Movement protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Movement protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AMD8_LEIMU

TriTrypDb:

LmxM.08.0580

Length:

165

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AMD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.623
CLV_C14_Caspase3-7	132	136	PF00656	0.681
CLV_NRD_NRD_1	101	103	PF00675	0.518
CLV_NRD_NRD_1	155	157	PF00675	0.420
CLV_NRD_NRD_1	69	71	PF00675	0.410
CLV_PCSK_FUR_1	99	103	PF00082	0.492
CLV_PCSK_KEX2_1	155	157	PF00082	0.415
CLV_PCSK_KEX2_1	99	101	PF00082	0.487
CLV_PCSK_SKI1_1	31	35	PF00082	0.620
CLV_PCSK_SKI1_1	70	74	PF00082	0.414
DEG_MDM2_SWIB_1	34	42	PF02201	0.382
DEG_SCF_FBW7_1	1	7	PF00400	0.409
DOC_CKS1_1	1	6	PF01111	0.458
DOC_USP7_MATH_1	117	121	PF00917	0.724
DOC_USP7_MATH_1	15	19	PF00917	0.402
DOC_USP7_MATH_1	159	163	PF00917	0.601
DOC_USP7_MATH_1	24	28	PF00917	0.387
DOC_USP7_MATH_1	29	33	PF00917	0.418
LIG_14-3-3_CanoR_1	109	113	PF00244	0.697
LIG_14-3-3_CanoR_1	23	29	PF00244	0.342
LIG_14-3-3_CterR_2	161	165	PF00244	0.660
LIG_BRCT_BRCA1_1	29	33	PF00533	0.360
LIG_BRCT_BRCA1_1	82	86	PF00533	0.549
LIG_FHA_1	108	114	PF00498	0.652
LIG_FHA_1	38	44	PF00498	0.295
LIG_FHA_1	49	55	PF00498	0.266
LIG_FHA_2	136	142	PF00498	0.642
LIG_FHA_2	8	14	PF00498	0.429
LIG_HCF-1_HBM_1	144	147	PF13415	0.591
LIG_HCF-1_HBM_1	77	80	PF13415	0.546
LIG_LIR_Gen_1	51	60	PF02991	0.223
LIG_LIR_Nem_3	144	150	PF02991	0.650
LIG_LIR_Nem_3	36	42	PF02991	0.307
LIG_LIR_Nem_3	51	56	PF02991	0.201
LIG_LIR_Nem_3	82	88	PF02991	0.653
LIG_MLH1_MIPbox_1	82	86	PF16413	0.549
LIG_Pex14_2	34	38	PF04695	0.409
LIG_SH2_CRK	39	43	PF00017	0.235
LIG_SH2_PTP2	147	150	PF00017	0.635
LIG_SH2_PTP2	53	56	PF00017	0.398
LIG_SH2_STAT3	66	69	PF00017	0.652
LIG_SH2_STAT5	147	150	PF00017	0.635
LIG_SH2_STAT5	39	42	PF00017	0.416
LIG_SH2_STAT5	53	56	PF00017	0.359
LIG_SH2_STAT5	80	83	PF00017	0.683
LIG_SH3_3	9	15	PF00018	0.464
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.300
LIG_SUMO_SIM_par_1	45	51	PF11976	0.212
MOD_CK1_1	105	111	PF00069	0.718
MOD_CK1_1	134	140	PF00069	0.739
MOD_CK1_1	27	33	PF00069	0.355
MOD_CK2_1	101	107	PF00069	0.647
MOD_CK2_1	135	141	PF00069	0.768
MOD_CK2_1	7	13	PF00069	0.433
MOD_GlcNHglycan	104	107	PF01048	0.443
MOD_GlcNHglycan	131	134	PF01048	0.420
MOD_GlcNHglycan	82	85	PF01048	0.346
MOD_GSK3_1	101	108	PF00069	0.702
MOD_GSK3_1	129	136	PF00069	0.722
MOD_GSK3_1	29	36	PF00069	0.422
MOD_NEK2_1	33	38	PF00069	0.357
MOD_NEK2_1	88	93	PF00069	0.567
MOD_NEK2_2	29	34	PF00069	0.377
MOD_PKA_1	100	106	PF00069	0.673
MOD_PKA_2	100	106	PF00069	0.675
MOD_PKA_2	108	114	PF00069	0.710
MOD_PKB_1	99	107	PF00069	0.711
MOD_Plk_1	124	130	PF00069	0.669
MOD_Plk_4	108	114	PF00069	0.651
MOD_Plk_4	15	21	PF00069	0.444
MOD_Plk_4	29	35	PF00069	0.377
TRG_ENDOCYTIC_2	147	150	PF00928	0.643
TRG_ENDOCYTIC_2	39	42	PF00928	0.293
TRG_ENDOCYTIC_2	53	56	PF00928	0.356
TRG_ER_diArg_1	160	163	PF00400	0.658
TRG_ER_diArg_1	99	102	PF00400	0.682
TRG_NLS_MonoExtC_3	69	74	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	46%	78%
A0A3S5H659	Leishmania donovani	75%	99%
A0A3S7WQ87	Leishmania donovani	32%	100%
A4H5C6	Leishmania braziliensis	37%	100%
A4H5C7	Leishmania braziliensis	56%	100%
A4HTK6	Leishmania infantum	32%	100%
A4HTK7	Leishmania infantum	76%	99%
E9AMD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QIB1	Leishmania major	74%	100%
Q4QIB2	Leishmania major	35%	100%