Putative tuzin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Putative tuzin

Gene product:

tuzin, putative

Species:

Leishmania mexicana

UniProt:

E9AME6_LEIMU

TriTrypDb:

LmxM.08.0780

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

E9AME6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AME6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	16	22	PF00089	0.402
CLV_MEL_PAP_1	422	428	PF00089	0.451
CLV_NRD_NRD_1	126	128	PF00675	0.279
CLV_NRD_NRD_1	193	195	PF00675	0.630
CLV_NRD_NRD_1	268	270	PF00675	0.550
CLV_NRD_NRD_1	350	352	PF00675	0.507
CLV_NRD_NRD_1	424	426	PF00675	0.588
CLV_NRD_NRD_1	437	439	PF00675	0.603
CLV_NRD_NRD_1	91	93	PF00675	0.334
CLV_PCSK_KEX2_1	193	195	PF00082	0.657
CLV_PCSK_KEX2_1	350	352	PF00082	0.507
CLV_PCSK_KEX2_1	424	426	PF00082	0.590
CLV_PCSK_KEX2_1	437	439	PF00082	0.628
CLV_PCSK_KEX2_1	90	92	PF00082	0.338
CLV_PCSK_SKI1_1	149	153	PF00082	0.386
CLV_PCSK_SKI1_1	22	26	PF00082	0.375
CLV_PCSK_SKI1_1	236	240	PF00082	0.601
CLV_PCSK_SKI1_1	273	277	PF00082	0.494
CLV_PCSK_SKI1_1	292	296	PF00082	0.563
CLV_PCSK_SKI1_1	315	319	PF00082	0.631
CLV_PCSK_SKI1_1	385	389	PF00082	0.644
CLV_PCSK_SKI1_1	454	458	PF00082	0.461
CLV_PCSK_SKI1_1	493	497	PF00082	0.583
DEG_APCC_DBOX_1	235	243	PF00400	0.426
DEG_APCC_DBOX_1	453	461	PF00400	0.372
DEG_APCC_DBOX_1	94	102	PF00400	0.537
DEG_Nend_UBRbox_2	1	3	PF02207	0.595
DOC_MAPK_DCC_7	318	328	PF00069	0.344
DOC_MAPK_gen_1	105	114	PF00069	0.554
DOC_MAPK_gen_1	124	134	PF00069	0.498
DOC_MAPK_gen_1	269	280	PF00069	0.333
DOC_MAPK_gen_1	90	100	PF00069	0.570
DOC_MAPK_MEF2A_6	269	278	PF00069	0.301
DOC_MAPK_MEF2A_6	318	327	PF00069	0.352
DOC_PP1_RVXF_1	371	377	PF00149	0.319
DOC_PP1_RVXF_1	95	101	PF00149	0.439
DOC_PP2B_PxIxI_1	246	252	PF00149	0.311
DOC_USP7_MATH_1	10	14	PF00917	0.607
DOC_USP7_MATH_1	360	364	PF00917	0.280
DOC_USP7_MATH_1	55	59	PF00917	0.509
DOC_WW_Pin1_4	215	220	PF00397	0.526
DOC_WW_Pin1_4	4	9	PF00397	0.608
LIG_14-3-3_CanoR_1	127	131	PF00244	0.525
LIG_14-3-3_CanoR_1	194	200	PF00244	0.428
LIG_14-3-3_CanoR_1	493	501	PF00244	0.357
LIG_14-3-3_CanoR_1	68	77	PF00244	0.558
LIG_APCC_ABBAyCdc20_2	273	279	PF00400	0.357
LIG_deltaCOP1_diTrp_1	158	164	PF00928	0.588
LIG_deltaCOP1_diTrp_1	492	496	PF00928	0.325
LIG_FHA_1	233	239	PF00498	0.249
LIG_FHA_1	286	292	PF00498	0.388
LIG_FHA_1	41	47	PF00498	0.578
LIG_FHA_1	495	501	PF00498	0.343
LIG_FHA_1	76	82	PF00498	0.606
