Cyclopropane-fatty-acyl-phospholipid synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclopropane-fatty-acyl-phospholipid synthase

Species:

Leishmania mexicana

UniProt:

E9AMD4_LEIMU

TriTrypDb:

LmxM.08.0545

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.426
CLV_NRD_NRD_1	128	130	PF00675	0.346
CLV_NRD_NRD_1	131	133	PF00675	0.383
CLV_NRD_NRD_1	196	198	PF00675	0.267
CLV_NRD_NRD_1	315	317	PF00675	0.336
CLV_NRD_NRD_1	352	354	PF00675	0.229
CLV_PCSK_KEX2_1	128	130	PF00082	0.346
CLV_PCSK_KEX2_1	160	162	PF00082	0.304
CLV_PCSK_KEX2_1	196	198	PF00082	0.236
CLV_PCSK_KEX2_1	315	317	PF00082	0.208
CLV_PCSK_KEX2_1	352	354	PF00082	0.229
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.304
CLV_PCSK_SKI1_1	160	164	PF00082	0.319
CLV_PCSK_SKI1_1	211	215	PF00082	0.272
CLV_PCSK_SKI1_1	303	307	PF00082	0.234
CLV_PCSK_SKI1_1	319	323	PF00082	0.204
CLV_PCSK_SKI1_1	352	356	PF00082	0.210
CLV_PCSK_SKI1_1	384	388	PF00082	0.229
CLV_PCSK_SKI1_1	92	96	PF00082	0.351
DEG_MDM2_SWIB_1	429	437	PF02201	0.371
DEG_Nend_UBRbox_1	1	4	PF02207	0.532
DOC_CYCLIN_RxL_1	349	359	PF00134	0.429
DOC_MAPK_gen_1	128	138	PF00069	0.390
DOC_MAPK_gen_1	257	266	PF00069	0.429
DOC_MAPK_gen_1	303	313	PF00069	0.414
DOC_MAPK_gen_1	440	448	PF00069	0.398
DOC_MAPK_gen_1	91	99	PF00069	0.382
DOC_MAPK_MEF2A_6	176	183	PF00069	0.342
DOC_MAPK_MEF2A_6	306	313	PF00069	0.433
DOC_MAPK_MEF2A_6	326	335	PF00069	0.385
DOC_PP1_RVXF_1	225	232	PF00149	0.371
DOC_USP7_MATH_1	424	428	PF00917	0.426
DOC_USP7_UBL2_3	283	287	PF12436	0.463
DOC_USP7_UBL2_3	91	95	PF12436	0.358
DOC_WW_Pin1_4	472	477	PF00397	0.288
LIG_14-3-3_CanoR_1	217	225	PF00244	0.454
LIG_14-3-3_CanoR_1	329	334	PF00244	0.429
LIG_Actin_WH2_2	246	263	PF00022	0.420
LIG_deltaCOP1_diTrp_1	144	152	PF00928	0.306
LIG_deltaCOP1_diTrp_1	379	387	PF00928	0.429
LIG_FHA_1	235	241	PF00498	0.383
LIG_FHA_1	402	408	PF00498	0.371
LIG_FHA_1	61	67	PF00498	0.586
LIG_FHA_2	240	246	PF00498	0.429
LIG_FHA_2	290	296	PF00498	0.429
LIG_LIR_Apic_2	168	172	PF02991	0.454
LIG_LIR_Gen_1	114	125	PF02991	0.329
LIG_LIR_Gen_1	324	335	PF02991	0.463
LIG_LIR_Gen_1	479	488	PF02991	0.388
LIG_LIR_Gen_1	84	94	PF02991	0.364
LIG_LIR_Nem_3	114	120	PF02991	0.336
LIG_LIR_Nem_3	149	155	PF02991	0.308
LIG_LIR_Nem_3	156	162	PF02991	0.294
LIG_LIR_Nem_3	324	330	PF02991	0.450
LIG_LIR_Nem_3	379	385	PF02991	0.429
LIG_LIR_Nem_3	445	451	PF02991	0.429
LIG_LIR_Nem_3	479	485	PF02991	0.371
LIG_LIR_Nem_3	84	89	PF02991	0.368
LIG_LIR_Nem_3	93	99	PF02991	0.357
LIG_PCNA_yPIPBox_3	176	187	PF02747	0.349
LIG_Pex14_1	381	385	PF04695	0.429
LIG_Pex14_1	425	429	PF04695	0.429
LIG_Pex14_2	323	327	PF04695	0.429
LIG_Pex14_2	429	433	PF04695	0.429
LIG_Pex14_2	447	451	PF04695	0.429
LIG_PTB_Apo_2	204	211	PF02174	0.429
LIG_PTB_Apo_2	410	417	PF02174	0.429
LIG_REV1ctd_RIR_1	156	165	PF16727	0.281
LIG_REV1ctd_RIR_1	207	215	PF16727	0.429
LIG_REV1ctd_RIR_1	345	353	PF16727	0.429
LIG_REV1ctd_RIR_1	445	453	PF16727	0.463
LIG_SH2_CRK	117	121	PF00017	0.369
LIG_SH2_CRK	482	486	PF00017	0.344
LIG_SH2_CRK	69	73	PF00017	0.480
LIG_SH2_NCK_1	220	224	PF00017	0.429
LIG_SH2_NCK_1	482	486	PF00017	0.344
LIG_SH2_PTP2	385	388	PF00017	0.429
LIG_SH2_SRC	203	206	PF00017	0.463
LIG_SH2_STAP1	117	121	PF00017	0.528
LIG_SH2_STAP1	220	224	PF00017	0.429
