Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMD7_LEIMU

TriTrypDb:

LmxM.08.0570

Length:

179

Annotations

LeishMANIAdb annotations

This protein family is endemic to Kinetoplastids, might have emerged de novo and also expanded. . The family also contains Leishmaniid members lacking the signal peptide and only having an MTTPA- start sequence

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AMD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.457
CLV_PCSK_FUR_1	137	141	PF00082	0.451
CLV_PCSK_KEX2_1	139	141	PF00082	0.455
DEG_MDM2_SWIB_1	61	69	PF02201	0.424
DEG_SCF_FBW7_1	1	7	PF00400	0.391
DEG_SPOP_SBC_1	26	30	PF00917	0.347
DOC_CKS1_1	1	6	PF01111	0.435
DOC_CYCLIN_yCln2_LP_2	161	167	PF00134	0.703
DOC_MAPK_gen_1	137	145	PF00069	0.591
DOC_MAPK_MEF2A_6	137	145	PF00069	0.576
DOC_USP7_MATH_1	11	15	PF00917	0.410
DOC_USP7_MATH_1	135	139	PF00917	0.692
DOC_USP7_MATH_1	146	150	PF00917	0.680
DOC_USP7_MATH_1	17	21	PF00917	0.415
DOC_WW_Pin1_4	160	165	PF00397	0.682
LIG_14-3-3_CanoR_1	140	146	PF00244	0.726
LIG_BIR_III_4	119	123	PF00653	0.626
LIG_BRCT_BRCA1_1	141	145	PF00533	0.609
LIG_eIF4E_1	66	72	PF01652	0.315
LIG_EVH1_2	56	60	PF00568	0.427
LIG_FHA_1	125	131	PF00498	0.683
LIG_FHA_1	26	32	PF00498	0.351
LIG_FHA_1	5	11	PF00498	0.429
LIG_Pex14_2	61	65	PF04695	0.450
LIG_SH2_PTP2	66	69	PF00017	0.336
LIG_SH2_PTP2	80	83	PF00017	0.451
LIG_SH2_STAT3	48	51	PF00017	0.454
LIG_SH2_STAT5	24	27	PF00017	0.364
LIG_SH2_STAT5	66	69	PF00017	0.428
LIG_SH2_STAT5	80	83	PF00017	0.419
LIG_SH3_3	37	43	PF00018	0.456
LIG_SH3_3	51	57	PF00018	0.478
LIG_SUMO_SIM_par_1	162	169	PF11976	0.579
MOD_CK1_1	106	112	PF00069	0.623
MOD_CK1_1	149	155	PF00069	0.684
MOD_CK1_1	16	22	PF00069	0.426
MOD_CK1_1	160	166	PF00069	0.702
MOD_CK2_1	160	166	PF00069	0.785
MOD_GlcNHglycan	13	16	PF01048	0.560
MOD_GlcNHglycan	33	36	PF01048	0.657
MOD_GlcNHglycan	4	7	PF01048	0.616
MOD_GSK3_1	13	20	PF00069	0.523
MOD_GSK3_1	135	142	PF00069	0.709
MOD_GSK3_1	22	29	PF00069	0.393
MOD_PKA_1	139	145	PF00069	0.661
MOD_PKA_2	139	145	PF00069	0.736
MOD_PKB_1	137	145	PF00069	0.693
MOD_Plk_1	152	158	PF00069	0.706
MOD_Plk_4	22	28	PF00069	0.331
MOD_Plk_4	4	10	PF00069	0.363
MOD_ProDKin_1	160	166	PF00069	0.681
TRG_ENDOCYTIC_2	66	69	PF00928	0.307
TRG_ENDOCYTIC_2	80	83	PF00928	0.313
TRG_ER_diArg_1	137	140	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P923	Leptomonas seymouri	40%	85%
A0A3S5H659	Leishmania donovani	36%	100%
A0A3S7WQ87	Leishmania donovani	83%	100%
A4H5C6	Leishmania braziliensis	55%	100%
A4H5C7	Leishmania braziliensis	36%	100%
A4HTK6	Leishmania infantum	83%	100%
A4HTK7	Leishmania infantum	36%	100%
E9AMD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QIB1	Leishmania major	34%	100%
Q4QIB2	Leishmania major	82%	100%