LIG_FHA_2	207	213	PF00498	0.448
LIG_FHA_2	23	29	PF00498	0.722
LIG_FHA_2	327	333	PF00498	0.353
LIG_IRF3_LxIS_1	361	367	PF10401	0.237
LIG_LIR_Apic_2	375	380	PF02991	0.343
LIG_LIR_Gen_1	14	24	PF02991	0.519
LIG_LIR_Gen_1	304	313	PF02991	0.330
LIG_LIR_Gen_1	74	84	PF02991	0.477
LIG_LIR_Nem_3	14	20	PF02991	0.579
LIG_LIR_Nem_3	158	164	PF02991	0.566
LIG_LIR_Nem_3	173	179	PF02991	0.287
LIG_LIR_Nem_3	304	308	PF02991	0.340
LIG_LIR_Nem_3	375	379	PF02991	0.320
LIG_MYND_3	296	300	PF01753	0.279
LIG_NRBOX	97	103	PF00104	0.527
LIG_Pex14_2	185	189	PF04695	0.379
LIG_SH2_CRK	377	381	PF00017	0.352
LIG_SH2_CRK	487	491	PF00017	0.356
LIG_SH2_NCK_1	377	381	PF00017	0.304
LIG_SH2_NCK_1	487	491	PF00017	0.351
LIG_SH2_PTP2	17	20	PF00017	0.593
LIG_SH2_SRC	487	490	PF00017	0.373
LIG_SH2_STAP1	357	361	PF00017	0.325
LIG_SH2_STAP1	77	81	PF00017	0.468
LIG_SH2_STAT3	163	166	PF00017	0.607
LIG_SH2_STAT3	192	195	PF00017	0.353
LIG_SH2_STAT3	431	434	PF00017	0.291
LIG_SH2_STAT5	125	128	PF00017	0.560
LIG_SH2_STAT5	163	166	PF00017	0.534
LIG_SH2_STAT5	17	20	PF00017	0.567
LIG_SH2_STAT5	305	308	PF00017	0.333
LIG_SH2_STAT5	390	393	PF00017	0.350
LIG_SH2_STAT5	431	434	PF00017	0.352
LIG_SH2_STAT5	465	468	PF00017	0.394
LIG_SH2_STAT5	77	80	PF00017	0.548
LIG_SH3_3	216	222	PF00018	0.509
LIG_SH3_3	366	372	PF00018	0.320
LIG_SUMO_SIM_anti_2	60	66	PF11976	0.645
LIG_SUMO_SIM_par_1	322	329	PF11976	0.346
LIG_SUMO_SIM_par_1	60	66	PF11976	0.583
LIG_TRAF2_1	229	232	PF00917	0.383
LIG_TYR_ITIM	485	490	PF00017	0.330
LIG_UBA3_1	132	137	PF00899	0.439
MOD_CK1_1	334	340	PF00069	0.356
MOD_CK1_1	40	46	PF00069	0.603
MOD_CK1_1	69	75	PF00069	0.644
MOD_CK2_1	326	332	PF00069	0.323
MOD_CK2_1	424	430	PF00069	0.368
MOD_GlcNHglycan	168	171	PF01048	0.286
MOD_GlcNHglycan	172	175	PF01048	0.279
MOD_GlcNHglycan	265	268	PF01048	0.570
MOD_GlcNHglycan	470	473	PF01048	0.577
MOD_GlcNHglycan	85	88	PF01048	0.350
MOD_GSK3_1	166	173	PF00069	0.446
MOD_GSK3_1	204	211	PF00069	0.429
MOD_GSK3_1	259	266	PF00069	0.341
MOD_GSK3_1	307	314	PF00069	0.422
MOD_GSK3_1	360	367	PF00069	0.278
MOD_N-GLC_1	340	345	PF02516	0.515
MOD_N-GLC_1	40	45	PF02516	0.381
MOD_NEK2_1	126	131	PF00069	0.494
MOD_NEK2_1	242	247	PF00069	0.408
MOD_NEK2_1	263	268	PF00069	0.309
MOD_NEK2_1	326	331	PF00069	0.314
MOD_NEK2_1	364	369	PF00069	0.349
MOD_NEK2_1	403	408	PF00069	0.324
MOD_NEK2_1	47	52	PF00069	0.691
MOD_NEK2_2	180	185	PF00069	0.285
MOD_PIKK_1	55	61	PF00454	0.613
