNHglycan	268	271	PF01048	0.351
MOD_GlcNHglycan	276	279	PF01048	0.286
MOD_GlcNHglycan	319	322	PF01048	0.724
MOD_GlcNHglycan	34	38	PF01048	0.524
MOD_GlcNHglycan	340	343	PF01048	0.676
MOD_GSK3_1	17	24	PF00069	0.689
MOD_GSK3_1	187	194	PF00069	0.499
MOD_GSK3_1	219	226	PF00069	0.519
MOD_GSK3_1	295	302	PF00069	0.415
MOD_GSK3_1	328	335	PF00069	0.563
MOD_GSK3_1	381	388	PF00069	0.329
MOD_GSK3_1	440	447	PF00069	0.451
MOD_GSK3_1	484	491	PF00069	0.306
MOD_GSK3_1	526	533	PF00069	0.236
MOD_GSK3_1	76	83	PF00069	0.514
MOD_GSK3_1	9	16	PF00069	0.675
MOD_N-GLC_1	144	149	PF02516	0.381
MOD_N-GLC_1	504	509	PF02516	0.545
MOD_NEK2_1	276	281	PF00069	0.343
MOD_NEK2_1	386	391	PF00069	0.295
MOD_NEK2_1	488	493	PF00069	0.376
MOD_NEK2_1	506	511	PF00069	0.347
MOD_NEK2_1	527	532	PF00069	0.327
MOD_NEK2_1	597	602	PF00069	0.347
MOD_NEK2_1	612	617	PF00069	0.355
MOD_NEK2_1	621	626	PF00069	0.320
MOD_NEK2_2	284	289	PF00069	0.292
MOD_PIKK_1	115	121	PF00454	0.712
MOD_PIKK_1	228	234	PF00454	0.495
MOD_PIKK_1	506	512	PF00454	0.356
MOD_PIKK_1	621	627	PF00454	0.238
MOD_PIKK_1	76	82	PF00454	0.479
MOD_PK_1	438	444	PF00069	0.270
MOD_PKA_1	39	45	PF00069	0.560
MOD_PKA_2	234	240	PF00069	0.515
MOD_PKA_2	3	9	PF00069	0.598
MOD_PKA_2	30	36	PF00069	0.626
MOD_PKA_2	343	349	PF00069	0.418
MOD_PKA_2	38	44	PF00069	0.587
MOD_Plk_1	33	39	PF00069	0.603
MOD_Plk_1	406	412	PF00069	0.416
MOD_Plk_1	597	603	PF00069	0.335
MOD_Plk_4	234	240	PF00069	0.501
MOD_Plk_4	39	45	PF00069	0.579
MOD_Plk_4	490	496	PF00069	0.288
MOD_Plk_4	80	86	PF00069	0.560
MOD_ProDKin_1	444	450	PF00069	0.286
MOD_ProDKin_1	548	554	PF00069	0.373
MOD_ProDKin_1	90	96	PF00069	0.588
TRG_DiLeu_BaEn_1	214	219	PF01217	0.538
TRG_ENDOCYTIC_2	179	182	PF00928	0.537
TRG_ENDOCYTIC_2	272	275	PF00928	0.304
TRG_ENDOCYTIC_2	512	515	PF00928	0.362
TRG_ENDOCYTIC_2	613	616	PF00928	0.350
TRG_ER_diArg_1	265	267	PF00400	0.659
TRG_ER_diArg_1	349	351	PF00400	0.419
TRG_ER_diArg_1	38	40	PF00400	0.657
TRG_ER_diArg_1	564	566	PF00400	0.457
TRG_ER_diArg_1	67	69	PF00400	0.697
TRG_NES_CRM1_1	408	423	PF08389	0.361
TRG_NES_CRM1_1	513	525	PF08389	0.368
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	40%	97%
A0A0N1PB02	Leptomonas seymouri	48%	97%
A0A0S4J6C6	Bodo saltans	43%	98%
A0A1X0P9A6	Trypanosomatidae	42%	93%
A0A3Q8IHH1	Leishmania donovani	37%	87%
A0A3R7K2Y9	Trypanosoma rangeli	50%	93%
A0A3S5H668	Leishmania donovani	47%	100%
A0A3S5H669	Leishmania donovani	94%	100%
A0A3S7X835	Leishmania donovani	45%	100%
A4H5C9	Leishmania braziliensis	44%	100%
A4H5D0	Leishmania braziliensis	75%	99%
A4HAZ7	Leishmania braziliensis	43%	98%
A4HAZ9	Leishmania braziliensis	44%	100%
A4HB01	Leishmania braziliensis	45%	100%
A4HTM0	Leishmania infantum	47%	100%
A4HTM1	Leishmania infantum	94%	100%
A4IA57	Leishmania infantum	45%	100%
C6K3V8	Leptomonas seymouri	44%	100%
C6K3V9	Leptomonas seymouri	71%	97%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	94%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q1U8	Leishmania major	38%	100%
Q4Q2R4	Leishmania major	46%	99%
Q4Q310	Leishmania major	37%	100%
Q4Q312	Leishmania major	37%	100%
Q4Q340	Leishmania major	38%	100%
Q4Q342	Leishmania major	38%	100%
Q4QI90	Leishmania major	91%	100%
Q4QI91	Leishmania major	44%	93%