Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AME3_LEIMU

TriTrypDb:

LmxM.08.0640

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AME3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AME3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.392
CLV_NRD_NRD_1	281	283	PF00675	0.537
CLV_PCSK_KEX2_1	281	283	PF00082	0.537
DEG_SCF_FBW7_2	55	61	PF00400	0.381
DEG_SPOP_SBC_1	163	167	PF00917	0.396
DOC_CKS1_1	55	60	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.383
DOC_MAPK_MEF2A_6	189	197	PF00069	0.479
DOC_MAPK_MEF2A_6	71	80	PF00069	0.403
DOC_USP7_MATH_1	163	167	PF00917	0.461
DOC_USP7_MATH_1	223	227	PF00917	0.516
DOC_USP7_MATH_1	41	45	PF00917	0.365
DOC_USP7_MATH_1	83	87	PF00917	0.358
DOC_USP7_UBL2_3	67	71	PF12436	0.475
DOC_WW_Pin1_4	54	59	PF00397	0.376
LIG_Actin_WH2_2	167	184	PF00022	0.389
LIG_BRCT_BRCA1_1	245	249	PF00533	0.372
LIG_BRCT_BRCA1_1	99	103	PF00533	0.250
LIG_deltaCOP1_diTrp_1	253	259	PF00928	0.476
LIG_EH_1	234	238	PF12763	0.440
LIG_FHA_1	12	18	PF00498	0.437
LIG_FHA_1	132	138	PF00498	0.453
LIG_FHA_1	173	179	PF00498	0.420
LIG_FHA_1	225	231	PF00498	0.556
LIG_FHA_1	269	275	PF00498	0.372
LIG_FHA_1	29	35	PF00498	0.488
LIG_FHA_1	45	51	PF00498	0.364
LIG_FHA_2	202	208	PF00498	0.392
LIG_FHA_2	248	254	PF00498	0.479
LIG_LIR_Gen_1	106	116	PF02991	0.494
LIG_LIR_Gen_1	242	252	PF02991	0.443
LIG_LIR_Gen_1	257	266	PF02991	0.356
LIG_LIR_LC3C_4	271	276	PF02991	0.381
LIG_LIR_Nem_3	106	111	PF02991	0.483
LIG_LIR_Nem_3	113	119	PF02991	0.566
LIG_LIR_Nem_3	213	219	PF02991	0.390
LIG_LIR_Nem_3	257	262	PF02991	0.356
LIG_SH2_CRK	216	220	PF00017	0.384
LIG_SH2_GRB2like	151	154	PF00017	0.415
LIG_SH2_NCK_1	56	60	PF00017	0.368
LIG_SH2_STAP1	151	155	PF00017	0.496
LIG_SH2_STAT5	145	148	PF00017	0.387
LIG_SH2_STAT5	196	199	PF00017	0.408
LIG_SH2_STAT5	56	59	PF00017	0.385
LIG_SH3_3	185	191	PF00018	0.413
LIG_SUMO_SIM_anti_2	175	182	PF11976	0.384
LIG_SUMO_SIM_anti_2	271	279	PF11976	0.441
LIG_SUMO_SIM_anti_2	290	297	PF11976	0.715
LIG_WRC_WIRS_1	111	116	PF05994	0.612
LIG_WRC_WIRS_1	241	246	PF05994	0.534
LIG_WRC_WIRS_1	66	71	PF05994	0.401
MOD_CK1_1	112	118	PF00069	0.680
MOD_CK1_1	206	212	PF00069	0.428
MOD_CK1_1	243	249	PF00069	0.368
MOD_CK1_1	3	9	PF00069	0.712
MOD_CK1_1	44	50	PF00069	0.369
MOD_CK1_1	54	60	PF00069	0.432
MOD_CK2_1	247	253	PF00069	0.485
MOD_GlcNHglycan	199	202	PF01048	0.607
MOD_GlcNHglycan	2	5	PF01048	0.431
MOD_GlcNHglycan	290	293	PF01048	0.543
MOD_GSK3_1	110	117	PF00069	0.638
MOD_GSK3_1	158	165	PF00069	0.429
MOD_GSK3_1	172	179	PF00069	0.401
MOD_GSK3_1	197	204	PF00069	0.436
MOD_GSK3_1	239	246	PF00069	0.363
MOD_GSK3_1	264	271	PF00069	0.243
MOD_GSK3_1	42	49	PF00069	0.402
MOD_GSK3_1	50	57	PF00069	0.363
MOD_N-GLC_1	157	162	PF02516	0.675
MOD_N-GLC_1	42	47	PF02516	0.656
MOD_NEK2_1	11	16	PF00069	0.587
MOD_NEK2_1	110	115	PF00069	0.599
MOD_NEK2_1	131	136	PF00069	0.506
MOD_NEK2_1	197	202	PF00069	0.403
MOD_NEK2_1	247	252	PF00069	0.519
MOD_NEK2_1	270	275	PF00069	0.339
MOD_NEK2_1	42	47	PF00069	0.285
MOD_NEK2_1	50	55	PF00069	0.320
MOD_NEK2_1	98	103	PF00069	0.453
MOD_NEK2_2	240	245	PF00069	0.532
MOD_NEK2_2	51	56	PF00069	0.282
MOD_PIKK_1	44	50	PF00454	0.359
MOD_PKA_1	281	287	PF00069	0.690
MOD_PKA_2	11	17	PF00069	0.519
MOD_PKA_2	281	287	PF00069	0.684
MOD_Plk_1	157	163	PF00069	0.466
MOD_Plk_1	206	212	PF00069	0.394
MOD_Plk_1	42	48	PF00069	0.493
MOD_Plk_4	11	17	PF00069	0.502
MOD_Plk_4	176	182	PF00069	0.502
MOD_Plk_4	270	276	PF00069	0.381
MOD_Plk_4	46	52	PF00069	0.347
MOD_Plk_4	65	71	PF00069	0.406
MOD_Plk_4	84	90	PF00069	0.257
MOD_Plk_4	98	104	PF00069	0.370
MOD_ProDKin_1	54	60	PF00069	0.376
TRG_DiLeu_BaEn_1	176	181	PF01217	0.382
TRG_DiLeu_BaEn_1	299	304	PF01217	0.648
TRG_DiLeu_LyEn_5	299	304	PF01217	0.700
TRG_ENDOCYTIC_2	216	219	PF00928	0.386
TRG_ER_diArg_1	119	122	PF00400	0.714
TRG_ER_diArg_1	281	283	PF00400	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I287	Leptomonas seymouri	38%	100%
A0A3S7WQ88	Leishmania donovani	73%	100%
A4H5G2	Leishmania braziliensis	56%	96%
A4HTL2	Leishmania infantum	72%	100%
Q4QIA5	Leishmania major	71%	98%