Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AME0_LEIMU

TriTrypDb:

LmxM.08.0600

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AME0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AME0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	51	53	PF00675	0.631
CLV_NRD_NRD_1	99	101	PF00675	0.450
CLV_PCSK_KEX2_1	14	16	PF00082	0.656
CLV_PCSK_KEX2_1	51	53	PF00082	0.631
CLV_PCSK_KEX2_1	98	100	PF00082	0.439
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.656
CLV_PCSK_SKI1_1	14	18	PF00082	0.693
DEG_Nend_UBRbox_2	1	3	PF02207	0.705
DEG_SCF_FBW7_1	41	47	PF00400	0.531
DOC_CKS1_1	41	46	PF01111	0.537
DOC_CYCLIN_RxL_1	11	21	PF00134	0.469
DOC_MAPK_gen_1	14	22	PF00069	0.546
DOC_MAPK_gen_1	51	58	PF00069	0.377
DOC_MAPK_MEF2A_6	51	60	PF00069	0.380
DOC_WW_Pin1_4	138	143	PF00397	0.725
DOC_WW_Pin1_4	40	45	PF00397	0.453
LIG_14-3-3_CanoR_1	129	139	PF00244	0.811
LIG_14-3-3_CanoR_1	15	22	PF00244	0.453
LIG_14-3-3_CanoR_1	51	55	PF00244	0.529
LIG_EH1_1	68	76	PF00400	0.389
LIG_FHA_1	45	51	PF00498	0.433
LIG_GBD_Chelix_1	22	30	PF00786	0.574
LIG_LIR_Nem_3	62	67	PF02991	0.364
LIG_NRP_CendR_1	140	143	PF00754	0.437
LIG_Pex14_1	65	69	PF04695	0.292
LIG_Pex14_2	61	65	PF04695	0.393
LIG_SH2_CRK	84	88	PF00017	0.389
LIG_SH2_NCK_1	84	88	PF00017	0.389
LIG_SH2_STAT5	49	52	PF00017	0.442
LIG_SH3_3	38	44	PF00018	0.699
LIG_SH3_3	53	59	PF00018	0.348
LIG_TYR_ITSM	60	67	PF00017	0.376
MOD_CDK_SPK_2	138	143	PF00069	0.600
MOD_CDK_SPK_2	40	45	PF00069	0.424
MOD_CK1_1	130	136	PF00069	0.810
MOD_GlcNHglycan	111	114	PF01048	0.445
MOD_GlcNHglycan	129	132	PF01048	0.545
MOD_GSK3_1	127	134	PF00069	0.765
MOD_GSK3_1	40	47	PF00069	0.475
MOD_PIKK_1	118	124	PF00454	0.729
MOD_PIKK_1	59	65	PF00454	0.422
MOD_PKA_2	50	56	PF00069	0.427
MOD_PKB_1	107	115	PF00069	0.627
MOD_Plk_1	103	109	PF00069	0.656
MOD_ProDKin_1	40	46	PF00069	0.454
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.559
TRG_ENDOCYTIC_2	64	67	PF00928	0.371
TRG_ENDOCYTIC_2	84	87	PF00928	0.189
TRG_ER_diArg_1	107	110	PF00400	0.615
TRG_ER_diArg_1	50	52	PF00400	0.438
TRG_ER_diArg_1	97	100	PF00400	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC93	Leptomonas seymouri	53%	100%
A0A3S5H661	Leishmania donovani	86%	100%
A4H5E7	Leishmania braziliensis	60%	100%
A4HTK9	Leishmania infantum	87%	100%
Q4QIA9	Leishmania major	80%	100%