Mitochondrial zinc maintenance protein 1, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMD3_LEIMU

TriTrypDb:

LmxM.08.0540

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMD3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.728
CLV_NRD_NRD_1	133	135	PF00675	0.620
CLV_NRD_NRD_1	214	216	PF00675	0.472
CLV_NRD_NRD_1	227	229	PF00675	0.434
CLV_NRD_NRD_1	245	247	PF00675	0.420
CLV_NRD_NRD_1	82	84	PF00675	0.569
CLV_PCSK_KEX2_1	133	135	PF00082	0.620
CLV_PCSK_KEX2_1	213	215	PF00082	0.478
CLV_PCSK_KEX2_1	226	228	PF00082	0.441
CLV_PCSK_KEX2_1	245	247	PF00082	0.420
CLV_PCSK_KEX2_1	82	84	PF00082	0.569
CLV_PCSK_PC7_1	222	228	PF00082	0.436
CLV_PCSK_SKI1_1	17	21	PF00082	0.547
CLV_PCSK_SKI1_1	200	204	PF00082	0.391
DEG_APCC_DBOX_1	199	207	PF00400	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DOC_PP1_RVXF_1	15	22	PF00149	0.540
DOC_PP2B_LxvP_1	342	345	PF13499	0.600
DOC_USP7_MATH_1	288	292	PF00917	0.660
DOC_WW_Pin1_4	183	188	PF00397	0.467
DOC_WW_Pin1_4	2	7	PF00397	0.547
LIG_14-3-3_CanoR_1	133	139	PF00244	0.486
LIG_14-3-3_CanoR_1	178	184	PF00244	0.507
LIG_14-3-3_CanoR_1	213	218	PF00244	0.454
LIG_14-3-3_CanoR_1	228	237	PF00244	0.436
LIG_BRCT_BRCA1_1	181	185	PF00533	0.486
LIG_BRCT_BRCA1_1	327	331	PF00533	0.583
LIG_Clathr_ClatBox_1	161	165	PF01394	0.573
LIG_DCNL_PONY_1	1	4	PF03556	0.670
LIG_FHA_1	230	236	PF00498	0.439
LIG_FHA_2	272	278	PF00498	0.556
LIG_LIR_Gen_1	262	271	PF02991	0.556
LIG_NRBOX	193	199	PF00104	0.416
LIG_Pex14_2	20	24	PF04695	0.564
LIG_SH2_CRK	199	203	PF00017	0.408
LIG_SH2_CRK	209	213	PF00017	0.535
LIG_SH2_STAP1	138	142	PF00017	0.492
LIG_SH2_STAT5	249	252	PF00017	0.460
LIG_SH3_2	173	178	PF14604	0.615
LIG_SH3_3	167	173	PF00018	0.533
LIG_SH3_3	282	288	PF00018	0.560
LIG_SH3_3	341	347	PF00018	0.620
LIG_SH3_3	56	62	PF00018	0.710
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.507
LIG_TRAF2_1	156	159	PF00917	0.535
LIG_TRAF2_2	113	118	PF00917	0.540
LIG_TYR_ITIM	197	202	PF00017	0.394
MOD_CDK_SPxxK_3	185	192	PF00069	0.450
MOD_CK1_1	77	83	PF00069	0.716
MOD_CK2_1	277	283	PF00069	0.550
MOD_GlcNHglycan	27	30	PF01048	0.622
MOD_GlcNHglycan	316	319	PF01048	0.607
MOD_GlcNHglycan	32	35	PF01048	0.627
MOD_GSK3_1	179	186	PF00069	0.506
MOD_GSK3_1	255	262	PF00069	0.541
MOD_GSK3_1	30	37	PF00069	0.620
MOD_GSK3_1	41	48	PF00069	0.617
MOD_GSK3_1	71	78	PF00069	0.712
MOD_N-GLC_1	255	260	PF02516	0.527
MOD_N-GLC_1	296	301	PF02516	0.660
MOD_NEK2_1	12	17	PF00069	0.571
MOD_NEK2_1	19	24	PF00069	0.623
MOD_NEK2_1	257	262	PF00069	0.569
MOD_NEK2_1	71	76	PF00069	0.651
MOD_NEK2_1	86	91	PF00069	0.574
MOD_NEK2_2	244	249	PF00069	0.509
MOD_PIKK_1	154	160	PF00454	0.686
MOD_PKA_1	213	219	PF00069	0.454
MOD_PKA_2	179	185	PF00069	0.503
MOD_PKA_2	213	219	PF00069	0.454
MOD_PKA_2	244	250	PF00069	0.516
MOD_PKA_2	30	36	PF00069	0.639
MOD_Plk_1	288	294	PF00069	0.642
MOD_Plk_2-3	277	283	PF00069	0.550
MOD_Plk_4	190	196	PF00069	0.525
MOD_Plk_4	277	283	PF00069	0.550
MOD_Plk_4	42	48	PF00069	0.686
MOD_ProDKin_1	183	189	PF00069	0.468
MOD_ProDKin_1	2	8	PF00069	0.549
MOD_SUMO_for_1	331	334	PF00179	0.681
MOD_SUMO_rev_2	184	194	PF00179	0.445
MOD_SUMO_rev_2	273	280	PF00179	0.554
MOD_SUMO_rev_2	319	328	PF00179	0.622
MOD_SUMO_rev_2	334	342	PF00179	0.511
TRG_DiLeu_BaEn_1	190	195	PF01217	0.431
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.536
TRG_ENDOCYTIC_2	199	202	PF00928	0.411
TRG_ENDOCYTIC_2	209	212	PF00928	0.533
TRG_ENDOCYTIC_2	220	223	PF00928	0.471
TRG_ER_diArg_1	133	135	PF00400	0.620
TRG_ER_diArg_1	212	215	PF00400	0.490
TRG_ER_diArg_1	225	228	PF00400	0.431
TRG_ER_diArg_1	81	83	PF00400	0.556
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I921	Leptomonas seymouri	74%	97%
A0A3S7WQ84	Leishmania donovani	91%	100%
A4H5C2	Leishmania braziliensis	86%	100%
A4HTK2	Leishmania infantum	92%	100%
Q4QIB5	Leishmania major	94%	100%