LIG_SH2_STAP1	482	486	PF00017	0.344
LIG_SH2_STAT5	170	173	PF00017	0.449
LIG_SH2_STAT5	382	385	PF00017	0.429
LIG_SH2_STAT5	405	408	PF00017	0.429
LIG_SH2_STAT5	454	457	PF00017	0.429
LIG_SH2_STAT5	96	99	PF00017	0.420
LIG_SH3_3	118	124	PF00018	0.314
LIG_SH3_3	470	476	PF00018	0.478
LIG_SH3_3	482	488	PF00018	0.483
LIG_SUMO_SIM_anti_2	361	368	PF11976	0.463
LIG_SUMO_SIM_par_1	16	27	PF11976	0.476
LIG_SUMO_SIM_par_1	361	368	PF11976	0.463
LIG_UBA3_1	178	185	PF00899	0.476
LIG_UBA3_1	365	372	PF00899	0.426
LIG_UBA3_1	78	83	PF00899	0.406
LIG_WRC_WIRS_1	344	349	PF05994	0.429
MOD_CDK_SPK_2	472	477	PF00069	0.336
MOD_CK1_1	21	27	PF00069	0.553
MOD_CK1_1	371	377	PF00069	0.429
MOD_CK1_1	394	400	PF00069	0.426
MOD_CK1_1	401	407	PF00069	0.400
MOD_CK1_1	436	442	PF00069	0.429
MOD_CK1_1	59	65	PF00069	0.615
MOD_CK1_1	77	83	PF00069	0.404
MOD_CK2_1	162	168	PF00069	0.350
MOD_CK2_1	239	245	PF00069	0.476
MOD_CK2_1	289	295	PF00069	0.445
MOD_GlcNHglycan	164	167	PF01048	0.402
MOD_GlcNHglycan	376	379	PF01048	0.229
MOD_GlcNHglycan	457	460	PF01048	0.229
MOD_GlcNHglycan	58	61	PF01048	0.472
MOD_GSK3_1	188	195	PF00069	0.449
MOD_GSK3_1	29	36	PF00069	0.701
MOD_GSK3_1	291	298	PF00069	0.390
MOD_GSK3_1	370	377	PF00069	0.429
MOD_GSK3_1	394	401	PF00069	0.371
MOD_GSK3_1	472	479	PF00069	0.288
MOD_GSK3_1	56	63	PF00069	0.633
MOD_N-GLC_1	309	314	PF02516	0.342
MOD_N-GLC_1	433	438	PF02516	0.229
MOD_N-GLC_1	74	79	PF02516	0.437
MOD_N-GLC_2	105	107	PF02516	0.278
MOD_NEK2_1	218	223	PF00069	0.421
MOD_NEK2_1	365	370	PF00069	0.426
MOD_NEK2_1	455	460	PF00069	0.429
MOD_NEK2_2	481	486	PF00069	0.384
MOD_NEK2_2	74	79	PF00069	0.472
MOD_PK_1	329	335	PF00069	0.429
MOD_PKA_1	132	138	PF00069	0.391
MOD_PKA_2	29	35	PF00069	0.560
MOD_Plk_1	24	30	PF00069	0.508
MOD_Plk_1	309	315	PF00069	0.463
MOD_Plk_1	319	325	PF00069	0.408
MOD_Plk_1	433	439	PF00069	0.371
MOD_Plk_4	309	315	PF00069	0.429
MOD_Plk_4	343	349	PF00069	0.429
MOD_Plk_4	401	407	PF00069	0.468
MOD_Plk_4	418	424	PF00069	0.421
MOD_Plk_4	481	487	PF00069	0.395
MOD_Plk_4	74	80	PF00069	0.473
MOD_ProDKin_1	472	478	PF00069	0.291
MOD_SUMO_rev_2	244	251	PF00179	0.429
MOD_SUMO_rev_2	320	327	PF00179	0.463
MOD_SUMO_rev_2	436	442	PF00179	0.371
MOD_SUMO_rev_2	84	94	PF00179	0.340
TRG_DiLeu_BaEn_1	361	366	PF01217	0.426
TRG_DiLeu_BaEn_4	84	90	PF01217	0.342
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.429
TRG_ENDOCYTIC_2	117	120	PF00928	0.365
TRG_ENDOCYTIC_2	344	347	PF00928	0.429
TRG_ENDOCYTIC_2	405	408	PF00928	0.429
TRG_ENDOCYTIC_2	452	455	PF00928	0.429
TRG_ENDOCYTIC_2	482	485	PF00928	0.388
TRG_ENDOCYTIC_2	86	89	PF00928	0.356
TRG_ENDOCYTIC_2	96	99	PF00928	0.363
TRG_ER_diArg_1	127	129	PF00400	0.340
TRG_ER_diArg_1	196	198	PF00400	0.426
TRG_ER_diArg_1	258	261	PF00400	0.463
TRG_ER_diArg_1	314	316	PF00400	0.371
TRG_ER_diArg_1	351	353	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P927	Leptomonas seymouri	72%	100%
A0A3S5H657	Leishmania donovani	89%	100%
A4H5C3	Leishmania braziliensis	80%	100%
A4HTK3	Leishmania infantum	89%	100%
O53732	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
O69687	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
P0A9H7	Escherichia coli (strain K12)	50%	100%
P0A9H8	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	50%	100%