J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AME4_LEIMU

TriTrypDb:

LmxM.08.0650

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AME4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AME4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	277	279	PF00675	0.529
CLV_NRD_NRD_1	47	49	PF00675	0.278
CLV_NRD_NRD_1	70	72	PF00675	0.453
CLV_NRD_NRD_1	97	99	PF00675	0.753
CLV_PCSK_KEX2_1	277	279	PF00082	0.529
CLV_PCSK_KEX2_1	69	71	PF00082	0.354
CLV_PCSK_KEX2_1	97	99	PF00082	0.753
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.259
CLV_PCSK_SKI1_1	219	223	PF00082	0.643
DEG_Nend_UBRbox_3	1	3	PF02207	0.587
DEG_SCF_FBW7_1	240	246	PF00400	0.626
DOC_CKS1_1	240	245	PF01111	0.625
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.335
DOC_PP1_RVXF_1	224	231	PF00149	0.467
DOC_PP2B_LxvP_1	8	11	PF13499	0.335
DOC_USP7_MATH_1	114	118	PF00917	0.697
DOC_USP7_MATH_1	266	270	PF00917	0.609
DOC_WW_Pin1_4	201	206	PF00397	0.585
DOC_WW_Pin1_4	239	244	PF00397	0.701
DOC_WW_Pin1_4	245	250	PF00397	0.815
DOC_WW_Pin1_4	89	94	PF00397	0.519
LIG_14-3-3_CanoR_1	126	132	PF00244	0.480
LIG_14-3-3_CanoR_1	83	93	PF00244	0.547
LIG_14-3-3_CanoR_1	9	19	PF00244	0.214
LIG_FHA_1	128	134	PF00498	0.589
LIG_FHA_1	170	176	PF00498	0.713
LIG_FHA_1	211	217	PF00498	0.660
LIG_FHA_1	77	83	PF00498	0.558
LIG_FHA_2	1	7	PF00498	0.335
LIG_FHA_2	186	192	PF00498	0.726
LIG_FHA_2	246	252	PF00498	0.536
LIG_Integrin_RGD_1	159	161	PF01839	0.597
LIG_LIR_Apic_2	165	170	PF02991	0.484
LIG_LIR_Gen_1	227	238	PF02991	0.487
LIG_LIR_Gen_1	3	12	PF02991	0.335
LIG_LIR_Nem_3	227	233	PF02991	0.483
LIG_LIR_Nem_3	3	8	PF02991	0.335
LIG_LIR_Nem_3	73	77	PF02991	0.383
LIG_PDZ_Class_2	283	288	PF00595	0.613
LIG_PTB_Apo_2	56	63	PF02174	0.294
LIG_PTB_Phospho_1	56	62	PF10480	0.294
LIG_SH2_CRK	167	171	PF00017	0.715
LIG_SH2_CRK	23	27	PF00017	0.335
LIG_SH2_CRK	5	9	PF00017	0.335
LIG_SH2_CRK	62	66	PF00017	0.453
LIG_SH2_GRB2like	167	170	PF00017	0.713
LIG_SH2_SRC	167	170	PF00017	0.713
LIG_SH2_STAP1	212	216	PF00017	0.550
LIG_SH2_STAP1	74	78	PF00017	0.452
LIG_SH2_STAT5	212	215	PF00017	0.604
LIG_SH2_STAT5	23	26	PF00017	0.214
LIG_SH2_STAT5	77	80	PF00017	0.484
LIG_SH3_3	237	243	PF00018	0.654
LIG_SH3_3	246	252	PF00018	0.654
LIG_SH3_3	262	268	PF00018	0.572
LIG_SH3_3	270	276	PF00018	0.614
LIG_SH3_3	93	99	PF00018	0.562
LIG_SUMO_SIM_anti_2	206	215	PF11976	0.645
MOD_CK1_1	162	168	PF00069	0.495
MOD_CK1_1	201	207	PF00069	0.654
MOD_CK1_1	217	223	PF00069	0.515
MOD_CK1_1	245	251	PF00069	0.716
MOD_CK1_1	84	90	PF00069	0.631
MOD_CK2_1	12	18	PF00069	0.306
MOD_CK2_1	150	156	PF00069	0.720
MOD_CK2_1	185	191	PF00069	0.724
MOD_GlcNHglycan	118	121	PF01048	0.705
MOD_GlcNHglycan	12	15	PF01048	0.389
MOD_GlcNHglycan	147	150	PF01048	0.637
MOD_GlcNHglycan	259	262	PF01048	0.755
MOD_GlcNHglycan	86	89	PF01048	0.669
MOD_GSK3_1	134	141	PF00069	0.530
MOD_GSK3_1	194	201	PF00069	0.601
MOD_GSK3_1	206	213	PF00069	0.620
MOD_GSK3_1	239	246	PF00069	0.734
MOD_N-GLC_1	114	119	PF02516	0.634
MOD_N-GLC_1	38	43	PF02516	0.335
MOD_N-GLC_1	84	89	PF02516	0.586
MOD_NEK2_1	175	180	PF00069	0.659
MOD_PIKK_1	12	18	PF00454	0.344
MOD_PIKK_1	162	168	PF00454	0.521
MOD_Plk_1	114	120	PF00069	0.635
MOD_Plk_1	38	44	PF00069	0.346
MOD_Plk_1	84	90	PF00069	0.595
MOD_Plk_4	206	212	PF00069	0.705
MOD_ProDKin_1	201	207	PF00069	0.584
MOD_ProDKin_1	239	245	PF00069	0.706
MOD_ProDKin_1	89	95	PF00069	0.519
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.453
TRG_ENDOCYTIC_2	23	26	PF00928	0.335
TRG_ENDOCYTIC_2	5	8	PF00928	0.335
TRG_ENDOCYTIC_2	62	65	PF00928	0.459
TRG_ER_diArg_1	276	278	PF00400	0.562
TRG_ER_diArg_1	96	98	PF00400	0.730
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P924	Leptomonas seymouri	32%	100%
A0A3S7WQB1	Leishmania donovani	79%	97%
A4H5G3	Leishmania braziliensis	55%	100%
A4HTL3	Leishmania infantum	78%	97%
Q4QIA4	Leishmania major	82%	99%