LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AMD7_LEIMU
TriTrypDb:
LmxM.08.0570
Length:
179

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 9
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
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Expansion

Sequence features

E9AMD7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD7

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 139 141 PF00675 0.457
CLV_PCSK_FUR_1 137 141 PF00082 0.451
CLV_PCSK_KEX2_1 139 141 PF00082 0.455
DEG_MDM2_SWIB_1 61 69 PF02201 0.424
DEG_SCF_FBW7_1 1 7 PF00400 0.391
DEG_SPOP_SBC_1 26 30 PF00917 0.347
DOC_CKS1_1 1 6 PF01111 0.435
DOC_CYCLIN_yCln2_LP_2 161 167 PF00134 0.703
DOC_MAPK_gen_1 137 145 PF00069 0.591
DOC_MAPK_MEF2A_6 137 145 PF00069 0.576
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P923 Leptomonas seymouri 40% 85%
A0A3S5H659 Leishmania donovani 36% 100%
A0A3S7WQ87 Leishmania donovani 83% 100%
A4H5C6 Leishmania braziliensis 55% 100%
A4H5C7 Leishmania braziliensis 36% 100%
A4HTK6 Leishmania infantum 83% 100%
A4HTK7 Leishmania infantum 36% 100%
E9AMD8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
Q4QIB1 Leishmania major 34% 100%
Q4QIB2 Leishmania major 82% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS