DCD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMD6_LEIMU

TriTrypDb:

LmxM.08.0560

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD6

PDB structure(s): 7aih_Ad , 7am2_Ad , 7ane_Ad

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	4	6	PF00675	0.761
CLV_PCSK_KEX2_1	4	6	PF00082	0.761
CLV_PCSK_SKI1_1	206	210	PF00082	0.394
CLV_PCSK_SKI1_1	225	229	PF00082	0.362
CLV_PCSK_SKI1_1	74	78	PF00082	0.470
DEG_Nend_UBRbox_3	1	3	PF02207	0.643
DOC_ANK_TNKS_1	30	37	PF00023	0.678
DOC_CDC14_PxL_1	24	32	PF14671	0.614
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.416
DOC_PP2B_LxvP_1	69	72	PF13499	0.430
DOC_USP7_MATH_1	37	41	PF00917	0.724
DOC_WW_Pin1_4	10	15	PF00397	0.726
DOC_WW_Pin1_4	116	121	PF00397	0.742
LIG_14-3-3_CanoR_1	211	216	PF00244	0.499
LIG_14-3-3_CanoR_1	58	68	PF00244	0.435
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.418
LIG_FHA_1	203	209	PF00498	0.404
LIG_FHA_1	98	104	PF00498	0.449
LIG_FHA_2	100	106	PF00498	0.575
LIG_LIR_Gen_1	62	73	PF02991	0.421
LIG_LIR_Nem_3	62	68	PF02991	0.408
LIG_LIR_Nem_3	79	83	PF02991	0.420
LIG_MYND_1	142	146	PF01753	0.453
LIG_MYND_1	47	51	PF01753	0.700
LIG_PDZ_Class_2	232	237	PF00595	0.351
LIG_REV1ctd_RIR_1	153	163	PF16727	0.407
LIG_SH2_CRK	140	144	PF00017	0.501
LIG_SH2_CRK	182	186	PF00017	0.482
LIG_SH2_NCK_1	129	133	PF00017	0.637
LIG_SH2_NCK_1	24	28	PF00017	0.621
LIG_SH2_SRC	140	143	PF00017	0.517
LIG_SH2_SRC	24	27	PF00017	0.628
LIG_SH2_STAP1	170	174	PF00017	0.460
LIG_SH2_STAP1	65	69	PF00017	0.404
LIG_SH2_STAT5	216	219	PF00017	0.368
LIG_SH3_1	140	146	PF00018	0.455
LIG_SH3_3	117	123	PF00018	0.675
LIG_SH3_3	140	146	PF00018	0.367
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.577
LIG_UBA3_1	199	207	PF00899	0.397
MOD_CK1_1	116	122	PF00069	0.681
MOD_CK1_1	54	60	PF00069	0.596
MOD_CK2_1	99	105	PF00069	0.500
MOD_GlcNHglycan	135	138	PF01048	0.547
MOD_GlcNHglycan	97	100	PF01048	0.655
MOD_GSK3_1	112	119	PF00069	0.627
MOD_GSK3_1	15	22	PF00069	0.721
MOD_GSK3_1	95	102	PF00069	0.642
MOD_N-GLC_1	116	121	PF02516	0.676
MOD_N-GLC_1	95	100	PF02516	0.725
MOD_NEK2_1	19	24	PF00069	0.715
MOD_NEK2_1	209	214	PF00069	0.392
MOD_NEK2_2	37	42	PF00069	0.434
MOD_PK_1	211	217	PF00069	0.381
MOD_PKA_2	133	139	PF00069	0.496
MOD_PKA_2	158	164	PF00069	0.412
MOD_Plk_4	173	179	PF00069	0.576
MOD_Plk_4	211	217	PF00069	0.381
MOD_ProDKin_1	10	16	PF00069	0.722
MOD_ProDKin_1	116	122	PF00069	0.738
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.648
TRG_ENDOCYTIC_2	128	131	PF00928	0.610
TRG_ENDOCYTIC_2	182	185	PF00928	0.409
TRG_ENDOCYTIC_2	65	68	PF00928	0.398
TRG_ER_diArg_1	3	5	PF00400	0.757
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9E3	Leptomonas seymouri	73%	83%
A0A1X0NP31	Trypanosomatidae	60%	100%
A0A3R7M469	Trypanosoma rangeli	59%	100%
A0A3S7WQ78	Leishmania donovani	96%	100%
A4H5C5	Leishmania braziliensis	90%	100%
A4HTK5	Leishmania infantum	96%	100%
C9ZPG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q4QIB3	Leishmania major	96%	100%
V5B1E9	Trypanosoma cruzi	59%	100%