MOD_PIKK_1	69	75	PF00454	0.604
MOD_PK_1	424	430	PF00069	0.376
MOD_PKA_1	424	430	PF00069	0.417
MOD_PKA_2	126	132	PF00069	0.521
MOD_PKA_2	232	238	PF00069	0.311
MOD_PKA_2	424	430	PF00069	0.368
MOD_PKA_2	69	75	PF00069	0.600
MOD_Plk_1	283	289	PF00069	0.391
MOD_Plk_1	334	340	PF00069	0.302
MOD_Plk_1	391	397	PF00069	0.415
MOD_Plk_4	180	186	PF00069	0.237
MOD_Plk_4	259	265	PF00069	0.283
MOD_Plk_4	340	346	PF00069	0.334
MOD_ProDKin_1	215	221	PF00069	0.526
MOD_ProDKin_1	4	10	PF00069	0.595
MOD_SUMO_rev_2	266	275	PF00179	0.347
MOD_SUMO_rev_2	427	436	PF00179	0.266
TRG_DiLeu_BaEn_1	147	152	PF01217	0.589
TRG_DiLeu_BaEn_1	322	327	PF01217	0.313
TRG_DiLeu_BaEn_2	461	467	PF01217	0.251
TRG_DiLeu_BaEn_2	95	101	PF01217	0.504
TRG_ENDOCYTIC_2	168	171	PF00928	0.296
TRG_ENDOCYTIC_2	17	20	PF00928	0.593
TRG_ENDOCYTIC_2	305	308	PF00928	0.333
TRG_ENDOCYTIC_2	487	490	PF00928	0.352
TRG_ENDOCYTIC_2	77	80	PF00928	0.538
TRG_ER_diArg_1	192	194	PF00400	0.457
TRG_ER_diArg_1	350	352	PF00400	0.291
TRG_ER_diArg_1	424	426	PF00400	0.435
TRG_ER_diArg_1	436	438	PF00400	0.442
TRG_ER_diArg_1	68	71	PF00400	0.640
TRG_ER_diArg_1	89	92	PF00400	0.564
TRG_NES_CRM1_1	285	300	PF08389	0.348
TRG_NES_CRM1_1	416	430	PF08389	0.263
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	42%	77%
A0A0N1PB02	Leptomonas seymouri	52%	78%
A0A0S4J6C6	Bodo saltans	42%	79%
A0A1X0P9A6	Trypanosomatidae	51%	75%
A0A3Q8IHH1	Leishmania donovani	39%	70%
A0A3R7K2Y9	Trypanosoma rangeli	49%	74%
A0A3S5H668	Leishmania donovani	93%	100%
A0A3S5H669	Leishmania donovani	48%	80%
A0A3S7X835	Leishmania donovani	50%	91%
A4H5C9	Leishmania braziliensis	76%	100%
A4H5D0	Leishmania braziliensis	44%	100%
A4HAZ7	Leishmania braziliensis	45%	100%
A4HAZ9	Leishmania braziliensis	47%	100%
A4HB01	Leishmania braziliensis	47%	100%
A4HTM0	Leishmania infantum	93%	100%
A4HTM1	Leishmania infantum	46%	80%
A4IA57	Leishmania infantum	50%	91%
C6K3V8	Leptomonas seymouri	80%	84%
C6K3V9	Leptomonas seymouri	43%	78%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	75%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	80%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	92%
Q4Q1U8	Leishmania major	39%	100%
Q4Q2R4	Leishmania major	51%	100%
Q4Q310	Leishmania major	39%	100%
Q4Q312	Leishmania major	38%	100%
Q4Q340	Leishmania major	39%	100%
Q4Q342	Leishmania major	39%	100%
Q4QI90	Leishmania major	47%	100%
Q4QI91	Leishmania major	92%	100%